|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Simple, safe, and successful evacuation of severe organized clot retention using a catheter connected with wall suction : suction and fishing method 显示文摘 | YU HS HAM WS HAH YS | 2011 | Urology2011，78，5： | 1 |
| 2 | Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations 显示文摘 | Takase H Yu CR Ham DI | 2006 | J Leukoc Biol2006，80，3： | 1 |
| 3 | The effects of sling exercise to pain degree and muscle activity degree in low back pain patients显示文摘 | Park HS Ham YU | 2009 | Journal of Sports and Leisure Studies2009，36，65： | 1 |
| 4 | Intercultural communication and mediation:A framework for analyzing the intercultural competence of Chinese tour guides显示文摘 | YU X WEILER B HAM S | 2001 | Journal of Vocation Marketing2001，8，1： | 1 |
| 5 | Ultrastructural characterization of whole hydrosalpinx from infertile Chinese women显示文摘 | Louis Chukwuemeka Ajonuma Ernest Hung Yu Ng Lin Nga Chan Pak Ham Chow Lai Sin Kung Annie Nga Yin Cheung Lok Sze Ho Christine Briton-Jones Ingrid H. Lok Christopher J. Haines Hsiao Chang Chan | 2005 | Cell Biology International2005，，10： | 1 |
| 6 | Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity显示文摘 | Yong-Xu Wang Chih-Hao Lee Sambath Tiep Ruth T Yu Jungyeob Ham Heonjoong Kang Ronald M Evans | 2003 | Cell2003，，2： | 1 |
| 7 | Simple, safe, and successful evacuation of severe organized clot retention using a catheter connected with wall suction: suction ang fishing methoh 显示文摘 | Yu HS Ham WS Hah YS | 2011 | Urology2011，78，5： | 1 |
| 8 | Local thermal sensati- on and comfort study in a field environment chamber sm'ved by displacement ventilation system in the tropics显示文摘 | K W D Cheong W J Yu K W ham | | 0，，： | 1 |
| 9 | The pmvalenee ofthe 235delC GJB2 mutation in a Chinese deaf population 显示文摘 | Dai P Yu F Ham B | 2007 | Genet Med2007，9，5： | 1 |
| 10 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 11 | Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity 显示文摘 | Wang YX Lee CH Tiep S Yu RT Ham J Kang H | 2003 | Cell2003，113，2： | 1 |
| 12 | Simpie, safe, and successful evacuation of severe organized clot retention using a catheter connected with wall suction: suction and fishing method显示文摘 | YU HO SONG HAM WON SIK HAH YOON SOO | 2011 | Urology2011，78，5： | 1 |
| 13 | Restricted feeding regimens improve white striping associated muscular defects in broiler chickens显示文摘The current study investigated the effects of intermittent feeding(IF)and fasting strategies at different times post–hatch on muscle growth and white striping(WS)breast development.In the first trial,32 one-day-old Abor Acre broilers were fed ad libitum(AL)for 3 d post–hatch and then randomly allotted into 4 feeding strategies including AL,1h-IF group(1 h IF,4 times feeding/d,1 h each time),1.5h-IF(1.5 h IF,4 times feeding/d,1.5 h each time),and fasting(1d acute fasting,6 d free access to feed)groups and fed for 7 d.Although angiogenic genes including VEGFA,VEGFR1,and VEGFR2,and myogenic genes including MYOG and MYOD were upregulated(P<0.05),the breast muscle satellite cell(SC)number and PAX7,MYF5 expression were decreased by the IF strategies(P<0.05).One-day fasting at 6 d of age also upregulated angiogenic genes and MYOD expression(P<0.05),downregulated MYF5 expression(P<0.05),but did not change SC number(P>0.05).In the second trial,384 one-day-old birds were fed AL for 1 wk and then randomly allotted to the above 4 feeding strategies starting at 8 d of age until 42 d of age.Similarly,IF and fasting strategies upregulated the expression of angiogenic and myogenic genes(P<0.05).Both 1h-IF and 1.5h-IF increased breast muscle SC number(P<0.05).At slaughter,breast muscle fiber diameter of 1.5h-IF was smaller but the SC number was larger than that of the birds fed AL(P<0.05).The IF and fasting strategies prevented WS development,and reduced breast WS scores and triglyceride content(P<0.05)without changing the body weight(P>0.05).Fasting and 1h-IF reduced the expression of adipogenic genes ZNF423 and PDGFRα(P<0.05).Moreover,IF and fasting strategies reduced fibrosis in breast muscle and reduced skeletal muscle-specific E3 ubiquitin ligases(TRIM63 and MAFBX)(P<0.05).Fasting significantly reduced CASPASE-3 in breast muscle(P<0.05).In conclusion,IF starting in the first week decreases SC number.Compared to AL,IF or fasting promotes muscular angiogenesis,increases SC number,prevents muscle degeneration,and prevents the development of WS without impairing the growth performance of broiler chickens. | Hammed Ayansola Yanhui Luo Yan Wan Xiaoxiao Yu Jiaqi Lei Kewei Yu Chaoyong Liao Yuming Guo Bingkun Zhang Bo Wang | 2023 | Animal Nutrition2023，，1： | 0 |
| 14 | Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models显示文摘The link between chronic inflammation and cancer development is well acknowledged.Inflammatory bowel disease including ulcerative colitis and Crohn’s disease frequently promotes colon cancer development.Thus,control of intestinal inflammation is a therapeutic strategy to prevent and manage colitis-associated colorectal cancer(CRC).Recently,gut mucosal damage-associated molecular patterns S100A8 and S100A9,acting via interactions with their pattern recognition receptors(PRRs),especially TLR4 and RAGE,have emerged as key players in the pathogenesis of colonic inflammation.We found elevated serum levels of S100A8 and S100A9 in both colitis and colitis-associated CRC mouse models along with significant increases in their binding with PRR,TLR4,and RAGE.In this study we developed a dual PRR-inhibiting peptide system(rCT-S100A8/A9)that consisted of TLR4-and RAGE-inhibiting motifs derived from S100A8 and S100A9,and conjugated with a CT peptide(TWYKIAFQRNRK)for colon-specific delivery.In human monocyte THP-1 and mouse BMDMs,S100A8/A9-derived peptide comprising TLR4-and RAGE-interacting motif(0.01,0.1,1μM)dose-dependently inhibited the binding of S100 to TLR4 or RAGE,and effectively inhibited NLRP3 inflammasome activation.We demonstrated that rCT-S100A8/A9 had appropriate drug-like properties including in vitro stabilities and PK properties as well as pharmacological activities.In mouse models of DSS-induced acute and chronic colitis,injection of rCT-S100A8/A9(50μg·kg^(-1)·d^(-1),i.p.for certain consecutive days)significantly increased the survival rates and alleviated the pathological injuries of the colon.In AOM/DSS-induced colitis-associated colorectal cancer(CAC)mouse model,injection of rCT-S100A8/A9(50μg·kg^(-1)·d^(-1),i.p.)increased the body weight,decreased tumor burden in the distal colon,and significantly alleviated histological colonic damage.In mice bearing oxaliplatin-resistant CRC xenografts,injection of rCT-S100A8/A9(20μg/kg,i.p.,every 3 days for 24–30 days)significantly inhibited the tumor growth with reduced EMT-associated markers in tumor tissues.Our results demonstrate that targeting the S100-PRR axis improves colonic inflammation and thus highlight this axis as a potential therapeutic target for colitis and CRC. | Euni Cho Seok-Jun Mun Hyo Keun Kim Yu Seong Ham Woo Jin Gil Chul-Su Yang | 2024 | Acta Pharmacologica Sinica2024，45，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员