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| 1 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 2 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 3 | Discovery of a high-altitude ecotype and ancient lineage of Arabidopsis thaliana from Tibet显示文摘Arabidopsis thaliana(A.thaliana)has long been a model species for dicotyledon study,and was the first flowering plant to get its genome completed sequenced[1].Although most wild A.thaliana are collected in Europe,several studies have found a rapid A.thaliana west-east expansion from Central Asia[2].The Qinghai-Tibet Plateau(QTP)is close to Central Asia and known for its high alti- | Liyan Zeng Zhuoya Gu Min Xu Ning Zhao Weidong Zhu Takahiro Yonezawa Tianmeng Liu Lha Qiong Tashi Tersing Lingli Xu Yang Zhang Rongyan Xu Ningyu Sun Yanyan Huang Jiankun Lei Liang Zhang Feng Xie Fang Zhang Hongya Gu Yupeng Geng Masami Hasegawa Ziheng Yang M. James C. Crabbe Fan Chen Yang Zhong | 2017 | Science Bulletin2017，62，24： | 3 |
| 4 | Determination of the Li/Nb Ratio in LiNbO3 Crystals Prepared by Vapor Transport Equilibration Method 显示文摘 | Chen Yunlin Zhang Wanlin Shu Yongchun Lou Cibo Kong Yongfa Huang Ziheng Xu Jingjun and Zhang Guangyin | 2003 | Optical Materials2003，23，12： | 1 |
| 5 | Downregulation of cancer stem cell properties via mTOR signaling pathwayinhibition by rapamycin in nasopharyngeal carcinoma显示文摘 | Chunguang Yang Yue Zhang Yu Zhang Ziheng Zhang Jianhua Peng Zhi Li Liang Han Quanjie You Xiaoyu Chen Xingwang Rao Yi Zhu Zhisu Liao | 2015 | International Journal of Oncology2015，，3： | 1 |
| 6 | Scalable spray coated high performance sulfurized electron transporter for efficient and stable perovskite solar modules显示文摘The stability issue has been acknowledged as the bottleneck in the practical application of perovskite photovoltaics,while the stabilized interface between the perovskites and charge transport layers dominates their stability performance under different stresses.Here,we developed a high-performance sulfurized zinc-titanium mixed oxide(ZTO-S)electron transport layer(ETL)to fabricate large-area efficient and long-term 85℃/85%RH stable perovskite solar modules.The scalably prepared ZTO-S using the facile spray coating method demonstrates excellent electron mobility close to that of Zn O,in addition to promoting the uniform crystallization of perovskite film across the entire module via the interaction between surface S and Pb^(2+).Furthermore,this novel coordination stabilized the interface and reduced the interfacial non-radiative recombination defects within the devices,yielding an efficient and stable performance for the modules.High efficiency of 21.73%and 17.50%was achieved for blade-coated 36 cm^(2)and 100 cm^(2)perovskite solar modules,respectively.In addition,the encapsulated module(36 cm^(2))shows an attractive humidity and heat stability(85℃/85%RH)performance with a maintained 93.5%of the initial PCE over 1000 h. | Siqing Nie Qifan Feng Ziheng Tang Yaolin Hou Xiaofeng Huang Ruihao Chen Fang Cao Binghui Wu Jun Yin Jing Li Nanfeng Zheng | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 7 | Regulation of root secondary metabolites by partial root-associated microbiotas under the shaping of licorice ecotypic differentiation in northwest China显示文摘Interactions between plant hosts and their microbiotas are becoming increasingly evident,while the effects of plant communities on microbial communities in different geographic environments are poorly understood.Here,the differentiation of licorice plant ecotypes and the distribution of rootassociated microbiotas were investigated across five sampling sites in northwest China.The interactions between the environment,plant and microbial communities,and their effects on licorice root secondary metabolites,were elucidated.The plant community was clearly differentiated into distinct ecotypes based on genotyping-by-sequencing and was primarily driven by geographic distance and available soil nitrogen.The bulk soil and rootassociated microbiotas(rhizosphere soil and root endosphere)partially correlated with plant community,but all were significantly discriminated by plant clade.Moreover,these microbiotas were explained to different extents by distinct combinations of environment,geography,and plant community.Similarly,three structural equation models showed that licorice root secondary metabolites were complicatedly modulated by multiple abiotic and biotic factors,and were mostly explained by these factors in the rhizosphere model.Collectively,the results provide novel insights into the role of environment–plant–microbiota interactions in regulating root secondary metabolites.That should be accounted for when selecting appropriate licorice planting sites and management measures. | Yang Liu Hao Wang Ziheng Peng Da Li Weimin Chen Shuo Jiao Gehong Wei | 2021 | Journal of Integrative Plant Biology2021，63，12： | 1 |
| 8 | Soil phosphorus determines the distinct assembly strategies for abundant and rare bacterial communities during successional reforestation显示文摘Uncovering the mechanisms underlying the diversity patterns of abundant and rare species is crucial for terrestrial biodiversity maintenance.However,the response of abundant and rare community assembly to ecological succession has not been explored,particularly considering soil profiles.Here 300 soil samples were collected from reforestation ecosystems from depths of up to 300 cm and horizontal distances of 30–90 cm from a tree.We revealed that soil phosphorus not only affected alpha diversity and community structure,but also mediated the balance of stochastic and deterministic processes for abundant and rare sub-communities,which exhibited contrasting assembly strategies.The abundant sub-community changed from variable selection to stochasticity with the increase of phosphorus,while the rare sub-community shifted from homogeneous selection to stochasticity.Dispersal limitation was the main assembly process in the abundant sub-community,while the rare sub-community was governed primarily by homogeneous selection.Moreover,the relative influence of deterministic processes increased with succession for both sub-communities.At the scale of a single tree,stochastic processes increased with soil depth in rare sub-community,while deterministic processes increased with the radius from a single tree in the abundant subcommunity.Overall,our results highlight the importance of the soil phosphorus-driven assembly process in understanding the re-assembly and maintenance of soil bacterial diversity. | Ziheng Peng Zhifeng Wang Yu Liu Tongyao Yang Weimin Chen Gehong Wei Shuo Jiao | 2021 | Soil Ecology Letters2021，3，4： | 1 |
| 9 | Multifunctional phase change composites based on biomass/MXenederived hybrid scaffolds for excellent electromagnetic interference shielding and superior solar/electro-thermal energy storage显示文摘With the rapid development of new generations of miniaturized,integrated,and high-power electronic devices,it is particularly important to develop advanced composite materials with efficient thermal management capability and excellent electromagnetic interference(EMI)shielding performance.Herein,an innovative biomass/MXene-derived conductive hybrid scaffold,cellulose nanocrystal(CNC)-konjac glucomannan(KGM)/MXene(CKM),was prepared by freeze-drying and thermal annealing,and then paraffin wax(PW)was encapsulated in CKM using vacuum impregnation method to obtain CNC-KGM/MXene@PW phase change composites(CKMPCCs).The results show that the obtained CKMPCCs possess considerable reusable stabilities,excellent EMI shielding properties,and thermal energy management capacities.Among them,the CKMPCC-6 with 2.3 wt.%MXene exhibits excellent solar-thermal and electro-thermal conversion capabilities.In addition,the EMI shielding effectiveness value is as high as 45.0 dB at 8.2–12.4 GHz and the corresponding melting enthalpy value is 215.7 J/g(relative enthalpy efficiency of 99.9%).In conclusion,the synthesized multifunctional phase change composites provide great potential for integrating outstanding EMI shielding and advanced thermal energy management applications. | Yan Cao Ziheng Zeng Danyuan Huang Ying Chen Li Zhang Xinxin Sheng | 2022 | Nano Research2022，15，9： | 1 |
| 10 | Low External Electric Field Periodic Poling of Thick LiTaO3显示文摘A promising method of ferroelectric domain inverted structures was demonstrated, which allows us to fabricate thicker domain inverted patterns by applying a lower external electric field in LiTaO3 crystal. The external field for the domain reversal of the 1.5 mm thick LiTaO3 at 500 ℃ was only 6 V·mm-1, which is lower by three orders of magnitude than that in LiTaO3 crystal at room temperature. The process of the domain inversion structure was also studied. The fabrication techniques are based on controlled temperature and field duration time. | Chen Yunlin Guo Juan Lou Cibo Huang Ziheng Chen Shaolin Zhang Guangyin | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 11 | Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells显示文摘Alcohol abuse has recently become a serious health concern worldwide,and the incidence of alcoholic liver disease(ALD)is rapidly increasing with high morbidity and mortality.Ferroptosis is a newly recognized form of regulated cell death caused by the iron-dependent accumulation of lipid peroxidation.Here we showed that the circadian clock protein brain and muscle arnt-like protein-1(BMAL1)in hepatocytes is both necessary and sufficient to protect against ALD by mitigating ferroptosis.U pon exposure to alcohol(5%Lieber-DeCarli liquid alcohol diet for 10 days before binged alcohol with 5 g/kg body weight in vivo,300 mmol/L for 12 h in vitro,respectively),the content of iron,reactive oxygen species(ROS)and malondialdehyde(MDA)was boosted signifi cantly while glutathione(GSH)was decreased that mainly based on the downregulated protein expression of ferritin heavy chain(FTH),ferroportin(FPN),heme oxygenase1(HO-1)and anti-cystine/glutamate antiporter(SLC7A11),while these changes could be abolished by ferroptosis inhibitor Ferrostatin-1[Fer-1(5 mg/kg body weight for 10 days in vivo,10μmol/L for 2 h in vitro,respectively)].Further study indicated that the alcohol could activate the protein expression of BMAL1 which exerts a protective effect against ferroptosis through promoting nuclear factor erythroid 2-related factor 2(Nrf2)translocation into nuclear and subsequently stimulating its downstream proteins FTH,FPN,glutathione peroxidase 4 activity(GPX4),HO-1,SLC7A11,while knockdown of BMAL1 and Nrf2 by RNA interference further downregulated the expression of these protein and thus promoting ferroptosis in response to alcohol.Collectively,our results unveiled that the protective action of BMAL1 during alcohol challenge depends on its ability to activate Nrf2-ARE antiferroptosis pathway and targeting hepatic BMAL1 to dampen hepatic ferroptosis signaling may have therapeutic potential for ALD. | Yanan Zhao Ranran Zhang Ziheng Chen Ziyi Wang Shuang Guan Jing Lu | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
| 12 | Editorial for the special issue“Machine learning and artificial intelligence for energy materials”显示文摘With the development of advanced methods in the area of machine learning(ML),artificial intelligence(AI)is rapidly revolutionizing many fields and is starting to change the landscapes of physics and chemistry.Over the past decade,AI-assisted designs of novel materials have been gradually reshaping how researchers explore new chemistries for energy conversion and storage.In addition,innovative data-driven techniques have led to unprecedented perspectives on the physics and chemistries of the reactions/processes involved.With this background in mind,this themed issue of“Machine Learning and Artificial Intelligence for Energy Materials”presents a collection of 5 highly selected papers in machine learning and artificial intelligence for energy materials.1–5 By including comprehensive reviews,and original research report,this issue aims at providing a broad overview of the theoretical advancements and applications of related methods in the areas of energy storage and conversion. | Ziheng Lu Francesco Ciucci Chi Chen | 2021 | Materials Reports(Energy)2021，1，3： | 0 |
| 13 | Microwave heating as a universal method to transform confined molecules into armchair graphene nanoribbons显示文摘Armchair graphene nanoribbons(AGNRs)with sub-nanometer width are potential materials for the fabrication of novel nanodevices thanks to their moderate direct band gaps.AGNRs are usually synthesized by polymerizing precursor molecules on substrate surface.However,it is time-consuming and not suitable for large-scale production.AGNRs can also be grown by transforming precursor molecules inside single-walled carbon nanotubes(SWCNTs)via furnace annealing,but the obtained AGNRs are normally twisted.In this work,microwave heating is applied for transforming precursor molecules into AGNRs.The fast heating process allows synthesizing the AGNRs in seconds.Several different molecules were successfully transformed into AGNRs,suggesting that it is a universal method.More importantly,as demonstrated by Raman spectroscopy,aberrationcorrected high-resolution transmission electron microscopy and theoretical calculations,less twisted AGNRs are synthesized by the microwave heating than the furnace annealing.Our results reveal a route for rapid production of AGNRs in large scale,which would benefit future applications in novel AGNRs-based semiconductor devices. | Haoyuan Zhang Yingzhi Chen Kunpeng Tang Ziheng Lin Xuan Li Hongwei Zhang Yifan Zhang Chi Ho Wong Chi Wah Leung Chee Leung Mak Yuan Hu Weili Cui Kecheng Cao Lei Shi | 2023 | Nano Research2023，16，7： | 0 |
| 14 | Atomic interface regulation of rare-marth metal single atom catalysts for energy conversion显示文摘Efficient photocatalysis and electrocatalysis in energy conversion have been important strategies to alleviate energy crises and environmental issues.In recent years,with the rapid development of emerging catalysts,significant progress has been made in photocatalysis for converting solar energy into chemical energy and electrocatalysis for converting electrical energy into chemical energy.However,their selectivity and efficiency of the products are poor.Rare earth(RE)can achieve atomic level fine regulation of catalysts and play an crucial role in optimizing catalyst performance by their unique electronic and orbital structures.However,there is a lack of systematic review on the atomic interface regulation mechanism of RE and their role in energy conversion processes.Single atom catalysts(SACs)provide clear active sites and 100%atomic utilization,which is conducive to exploring the regulatory mechanisms of RE.Therefore,this review mainly takes atomic level doped RE as an example to review and discuss the atomic interface regulation role of RE elements in energy conversion.Firstly,a brief introduction was given to the synthesis strategies that can effectively exert the atomic interface regulation effect of RE,with a focus on the atomic interface regulation mechanism of RE.Meanwhile,the regulatory mechanisms of RE atoms have been systematically summarized in various energy conversion applications.Finally,the challenges faced by RE in energy conversion,as well as future research directions and prospects,were pointed out. | Ziheng Zhan Zhiyi Sun Zihao Wei Yaqiong Li Wenxing Chen Shenghua Li Siping Pang | 2024 | Nano Research2024，17，5： | 0 |
| 15 | Length matters:Scalable fast encrypted internet traffic service classification based on multiple protocol data unit length sequence with composite deep learning显示文摘As an essential function of encrypted Internet traffic analysis,encrypted traffic service classification can support both coarse-grained network service traffic management and security supervision.However,the traditional plaintext-based Deep Packet Inspection(DPI)method cannot be applied to such a classification.Moreover,machine learning-based existing methods encounter two problems during feature selection:complex feature overcost processing and Transport Layer Security(TLS)version discrepancy.In this paper,we consider differences between encryption network protocol stacks and propose a composite deep learning-based method in multiprotocol environments using a sliding multiple Protocol Data Unit(multiPDU)length sequence as features by fully utilizing the Markov property in a multiPDU length sequence and maintaining suitability with a TLS-1.3 environment.Control experiments show that both Length-Sensitive(LS)composite deep learning model using a capsule neural network and LS-long short time memory achieve satisfactory effectiveness in F1-score and performance.Owing to faster feature extraction,our method is suitable for actual network environments and superior to state-of-the-art methods. | Zihan Chen Guang Cheng Ziheng Xu Shuyi Guo Yuyang Zhou Yuyu Zhao | 2022 | Digital Communications and Networks2022，8，3： | 0 |
| 16 | Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons显示文摘Essential amino acids(EAAs)are crucial nutrients,whose levels change in rodents and patients with depression.However,how the levels of a single EAA affects depressive behaviors remains elusive.Here,we demonstrate that although deprivation of the EAA leucine has no effect in unstressed mice,it remarkably reverses the depression-like behaviors induced by chronic restraint stress(CRS).This beneficial effect is independent of feeding and is applicable to the dietary deficiency of other EAAs.Furthermore,the effect of leucine deprivation is suppressed by central injection of leucine or mimicked by central injection of leucinol.Moreover,hypothalamic agouti-related peptide(AgRP)neural activity changes during CRS and leucine deprivation,and chemogenetically inhibiting AgRP neurons eliminates the antidepressant effects of leucine deprivation.Finally,the leucine deprivation-regulated behavioral effects are mediated by amino acid sensor general control non-derepressible 2(GCN2)in AgRP neurons.Taken together,our results suggest a new drug target and/or dietary intervention for the reduction of depressive symptoms. | Feixiang Yuan Shangming Wu Ziheng Zhou Fuxin Jiao Hanrui Yin Yuguo Niu Haizhou Jiang Shanghai Chen Feifan Guo | 2023 | Life Metabolism2023，2，1： | 0 |
| 17 | Item Response Theory Based Ensemble in Machine Learning显示文摘In this article,we propose a novel probabilistic framework to improve the accuracy of a weighted majority voting algorithm.In order to assign higher weights to the classifiers which can correctly classify hard-to-classify instances,we introduce the item response theory(IRT)framework to evaluate the samples′difficulty and classifiers′ability simultaneously.We assigned the weights to classifiers based on their abilities.Three models are created with different assumptions suitable for different cases.When making an inference,we keep a balance between the accuracy and complexity.In our experiment,all the base models are constructed by single trees via bootstrap.To explain the models,we illustrate how the IRT ensemble model constructs the classifying boundary.We also compare their performance with other widely used methods and show that our model performs well on 19 datasets. | Ziheng Chen Hongshik Ahn | 2020 | International Journal of Automation and computing2020，17，5： | 0 |
| 18 | Identification of the Discrete Element Model Parameters for Rock-Like Brittle Materials显示文摘An inverse method for parameters identification of discrete element model combined with experiment is proposed.The inverse problem of parameter identification is transmitted to solve an optimization problem by minimizing the distance between the numerical calculations and experiment responses.In this method,the discrete element method is employed as numerical calculator for the forward problem.Then,the orthogonal experiment design with range analysis was used to carry out parameters sensitivity analysis.In addition,to improve the computational efficiency,the approximate model technique is used to replace the actual computational model.The intergeneration projection genetic algorithm(IP-GA)is employed as the optimization algorithm.Consequently,the parameters of the discrete element model are determined.To verify the effectiveness and accuracy of the inverse results,the comparisons of shape deviation experiments with discrete element simulations are provided.It indicates that the effective and reliable discrete element model parameters can be quickly obtained through several sets of experimental data.Hence,this inverse method can be applied more widely to determine the parameters of discrete element model for other materials. | Rui Chen Yong Wang Ruitao Peng Shengqiang Jiang Congfang Hu Ziheng Zhao | 2020 | Computer Modeling in Engineering & Sciences2020，，5： | 0 |
| 19 | NbN quantum dots anchored hollow carbon nanorods as efficient polysulfide immobilizer and lithium stabilizer for Li-S full batteries显示文摘The shuttle effect of lithium polysulfides(LiPSs)and uncontrollable lithium dendrite growth seriously hinder the practical application of lithium-sulfur(Li-S)batteries.To simultaneously address such issues,monodispersed Nb N quantum dots anchored on nitrogen-doped hollow carbon nanorods(NbN@NHCR)are elaborately developed as efficient Li PSs immobilizer and Li stabilizer for high-performance Li-S full batteries.Density functional theory(DFT)calculations and experimental characterizations demonstrate that the sulfiphilic and lithiophilic NbN@NHCR hybrid can not only efficiently immobilize the soluble Li PSs and facilitate diffusion-conversion kinetics for alleviating the shuttling effect,but also homogenize the distribution of Li+ions and regulate uniform Li deposition for suppressing Li-dendrite growth.As a result,the assembled Li-S full batteries(NbN@NHCR-S||Nb N@NHCR-Li)deliver excellent long-term cycling stability with a low decay rate of 0.031%per cycle over 1000 cycles at high rate of 2 C.Even at a high S loading of 5.8 mg cm^(-2)and a low electrolyte/sulfur ratio of 5.2μL mg^(-1),a large areal capacity of 6.2 mA h cm^(-2)can be achieved in Li-S pouch cell at 0.1 C.This study provides a new perspective via designing a dual-functional sulfiphilic and lithiophilic hybrid to address serious issues of the shuttle effect of S cathode and dendrite growth of Li anode. | Fei Ma Zhuo Chen Katam Srinivas Ziheng Zhang Yu Wu Dawei Liu Hesheng Yu Yue Wang Xinsheng Li Ming-qiang Zhu Qi Wu Yuanfu Chen | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
| 20 | Bionic microchannels for step lifting transpiration显示文摘Those various cross-sectional vessels in trees transfer water to as high as 100 meters,but the traditional fabrication methods limit the manufacturing of those vessels,resulting in the non-availability of those bionic microchannels.Herein,we fabricate those bionic microchannels with various cross-sections by employing projection micro-stereolithography(PμSL)based 3D printing technique.The circumradius of bionic microchannels(pentagonal,square,triangle,and five-pointed star)can be as small as 100μm with precisely fabricated sharp corners.What's more,those bionic microchannels demonstrate marvelous microfluidic performance with strong precursor effects enabled by their sharp corners.Most significantly,those special properties of our bionic microchannels enable them outstanding step lifting performance to transport water to tens of millimeters,though the water can only be transported to at most 20 mm for a single bionic microchannel.The mimicked transpiration based on the step lifting of water from bionic microchannels is also achieved.Those precisely fabricated,low-cost,various cross-sectional bionic microchannels promise applications as microfluidic chips,long-distance unpowered water transportation,step lifting,mimicked transpiration,and so on. | Zhaolong Wang Qiu Yin Ziheng Zhan Wenhao Li Mingzhu Xie Huigao Duan Ping Cheng Ce Zhang Yongping Chen Zhichao Dong | 2023 | International Journal of Extreme Manufacturing2023，5，2： | 0 |
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