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| 1 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 2 | The First OCCCO Pentadentate Chelates:Osmium Mediated Stepwise Oxidations of Terminal Alkynes by Pyridine N-Oxide显示文摘of main observation and conclusion Oxygen atom transfer reactions between alkynes and heteroarene N-oxides are currently mediated by transition metal,such as gold,ruthenium or rhodium,but they have never been catalyzed by osmium.Herein,we report stepwise oxidations of terminal alkynes mediated by an osmium carbolong complex,using pyridine N-oxide as the oxidant,yielding novel aldehyde-or carboxylic acid-coordinated osmapentalyne derivatives selectively.The mechanism was illustrated by density functional theory calculations,providing a new route for oxygen atom transfer between heteroarene N-oxides and alkynes. | Jianfeng Lin Qiannan Xu Xinlei Lin Yuhui Hua Dafa Chen Yonghong Ruan Hong Zhang Haiping Xia | 2020 | Chinese Journal of Chemistry2020，38，11： | 4 |
| 3 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 4 | In vivo degradation and endothelialization of an iron bioresorbable scaffold显示文摘Detection of in vivo biodegradation is critical for development of next-generation medical devices such as bioresorbable stents or scaffolds(BRSs).In particular,it is urgent to establish a nondestructive approach to examine in vivo degradation of a new-generation coronary stent for interventional treatment based on mammal experiments;otherwise it is not available to semi-quantitatively monitor biodegradation in any clinical trial.Herein,we put forward a semi-quantitative approach to measure degradation of a sirolimus-eluting iron bioresorbable scaffold(IBS)based on optical coherence tomography(OCT)images;this approach was confirmed to be consistent with the present weight-loss measurements,which is,however,a destructive approach.The IBS was fabricated by a metal-polymer composite technique with a polylactide coating on an iron stent.The efficacy as a coronary stent of this new bioresorbable scaffold was compared with that of a permanent metal stent with the name of trade mark Xience,which has been widely used in clinic.The endothelial coverage on IBS was found to be greater than on Xience after implantation in a rabbit model;and our well-designed ultrathin stent exhibited less individual variation.We further examined degradation of the IBSs in both minipig coronary artery and rabbit abdominal aorta models.The present result indicated much faster iron degradation of IBS in the rabbit model than in the porcine model.The semi-quantitative approach to detect biodegradation of IBS and the finding of the species difference might be stimulating for fundamental investigation of biodegradable implants and clinical translation of the next-generation coronary stents. | Wenjiao Lin Hongjie Zhang Wanqian Zhang Haiping Qi Gui Zhang Jie Qian Xin Li Li Qin Haifeng Li Xiang Wang Hong Qiu Xiaoli Shi Wei Zheng Deyuan Zhang Runlin Gao Jiandong Ding | 2021 | Bioactive Materials2021，6，4： | 3 |
| 5 | Alternation of Metal-Bridged Metallacycle Skeletons:From Ruthena- pentalyne to Ruthenapentalene and Ruthenaindene Derivative显示文摘The reaction of ruthenapentalyne with one equivalent of isocyanide led to the formation of a rare ruthenapentalene complex by nucleophilic addition.When excess isocyanides were used,the metal-bridged ruthenaindene derivatives can be isolated and were formed by one carbon of isocyanide insertion into the ruthenacycle.Complexes 3 represent the first metallaindene derivatives with a second-row transition metal at the bridge-head position.The transformations from ruthenapentalyne via ruthenapentalene to ruthenaindene derivatives are of interest and can be extended to the syntheses of other polycyclic ruthenacycles.These unique metallacycles exhibit considerable stability and broad spectral absorption spanning the visible spectrum,enabling their potential applications in photoelectric materials. | Jinhua Li Huijun Kang Kaiyue Zhuo qingde Zhuo Hong Zhang Yu-Mei Lin Haiping Xia | 2018 | Chinese Journal of Chemistry2018，36，12： | 3 |
| 6 | Pollination ecology in China from 1977 to 2017显示文摘China is one of most biodiverse countries in the world, containing at least 10% of all angiosperm species.Therefore, we should anticipate a diverse, pollinator fauna. China also has a long history of applied ethnobiology, including a sustainable agriculture based on apiculture and plant-pollinator interactions.However, the science of pollination ecology is a far younger sub-discipline in China, compared to in the West. Chinese studies in pollination ecology began in the 1970 s. For this review, we compiled a complete reference database(>600 publications) of pollination studies in China. Using this database, we identified and analyzed gaps and limitations in research on the pollination systems of native and naturalized species. Specifically, we asked the following questions: 1) What do we know about the pollination systems of native, Chinese species? 2) How does Chinese pollination ecology compare with the development of pollination research abroad and which aspects of research should be pursued by Chinese anthecologists in the near future? 3) What research on pollination in China will advance our understanding and contribute to our ongoing analyses of endemism and conservation? Subsequently, we segregated and identified prospective lines of future research that are unique to China and can only be done in China. This requires discussing priorities within a systematic approach. | Zongxin Ren Yanhui Zhao Huan Liang Zhibin Tao Hui Tang Haiping Zhang Hong Wang | 2018 | Plant Diversity2018，40，4： | 3 |
| 7 | 多壁碳纳米管负载的碳化钼催化剂在玉米油加氢脱氧反应中的应用显示文摘将多壁碳纳米管负载的碳化钼催化剂用于玉米油的加氢脱氧反应以制备柴油类烃,结果表明,该类催化剂对玉米油加氢脱氧反应具有极高的转化率和选择性.结合XRD、Raman、TEM、IR、TG等催化剂表征技术,考察了载体多壁碳纳米管的预处理条件、管径、表面缺陷浓度等因素对催化剂活性和玉米油加氢脱氧反应的影响.在氢压2.5 MPa、反应温度260℃、搅拌速率500r·min-1的实验条件下反应3h后,玉米油在Mo2C/MWCNT上加氢脱氧制备柴油类烃的反应转化率接近90%,烃类选择性达到了98%. | 曹丹艳 陈平 楼辉 HONG Haiping | 2015 | 浙江大学学报(理学版)2015，42，6： | 2 |
| 8 | Synthesis and characterization of stable osmafuran starting from HC≡CCH(OH)C≡CH and OsHCl(CO)(PPh_3)_3显示文摘This paper presents a new convenient route to prepare osmafuran starting from readily accessible HC≡C CH(OH)C≡CH and OsHCl(CO)(PPh3)3.Treatment of a solution of OsHCl(CO)(PPh3)3 in dichloromethane with HC≡C CH(OH)C≡CH,followed by the addition of acetic acid,produced osmafuran [Os(CHC(PPh3)CO(CH2CH3))Cl(CO)(PPh3)2]Cl(2).2 has been isolated in good yield and fully characterized.1H and 13C NMR spectra show the characteristic downfield chemical shifts of the ring hydrogen and carbon atoms.NMR and X-ray diffraction data provide strong evidence for the aromatic nature of 2.Probably due to the effect of the phosphonium substituent,2 exhibits remarkable thermal stability,air stability and lower reactivity. | ZHANG Hong,LIN Ran,LUO Ming & XIA HaiPing State Key Laboratory for Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China | 2010 | Science China Chemistry2010，53，9： | 2 |
| 9 | Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway显示文摘Cellular senescence is closely associated with age-related diseases.Ovarian aging,a special type of organ senescence,is the pathophysiological foundation of the diseases of the reproductive system.It is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells(HOSEpiCs).To contribute to the research on delaying ovarian aging,we aimed to investigate the novel epigenetic mechanism of melatonin in protecting HOSEpiCs.We discovered that melatonin has antagonistic effects against the oncogene-induced senescence(OIS)of HOSEpiCs.Mechanistically,the oncogene Ras decreased the expression of YTHDF2,which is the reader of RNA-m6A,by stimulating the generation of reactive oxygen species(ROS).Moreover,we found that the suppression of YTHDF2 increased the expression of MAP2K4 and MAP4K4 by enhancing the stability of the transcription of their mRNAs,thereby upregulating the expression of the senescence-associated secretory phenotype(SASP)through the activation of the MAP2K4 and MAP4K4-dependent nuclear factor-κB(NF-κB)signaling pathways.We further determined that melatonin has antagonistic effects against the OIS of HOSEpiCs by inhibiting the ROS-YTHDF2-MAPK-NF-κB pathway.These findings provide key insights into the potential avenues for preventing and treating ovarian aging. | Ruigong Zhu Xian Ji Xuan Wu Jiajing Chen Xuesong Li Hong Jiang Haiping Fu Hui Wang Zhe Lin Xin Tang Shixiu Sun Qingguo Li Bingjian Wang Hongshan Chen | 2022 | Genes & Diseases2022，9，2： | 2 |
| 10 | Predicting chaotic time series with wavelet networks显示文摘 | Cao Liangyue Hong Yiguang Fang Haiping | 1995 | Physica D1995，85，12： | 2 |
| 11 | Heat transfer nanofluids based on carbon nanotubes显示文摘 | Hong Haiping Wensel Jesse Liang Feng | 2007 | Journal of Thermophysics and HeatTransfer2007，21，1： | 1 |
| 12 | Predicting chaotic time series with wavelet networks 显示文摘 | Cao Liangyue Hong Yiguang Fang haiping | 1998 | IEEE Proc1998，，： | 1 |
| 13 | Predicting chaotic time series with wavelet networks显示文摘 | Cao Liangyue Hong Yiguang Fang Haiping | 1995 | Physica D1995，85，： | 1 |
| 14 | Synthesis, Characterization, and Reactivity of Metalla- Chalcogenirenium Compounds显示文摘Chalcogenirenium cations,featuring an unsaturated three-membered organic ring,are limited but known to be synthesizable from alkynes with bulky electron-donating groups.Metalla-chalcogenirenium compounds have been synthesized as stable compounds through the reactions of a cyclic metal-carbyne complex-metallapentalyne with PhSCI,PhSeCI or PhTeCI.As a result of the high strain in the three-membered metallacycles,the metalla-chalcogenirenium cations react readily with the base or chloride ions.These reactions furnish a series of unprecedented chalcogenirenium cations with intact M=C bonds.The intrinsic stabilization effect of aromaticity is further elucidated by density functional calculations. | Ming Luo Yapeng Cai Xinlei Lin Lipeng Long Hong Zhang Haiping Xia | 2021 | Chinese Journal of Chemistry2021，39，6： | 1 |
| 15 | Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver显示文摘 | Lifang Zhang Xiaoman Chu Hong Wang Hao Xie Cen Guo Lijuan Cao Xueyan Zhou Guangji Wang Haiping Hao | 2013 | European Journal of Pharmacology . 2013 (1-3)2013，，1： | 1 |
| 16 | Nickel Complexes with Non-innocent Ligands as Highly Active Electrocatalysts for Hydrogen Evolution显示文摘Rational design of a molecular catalyst for a hydrogen evolution reaction (HER)with both high rates and low overpotential remains a chal- lenge.Here we report a series of Ni-based catalysts incorporating non-innocent ligands and aimed at reduction of the overpotential by reserving electrons in the ligand,which could decouple the correlation between metal center reduction and metal hydride formation.The third-order rate constant of our catalysts can be increased by 2 orders of magnitude without increase of overpotential by altering the substituents in the imide since the electronic effect of substituents can change the kinetics of metal hydride formation dramatically.Furthermore,constructing a proton shuttle in the ligand further improves the activity.The catalyst with both of these features can catalyze HER at a turnover frequency of 2572s^-1 with low concentrations of acid and an extremely high third-order rate constant of 2.7×10^6M^-2·s^-1 at a low overpotential. | Zhixin Chen Tao Wang Tingting Sun Zhiyong Chen Tian Sheng Yu-Hao Hong Zi-Ang Nan Jun Zhu Zhi-You Zhou Haiping Xia Shi-Gang Sun | 2018 | Chinese Journal of Chemistry2018，36，12： | 1 |
| 17 | Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential显示文摘 | Shengjuan Hu Xinning Guo Huahong Xie Yulei Du Yanglin Pan Yongquan Shi Jun Wang Liu Hong Shuang Han Dongtao Zhang Dawei Huang Kedong Zhang Feihu Bai Haiping Jiang Huihong Zhai Yongzhan Nie Kaichun Wu Daiming Fan | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 18 | Predicting Chaotic Time Series with Wavelet Networks显示文摘 | Cao Liangyue Hong Yiguang Fang Haiping | 1995 | Physica D1995，85，： | 1 |
| 19 | Proteome Analysis and Tissue Microarray for Profiling Protein Markers Associated with Lymph Node Metastasis in Colorectal Cancer显示文摘 | Haiping Pei Hong Zhu Shan Zeng | | 0，，： | 1 |
| 20 | Predicting chaotic time series with wavelet networks显示文摘 | Liangyue Cao Yiguang Hong Haiping Fang Guowei He | 1995 | Physica D: Nonlinear Phenomena1995，，1： | 1 |
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