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| 1 | Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation显示文摘错误褶层蛋白质能被选择 autophagy 降级。占优势的看法由 autophagosomes 是标注 ubiquitin 的错误褶层蛋白质被支架蛋白质 p62 装配进总数,并且总数然后被吞没并且降级。这里,我们报导 p62 在在 photobleaching 以后有象高球状,经历熔化的能力,和恢复那样的像液体的性质的 vivo 形成微滴。Recombinant p62 不在 vitro 经历阶段分离;然而,补充说到 p62 的 K63 polyubiquitin 链导致 p62 阶段分离,它导致高度分子的重量 ubiquitin 的丰富在 p62 微滴发信号。从 p62 / 房间与 cytosol 混合 recombinant p62 也以一种 polyubiquitination 依赖的方式导致 p62 阶段分离。机械学地, p62 阶段分离依赖于 p62 聚合,在 p62 和 ubiquitin 之间的相互作用,和 polyubiquitin 链的原子价。而且, p62 阶段分离能被象 phosphorylation 那样的 translational 以后修正调整。最后,我们证明在 p62 的联系疾病的变化能影响阶段分离。我们建议那 polyubiquitin 导致链的 p62 阶段分离运动 autophagic 货物集中和分离。 | Daxiao Sun Rongbo Wu Jingxiang Zheng Pilong Li Li YU | 2018 | Cell Research2018，28，4： | 21 |
| 2 | Liquid-liquid phase separation in biology: mechanisms,physiological functions and human diseases显示文摘Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecular mechanisms underlying the dynamics of membrane-bound organelles, such as their fusion and fission, vesicle-mediated trafficking and membrane contactmediated inter-organelle interactions, have been extensively characterized. However, the molecular details of the assembly and functions of membraneless compartments remain elusive. Mounting evidence has emerged recently that a large number of membraneless compartments, collectively called biomacromolecular condensates, are assembled via liquid-liquid phase separation(LLPS). Phase-separated condensates participate in various biological activities, including higher-order chromatin organization,gene expression, triage of misfolded or unwanted proteins for autophagic degradation, assembly of signaling clusters and actin-and microtubule-based cytoskeletal networks, asymmetric segregations of cell fate determinants and formation of pre-and post-synaptic density signaling assemblies. Biomacromolecular condensates can transition into different material states such as gel-like structures and solid aggregates. The material properties of condensates are crucial for fulfilment of their distinct functions, such as biochemical reaction centers, signaling hubs and supporting architectures. Cells have evolved multiple mechanisms to ensure that biomacromolecular condensates are assembled and disassembled in a tightly controlled manner. Aberrant phase separation and transition are causatively associated with a variety of human diseases such as neurodegenerative diseases and cancers. This review summarizes recent major progress in elucidating the roles of LLPS in various biological pathways and diseases. | Hong Zhang Xiong Ji Pilong Li Cong Liu Jizhong Lou Zheng Wang Wenyu Wen Yue Xiao Mingjie Zhang Xueliang Zhu | 2020 | Science China(Life Sciences)2020，63，7： | 11 |
| 3 | Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation显示文摘Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide with H3K27me3, and is the functional homolog of Polycomb protein. This raises the question whether genuine HP1 homologs exist in plants. Here, we report on the discovery of ADCP1, a plant-specific triple tandem Agenet protein, as a multivalent H3K9me reader in Arabidopsis, and establish that ADCP1 is essential for heterochromatin formation and transposon silencing through modulating H3K9 and DNA methylation levels. Structural studies revealed the molecular basis underlying H3K9me-specific recognition by tandem Agenet of ADCP1. Similar to human HP1α and fly HP1a, ADCP1 mediates heterochromatin phase separation. Our results demonstrate that despite its distinct domain compositions, ADCP1 convergently evolves as an HP1-equivalent protein in plants to regulate heterochromatin formation. | Shuai Zhao Lingling Cheng Yifei Gao Baichao Zhang Xiangdong Zheng Liang Wang Pilong Li Qianwen Sun Haitao Li | 2019 | Cell Research2019，29，1： | 10 |
| 4 | Multivalent m^6A motifs promote phase separation of YTHDF proteins显示文摘Dear Editor,Posttranscriptional modifications of coding and non-coding RNAs are prevale nt in cells.N6-methylade no sine (m6A) is the most abundant type of modification on eukaryotic messenger RNAs (mRNAs).1 This modification plays important roles in multiple fundamental biological processes, for example, cell differentiation, tissue development and tumorigenesis. | Yifei Gao Gaofeng Pei Dongxue Li Ru Li Yanqiu Shao Qiangfeng Cliff Zhang Pilong Li | 2019 | Cell Research2019，29，9： | 7 |
| 5 | Formation mechanism and model for sand lens reservoirs in the Jiyang Sub-basin,East China显示文摘The Bohai Bay basin comprises some very important and well documented subtle traps known in China, which have been the major exploration focus and have become a major petroleum play since the 1990s. However, recent exploration showed that the oil-bearing proper-ties of some sand lens reservoirs may vary significantly and the accumulation mechanisms for these lithological subtle traps are not well understood. Based on statistical analysis of oil-bearing properties for 123 sand lens reservoirs in the Jiyang Sub-basin and combined with detailed anatomy of typical sand lens reservoirs and NMR experiments, it has been shown that the structural and sedimentary factors, hydrocarbon generation and expulsion conditions of the sur-rounding source rocks, as well as the petrophysical properties of sand lens reservoirs are the main controlling factors for the formation of sand lens reservoirs. The formation of a sand lens reservoir depends on the interaction between the hydrocarbon accumulation driving force and the resistance force. The driving force is made up of the differential capillary pressure between sandstones and sources rocks and the hydrocarbon diffusion force, and as well as the hydro-carbon expansion force. The resistance force is the friction resistance force for hydrocarbons and water to move through the pore throats of the sand lens. The sedimentary environment, source rock condition and sand reservoir properties can change from unfavorable to favorable depend-ing on the combination of these factors. When these three factors all reach certain thresholds, the sand lens reservoirs may begin to be filled by hydrocarbons. When all of these conditions be-come favorable for the formation of sand lens reservoirs, the reservoir would have high oil satu-ration. This approach has been applied to evaluating the potential of petroleum accumulation in the sand lens reservoirs in the third member of the Neogene Shahejie Formation in the Jiyang Sub-basin. | LI Pilong 1, PANG Xiongqi2,3, CHEN Dongxia2,3, ZHANG Shanwen1, JIN Zhijun4 & JIANG Zhenxue2,3 1. Shengli Oil Field Ltd, SINOPEC, Dongying 257051, China 2. University of Petroleum, Beijing 102249, China 3. Key Laboratory of Oil and Gas Accumulation, Ministry of Education, Beijing 102249, China 4. Research Institute of Petroleum Exploration and Exploitation, SINOPEC, Beijing 100083, China | 2004 | Science China Earth Sciences2004，47，z2： | 6 |
| 6 | Hydrocarbon Accumulation in Lacustrine Turbidite in the Rift Basin, Bohai Bay显示文摘Three types of turbidites are identified in the studied area, including proximal turbidite along the northern steep slope (alluvial fans, fan delta, and subaqueous fans via short-distance transportation), distal turbidites along the southern gentle slope (stacked sliding of delta and fan delta front), and fluxoturbidite in the central depression. Detailed studies of several case histories and the relationship between sedimentary facies and faults suggest a significant role of tectonic setting and faults in the development of turbidite, which created source areas, effected slope topography, controlled the climate and paleo-environment, and formed enough slope angle and slope break for sedimentary instabilities and massive block movement to form turbidite. According to statistics, 0-86%, with an average value of 40.3%, of the trap volumes in the 69 identified Tertiary lacustrine turbidites in the Jiyang Superdepression in the Bohai Bay Basin are filled with oil. The porosity and permeability of turbidite sands vary widely. The productive reservoirs are generally those from the braided channels of both distal and proximal turbidite, and from the main channel of proximal turbidite, with a low carbonate content and the porosity and permeability higher than 12% and 1 mD respectively. Most of the lithologic oil pools in the Jiyang Superdepression are enveloped by the effective source rocks, and the percentage of the trap volume generally increases with the hydrocarbon expulsion intensity of source rocks. This is in contrast with structural-lithologic traps (i.e. proximal turbidite along the steep slope and distal turbidite along the gentle slope), in which, graben-boundary faults play an important role in oil migration, as the turbidites are not in direct contact with effective hydrocarbon source rocks. | Chen Dongxia Pang Xiongqi Li Pilong Jiang Zhenxue | 2006 | Petroleum Science2006，3，1： | 4 |
| 7 | Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin显示文摘Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-causing mutations have been shown to affect this function.However,the mechanism by which MeCP2 organizes chromatin is unclear.In this study,we found that MeCP2 can induce compaction and liquid-liquid phase separation of nudeosomal arrays in vitro,and DNA methylation further enhances formation of chromatin condensates by MeCP2.Interestingly,RTT-causing mutations compromise MeCP2-mediated chromatin phase separation,while benign variants have little effect on this process.Moreover,MeCP2 competes with linker histone H1 to form mutually exclusive chromatin condensates in vitro and distinct heterochromatin foci in vivo.RTT-causing mutations reduce or even abolish the ability of MeCP2 to compete with histone H1 and to form chromatin condensates.Together,our results identify a novel mechanism by which phase separation underlies MeCP2-mediated heterochromatin formation and reveal the potential link between this process and the pathology of RTT. | Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li | 2020 | Cell Research2020，30，5： | 3 |
| 8 | Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish显示文摘Vertebrate embryogenesis involves a conserved and fundamental process, called the maternal-to-zygotic transition (MZT), which marks the switch from a maternal factors-dominated state to a zygotic factors-driven state. Yet the precise mechanism underlying MZT remains largely unknown. Here we report that the RNA helicase Ddx3xb in zebrafish undergoes liquid–liquid phase separation (LLPS) via its N-terminal intrinsically disordered region (IDR), and an increase in ATP content promotes the condensation of Ddx3xb during MZT. Mutant form of Ddx3xb losing LLPS ability fails to rescue the developmental defect of Ddx3xb-deficient embryos. Interestingly, the IDR of either FUS or hnRNPA1 can functionally replace the N-terminal IDR in Ddx3xb. Phase separation of Ddx3xb facilitates the unwinding of 5’ UTR structures of maternal mRNAs to enhance their translation. Our study reveals an unprecedent mechanism whereby the Ddx3xb phase separation regulates MZT by promoting maternal mRNA translation. | Boyang Shi Jian Heng Jia-Yi Zhou Ying Yang Wan-Ying Zhang Magdalena JKoziol Yong-Liang Zhao Pilong Li Feng Liu Yun-Gui Yang | 2022 | Cell Research2022，32，8： | 2 |
| 9 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 10 | Oil/Gas Distribution Patterns in DongyingDepression, Bohai Bay Basin 显示文摘 | Li Pilong | 2004 | Journal ofPetroleum Science and Engineering2004，41，123： | 1 |
| 11 | Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling显示文摘B-cell lymphoma 10(Bcl10) is a scaffolding protein that functions as an upstream regulator of NF-κB signaling by forming a complex with Mucosa-associated lymphoid tissue lymphoma translocation protein 1(Malt1) and CARD-coiled coil protein family. This study showed that Bcl10 was involved in type I interferon(IFN) expression in response to DNA virus infection and that Bcl10-deficient mice were more susceptible to Herpes simplex virus 1(HSV-1) infection than control mice. Mechanistically,DNA virus infection can trigger Bcl10 recruitment to the STING-TBK1 complex, leading to Bcl10 phosphorylation by TBK1.The phosphorylated Bcl10 undergoes droplet-like condensation and forms oligomers, which induce TBK1 phosphorylation and translocation to the perinuclear region. The activated TBK1 phosphorylates IRF3, which induces the expression of type I IFNs.This study elucidates that Bcl10 induces an innate immune response by undergoing droplet-like condensation and participating in signalosome formation downstream of the c GAS-STING pathway. | Dandan Yang Gaofeng Pei Shuangshuang Dong Wenhao Zhang Haiteng Deng Xueqiang Zhao Pilong Li Xin Lin | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 12 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 13 | UAV Laser scanning technology:a potential cost-effective tool for micro-topography detection over wooded areas for archaeological prospection显示文摘Airborne laser scanning(ALS)has recently been identified as a potential tool in topographic mapping for archaeological prospection.However,most existing applications in this field refers to manned ALS systems,for which the high operation and maintenance costs limits its application in small-scale archaeological investigation.In this paper,we conducted an exploratory study on the application of the unmanned aerial vehicle(UAV)laser scanning(ULS)system in ancient micro-topography detection over wooded areas.Compared with manned ALS technology,we analyzed the advantages and potentials of ULS technology for archaeological applications.Then we outlined existing mainstream survey-grade UAV-based laser scanners,data processing and visualization approaches.Furthermore,we performed case studies in three cultural heritage sites in Zhejiang Province,China using two representative mainstream survey-grade ULS systems.Results were then verified by an in-site investigation.Finally,the correct selection of ULS devices,the planning of data acquisition missions and the use of appropriate data processing methods specifically for archaeological prospection were discussed.This paper provides a cost-effective and flexible solution for micro-topography detection in wooded areas.ULS technology,as demonstrated here,can be an important supplement to existing archaeological investigation methods,particularly for small-scale areas,and has promising prospects in archaeological applications. | Wei Zhou Fulong Chen Huadong Guo Mingyuan Hu Qi Li Panpan Tang Wenwu Zheng Jian’an Liu Rupeng Luo Kaikai Yan Ru Li Pilong Shi Sheng Nie | 2020 | International Journal of Digital Earth2020，13，11： | 1 |
| 14 | Myosin 1D and the branched actin network control the condensation of p62 bodies显示文摘Biomolecular condensation driven by liquid-liquid phase separation(LLPS)is key to assembly of membraneless organelles in numerous crucial pathways.It is largely unknown how cellular structures or components spatiotemporally regulate LLPS and condensate formation.Here we reveal that cytoskeletal dynamics can control the condensation of p62 bodies comprising the autophagic adaptor p62/SQSTM1 and poly-ubiquitinated cargos.Branched actin networks are associated with p62 bodies and are required for their conden satio n.Myosi n 1D,a bran ched acti n-associated motor protein,drives coalesce nee of small nano scale p62 bodies into large micron-scale condensates along the branched actin network.Impairment of actin cytoskeletal networks compromises the condensation of p62 bodies and retards substrate degradation by autophagy in both cellular models and Myosin ID knockout mice.Coupling of LLPS scaffold to cytoskeleton systems may represent a general mechanism by which cells exert spatiotemporal control over phase condensation processes. | Xuezhao Feng Wanqing Du Mingrui Ding Wenkang Zhao Xirenayi Xirefu Meisheng Ma Yuhui Zhuang Xiaoyu Fu Jiangfeng Shen Jinpei Zhang Xiuying Lei Daxiao Sun Qing Xi Yiliyasi Aisa Qian Chenr Ying Li Wenjuan Wang Shanjin Huang Li Yu Pilong Li Na Mi | 2022 | Cell Research2022，32，7： | 1 |
| 15 | Phase separation of the nuclear pore complex facilitates selective nuclear transport to regulate plant defense against pathogen and pest invasion显示文摘The nuclear pore complex(NPC),the sole exchange channel between the nucleus and cytoplasm,is composed of several subcomplexes,among which the central barrier determines the permeability/selectivity of the NPC to dominate the nucleocytoplasmic trafficking essential for many important signaling events in yeast and mammals.How plant NPC central barrier controls selective transport is a crucial question remaining to be elucidated.In this study,we uncovered that phase separation of the central barrier is critical for the permeability and selectivity of plant NPC in the regulation of various biotic stresses.Phenotypic assays of nup62 mutants and complementary lines showed that NUP62 positively regulates plant defense against Botrytis cinerea,one of the world’s most disastrous plant pathogens.Furthermore,in vivo imaging and in vitro biochemical evidence revealed that plant NPC central barrier undergoes phase separation to regulate selective nucleocytoplasmic transport of immune regulators,as exemplified by MPK3,essential for plant resistance to B.cinerea.Moreover,genetic analysis demonstrated that NPC phase separation plays an important role in plant defense against fungal and bacterial infection as well as insect attack.These findings reveal that phase separation of the NPC central barrier serves as an important mechanism to mediate nucleocytoplasmic transport of immune regulators and activate plant defense against a broad range of biotic stresses. | Jiaojiao Wang Gaofeng Pei Yupei Wang Dewei Wu Xiaokang Liu Gaoming Li Jianfang He Xiaolin Zhang Xiaoyi Shan Pilong Li Daoxin Xie | 2023 | Molecular Plant2023，16，6： | 1 |
| 16 | CEBIT screening for inhibitors of the interaction between SARS-CoV-2 spike and ACE2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-Cov-2)infection,causing CovID-19,is the most challenging pandemic of the modern era.It has resulted in over 5 million deaths worldwide.To quickly explore therapeutics for COVID-19,we utilized a previously-established system,namely CEBIT.We performed a highthroughput screening of FDA-approved drugs to inhibit the interaction between the receptor-binding domain(RBD)of SARS-CoV-2 spike protein and its obligate receptor ACE2.This interaction is essential for viral entry and therefore represents a promising therapeutic target.Based on the recruitment of interacting molecules into phase-separated condensates as a readout,we identified six positive candidates from a library of 2572 compounds,most of which have been reported to inhibit the entry of SARs-Cov-2 into host cells.Our surface plasmon resonance(SPR)and molecular docking analyses revealed the possible mechanisms via which these compounds interfere with the interaction between RBD and ACE2.Hence,our results indicate that CEBIT is highly versatile for identifying drugs against SARS-Cov-2 entry,and targeting Cov-2 entry by small molecule drugs is a viable therapeutic option to treat CovID-19 in addition to commonly used monoclonal antibodies. | Gaofeng Pei Weifan Xu Jun Lan Xinquan Wang Pilong Li | 2022 | Fundamental Research2022，2，4： | 0 |
| 17 | Preface to the special issue of Phase Separation: methodologies tailored for studying biomolecular condensates显示文摘Cells are super-complex systems that are held far away from equilibrium.One hallmark of the off-equilibrium state is the presence and constant maintenance of subcellular compartments for efficient control of biochemical reactions,material exchange,and information flow.Eukaryotic cells have evolved at least two major ways to compartmentalize their cellular spaces,one aided by enclosure within phospholipid bilayers and the other w让hout. | Pilong Li | 2022 | Biophysics Reports2022，8，1： | 0 |
| 18 | Abnormal phase separation of biomacromolecules in human diseases显示文摘Membrane-less organelles(MLOs)formed through liquid-liquid phase separation(LLPS)are associated with numerous important biological functions,but the abnormal phase separation will also dysregulate the physiological processes.Emerging evidence points to the importance of LLPS in human health and diseases.Nevertheless,despite recent advancements,our knowledge of the molecular relationship between LLPS and diseases is frequently incomplete.In this review,we outline our current understanding about how aberrant LLPS affects developmental disorders,tandem repeat disorders,cancers and viral infection.We also examine disease mechanisms driven by aberrant condensates,and highlight potential treatment approaches.This study seeks to expand our understanding of LLPS by providing a valuable new paradigm for understanding phase separation and human disorders,as well as to further translate our current knowledge regarding LLPS into therapeutic discoveries. | Songhao Zhang Gaofeng Pei Boya Li Pilong Li Yi Lin | 2023 | Acta Biochimica et Biophysica Sinica2023，55，7： | 0 |
| 19 | Remote sensing-based deformation monitoring of pagodas at the Bagan cultural heritage site,Myanmar显示文摘As a World Cultural Heritage site with sacred landscape featuring an exceptional range of Buddhist art and architecture,much attention has been focused on the sustainable development of Bagan(Myanmar).Particularly,the monitoring of landscape surface subsidence and monument instability is of great importance to the protection and development planning of the Bagan heritage site.In this study,we applied high resolution TerraSAR-X imagery acquired from 2019 to 2020 for deformation monitoring based on the small baseline subset(SBAS)and persistent scatterer synthetic aperture radar interferometry(PSInSAR)approaches.We identified several hotspots and pagodas with displacement anomalies linked to land cover change and previous earthquakes.The cross comparison between SBAS and PSInSAR and the precision of height estimates derived by PSInSAR indicated a millimetric precision of the derived deformation products.The combination of the two multi-temporal SAR interferometry approaches satisfies the two-scale monitoring requirements from landscapes to monuments,particularly for large-scale World Heritage sites.The non-contact monitoring method has potential when traditional methods using field accessibility and surveillance are constrained. | Fulong Chen Wei Zhou Yunwei Tang Ru Li Hui Lin Timo Balz Jin Luo Pilong Shi Meng Zhu Chaoyang Fang | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
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