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| 1 | ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner显示文摘对 RNA (ADAR ) 起作用的腺苷脱氨基酶涉及编辑的 adenosine-to-inosine RNA 并且在开发和疾病被含有。这里,我们观察到在人的胚胎的干细胞(hESCs ) 的那 ADAR1 缺乏显著地在 mRNA 和 miRNA 表示与普遍变化影响了 hESC 区别和神经正式就职,包括 self-renewal-related miRNAs 的 upregulation,例如 miR302s。全球编辑分析表明编辑活动的 ADAR1 在神经正式就职之上在 ADAR1 缺乏的 hESCs 贡献很少到改变的 miRNA/mRNA 表示。染色体宽的 iCLIP 研究鉴别 ADAR1 直接绑在 pri-miRNAs 防碍 miRNA 由充当 RNA 有约束力的蛋白质处理。重要地,在神经区别之上在弄空 ADAR1 的 hESCs 观察的 miRNAs 和显型的异常表示能被酶地不活跃的 ADAR1 异种,然而并非由 RNA-binding-null ADAR1 异种颠倒。这些调查结果揭示那 ADAR1,然而并非它的编辑活动,由经由直接 RNA 调整 miRNA 生物的续生说为 hESC 区别和神经正式就职是批评的相互作用。 | Tian Chen Jian-Feng Xiang Shanshan Zhu Siye Chen Qing-Fei Yin Xiao-Ou Zhang Jun Zhang Hua Feng Rui Dong Xue-Jun Li Li Yang Ling-Ling Chen | 2015 | Cell Research2015，25，4： | 10 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | Bone Loss Induced by Simulated Microgravity,Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats显示文摘Objective To better understand the pathological causes of bone loss in a space environment, including microgravity, ionizing radiation, and ultradian rhythms. Methods Sprague Dawley(SD) rats were randomly divided into a baseline group, a control group, a hindlimb suspension group, a radiation group, a ultradian rhythms group and a combined-three-factor group. After four weeks of hindlimb suspension followed by X-ray exposure and/or ultradian rhythms, biomechanical properties, bone mineral density, histological analysis, microstructure parameters, and bone turnover markers were detected to evaluate bone loss in hindlimbs of rats. Results Simulated microgravity or combined-three factors treatment led to a significant decrease in the biomechanical properties of bones, reduction in bone mineral density, and deterioration of trabecular parameters. Ionizing radiation exposure also showed adverse impact while ultradian rhythms had no significant effect on these outcomes. Decrease in the concentration of the turnover markers bone alkaline phosphatase(b ALP), osteocalcin(OCN), and tartrate-resistant acid phosphatase-5 b(TRAP-5 b) in serum was in line with the changes in trabecular parameters. Conclusion Simulated microgravity is the main contributor of bone loss. Radiation also results in deleterious effects but ultradian rhythms has no significant effect. Combined-three factors treatment do not exacerbate bone loss when compared to simulated microgravity treatment alone. | ZHANG Ya Nan SHI Wen Gui LI He HUA Jun Rui FENG Xiu WEI Wen Jun WANG Ju Fang HE Jin Peng LEI Su Wen | 2018 | Biomedical and Environmental Sciences2018，31，2： | 4 |
| 4 | National Nutrition and Health Systematic Survey for Children 0–17 Years of Age in China显示文摘The main purpose of the National Nutrition and Health Systematic Survey for children 0-17 years of age in China(CNHSC)was to collect basic data on the nutrition,development,and health status for children in different regions across China using evidence-based,reliable,and cost-effective approaches.Children and their parents or guardians from seven regions(south,southwest,north,northwest,eastern,central,and northeast China)in China were recruited.A multi-stage stratified randomized sampling method was used.Two provinces were randomly sampled from each of the seven regions,from which one urban district and one rural country were also randomly sampled,resulting in a total of 28 survey counties/districts.Dietary surveys,health examinations,laboratory testing,and questionnaires were used to collect dietary intake,nutritional status,child development,and health status information.Nutrition,health,and lifestyle assessment of children and their parents was determined using the Knowledge Attitude Practice(KAP)survey.Greater than 100,000 children(38,000 children<6 years of age and 66,000 children6-17 years of age)completed the survey.The survey provided comprehensive data on child nutrition and health status for future studies and will serve as the basis for an integrated nutrition and health improvement strategies proposal for children in China. | YANG Zhen Yu ZHANG Qian ZHAI Yi XU Tao WANG Yu Ying CHEN Bo Wen TANG Xue Jun YUAN Xiao Lin FANG Hong Yun ZHU Yan PANG Xue Hong WANG Shuo XU Juan LI Rui Li SI Xiang ZHAO Wen Hua | 2021 | Biomedical and Environmental Sciences2021，34，11： | 3 |
| 5 | Visual Detection of Murray Valley Encephalitis Virus by Reverse Transcription Loop-Mediated Isothermal Amplification显示文摘A sensitive reverse transcription loop-mediated isothermal amplification(RT-LAMP)assay was developed for rapid visual detection of Murray valley encephalitis virus(MVEV)infection.The reaction was performed in one step in a single tube at 63°C for 60 min with the addition of the hydroxynaphthol blue(HNB)dye prior to amplification.The detection limit of the RT-LAMP assay was 100 copies per reaction based on | GONG Rui WANG Han Hua QIN Hong GUO Xiao Ping MA Xue Jun | 2015 | Biomedical and Environmental Sciences2015，28，3： | 3 |
| 6 | A Novel Dimer──Heteropolytungstate with a Vanadium Atom as the Centre ──Synthesis and Structural Characterization of (H_3O)_4[VW_(12)O_(40)Na(H_2O)_4]_2显示文摘A novel dimer tungstovanadate, (H 3O) 4[VW 12 O 40 Na(H 2O) 4] 2, was hydrothermally synthesized and structurally characterized by single crystal X ray diffraction, IR spectra, TGA DSC thermal analysis and polarograpy. The yellowish crystal crystallized in the triclinic system, space group P1, a =1 464 5(3) nm, b =1 468 6(3) nm, c =1 411 1(3) nm, α=111 82(2)°, β=93 17(3)°, γ=117 47(3)°, V =2 210 6(8) nm 3, Z=1, D c=4 552 g·cm -3 , λ (Mo Kα )=0 071 073 nm, μ =31 402 mm -1 , F(000)=2 648, R =0 078 0. The title compound consists of two Keggin structure units linked together with two hydrated sodium cations to form a dimer with a porous structure with the pore dimension of 0 766 nm×0 778 5 nm. [WT5FZ] | LIU Zong rui 1,2 , XU Lin 1, WANG En bo 1,** , PENG Jun 1, HU Chang wen 1 XING Yan 3, LIN Yong hua 3 and JIA Heng qing 3 (1. Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China 2. Inner Mongolia Teac | 2000 | Chemical Research in Chinese Universities2000，16，3： | 2 |
| 7 | Association between Vitamin D Levels and the Risk of Metabolic Syndrome in a Rural Chinese Population显示文摘Metabolic syndrome(MS)is a cluster of metabolic abnormalities that include obesity,dyslipidemia,hyperglycemia,and high blood pressure(BP)[1].Previous studies have shown that the prevalence of MS is increasing in both developing and developed countries[2].Currently,about a quarter of the adult population worldwide have MS,which has become a serious global public health problem. | SUN Hua Lei LONG Shao Rong FU San Xian CHEN Gai Yun WANG Ya Juan LIANG Rui WANG Su Fan ZHANG Li Ke ZHOU Li Wei LU Quan Jun LI Wen Jie | 2021 | Biomedical and Environmental Sciences2021，34，4： | 2 |
| 8 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 9 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 10 | High expression of human augmenter of liver regeneration in E.coli显示文摘INTRODUCTIONHeatstablehepatocytestimulatoryactivityhasbeendescribedintheliverofweanlingratsandpigs.Thisgrowthfactoriscaledhe... | YI Xue Rui, KONG Xiang Ping, ZHANG Yi Jun, TONG Ming Hua, YANG Lian Ping and LI Ru Bin | 1998 | World Journal of Gastroenterology1998，4，5： | 1 |
| 11 | Levofloxacin‐containing Triple and Sequential Therapy or Standard Sequential Therapy as the First Line Treatment for Helicobacter pylori Eradication in China显示文摘 | Juan Qian Feng Ye Jun Zhang Yan‐Mei Yang Hui‐Ming Tu Qi Jiang Li Shang Xiao‐Lin Pan Rui‐Hua Shi Guo‐Xin Zhang | 2012 | Helicobacter2012，，6： | 1 |
| 12 | Positive solutions of a generalized second order three-point boundary value problems显示文摘 | Liang Rui xi Peng Jun Shen Jian hua | 2008 | Appl Math Comput2008，196，： | 1 |
| 13 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 14 | Levofloxacin‐containing Triple and Sequential Therapy or Standard Sequential Therapy as the First Line Treatment for Helicobacter pylori Eradication in China显示文摘 | Juan Qian Feng Ye Jun Zhang Yan‐Mei Yang Hui‐Ming Tu Qi Jiang Li Shang Xiao‐Lin Pan Rui‐Hua Shi Guo‐Xin Zhang | 2012 | Helicobacter2012，，6： | 1 |
| 15 | Hospital based epidemiological study for diabetic retinopathy:study design and preliminary results显示文摘AIM:To describe the design and preliminary results of the hospital based epidemiological study for diabetic retinopathy(HBESDR),an ongoing epidemiological study to estimate the prevalence of diabetic retinopathy(DR) and to elucidate the clinical,anthropometric,biochemical and any other risk factors associated with diabetic retinopathy.METHODS:Totally 2000 diabetes will be recruited from the Diabetes eye clinic in the First Affiliated Hospital of China Medical University.All subjects underwent blood sugar estimation and Oral Glucose Tolerance Test to diagnose diabetes.All diabetes would undergo complete questionnaire,a comprehensive eye examination.Blood and urine would be collected for biochemical investigations.All fundus photographs for any DR will be graded.Participants who need treatment will be sent to the ophthalmic clinic and follow-up interval program for all subjects will be suggested.A computerized database is created for the records.RESULTS:To date,1174 diabetes have been recruited,there were 350(29.81%) DR in all diabetes,most of them were with mild non-proliferative diabetic retinopathy(NPDR)(139,39.71%);71(20.29%) moderate NPDR,66(18.86%) severe NPDR,74(21.14%) proliferative diabetic retinopathy(PDR).Females,longer duration of diabetes,family history of diabetes and hypertension had a statistically significant increase in risk of any DR.CONCLUSION:The study is expected to provide an estimate of the overall prevalence of DR and the prevalence with different duration of diabetes and also a better understanding of the risk factors associated with DR. | Lei Liu Li-Min Liu Yue-Dong Hu Rui Hua Jun Chen Yun Zhou Chao Wan Le-Le Huang Jing-Yang Wu Jin Geng and Lei Chen | 2011 | International Journal of Ophthalmology(English edition)2011，4，5： | 1 |
| 16 | Effects of Cryogenic Treatment on Micro-Mechanical Properties of a Cu-Al Alloy显示文摘 | Wu Lai Lei Liu Lin Qi Mai Shun Liu Jian Hua Zhang Rui Jun | 2012 | Advanced Materials Research2012，，562： | 1 |
| 17 | HTR and GRIN2B Variant Associated with Cognition Dysfunction in Electric Workers显示文摘The frequency of an extremely low frequency electromagnetic field (ELF-EMF) ranges from 3 to 3, 000 Hz. Workers who are exposed to ELF-EMF include electric power installers and repairers, power plant operators, electricians, electrical fitters, other such professionals. The main work categories in an electrical company or for utility work can be defined according to the five main stages of electricity production and distribution. Studies on the central nervous system (CNS) reported depressed activity in the different neurotransmitter systems and decreased protein content in the brains of animals exposed to ELF-EMF. Some studies reported differences with respect to change in brain function after electromagnetic radiation among individuals[1]. | WANG Li Feng LI Hai Juan REN Cai Xia ZOU Yong QIAO Si Mo ZHI Wei Jia WANG Chang Zhen ZHAO Li DONG Ji XU Xin Ping HU Shao Hua PENG Rui Yun HU Xiang Jun | 2019 | Biomedical and Environmental Sciences2019，32，3： | 1 |
| 18 | Modification of alternative splicing in bovine somatic cell nuclear transfer embryos using engineered CRISPR-Cas13d显示文摘Animal cloning can be achieved by somatic cell nuclear transfer(SCNT),but the resulting live birth rate is relatively low.We previously improved the efficiency of bovine SCNT by exogenous melatonin treatment or by overexpression of lysine-specific demethylase 4D(KDM4D)and 4E(KDM4E).In this study,we revealed abundant alternative splicing(AS)transitions during fertilization and embryonic genome activation,and demonstrated abnormal AS in bovine SCNT embryos compared with in vitro fertilized embryos.We used the CRISPR-Cas13d RNA-targeting system to target cis-elements of ABI2 and ZNF106 pre-m RNA to modify AS,thus reducing the ratio of abnormal-isoform SCNT embryos by nearly 50%and achieving a high survival rate(11%–19%).These results indicate that this system may provide an efficient method for bovine cloning,while also paving the way for further improvements in the efficiency of SCNT. | Rui Cheng Xiaoman Zheng Yingmei Wang Xing Ma Xin Liu Wenjun Xu Mengyun Wang Yuanpeng Gao Xupeng Xing Chuan Zhou Hongzheng Sun Zekun Guo Fusheng Quan Jun Liu Song Hua Yongsheng Wang Yong Zhang Xu Liu | 2022 | Science China(Life Sciences)2022，65，11： | 1 |
| 19 | Advances in nuclear detection and readout techniques显示文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community. | Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 20 | The Patterns of Complementary Feeding and Growth among 12 to 23 Month-Old Children in China显示文摘Objective This study aimed to understand the characteristics of dietary patterns among children aged12 to 23 months and discusses the relationship between dietary patterns and the growth of children.Method Cross-sectional data were selected from the National Nutrition and Health Systematic Survey for 0 to 18 year-old children in China(n=2,449)to describe the patterns of complementary feeding and the growth of children.Cluster analysis was used to analyze complementary feeding patterns,and an analysis of variance and Bonferroni test were conducted to analyze the relationship between Z scores and complementary feeding patterns.Results Four dietary patterns were identified among the children via cluster analysis.In Pattern 4(n=104,4.2%),children still consumed milk as their staple food.They displayed the lowest grain,fruit,vegetable,egg,and flesh foods consumption,a medium frequency of breast milk consumption,and a high frequency of dairy product consumption.Pattern 4 had the lowest length-for-age Z scores and weight-for-age Z scores,with-0.10±1.34 and 0.24±1.00,respectively(F=7.940,P<0.001;F=5.317,P<0.001).Conclusion Although China is undergoing rapid urbanization and economic development,there is still a phenomenon of insufficient intake of protein-rich foods and dairy-based dietary patterns at the stage of complementary food introduced among children aged 12 to 23 months. | WANG Shuo MEI Yue MA Zhong Hua ZHAO Wen Hua TANG Xue Jun PANG Xue Hong ZHANG Qian LI Rui Li WANG Yu Ying XU Tao | 2021 | Biomedical and Environmental Sciences2021，34，11： | 0 |
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