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| 1 | China’s urban expansion from 1990 to 2010 determined with satellite remote sensing显示文摘Based on the same data source of Landsat TM/ETM+ in 1990s,2000s and 2010s,all urban built-up areas in China are mapped mainly by human interpretation.Mapping results were checked and refined by the same analyst with the same set of criteria.The results show during the last 20 years urban areas in China have increased exponentially more than 2 times.The greatest area of urbanization changed from Northeastern provinces in 1990s to the Southeast coast of China in Jiangsu,Guangdong,Shandong,and Zhejiang in 2010s.Urban areas are mostly converted from croplands in China.Approximately 17750 km 2 croplands were converted into urban lands.Furthermore,the conversion from 2000 to 2010 doubled that from 1990 to 2000.During the 20 years,the most urbanized provinces are Jiangsu,Guangdong,Shandong and Zhejiang.We also analyzed built-up areas,gross domestic production (GDP) and population of 147 cities with a population of greater than 500000 in 2009.The result shows coastal cities and resource-based cities are with high economic efficiency per unit of built-up areas,resource-based cities have the highest population density,and the economic efficiency of most coastal provinces are lower than central provinces and Guangdong.The newly created urban expansion dataset is useful in many fields including trend analysis of urbanization in China;simulation of urban development dynamics;analysis of the relationship among urbanization,population growth and migration;studies of carbon emissions and climate change;adaptation of climate change;as well as land use and urban planning and management. | WANG Lei LI CongCong YING Qing CHENG Xiao WANG XiaoYi LI XueYan HU LuanYun LIANG Lu YU Le HUANG HuaBing GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 64 |
| 2 | Black carbon aerosols and their radiative properties in the Pearl River Delta region显示文摘The climatic and environmental effects of atmospheric aerosols are a hot topic in global science community, and radiative properties of the aerosols are one of the important parameters in assessing climatic change. Here we studied the black carbon concentration and absorption coefficient measured with aethalometers, scattering coefficient measured with nephelometers, and single scattering albedo derived at an atmospheric composition watch station in Guangzhou from 2004 to 2007. Our main results are as follows. The data of black carbon concentration and absorption coefficients measured with instruments cannot be directly used until they are measured in parallel with internationally accepted instruments for comparison, calibration, and reduction. After evaluation of the data, the result shows that the monthly mean of BC concentration varies 3.1―14.8 μg·m-3 and the concentration decreases by about 1 μg·m-3 in average over the four years; It is higher in the dry season with a multi-year mean of 8.9 μg/m3 and lower in the rainy season with a multi-year mean of 8.0 μg·m-3; The extreme maximum of monthly mean concentration occurred in December 2004 and extreme minimum in July 2007, and a 4-year mean is 8.4 μg·m-3. It is also shown that monthly mean scattering coefficient derived varies 129 -565 Mm-1, monthly mean absorption coefficient 32-139 Mm-1, and monthly mean single scattering albedo 0.71-0.91, with annual mean values of 0.80, 0.82, 0.79 and 0.84 for 2004, 2005, 2006 and 2007, respectively. Three instruments were used to take simultaneous measurements of BC in PM10, PM2.5, and PM1 and the results showed that PM2.5 took up about 90% of PM10 and PM1 accounted for about 68% of PM2.5, and BC aerosols are mainly present in fine particulates. The variability of BC concentrations is quite consistent between the Nancun station (141 m above sea level) and the Panyu station (13 m above sea level), which are 8 km apart from each other. The concentration in higher altitude station (Panyu) is consistently lower than the lower altitude station (Nancun), and the difference of annual mean is about 4 μg·m-3. | WU Dui MAO JieTai DENG XueJiao TIE XueXi ZHANG YuanHang ZENG LiMin LI Fei TAN HaoBo BI XueYan HUANG XiaoYing CHEN Jing DENG Tao | 2009 | Science China Earth Sciences2009，52，8： | 58 |
| 3 | Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer显示文摘因为高发生和高死亡,肺癌症是在中国的最致命的癌症之一。Cyclooxygenase-2 (COX-2 ) 和容器 endothelial 生长因素 C (VEGF-C ) 被发现在恶意的肿瘤的 lymphangiogenesis 起一个重要作用。在这研究,我们调查了淋巴的 microvessel 密度(LMVD ) 是否与在非小的房间肺癌症(NSCLC ) 的预后有关是 COX-2 和 VEGF-C 的病人,和表情以便在 NSCLC lymphangiogenesis 决定 COX-2 和 VEGF-C 的可能的角色。嵌入的织物 NSCLC 取样的 65 修理福尔马林的石蜡被染色的 immunohistochemical 为 COX-2 和 VEGF-C 评估。估计肿瘤 lymphangiogenesis, LMVD 被 immunohistochemical 染色 VEGFR-3 polyclonal 决定抗体。在 COX-2 和 VEGF-C 表示, LMVD,和 clinicopathologic 参数之中的关系被分析。在 65 件样品之中,高 LMVD 显著地与淋巴节点转移和差的幸存被联系。Multivariate 幸存分析证明那 LMVD 价值和淋巴节点转移是独立预示的因素。COX-2 和 VEGF-C 的表示水平比邻近的纸巾的那些显著地高。在 NSCLC 的 COX-2 和 VEGF-C 表情显著地与淋巴节点转移,然而并非与耐心的性,年龄,肿瘤尺寸,或肿瘤相关,节点,转移分类舞台。COX-2- 或 VEGF-C-positive 肿瘤的吝啬的 LMVD 价值比 COX-2- 或 VEGF-C-negative 肿瘤的高。重要关联在 COX-2 和 VEGF-C 的表情之间被发现。这研究建议 LMVD 可以是为 NSCLC 病人的重要预示的因素之一。VEGF-C 可能在 COX-2 lymphangiogenic 小径起一个重要作用。COX-2 和 VEGF-C 可以由刺激 lymphangiogenesis 在肿瘤前进起一个重要作用。lymphangiogenesis, COX-2,或 VEGF-C 活动的抑制可以在 NSCLC 的控制有一个重要治疗学的好处。 | Xufeng Guo Yongbing Chen Zhonghua Xu Zhonghen Xu Yongyue Qian Xueyan Yu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 34 |
| 4 | Multi-block SSD based on small object detection for UAV railway scene surveillance显示文摘A method of multi-block Single Shot Multi Box Detector(SSD)based on small object detection is proposed to the railway scene of unmanned aerial vehicle surveillance.To address the limitation of small object detection,a multi-block SSD mechanism,which consists of three steps,is designed.First,the original input images are segmented into several overlapped patches.Second,each patch is separately fed into an SSD to detect the objects.Third,the patches are merged together through two stages.In the first stage,the truncated object of the sub-layer detection result is spliced.In the second stage,a sub-layer suppression and filtering algorithm applying the concept of non-maximum suppression is utilized to remove the overlapped boxes of sub-layers.The boxes that are not detected in the main-layer are retained.In addition,no sufficient labeled training samples of railway circumstance are available,thereby hindering the deployment of SSD.A two-stage training strategy leveraging to transfer learning is adopted to solve this issue.The deep learning model is preliminarily trained using labeled data of numerous auxiliaries,and then it is refined using only a few samples of railway scene.A railway spot in China,which is easily damaged by landslides,is investigated as a case study.Experimental results show that the proposed multi-block SSD method produces an overall accuracy of 96.6%and obtains an improvement of up to 9.2%compared with the traditional SSD. | Yundong LI Han DONG Hongguang LI Xueyan ZHANG Baochang ZHANG Zhifeng XIAO | 2020 | Chinese Journal of Aeronautics2020，33，6： | 19 |
| 5 | Expression Detection of DMRTs and Two sox9 Genes in Takifugu rubripes (Tetraodontidae, Vertebrata)显示文摘Sex determination and sex differentiation are important phenomena in fish, but the mechanisms of sex determination in Takifugu rubripes are poorly understood. In our study, the expression patterns of genes for DMRTs (DMRT1, DMRT2 and DMRT3), sox9a and sox9b in T. rubripes tissues were verified with the Reverse Transcription (RT)-PCR detection. It is showed that DMRT1 expressions in testis and ovaries were much lower, and no expressions were found in muscle, blood and tailfin. However, expressions for DMRT2 and DMRT3 were not found in the tissues stated above. Transcripts of sox9a were detected in muscle, fin, ovary and testis, but not in blood, whereas sox9b expression was only detected in ovary. The expression patterns of DMRTs, sox9a and sox9b in T. rubripes gonads suggest that these genes may not be sex-specific. | SHEN Xueyan CUI Jianzhou YANG Guanpin GONG Qingli GU Qianqun | 2007 | Journal of Ocean University of China2007，6，2： | 15 |
| 6 | Bird watching in China reveals bird distribution changes显示文摘Using China Bird Report(2003-2007) as data source in combination with descriptions about bird habitats,we built up the China Bird Watching Database.We also developed spherical GIS software 'Global Analyst' to create the point-based database which contains accurate spatial-temporal information.The China Bird Watching Database can reflect the achievement of Chinese bird watchers and complement the basic knowledge of bird distribution.Now a total of 30936 records from 17 Orders,70 Families and 1078 Species of 5 years are included in the database,representing over 80% of all bird species in China.Till 2007,the geographic coverage has encompassed all provincial level administrative districts in China,with the exception of Hong Kong and Taiwan.The China Bird Watching Database also recorded a group of species which are additions at national and provincial levels,including 14 species which are additions to the national checklist and 109 species which appeared outside their original distributions.Comparing the new records with their original distributions,we found the trend that species move to higher latitude and higher elevation regions and some species of waterfowls in Xinjiang Uygur Autonomous Region,including a suite of rare seabirds in the China's Mainland.The majority of bird watchers come from the Eastern Region of China,but their covering range is spreading northwest.At the same time,we appeal to adopting a suite of new technologies for observation,and building up sharing platform of bird watching data to capture the distribution dynamics of birds in China and provide a direct foundation for bird conservation. | LI XueYan LIANG Lu GONG Peng LIU Yang LIANG FeiFei | 2013 | Chinese Science Bulletin2013，58，6： | 13 |
| 7 | Numerical simulation of flow and heat transfer in a random packed bed显示文摘Random packed beds have more complex interior structure than structured beds and are widely used in industry and engineering. CFD simulation was carried out to investigate and analyze the local flow and heat transfer in a 120-sphere random packed bed. 3D Navier–Stokes equation was solved with a finite volume formulation based on the Chimera meshing technique. Investigation was focused on low Reynolds number flow (Re = 4.6–56.2), which typically occurs in packed bed reactors in bio-chemical fields. Detailed temperature field information was obtained. Inhomogeneity of flow and heat transfer due to the non-uniform distribution of void fraction was discussed and analyzed. | Xueyan Guo Ren Dai | 2010 | Particuology2010，8，3： | 13 |
| 8 | Changes in the Contents of ATP and Its Related Breakdown Compounds in Various Tissues of Oyster During Frozen Storage显示文摘The changes in the contents of adenosine 5’-triphosphate (ATP) and its related breakdown compounds were investigated in the adductor muscle, mantle, gill and body trunk of oyster (Crassostrea gigas) during frozen storage at -20℃ and -30℃ and compared with that of the fresh oyster. The investigation was performed using an HPLC system. Different extents of ATP decomposi- tion were found in various tissues frozen at the two temperatures. The K, K’ and A.E.C values were calculated as the chemical fresh- ness indices. Considering the results of sensory evaluation, the A.E.C. value in body trunk at -20℃ and -30℃ could be used as the best freshness index for frozen oyster. | WANG Qi XUE Changhu LI Zhaojie FU Xueyan XU Jie XUE Yong | 2007 | Journal of Ocean University of China2007，6，4： | 13 |
| 9 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 10 | Heavy metal (Pb,Zn) uptake and chemical changes in rhizosphere soils of four wetland plants with different radial oxygen loss显示文摘Lead and Zn uptake and chemical changes in rhizosphere soils of four emergent-rooted wetland plants;Aneilema bracteatum,Cyperus alternifolius,Ludwigia hyssopifolia and Veronica serpyllifolia were investigated by two experiments:(1) rhizobag filled with 'clean' or metal-contaminated soil for analysis of Pb and Zn in plants and rhizosphere soils;and (2) applied deoxygenated solution for analyzing their rates of radial oxygen loss (ROL).The results showed that the wetland plants with different ROL rates had significant effects on the mobility and chemical forms of Pb and Zn in rhizosphere under flooded conditions.These effects were varied with different metal elements and metal concentrations in the soils.Lead mobility in rhizosphere of the four plants both in the 'clean' and contaminated soils was decreased,while Zn mobility was increased in the rhizosphere of the 'clean' soil,but decreased in the contaminated soil.Among the four plants,V.serpyllifolia,with the highest ROL,formed the highest degree of Fe plaque on the root surface,immobilized more Zn in Fe plaque,and has the highest effects on the changes of Zn form (EXC-Zn) in rhizosphere under both 'clean' and contaminated soil conditions.These results suggested that ROL of wetland plants could play an important role in Fe plaque formation and mobility and chemical changes of metals in rhizosphere soil under flood conditions. | Junxing Yang Zuoluo Ma Zhihong Ye Xueyan Guo Rongliang Qiu | 2010 | Journal of Environmental Sciences2010，22，5： | 11 |
| 11 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 12 | Early filiform needle acupuncture for poststroke depression: a meta-analysis of 17 randomized controlled clinical trials显示文摘OBJECTIVE: To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL: We retrieved data from the Chinese National Knowledge Infrastructure(1979–2012), Wanfang(1980–2012), VIP(1989–2012), Chinese Biomedical Literature(1975–2012), PubMed(1966–2012), Ovid Lww(–2012), and Cochrane Library(–2012) Database using the internet. SELECTION CRITERIA: Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the included articles scored at least 4 points on the Jadad scale. Exclusion criteria: other acupuncture therapies as treatment group, not stroke-induced depression patients, score < 4 points, non-randomized controlled trials, or animal trials. MAIN OUTCOME MEASURES: These were the Hamilton Depression Scale scores, clinical effective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS: A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with filiform needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval(CI): 1.03–1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale(17 items) scores were lower than in the antidepressant drug group(mean difference =-2.34, 95%CI:-3.46 to-1.22, P < 0.000,1). At 4 weeks, Hamilton Depression Scale(24 items) scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 articles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION: Early filiform needle acupuncture for poststroke depression can perfectly control depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs. | Jiping Zhang Jing Chen Junqi Chen Xiaohui Li Xueyan Lai Shaoqun Zhang Shengxu Wang | 2014 | Neural Regeneration Research2014，9，7： | 11 |
| 13 | Responses of Different Pakchoi (Brassica chinensis L.) Cultivars to Cu Toxicity显示文摘Two pot experiments with a completely random design and 4 replications were performed in a greenhouse to examine the response difference of 17 cultivars of pakchoi (Brassica chinensis L.) grown in a Cu-spiked and a clean soil to Cu.relatively tolerant. When the 17 cultivars of pakchoi grew in clean garden soil, the Cu concentrations in the aboveground part were positively correlated (r = 0.6693) with their root Cu concentrations. However, when they grew in the Cu-spiked soil a highly negative correlation coefficient (r = -0.5376) was obtained in the Cu concentration between the aboveground part and the root. This meant that the Cu tolerant cultivars had a weak ability to transfer Cu from their root to their aboveground part, and therefore stored much more Cu in their root than the Cu sensitive cultivars. | ZHOUDong-Mei XUEYan LIUXiao-Hong HAOXiu-Zhen CHENHuai-Man SHENZhen-Guo SIYou-Bin | 2005 | Pedosphere2005，15，1： | 11 |
| 14 | Qingnaoyizhi decoction suppresses the formation of glial fibrillary acidic protein-positive cells in cultured neural stem cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway显示文摘OBJECTIVE: Inactivation of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling axis plays a crucial role in determining the fate of neural stem cells(NSCs).Qingnaoyizhi decoction(QNYZD) has been used for the treatment of vascular dementia and has shown to improve synaptic remodeling. The aim of this study was to evaluate the effect of cerebrospinal fluid(CSF) containing QNYZD(CSF-QNYZD) on the differentiation of cultured NSCs and the involvement of the JAK2/STAT3 pathway.METHODS: The protein expression levels of glial fibrillary acidic protein(GFAP), tubulin, drosophila mothers against decapentaplegic protein(SMAD-1), STAT3, and phosphorylated-STAT3 were detected by western immunoblot analysis in the groups: control, CSF, JAK/STAT inhibitor(AG490),CSF-QNYZD, and CSF-XDZ(CSF-Xidezhen). The differentiation of NSCs was determined by immunofluorescence staining. The proliferation of NSCs was measured using the Cell Counting Kit-8 proliferation assay.RESULTS: Compared with the control group,CSF-QNYZD and AG490 significantly increased the number and expression of tubulin-positive cells, reduced the number and expression of GFAP-positive cells, and down-regulated the expression of p-STAT3. However, CSF-QNYZD also decreased the expression of SMAD-1 and STAT3.CONCLUSION: Enhanced neuronal differentiation may be associated with the down-regulation of glial differentiation instead of promoting proliferationin treated NSCs. Furthermore, QNYZD may play a direct role in suppressing the formation of GFAP-positive cells and enhancing neuronal differentiation by inhibiting JAK2/STAT3 activation. Overall, these results provide insights into the possible mechanism underlying QNYZD-mediated neurogenesis. | Wu Yanqing Jing Zhiwei Qin Xiude Zhou Zhen Wang Kai Song Wanshan Wang Xueyan Hou Mengmeng Zhang Yulian Kang Liyuan | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 11 |
| 15 | Effect of atmospheric aerosol on surface ozone variation over the Pearl River Delta region显示文摘Our analysis of the surface aerosol and ultraviolet(UV) measurements in Pearl River Delta(PRD) region shows that the sur-face UV radiation is reduced by more than 50% due to high aerosol concentrations.This has important impacts on urban eco-system and photochemistry,especially on ozone photochemical production over the region.The quantitative effect of aerosols on surface ozone is evaluated by analyzing surface observations(including ozone,ultraviolet radiation,aerosol radiative pa-rameters) and by using radiative and chemical models.A case study shows that the aerosol concentrations and UV radiation are significantly correlated with ozone concentrations.The correlation coefficient between the aerosol optical depth(AOD) and the PM10 mass concentration is very high,with a maximum of 0.98,and the AOD and UV radiation/ozone is anti-correlated,with a correlation coefficient of -0.90.The analysis suggests that ozone productivity is significantly decreased due to the reduction of UV radiation.The noon-time ozone maximum is considerably depressed when AOD is 0.6,and is further decreased when AOD is up to 1.2 due to the reduction of ozone photochemical productivity.Because the occurring probability of aerosol optical depth for AOD550 nm≥0.6 and AOD340 nm≥1.0 is 47,and 55% respectively during the dry season(October,November,December,January),this heavy aerosol condition explains the low ozone maximum that often occurs in the dry season over the Guangzhou region.The analysis also suggests that the value of single scattering albedo(SSA) is very sensitive to the aerosol radiative effect when the radiative and chemical models are applied,implying that the value of SSA needs to be carefully studied when the models are used in calculating ozone production. | DENG XueJiao ZHOU XiuJi WU Dui TIE XueXi TAN HaoBo LI Fei BI XueYan DENG Tao JIANG DeHai | 2011 | Science China Earth Sciences2011，54，5： | 10 |
| 16 | CDR3δ-grafted γ9δ2T cells mediate effective antitumor reactivity显示文摘采纳房间转移治疗(幕) 被报导了压制成长肿瘤并且在动物模型克服肿瘤逃跑。作为一个候选人幕受动器, γ 9 δ 2T 房间能在 vitro 并且在 vivo 和显示被激活并且膨胀对 colorectal 的强壮的 antitumor 活动,肺,前列腺,卵巢、肾的房间癌。然而,获得 γ 的一个足够大的数字是困难的; δ为能克服癌症病人的有免疫力的镇压肿瘤微型环境的免疫疗法满足需要的 T 房间。在以前的研究,我们的实验室证实了那 γ 9 δ 2T 房间经由 CDR3δ 认出了肿瘤房间;γ 的区域; δ -T-cell 受体(TCR ) 。我们构造了导出的全身的人的外部血 mononuclear 房间(PBMC )γ 9 并且 δ CDR3 区域被卵巢的上皮的癌(OEC ) 在代替的 2 链导出 CDR3。我们转移了 CDR3δ -grafted γ 9 δ进外部血淋巴细胞(PBL ) 的 2TCR 修改了 γ 遗传上发展; 9 δ 2T 房间。在 vitro,研究显示出那这些 CDR3δ -grafted γ 9 δ 2T 房间能向肿瘤房间与肿瘤房间摘录和展览 cytotoxicity 在刺激以后生产 cytokines,包括人的 OEC 和颈的腺癌。CDR3δ -grafted γ 9 δ采纳地变成忍受一根人的 OEC 房间线的裸体老鼠的 2T 房间表明了重要 antitumor 效果。这些结果显示那 CDR3δ -grafted γ 9 δ 2T 房间可能是临床的肿瘤免疫疗法的候选人。 | Hui Zhao Xueyan Xi Lianxian Cui Wei He | 2012 | Cellular & Molecular Immunology2012，9，2： | 10 |
| 17 | Significant Improvement of Cotton Verticillium Wilt Resistance by Manipulating the Expression of Gastrodia Anlffungal Proteins显示文摘 | Yiqin Wang Chengzhen Liang Shenjie Wu Xueyan Zhang Jiuyou Tang Guijiang Jian Gaili Jiao Fuguang Li Chengcai Chu | 2016 | Molecular Plant2016，9，10： | 8 |
| 18 | Projected impacts of climate change on protected birds and nature reserves in China显示文摘Knowledge about climate change impacts on species distribution at national scale is critical to biodiversity conservation and design of management programs.Although China is a biodiversity hot spot in the world,potential influence of climate change on Chinese protected birds is rarely studied. Here, we assess the impact of climate change on 108 protected bird species and nature reserves using species distribution modeling at a relatively fine spatial resolution(1 km) for the first time. We found that a large proportion of protected species would have potential suitable habitat shrink and northward range shift by 77–90 km in response to projected future climate change in 2080. Southeastern China would suffer from losing climate suitability, whereas the climate conditions in Qinghai–Tibet Plateau and northeastern China were projected to become suitable for more protected species. Onaverage, each protected area in China would experience a decline of suitable climate for 3–4 species by 2080. Climate change will modify which species each protected area will be suitable for. Our results showed that the risk of extinction for Chinese protected birds would be high, even in the moderate climate change scenario. These findings indicate that the management and design of nature reserves in China must take climate change into consideration. | Xueyan Li Nicholas Clinton Yali Si Jishan Liao Lu Liang Peng Gong | 2015 | Science Bulletin2015，60，19： | 8 |
| 19 | Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins显示文摘Members of the RAS proto-oncogene superfamily are indispensable molecular switches that play critical roles in cell proliferation, differentiation, and cell survival. Recent studies have attempted to prevent the interaction of RAS/GTP with RAS guanine nucleotide exchange factors(GEFs), impair RASeffector interactions, and suppress RAS localization to prevent oncogenic signalling. The present study aimed to investigate the effect of the natural triterpenoic acid inhibitor glycyrrhetinic acid, which is isolated from the roots of Glycyrrhiza plant species, on RAS stability. We found that glycyrrhetinic acid may bind to the P-loop of RAS and alter its stability. Based on our biochemical tests and structural analysis results, glycyrrhetinic acid induced a conformational change in RAS. Meanwhile, glycyrrhetinic acid abolishes the function of RAS by interfering with the effector protein RAF kinase activation and RAS/MAPK signalling. | Yuan Zhang Zhihua Wang Xiaoyao Ma Shengnan Yang Xueyan Hu Jin Tao Yuanyuan Houn Gang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 20 | Wide-steering-angle high-resolution optical phased array显示文摘Optical phased array(OPA)technology is considered a promising solution for solid-state beam steering to supersede the traditional mechanical beam steering.As a key component of the LIDAR system for long-range detection,OPAs featuring a wide steering angle and high resolution without beam aliasing are highly desired.However,a wide steering range requires a waveguide pitch less than half of the wavelength,which is easily subjected to cross talk.Besides,high resolution requires a large aperture,and it is normally achieved by a high count number of waveguides,which complicates the control system.To solve the mentioned issues,we design two high-performance 128-channel OPAs fabricated on a multilayered SiN-on-SOI platform.Attributed to the nonuniform antenna pitch,only 128 waveguides are used to achieve a 4 mm wide aperture.Besides,by virtue of innovative dual-level silicon nitride(Si_(3)N_(4))waveguide grating antennas,the fishbone antenna OPA achieves a 100°×19.4°field of view(FOV)with divergence of 0.021°×0.029°,and the chain antenna OPA realizes a 140°×19.23°FOV with divergence of 0.021°×0.1°.To our best knowledge,140°is the widest lateral steering range in two-dimensional OPA,and 0.029°is the smallest longitudinal divergence.Finally,we embed the OPA into a frequency-modulated continuous-wave system to achieve 100 m distance measurement.The reflected signal from 100 m distance is well detected with 26 dBm input transmitter power,which proves that OPA serves as a promising candidate for transceiving optical signal in a LIDAR system. | YINGZHI LI BAISONG CHEN QUANXIN NA QIJIE XIE MIN TAO LANXUAN ZHANG ZIHAO ZHI YUXUAN LI XIAOBIN LIU XIANSHU LUO GUOQIANG LO FENGLI GAO XUEYAN LI JUNFENG SONG | 2021 | Photonics Research2021，9，12： | 7 |
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