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| 1 | Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer显示文摘OBJECTIVE: To investigate the effect of thorascopic administration of ginseng polysaccharides(GPS)plus dendritic cells(DC) on T helper cell type 1/T helper cell type 2(Th1/Th2) balance in patients with non-small cell lung cancer(NSCLC).METHODS: A total of 96 NSCLC patients were divided evenly into two groups. The control group was treated with DCs alone and the treatment group was treated with DCs plus GPS. After DCs and GPS were administered thoracoscopically, once a week,4 times for 30 days, the patients' quality of life was measured with the Functional Assessment of Can-cer Treatment-Lung(FACT-L) questionnaire before and after treatment. Serum interferon-γ(INF-γ), interleukin-4(IL-4), IL-2 and IL-5 were examined before and after treatments.RESULTS: The level of Th1 cytokines(INF-γ, IL-2)and the ratio of Th1/Th2 cytokines(INF-γ/IL-4, IL-2/IL-5) increased in both treatment groups, while Th2cytokines(IL-4, IL-5) and FACT-L scores decreased(P<0.01). Furthermore, after treatment Th1 cytokines(INF-γ, IL-2) and the ratio of Th1/Th2 cytokines(INF-γ/IL-4, IL-2/IL-5) were higher in the DCs +GPS group than in the control group(P<0.05). Conversely, FACT-L scores and Th2 cytokines(IL-4, IL-5)were higher in the control group than in the DCs +GPS group(P<0.05).CONCLUSION: The treatment regime of DCs plus GPS had a greater effect on NSCLC patients' immune function as compared with DCs alone. This was evident by increased expression of Th1 cytokines(INF-γ, IL-2) and the ratio of Th1/Th2(INF-γ/IL-4, IL-2/IL-5), as well as by decreased FACT-L scores and the expression of Th2 cytokines(IL-4,IL-5). | Junjie Ma Huiping Liu Xiaolong Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 41 |
| 2 | The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice显示文摘动脉粥样硬化(作为) 疾病被多重因素导致,包括基因、环境的元素。现在的学习的目的是在致病上调查高胆固醇,高蛋氨酸食谱,和 apolipoprotein E 缺乏(ApoE/) 的全面效果作为。ApoE/ 老鼠用高胆固醇和蛋氨酸饮食被喂 15 个星期导致 hyperlipidemia 和 hyperhomocysteinemia。genomic DNA (gDNA ) 和 B1 的 methylation 层次在大动脉的纸巾的重复元素被两 methylation 依赖的限制分析测量并且嵌套 methylation 特定的聚合酶链反应(PCR ) 。Methylation 顺序偏爱模式是由有限制 endonuclease 消化的 DNA 接受甲基的能力的 assayed。DNA methyltransferase-1 的 mRNA 表示, 3 (DNMT1, 3 ) 被即时 PCR 检测。S-adenosylmethionine (SAM ) 和 S-adenosylhomocysteine (SAH ) 的集中被高效的液体层析决定。结果显示出 gDNA 和 B1 的 hypomethylation 重复元素。DNMT1 的 mRNA 表示被减少。SAM, SAH,和 SAM/SAH 比率的层次被增加。动脉粥样硬化患者损害区域强烈与风险因素相关。DNA demethylation 的分发被喜欢而不是 non-CpG 岛,它可以在 DNA 正直和 genomic 不稳定性上建议 hypomethylation 的主要影响。总的来说,我们的数据不含糊地证明高胆固醇,高蛋氨酸食谱,和 ApoE/ 的全面角色不与一个单个风险因素的角色一致地一致。DNA methylation 模式在这是相当复杂的并且取决于基因背景和许多深奥风险因素。 | Yideng Jiang Huiping Zhang Tao Sun Ju Wang Weiwei Sun Huihui Gong Binbin Yang Yingkang Shi Jun Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 16 |
| 3 | Technology and Experiments of 42CrMo Bearing Ring Forming Based on Casting Ring Blank显示文摘Bearing ring is the crucial component of bearing. With regard to such problems as material waste, low efficiency and high energy consumption in current process of producing large bearing ring, a new process named 'casting-rolling compound forming technology' is researched by taking the typical 42CrMo slew bearing as object. Through theoretical analysis, the design criteria of the main casting-rolling forming parameters are put forward at first. Then the constitutive relationship model of as-cast 42CrMo steel and its mathematical model of dynamic recrystallization are obtained according to the results of the hot compression experiment. By a coupled thermal-mechanical finite element model for radial-axial rolling of bearing ring, the fraction of dynamic recrystallization is calculated and recrystallized grains size are predicated. Meanwhile, the effects of the initial rolling temperature and feed rate of idle roll on material microstructure evolution are analyzed. Finally, the industrial rolling experiment is designed and performed, based on the simulation results. In addition, mechanical and metallographic tests are conducted on rolled bearing ring to get the mechanical parameters and metallographic structure. The experimental data and results show that the mechanical properties of bearing ring produced by casting-rolling compound forming technology are up to industrial standard, and a qualified bearing ring can be successfully formed by employing this new technology. Through the study, a process of forming large bearing ring directly by using casting ring blank is obtained, which could provide an effective theoretical guidance for manufacturing large ring parts. It also has an edge in saving material, lowering energy and improving efficiency. | LI Yongtang JU Li QI Huiping ZHANG Feng CHEN Guozhen WANG Mingli | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 16 |
| 4 | Microstructural characterization of titanium matrix composite coatings reinforced by in situ synthesized TiB + TiC fabricated on Ti6Al4V by laser cladding显示文摘Titanium-based composite coatings reinforced by in situ synthesized TiB and TiC particles between titanium and B4C were successfully fabricated on Ti6Al4V by laser cladding.Phase constituents of the coatings were predicted by thermodynamic calculations in the Ti-B4C-Al and Ti-B-C-Al systems,respectively,and were validated well by X-ray diffraction(XRD) analysis results.Microstructural and metallographic analyses were made by scanning electron microscopy(SEM) and electron probe micro-analysis(EPMA).The results show that the coatings are mainly composed of α-Ti cellular dendrites and the eutecticum in which a large number of needle-shaped TiB and a few equiaxial TiC particles are embedded.C is enriched in α-Ti cellular dendrites and far exceeds the theoretical maximum dissolubility,owing to the extension of saturation during laser cladding.The coatings have a good metallurgical bond with the substrate due to the existence of the dilution zone,in which a great amount of lamella β-Ti grains consisting of a thin needle-shaped martensitic microstructure are present and grow parallel to the heat flux direction;a few TiB and TiC reinforcements are observed at the boundaries of initial β-Ti grains. | LI Jun YU Zhishui WANG Huiping LI Manping | 2010 | Rare Metals2010，29，5： | 16 |
| 5 | Additive manufacturing of Ti-6Al-4V lattice structures with high structural integrity under large compressive deformation显示文摘Additively manufactured Ti-6 Al-4 V lattice structures have found important niche applications. However, they often show insufficient compressive ductility or insufficient structural integrity. In this study,a batch of 45 octahedral Ti-6 Al-4 V lattice structures was manufactured in three different strut diameters(0.5, 1.0, 1.5 mm) by selective electron beam melting(SEBM). The influence of post-SEBM annealing on the compressive deformation characteristics of the lattice structure was investigated. The as-built Ti-6 Al-4 V lattices fragmented when the compressive strain reached 13%–23% depending on strut diameter.Annealing at 950?C(β transus temperature: 995?C) only slightly improved the compressive ductility of the lattice structures. However, annealing at 1050?C(β-annealing) fundamentally changed the compressive deformation mode of the lattice structures. The resultant compressive stress-strain curve was featured by a long smooth plateau and no facture occurred even after significant densification of the lattice structure had taken place(>50% of compressive strain). | Kun Yang Jian Wang Liang Jia Guangyu Yang Huiping Tang Yuanyuan Li | 2019 | Journal of Materials Science & Technology2019，35，2： | 12 |
| 6 | Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice显示文摘Hyperhomocysteinemia (HHcy ) 是为心血管的疾病的一个风险因素并且与心失败有强壮的关联。然而,心脏的织物上的 HHcy 的效果仍然保持不太好理解。阐明在导致 HHcy 的心脏的损害的 p53 依赖的 apoptosis 的角色,我们用高蛋氨酸饮食喂了 ApoE/ 老鼠建立 HHcy 模型。浆液 Hcy,心脏的酶,和类脂化合物被测量。Noxa, DNMT1, caspases-3/9,和 p53 的蛋白质层次被连接酶的 immunosorbent 试金决定。Bcl-2 和 Bax 蛋白质被染色的 immunohistochemistry 检测。S-adenosyl 蛋氨酸和 S-adenosyl homocysteine 集中被高效的液体层析决定。p53 和 DNMT1 的 mRNA 层次被即时聚合酶链反应(PCR ) 分析, p53 的 methylation 层次被嵌套的 methylation-specific-PCR 分析。我们的数据证明浆液 Hcy 和类脂化合物的集中与 N 控制组相比在 Meth 组被增加,它显示模型成功地被建立。p53 和 Noxa 的表示层次在 Meth 组被增加,当 p53 的 methylation 地位是 hypomethylation 时。caspase-3/9 的活动与 N 控制组相比在 Meth 组被增加。另外,染色的 immunohistochemistry 证明 Bax 的表示显著地与 N 控制组相比在 Meth 和 Meth-F 组被增加。在摘要, HHcy 由 p53 依赖的 pro-apoptotic 的起来规定导致心脏的损害联系了基因 Noxa 和 Bax,当 p53 DNA hypomethylation 是在 HHcy 导致的病理学的过程的关键分子的机制时。 | ShengchaoMa Huiping Zhang Weiwei Sun HuiHui Gong YanhuaWang Changjian Ma Ju Wang Chengjian Cao Xiaoling Yang Jue Tian Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 12 |
| 7 | Efficacy and safety of trastuzumab combined with chemotherapy for first-line treatment and beyond progression of HER2-overexpressing advanced breast cancer显示文摘Objective: To observe the efficacy and safety of trastuzumab combined with chemotherapy in patients with human epidermal growth factor receptor 2(HER2)-overexpressing advanced breast cancer.Methods: A total of 90 patients with HER2-overexpressing advanced breast cancer were enrolled in this study. All patients were diagnosed with ductal invasive breast cancer by pathological analysis, and were aged between 31–73 years with a median of 51 years. HER2-positivity was defined as 3(+) staining in immunochemistry or amplification of fluorescence in situ hybridization(FISH, ratio ≥2.0). Trastuzumab was administered in combination with chemotherapy as first-line treatment and beyond progression as a secondline, third-line, and above treatment in 90, 34, 14, and 6 patients, respectively. The chemotherapy regimen was given according to normal clinical practice. The response rate was evaluated every two cycles, and the primary endpoints were progression-free survival(PFS) and overall survival(OS). Survival curves were estimated by using Kaplan-Meier graphs and were compared by using log-rank test statistics. Multivariate analysis was done using Cox's proportional hazards regression model, and the level of significance was P<0.05.Results: All 90 patients received at least one dose of trastuzumab, and efficacy could be evaluated in 85 patients. The median follow-up was 50 months. In total, 72(80.00%) patients had visceral metastasis, and 43(47.78%) patients had progressed after one or more extensive chemotherapy regimens for metastatic diseases. The median PFS for first-line trastuzumab was 10 months(range, 2–59 months), and the median OS after metastasis or initially local advanced disease was 22 months(range, 2–116 months).Conclusions: Trastuzumab combined with chemotherapy was active and well-tolerated as a first-line treatment and even beyond progression in HER2-overexpressing advanced breast cancer as a second-line or third-line treatment. However, its efficacy is certainly less beyond this point. | Huiping Li Bin Shao Yin Yan Guohong Song Xiaoran Liu Jing Wang Xu Liang | 2016 | Chinese Journal of Cancer Research2016，28，3： | 11 |
| 8 | Identification and screening of nitrogenefficient cotton genotypes under low and normal nitrogen environments at the seedling stage显示文摘Background: Large quantities of nitrogen(N) fertilizer applied to cotton cropping systems support high yields but cause adverse environmental impacts such as N_20 emission and water eutrophication. The development of cotton cultivars with higher N use efficiencies suitable for low-N conditions is therefore important for sustainable production. In this study, we evaluated 100 cotton genotypes in 2016 for N use efficiency and related traits at the seedling stage.Methods: Sand culture experiment was conducted with low N levels(0.01 g·kg^(-1)) or normal N levels(0.1 g·kg^(-1)).We investigated plant height, SPAD value(soil plant analysis development chlorophyll meter), dry weight, N accumulation, N utilization efficiency, and N uptake efficiency. Through descriptive statistics, principal component analysis and heatmap clustering analysis, we confirmed the evaluation index system of N-efficient genotypes and the classification of N-efficient genotypes.Results: Significant differences were observed among N levels and genotypes for all agronomic traits and N levels.Coefficients of variation varied greatly and ranged from 6.7~28.8 and 7.4~20.8 under low-N and normal-N treatment, respectively. All traits showed highly significant positive correlations with each other, except SPAD value.The principal components under both N levels were similar, showing that total dry weight, aboveground dry weight, total N accumulation, and N uptake efficiency were important components. We confirmed these four traits as suitable screening indexes for low N tolerance. Based on the results of heatmap clustering and scatter diagram analysis of N efficiency value, 10 genotypes were found low-N tolerant, in which five varieties were inefficient under both low and normal N conditions, while four varieties were found efficient under low-N conditions but inefficient under normal-N conditions. Only one variety was efficient under both low and normal-N conditions. Meanwhile, 20 genotypes were identified as low-N sensitive ones, in which 19 genotypes were inefficient under low-N conditions but efficient under normal-N conditions, one variety was inefficient under both low and normal-N conditions.Conclusion: We preliminarily identified Kashi as a low-N tolerant and N-efficient cotton genotype, and CCRI 64 as a lowN sensitive and N-inefficient cotton genotype. Further studies should be carried out to verify the yield and heritability effect of specific genotypes in the field. | ZHANG Hengheng FU Xiaoqiong WANG Xiangru GUI Huiping DONG Qiang PANG Nianchang WANG Zhun ZHANG Xiling SONG Meizhen | 2018 | Journal of Cotton Research2018，1，2： | 9 |
| 9 | Preliminary analysis on the source properties and seismogenic structure of the 2017 M_s7.0 Jiuzhaigou earthquake显示文摘At GMT time 13:19, August 8, 2017, an Ms7.0 earthquake struck the Jiuzhaigou region in Sichuan Province, China,causing severe damages and casualties. To investigate the source properties, seismogenic structures, and seismic hazards, we systematically analyzed the tectonic environment, crustal velocity structure in the source region, source parameters and rupture process, Coulomb failure stress changes, and 3-D features of the rupture plane of the Jiuzhaigou earthquake. Our results indicate the following:(1) The Jiuzhaigou earthquake occurred on an unmarked fault belonging to the transition zone of the east Kunlun fault system and is located northwest of the Huya fault.(2) Both the mainshock and aftershock rupture zones are located in a region where crustal seismic velocity changes dramatically. Southeast to the source region, shear wave velocity at the middle to lower crust is significantly low, but it rapidly increases northeastward and lies close to the background velocity across the rupture fault.(3) The aftershock zone is narrow and distributes along the northwest-southeast trend, and most aftershocks occur within a depth range of 5–20 km.(4) The focal mechanism of the Jiuzhaigou earthquake indicates a left-lateral strike-slip fault, with strike, dip, and rake angles of 152°, 74° and 8°, respectively. The hypocenter depth measures 20 km, whereas the centroid depth is about 6 km. The co-seismic rupture mainly concentrates at depths of 3–13 km, with a moment magnitude(M_w) of 6.5.(5) The co-seismic rupture also strengthens the Coulomb failure stress at the two ends of the rupture fault and the east segment of the Tazang fault. Aftershocks relocation results together with geological surveys indicate that the causative fault is a near vertical fault with notable spatial variations: dip angle varies within 66°–89° from northwest to southeast and the average dip angle measures ~84°. The results of this work are of fundamental importance for further studies on the source characteristics, tectonic environment, and seismic hazard evaluation of the Jiuzhaigou earthquake. | Zujun XIE Yong ZHENG Huajian YAO Lihua FANG Yong ZHANG Chengli LIU Maomao WANG Bin SHAN Huiping ZHANG Junjie REN Lingyun JI Meiqin SONG | 2018 | Science China Earth Sciences2018，61，3： | 8 |
| 10 | Capecitabine maintenance therapy for XT chemotherapy-sensitive patients with metastatic triple-negative breast cancer显示文摘Objective: To investigate the efficacy and safety of capecitabine maintenance therapy(MT) after initial capecitabine plus docetaxel(XT) chemotherapy in patients with metastatic triple-negative breast cancer(m TNBC).Methods: Fifty-five m TNBC patients treated with XT chemotherapy between May 2007 and June 2013 were retrospectively analyzed. When initial disease control was achieved by the combination chemotherapy, capecitabine was continued for 32 patients(MT), while 23 patients remained without any treatment(nonMT). We compared progression-free survival(PFS) and safety of both groups.Results: The median PFS of 55 patients was 8.1 months, overall median PFS time of 32 patients in the capecitabine MT group and 23 in the non-MT group was 10.1 vs. 6.7 months(P=0.032), respectively. When compared PFS time of maintenance treatment, single-agent capecitabine prolonged PFS by 7.1 months, for non-MT patients, the PFS without any treatment was 3.1 months, and this between-group difference was statistically significant(P=0.003). Adverse events, including of hematologic toxicity, gastrointestinal toxicities, hand-foot syndrome and abnormal liver function were not significantly different between two groups.Conclusions: After initial disease control was achieved with the XT combination chemotherapy, capecitabine MT can significantly prolong PFS time with a favorable safety profile in m TNBC patients. | Xu Liang Lijun Di Guohong Song Ying Yan Chaoying Wang Hanfang Jiang Huiping Li | 2014 | Chinese Journal of Cancer Research2014，26，5： | 8 |
| 11 | Effects of Nd^(3+)on the microstructure and magnetic properties of Ni-Zn ferrites显示文摘Ni0.4Zn0.6Fe2 ? 铁酸盐与 Nd2O3 的不同数量做了的 xNdxO4 (x = 0-0.07 ) 用标准陶器的技术被准备。样品单轴地被压并且在 1250D 的 | FAN Xiufeng REN Huiping ZHANG Yanghuan GUO Shihai WANG Xinlin | 2008 | Rare Metals2008，27，3： | 7 |
| 12 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 13 | Impact factors of fractal analysis of porous structure显示文摘Characterization of pore structure is one of the key problems for fabrication and application research on porous materials. But, complexity of pore structure makes it difficult to characterize pore structure by Euclidean geometry and traditional experimental methods. Fractal theory has been proved effective to characterize the complex pore structure. The box dimension method based on fractal theory was applied to characterizing the pore structure of fiber porous materials by analyzing the electronic scanning microscope (SEM) images of the porous materials in this paper. The influences of image resolution, threshold value, and image magnification on fractal analysis were investigated. The results indicate that such factors greatly affect fractal analysis process and results. The appropriate magnification threshold and fractal analysis are necessary for fractal analysis. | TANG HuiPing, ZHU JiLei, XI ZhengPing, DI XiaoBo, WANG JianYong & AO QingBo State Key Laboratory of Porous Metal Materials, Northwest Institute for Nonferrous Metal Research, Xi’an 710016, China | 2010 | Science China(Technological Sciences)2010，53，2： | 6 |
| 14 | Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism显示文摘Autism spectrum disorder(ASD) encompasses a complex set of developmental neurological disorders,characterized by de?cits in social communication and excessive repetitive behaviors. In recent years, ASD is increasingly being considered as a disease of the synapse.One main type of genetic aberration leading to ASD is gene duplication, and several mouse models have been generated mimicking these mutations. Here, we studied the effects of MECP2 duplication and human chromosome15q11-13 duplication on synaptic development and neural circuit wiring in the mouse sensory cortices. We showed that mice carrying MECP2 duplication had speci?c defects in spine pruning, while the 15q11-13 duplication mouse model had impaired spine formation. Our results demonstrate that spine pathology varies signi?cantly between autism models and that distinct aspects of neural circuit development may be targeted in different ASD mutations.Our results further underscore the importance of gene dosage in normal development and function of the brain. | Miao Wang Huiping Li Toru Takumi Zilong Qiu Xiu Xu Xiang Yu Wen-Jie Bian | 2017 | Neuroscience Bulletin2017，33，2： | 5 |
| 15 | Screening and evaluation of reliable traits of upland cotton(Gossypium hirsutum L.)genotypes for salt tolerance at the seedling growth stage显示文摘Background:Salt stress significantly inhibits the growth,development,and productivity of cotton because of osmotic,ionic,and oxidative stresses.Therefore,the screening and development of salt tolerant cotton cultivars is a key issue towards sustainable agriculture.This study subjected 11 upland cotton genotypes at the seedling growth stage to five different salt concentrations and evaluated their salt tolerance and reliable traits.Results:Several morpho-physiological traits were measured after 10 days of salinity treatment and the salt tolerance performance varied significantly among the tested cotton genotypes.The optimal Na Cl concentration for the evaluation of salt tolerance was 200 mmol·L-1.Membership function value and salt tolerance index were used to identify the most consistent salt tolerance traits.Leaf relative water content and photosynthesis were identified as reliable indicators for salt tolerance at the seedling stage.All considered traits related to salt tolerance indices were significantly and positively correlated with each other except for malondialdehyde.Cluster heat map analysis based on the morpho-physiological salt tolerance-indices clearly discriminated the 11 cotton genotypes into three different salt tolerance clusters.Cluster I represented the salt-tolerant genotypes(Z9807,Z0228,and Z7526)whereas clusters II(Z0710,Z7514,Z1910,and Z7516)and III(Z0102,Z7780,Z9648,and Z9612)represented moderately salttolerant and salt-sensitive genotypes,respectively.Conclusions:A hydroponic screening system was established.Leaf relative water content and photosynthesis were identified as two reliable traits that adequately represented the salt tolerance of cotton genotypes at the seedling growth stage.Furthermore,three salt-tolerant genotypes were identified,which might be used as genetic resources for the salt-tolerance breeding of cotton. | SIKDER Ripon Kumar WANG Xiangru JIN Dingsha ZHANG Hengheng GUI Huiping DONG Qiang PANG Nianchang ZHANG Xiling SONG Meizhen | 2020 | Journal of Cotton Research2020，3，2： | 5 |
| 16 | Gauge field theory of quantum and the mass empirical formulas of lepton and quarks显示文摘In this paper,we discuss the mathematical relation determined by the basic physical constant between three types of quarks and the masses of leptons with charges in detail.First,by further theoretical analysis,we wonderfully see that the result got from the mass empirical formula of quark and charged lepton is identical with the data received by theoretical estimating from the gauge field theory.Second,we also gladly see that the result got from quark and lepton(with charges)mass empirical formula is completely accordant with experiment data.These mass formulas reveal the essential relation between me,mμ,mτ and mq.At the same time,the empirical formula may also derive the mass formula of neu-trinos.As to the mass of neutrinos,at present we only know the square difference of its mass,and so this is meaningful to theoretically estimating the mass. | YOU YangMing ZHANG XueLong WANG BingZhang SHI HuiPing | 2008 | Chinese Science Bulletin2008，53，3： | 5 |
| 17 | Microstructure and mechanical properties of WMoTaNbTi refractory high-entropy alloys fabricated by selective electron beam melting显示文摘WMoTaNbTi RHEAs formed by SEBM with negative defocus distance were investigated.Four scanning speeds were applied,an electron beam with scanning speed at 2.5 m/s completely fused the premixed WMoTaNb alloyed powder and pure Ti powder.Significant vaporization of Nb and Ti elements happened during the formation of WMoTaNbTi RHEAs,however,the single BCC phase remains stable.Weakened solid-solute strengthening caused by elemental vaporization,dropping percentage of Nb and Ti solutes in the matrix as well as improved ductilizing effects with decreasing scanning speeds leads to falling microhardness and better local ductility.Microhardness of scanning speed at 4.0 m/s,3.5 m/s,3.0 m/s and 2.5 m/s is 578±17 HV,576±12 HV,573±10 HV and 511±2 HV,respectively.The as-deposited WMoTaNbTi RHEA formed at a scanning speed of 2.5 m/s displays ultimate strength of 1312 MPa. | Bang Xiao Wenpeng Jia Huiping Tang Jian Wang Lian Zhou | 2022 | Journal of Materials Science & Technology2022，，13： | 4 |
| 18 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 19 | The influence of nitroglycerin on the proliferation of endothelial progenitor cells from peripheral blood of patients with coronary artery disease显示文摘Endothelial 祖先房间(EPC ) 与脉管的修理和动脉粥样硬化患者损害的前进被联系。如果传播 EPC 失去他们的函数,它可以导致冠的动脉疾病(CAD ) 。连续硝化甘油(NTG ) 治疗原因增加了脉管的氧化应力和 endothelial 机能障碍。这研究的目的是在人的外部导出血的 EPC 的增长上调查 NTG 的效果。EPC 文化,从 60 个 CAD 病人镇定、为 712 天有教养,分别地为 72 h 与 NTG (0.0, 0.3, 1.0, 2.0, 7.5, 15.0,和 20.0 mg/l ) 的不同集中被对待。房间计数和 EPC 的 proliferative 活动;脉管的 endothelial 生长因素的层次 -- 一(VEGF -- 一) ,氮的氧化物(没有) 并且 peroxynitrite (在文化媒介的 ONOO ) ;并且在支持者房间的反应的氧种类(ROS ) 的水平被测量。与控制(0.0 mg/l NTG ) 相比,当与 1.0 mg/l NTG 对待并且当 NTG 集中是 7.5 mg/l 时,到达了最大的水平时, EPC 的房间数字和 proliferative 活动被增加。然而,当与 NTG (15.0 mg/l ) 的更高的剂量对待时,有重要减小。同时, VEGF -- 表情与 7.5 mg/l NTG 到达了它的最大的表示,但是逐渐地与 NTG 的更高的剂量由孵化衰退了。在没有水平和 NTG 集中之间有一种线性关系,但是当 EPC 与 0.37.5 mg/l NTG 被孵化时, ONOO 的变化和 ROS 层次都没被发现。然而,当与 15 和 20 mg/l NTG 孵化了时, ONOO 和 ROS 层次显著地被增加。我们的数据证明 NTG 的那中等剂量可以刺激从 CAD 病人孤立的 EPC 的 proliferative 活动。 | Xin Wang Caiyu Zeng Huiping Gong Hong He Mengxin Wang Qin Hu Falin Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 4 |
| 20 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
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