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| 1 | L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia显示文摘 | Peilon Lu | 2013 | Cell Research2013，23，5： | 23 |
| 2 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 3 | ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds显示文摘 | Yao, Ruifeng Wang, Fei Ming, Zhenhua Du, Xiaoxi Chen, Li Wang, Yupei Zhang, Wenhao Deng, Haiteng Xie, Daoxin | 2017 | Cell Research2017，27，6： | 15 |
| 4 | Branch-pipe-routing approach for ships using improved genetic algorithm显示文摘分支管子路由在轮船管子设计起基本、关键的作用。branch-pipe-routing 问题是一个复杂组合优化问题并且当仅仅取决于人的专家时,因此是困难的解决。一条修改 genetic-algorithm-based 途径在这篇论文被建议解决这个问题。简化布局空间首先被划分成 threedimensional (3D ) 造它的数学模型的格子。在布局空间的布朗奇管子被认为是几根二点的管子的联合,并且在二个连接之间的管子线路指用一个改进迷宫算法被产生。编码分支管子然后被定义,并且基因操作员特别被设计极大地加速集中速度的完全的转线路策略。最后,模拟测试表明建议方法的表演。 | Haiteng SUI Wentie NIU | 2016 | Frontiers of Mechanical Engineering2016，11，3： | 8 |
| 5 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 6 | The early-middle Miocene submarine fan system in the Pearl River Mouth Basin, South China Sea显示文摘Based on a large amount of seismic, drilling and core data, the characteristics of the earlymiddle Miocene submarine fans in the Baiyun Sag, northern South China Sea are investigated. By analyzing the sedimentary processes of submarine fans in SQ21 (SQ21 refers to the 3rd-order sequence with its bottom boundary 21 Ma), a sedimentary model of the sand-rich fans is established and the main factors controlling fan deposition are detailed. The results indicate that from early to middle Miocene the Pearl River Mouth Basin developed seven 3rd-order sequences in all, with each lowstand systems tract (LST) of the sequence corresponding to submarine fans. However, only the fans in SQ13.8 and SQ21 are sand-rich fans, the others being mud-rich fans. The cores reveal that the submarine fans in the Pearl River Mouth Basin developed five lithofacies: (1) mud clast-bearing sandstone, interpreted as channel deposits; (2) typical turbidite sandstones, also interpreted as channel deposits; (3) thin-bedded sandstone and mudstone, interpreted as channel-levee complex deposits; (4) massive sandstones, interpreted as lobe deposits; (5) massive mudstone, interpreted as hemipelagic mud. The sand-rich submarine fans in the Pearl River Mouth Basin mainly developed in LST, and in LST reverse faults were active, which led to the formation of accommodation on the shelf. Different from the theory of classic sequence stratigraphy, the accommodation on the shelf captures terrigenous debris transported by the Pearl River, and the uplift at the edge of shelf serves as a 'Linear Source' for the deep water area instead of the Pearl River. Therefore, the fans mainly derived from the eroded debris from the uplift. Factors controlling fan deposition include the basin's tectonic framework, the evolution of the slope break, relative sea-level changes as well as the evolution of the fault system, and the fans are formed under the combination of the above factors. | Wang Yongfeng Wang Yingmin Xu Qiang Li Dong Zhuo Haiteng Zhou Wei | 2012 | Petroleum Science2012，9，1： | 7 |
| 7 | Simple β-lactones are potent irreversible antagonists for strigolactone receptors显示文摘 | Haibo Xian Ruifeng Yao Tianfei Quan Fei Wang Li Chen Xiaoxi DU Wenhao Zhang Haiteng Deng Daoxin Xie Tuoping Luo | 2017 | Cell Research2017，27，12： | 5 |
| 8 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 9 | Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression显示文摘 | Xiaofei Wang Haiping Tang Yuling Chen Binghuan Chi Shiyu Wang Yang Lv Di WU Renshan Ge Haiteng Deng | 2016 | Protein & Cell2016，7，4： | 3 |
| 10 | Fasting-induced hormonal regulation of lysosomal function显示文摘 | Chen, Liqun Wang, Ke Long, Aijun Jia, Liangjie Zhang, Yuanyuan Deng, Haiteng Li, Yu Han, Jinbo Wang, Yiguo | 2017 | Cell Research2017，27，6： | 3 |
| 11 | Investigations on the general properties of biomass-based aldehyde tanned sheep fur for its selective post-tanning processing显示文摘Dialdehyde sodium alginate(DSA)is an alternative chrome-free tanning material for fur production.To obtain satisfactory resultant fur and provide suggestions for the usage of DSA in fur making,the general properties of DSA tanned sheep fur were systematically investigated.The tanning mechanism of DSA was analyzed and it was verified that DSA was mainly combined with collagen fiber by forming Schiff base covalent bonds while supplemented by a small number of hydrogen bonds and ionic bonds.Due to the acid sensitivity of Schiff base structure,DSA tanned fur had poor resistance to acid rinsing but had excellent resistance to washing and good fatliquoring performance.Also,it had good resistances to yellowing and reductant.After being retanned by chrome tanning agent,the fur was capable of enduring a high-temperature dyeing process(68°C for 8 h).Overall,DSA tanned sheep fur had favorable properties under appropriate post-tanning processing conditions to manufacture light-colored or dark-colored fur products with desirable physical properties. | Wei Ding Ya-nan Wang Jianfei Zhou Haiteng Liu Xiaoyan Pang Bi Shi | 2021 | Journal of Leather Science and Engineering2021，3，1： | 3 |
| 12 | Realizing stable operation of anaerobic ammonia oxidation at low temperatures treating low strength synthetic wastewater显示文摘The low activity of Anammox bacteria at low temperatures and competition from nitrite oxidation bacteria(NOB) when treating low strength wastewater have been major bottlenecks in implementing Anammox in mainstream wastewater treatment. By intermittent high strength feeding(IHSF) and stepwise temperature reduction, stable operation of a granular Anammox reactor was realized at low temperatures(down to 15°C) for 28 days when treating low strength synthetic wastewater. The nitrogen loading rate reached 1.23–1.34 kgN/m^3/day,and the total nitrogen removal rate reached 0.71–0.98 kgN/m^3/day. The IHSF enriched the Anammox sludge in high strength cycles and compensated for sludge loss in low strength cycles, and the high concentration of ammonium in high strength cycles inhibited NOB. The 16 SrRNA gene sequencing results revealed that Candidatus Kuenenia was predominant in the reactor at low temperatures. | Bowen Zhang Jian Zhao Jiane Zuo Xuchuan Shi Jiayi Gong Haiteng Ren | 2019 | Journal of Environmental Sciences2019，31，1： | 3 |
| 13 | Large-scale identification of potential phase-separation proteins from plants using a cell-free system显示文摘Dear Editor,Biomolecular condensates have emerged as key players in cellular processes and responses to stress(Alberti and Hyman,2021).Recent studies have revealed that most biomolecular condensates arise from liquid-liquid phase separation(Banani et al.,2017;Shin and Brangwynne,2017),a process that has been described in the field of polymer chemistry. | Honghong Zhang Fangyu Peng Chun He Yan Liu Haiteng Deng Xiaofeng Fang | 2023 | Molecular Plant2023，16，2： | 2 |
| 14 | Origin of Taiwan Canyon and its effects on deepwater sediment显示文摘The continental slope of the Taiwan Shoal, which has cultivated numerous submarine canyons, is located in a passive continental margin environment. However, the trend of the Taiwan Canyon, with its 45° intersection angle, is obviously different from that of the erosion valley downward along the continental slope. A distinct break is present in the lower segment of the Taiwan Canyon, which then extends from west to east parallel to the continental slope until finally joining the Manila Trench. By utilizing multiple-beam water depth data, high-resolution seismic data, and sediment cores, this study describes the topographic characteristics of the Taiwan Canyon and provides a preliminary discussion on the origin of the Taiwan Canyon and its effect on deepwater sediment. The terrain, landform, and sediment of the Taiwan Canyon exhibit segmentation characteristics. The upper segment is characterized primarily by erosion, downward cutting with a V shape, and wide development of sliding, slumping, and other gravity flow types. The middle segment is characterized mostly by U-shaped erosion-sedimentation transition and development of an inner levee. The lower segment is characterized primarily by sedimentation and development of a sediment wave. The bottom current has a significant reworking effect on the interior sediments of the canyon and forms reworked sands. The formation and evolution of the Taiwan Canyon is closely related to sediment supply, gravity sliding(slumping), faulting activities, and submarine impaling. Given the sufficient terrigenous clastic supply, the sediments along the continental shelf edge continuously proceed seaward; gliding and slumping in the front edge provide driving forces for the formation of the canyon. Faulting activities result in stratum crushing, and the gravity flow takes priority in eroding the relatively fragile stratum. Thus, the direction of the extension of the canyon crosses the surrounding erosion valley obliquely. Seamounts are formed through submarine impaling. Owing to seamount blocking, the lower segment of the canyon is turned toward the east–west direction. Large amounts of sediments overflow at the turning, forming sediment waves. | XU Shang WANG YingMin PENG XueChao ZOU HuaYao QIU Yan GONG ChengLin ZHUO HaiTeng | 2014 | Science China Earth Sciences2014，57，11： | 2 |
| 15 | p38α MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin显示文摘RCAN1,also known as DSCR1,is an endogenous regulator of calcineurin,a serine/threonine protein phosphatase that plays a critical role in many physiological processes.In this report,we demonstrate that p38 MAP kinase can phosphorylate RCAN1 at multiple sites in vitro and show that phospho-RCAN1 is a good protein substrate for calcineurin.In addition,we found that unphosphorylated RCAN1 noncompetitively inhibits calcineurin protein phosphatase activity and that the phosphorylation of RCAN1 by p38 MAP kinase decreases the binding affinity of RCAN1 for calcineurin.These findings reveal the molecular mechanism by which p38 MAP kinase regulates the function of RCAN1/calcineurin through phosphorylation. | MA Lei TANG HaiPing REN Yan DENG HaiTeng WU JiaWei WANG ZhiXin | 2012 | Science China(Life Sciences)2012，55，7： | 2 |
| 16 | Pipe-assembly approach for ships using modified NSGA-Ⅱ algorithm显示文摘Pipe-routing for ship is formulated as searching for the near-optimal pipe paths while meeting certain objectives in an environment scattered with obstacles. Due to the complex construction in layout space, the great number of pipelines, numerous and diverse design constraints and large amount of obstacles, finding the optimum route of ship pipes is a complicated and time-consuming process. A modified NSGA-Ⅱ algorithm based approach is proposed to find the near-optimal solution to solve the problem. By simplified equipment models, the layout space is firstly divided into three dimensional(3D) grids to build its mathematical model. In the modified NSGA-Ⅱ algorithm, the concept of auxiliary point is introduced to improve the search range of maze algorithm(MA) as well as to guarantee the diversity of chromosomes in initial population. Then the fix-length coding mechanism is proposed, Fuzzy set theory is also adopted to select the optimal solution in Pareto solutions. Finally, the effectiveness and efficiency of the proposed approach is demonstrated by the contrast test and simulation. The merit of the proposed algorithm lies in that it can provide more appropriate solutions for the designers while subject certain constrains. | Sui Haiteng Niu Wentie Niu Yaxiao Zhou Chongkai Gao Weigao | 2016 | Computer Aided Drafting,Design and Manufacturing2016，26，2： | 2 |
| 17 | The BAH domain of BAHD1 is a histone H3K27me3 reader显示文摘 | Dan Zhao (1) (2) Xiaojie Zhang (2) Haipeng Guan (2) Xiaozhe Xiong (2) Xiaomeng Shi (3) Haiteng Deng (3) Haitao Li (2) (4) | 2016 | Protein & Cell2016，7，3： | 2 |
| 18 | High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells显示文摘Clear cell renal cell carcinoma(ccRCC)is a frequently occurring renal cancer.The Von Hippel-Lindau disease tumor suppressor VHL,a known tumor suppressor gene,is frequently mutated in about 50%of patients with ccRCC.However,it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL.In the present study,we found that higher expression of VHL was correlated with the better disease-free survival(DFS)in ccRCC patients using The Cancer Genome Atlas(TCGA)datasets.We revealed that VHL overexpression in ccRCC cells inhibited epithelial-mesenchymal transition(EMT),sterol regulatory elementbinding protein 1(SREBP1)-regulated triglyceride synthesis,and cell proliferation.Proteomic analysis provided us a global view that VHL regulated four biological processes,including metabolism,immune regulation,apoptosis,and cell movement.Importantly,we found that VHL overexpression led to up-regulated expression of proteins associated with antigen processing and interferonresponsive proteins,thus rendering ccRCC cells more sensitive to interferon treatment.We defined an interferon-responsive signature(IRS)composed of ten interferon-responsive proteins,whose m RNA expression levels were positively correlated with DFS in ccRCC patients.Taken together,our results propose that the subset of ccRCC patients with high VHL expression benefit from immunotherapy. | Songbiao Zhu Wenxi Ding Yuling Chen Weixuan Wang Renhua Xu Chongdong Liu Xiaohui Liu Haiteng Deng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 19 | Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling显示文摘B-cell lymphoma 10(Bcl10) is a scaffolding protein that functions as an upstream regulator of NF-κB signaling by forming a complex with Mucosa-associated lymphoid tissue lymphoma translocation protein 1(Malt1) and CARD-coiled coil protein family. This study showed that Bcl10 was involved in type I interferon(IFN) expression in response to DNA virus infection and that Bcl10-deficient mice were more susceptible to Herpes simplex virus 1(HSV-1) infection than control mice. Mechanistically,DNA virus infection can trigger Bcl10 recruitment to the STING-TBK1 complex, leading to Bcl10 phosphorylation by TBK1.The phosphorylated Bcl10 undergoes droplet-like condensation and forms oligomers, which induce TBK1 phosphorylation and translocation to the perinuclear region. The activated TBK1 phosphorylates IRF3, which induces the expression of type I IFNs.This study elucidates that Bcl10 induces an innate immune response by undergoing droplet-like condensation and participating in signalosome formation downstream of the c GAS-STING pathway. | Dandan Yang Gaofeng Pei Shuangshuang Dong Wenhao Zhang Haiteng Deng Xueqiang Zhao Pilong Li Xin Lin | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 20 | Preparation of aerogel and its application progress in coatings: a mini overview显示文摘Aerogels are predominantly mesoporous,extremely lightweight,low density(∼0.003 g/cm 3)and thermally insulat-ing materials.Over the years,aerogels have gained increasing attention due to their extraordinary properties(light,heat,sound,electricity and force)and application potentials in varieties of fields.Several studies have been carried out regarding aerogel preparation and its applications in coatings on different substrates.In this review,an overview of aerogels preparation and their application progress in coatings of most common substrates is presented.Attention is paid to aerogel coatings of textiles,leather,and substrates other than leather and textiles for special functionali-ties that could address the application progress in coatings.This review will help to inspire scientists and engineers towards novel aerogel materials and technologies to boost the industrial fabrication of flexible advanced materials. | Berhanu Telay Mekonnen Wei Ding Haiteng Liu Song Guo Xiaoyan Pang Zhiwen Ding Mohammed Hussein Seid | 2021 | Journal of Leather Science and Engineering2021，3，1： | 1 |
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