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| 1 | Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155显示文摘The pro-inflammatory profile of M1 macrophage accumulation in adipose tissue is a central event leading to the metabolic complications of obesity.However,the mechanisms by which M1 macrophages are enriched in adipose tissue during weight gain remain incompletely understood.Here,we investigated the effects of adipocyte-derived microvesicles(ADM)on modulating macrophage phenotype in mice and explored the involved molecular signalling pathways.We found that,compared with ADM from lean mice(SD ADM),ADM from obese mice(HFD ADM)significantly enhanced M1 marker expression.The quantitative RTPCR assay demonstrated that miR-155 was upregulated in both HFD ADM and HFD ADM-treated macrophages.By depleting miR-155 expression in HFD ADM and increasing miR-155 level in SD ADM,we further illustrated that miR-155 in ADM-induced M1 macrophage polarization.Functionally,in contrast to SD ADM,HFD ADM significantly decreased the protein level of SOCS1,a proven miR-155 target,leading to activation of STAT1,and suppression of STAT6 signalling;these effects were reversed by silencing miR-155 in HFD ADM.Furthermore,the supernatant of bone marrow-derived macrophages pre-stimulated with miR-155-bearing ADM interfered with insulin signalling and insulin-induced glucose uptake in adipocytes.Collectively,these results provide the first evidence that M1 macrophage polarization can be mediated by miR-155-bearing ADM,which reciprocally regulates insulin signalling and glucose uptake in adipocytes.Our study reveals a novel mechanism through which obesity induces an imbalance in the M1-to-M2 macrophage ratio in adipose tissue,thus causing chronic inflammation and local insulin resistance. | Yaqin Zhang Hongliang Mei Xiaoai Chang Fang Chen Yunxia Zhu Xiao Han | 2016 | Journal of Molecular Cell Biology2016，8，6： | 11 |
| 2 | Seismic attributes and integrated prediction of fractured and caved carbonate reservoirs in the Tarim Basin,China显示文摘The carbonate reservoirs in the Tarim Basin are characterized by anisotropy and strong heterogeneity.Combined with an integrated analysis of data from seismic,geology,and drilling results,a series of attributes which are suitable for fractured and caved carbonate reservoir prediction is discussed,including amplitude,coherence analysis,spectra decomposition,seismic absorption attenuation analysis and impedance inversion.Moreover,3-D optimization of these attributes is achieved by integration of multivariate discriminant analysis and principle component analysis,where the logging data are taken as training samples.Using the optimized results,the spatial distribution and configuration features of the caved reservoirs can be characterized in detail.This technique not only improves the understanding of the spatial distribution of current reservoirs but also provides a significant basis for the discovery and production of carbonate reservoirs in the Tarim Basin. | Liu Lifeng Sam Zandong Sun Yang Haijun Han Jianfa Gao Hongliang Jing Bing Zhu Xinghui | 2011 | Petroleum Science2011，8，4： | 6 |
| 3 | Activin A prevents neuron-like PC12 cell apoptosis after oxygen-glucose deprivation显示文摘In this study, PC12 cells were induced to differentiate into neuron-like cells using nerve growth facto and were subjected to oxygen-glucose deprivation. Cells were treated with 0, 10, 20, 30, 50, 100 ng/mL exogenous Activin A. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide assay and Hoechst 33324 staining showed that the survival percentage of PC12 cells significantly decreased and the rate of apoptosis significantly increased after oxygen-glucose deprivation. Exogenous Activin A significantly increased the survival percentage of PC12 cells in a dose-dependent manner. Reverse transcription-PCR results revealed a significant increase in Activin receptor IIA, Smad3 and Smad4 mRNA levels, which are key sites in the Activin A/Smads signaling pathway, in neuron-like cells subjected to oxygen-glucose deprivation, while mRNA expression of the apoptosis-regulation gene caspase-3 decreased. Our experimental findings indicate that exogenous Activin A plays an anti-apoptotic role and protects neurons by means of activating the Activin A/Smads signaling pathway. | Guihua Xu Jinting He Hongliang Guo Chunli Mei Jiaoqi Wang Zhongshu Li Han Chen Jing Mang Hong Yang Zhongxin Xu | 2013 | Neural Regeneration Research2013，8，11： | 5 |
| 4 | Lotus seedpod-inspired internal vascularized 3D printed scaffold for bone tissue repair显示文摘In the field of bone defect repair,3D printed scaffolds have the characteristics of personalized customization and accurate internal structure.However,how to construct a well-structured vascular network quickly and effectively inside the scaffold is essential for bone repair after transplantation.Herein,inspired by the unique biological structure of“lotus seedpod”,hydrogel microspheres encapsulating deferoxamine(DFO)liposomes were prepared through microfluidic technology as“lotus seeds”,and skillfully combined with a three-dimensional(3D)printed bioceramic scaffold with biomimetic“lotus”biological structure which can internally grow blood vessels.In this composite scaffold system,DFO was effectively released by 36%in the first 6 h,which was conducive to promote the growth of blood vessels inside the scaffold quickly.In the following 7 days,the release rate of DFO reached 69%,which was fundamental in the formation of blood vessels inside the scaffold as well as osteogenic differentiation of bone mesenchymal stem cells(BMSCs).It was confirmed that the composite scaffold could significantly promote the human umbilical vein endothelial cells(HUVECs)to form the vascular morphology within 6 h in vitro.In vivo,the composite scaffold increased the expression of vascularization and osteogenic related proteins Hif1-α,CD31,OPN,and OCN in the rat femoral defect model,significantly cutting down the time of bone repair.To sum up,this“lotus seedpod”inspired porous bioceramic 3D printed scaffold with internal vascularization functionality has broad application prospects in the future. | Xiaoyu Han Mingjie Sun Bo Chen Qimanguli Saiding Junyue Zhang Hongliang Song Lianfu Deng Peng Wang Weiming Gong Wenguo Cui | 2021 | Bioactive Materials2021，6，6： | 4 |
| 5 | Parameter identifications for a rotor system based on its finite element model and with varying speeds显示文摘为了为旋转的颤动完成预言,机械,一个精确有限元素(FE ) 模型和转子系统的一个有效参数鉴定方法被要求。在这研究,一个测试钻塔被用作一个转子系统的一个原型基于一个 FE 模型验证一种新奇参数鉴定技术。在改变操作速度的转子柄颤动被测量并且与 FE 结果相关。第一, FE 建模的理论和鉴定技术被介绍。然后磁盘失衡参数,僵硬和测试钻塔上的适用的支持的抑制系数被识别。有识别参数的 FE 模型的计算回答与试验性的结果比较被学习。关键词转子系统 - 有限元素模型 - 参数鉴定 - 模型确认工程被中国(50775028 ) 和中国的科技的部的国家自然科学基础为 863 高技术计划(2007AA04Z418 ) 支持。 | Qingkai Han Hongliang Yao Bangchun Wen | 2010 | Acta Mechanica Sinica2010，26，2： | 4 |
| 6 | A new method to determine the synergistic effects of area ratio and microstructure on the galvanic corrosion of LAS A508/309 L/308 L SS dissimilar metals weld显示文摘The synergistic effects of area ratio and microstructure on the galvanic corrosion of A508/309 L/308 L dissimilar metals weld(DMW)are studied by a multi-analytical approach.It was demonstrated that decreasing the anode/cathode surface area ratio obviously enhances the corrosion rate of A508,both locally and globally.Deeper analyses of the AFM results enabled quantitative comparison of the corrosion behaviour of the different surface constituents.It was revealed that in the galvanic interaction of the DMW,the grain refined region corrodes most,followed by the partial grain refined region and base metal matrix of the A508,respectively.The electrochemical localization index(LI)estimation method and AFM analysis both confirmed the presence of a mixed(localized and uniform)corrosion phenomenon occurring on the surface of the A508 anode metal in the galvanic interaction of the dissimilar metals.Finally,the degree of synergism equation was utilized to describe the synergistic effects of anode/cathode area ratio and the microstructure of the samples on the galvanic corrosion of LAS A508/309 L/308 L SS DMW. | Bright O.Okonkwo Hongliang Ming Jianqiu Wang En-Hou Han Ehsan Rahimi Ali Davoodi Saman Hosseinpour | 2021 | Journal of Materials Science & Technology2021，，19： | 3 |
| 7 | Variations in OsSPL10 confer drought tolerance by directly regulating OsNAC2 expression and ROS production in rice显示文摘Drought is a major factor restricting the production of rice(Oryza sativa L.).The identification of natural variants for drought stress-related genes is an important step toward developing genetically improved rice varieties.Here,we characterized a member of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)family,OsSPL10,as a transcription factor involved in the regulation of drought tolerance in rice.OsSPL10 appears to play a vital role in drought tolerance by controlling reactive oxygen species(ROS)production and stomatal movements.Haplotype and allele frequency analyses of OsSPL10 indicated that most upland rice and improved lowland rice varieties harbor the OsSPL10Hap1allele,whereas the OsSPL10Hap2allele was mainly present in lowland and landrace rice varieties.Importantly,we demonstrated that the varieties with the OsSPL10Hap1allele showed low expression levels of OsSPL10 and its downstream gene,OsNAC2,which decreases the expression of OsAP37 and increases the expression of OsCOX11,thus preventing ROS accumulation and programmed cell death(PCD).Furthermore,the knockdown or knockout of OsSPL10 induced fast stomatal closure and prevented water loss,thereby improving drought tolerance in rice.Based on these observations,we propose that OsSPL10 confers drought tolerance by regulating OsNAC2 expression and that OsSPL10Hap1could be a valuable haplotype for the genetic improvement of drought tolerance in rice. | Yingxiu Li Shichen Han Xingming Sun Najeeb Ullah Khan Qun Zhong Zhanying Zhang Hongliang Zhang Feng Ming Zichao Li Jinjie Li | 2023 | Journal of Integrative Plant Biology2023，65，4： | 2 |
| 8 | Rice SPL10 positively regulates trichome development through expression of HL6 and auxin-related genes显示文摘Trichomes function in plant defenses against biotic and abiotic stresses;examination of glabrous lines,which lack trichomes,has revealed key aspects of trichome development and function.Tests of allelism in 51 glabrous rice(Oryza sativa)accessions collected worldwide identified OsSPL10 and OsWOX3B as regulators of trichome development in rice.Here,we report that OsSPL10 acts as a transcriptional regulator controlling trichome development.Haplotype and transient expression analyses revealed that variation in the approximately 700-bp OsSPL10 promoter region is the primary cause of the glabrous phenotype in the indica cultivar WD-17993.Disruption of OsSPL10 by genome editing decreased leaf trichome density and length in the NIL-HL6 background.Plants with genotype OsSPL10^(WD-17993)/HL6 generated by crossing WD-17993 with NIL-HL6 also had fewer trichomes in the glumes.HAIRY LEAF6(HL6)encodes another transcription factor that regulates trichome initiation and elongation,and OsSPL10 directly binds to the HL6 promoter to regulate its expression.Moreover,the transcript levels of auxin-related genes,such as OsYUCCA5 and OsPIN-FORMED1b,were altered in OsSPL10 overexpression and RNAi transgenic lines.Feeding tests using locusts(Locusta migratoria)demonstrated that non-glandular trichomes affect feeding by this herbivore.Our findings provide a molecular framework for trichome development and an ecological perspective on trichome functions. | Jinjie Li Bo Tang Yingxiu Li Chenguang Li Minjie Guo Haiyang Chen Shichen Han Jin Li Qijin Lou Wenqiang Sun Peng Wang Haifeng Guo Wei Ye Zhanying Zhang Hongliang Zhang Sibin Yu Long Zhang Zichao Li | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 9 | Effects of the Ratio of n-6∶n-3 Polyunsaturated Fatty Acids in the Maternal Diet on Immunoglobulins,Fatty Acid Composition,and Performance of Lactating Sows and Suckling Piglets under Conditions of Low Maternal Energy Intake显示文摘This experiment was conducted to investigate the effects of different ratios of n-6 ∶ n-3 polyunsaturated fatty acids (PUFA) in sow diets on the performance of lactating sows and their piglets at low digestible energy intakes. Twenty-one pregnant Landrace sows were assigned to one of three diets from day 108 of gestation until weaning (26 to 29 d) ,containing n-6∶n-3 PUFA ratios of 3 ∶1,8 ∶1 and 11 ∶1. The effects on sow and litter production traits and on sow body condition were examined. There were no differences among treatments in daily feed intakes or in changes in sow weight and back-fat levels during lactation. Litter size,litter weight at birth and weaning and litter average daily weight gain were also unaffected by treatment. As expected, large differences were observed in n-6 and n-3 fatty acids in the colostrum and plasma of sows and piglets (P < 0. 01) . The ratio of n6 ∶ n-3 PUFA the diet was positively correlated with those in colostrum,sow plasma and piglet plasma (R 2= 0. 55,0. 80 and 0. 80,respectively) . Sow plasma insulin and IGF-I levels at weaning were unaffected by the treatments. Plasma leptin (P < 0. 05) concentrations were increased in sows fed the diet with a n-6∶n-3 ratio of 8 ∶ 1. Immunoglobulin concentrations in colostrum were not altered by dietary treatment. Plasma IgG concentrations at d 14 were highest in piglets from sows fed the 8 ∶ 1 ratio of n-6∶n-3. Furthermore,this group had the highest IgA concentrations at day 21 of lactation compared with the other two groups (P < 0. 05) . In summary,our study demonstrated that at low digestible energy levels,altering the ratio of n-6 ∶ n-3 PUFA in the diets for lactating sows affected immune components and the fatty acid composition of lactating sows and their piglets. Further studies are needed to examine whether higher levels of fat supplementation than those used in the present study (1. 5%) can successfully enhance performance. | Wei Yao Hongliang Zhao Jie Li Zhijun Wang Yuhuang Han Shuren Dong Yuejiang Wang Fenglai Wang | 2011 | Journal of Animal Science and Biotechnology2011，2，3： | 2 |
| 10 | Effect of temperature on corrosion behavior of alloy 690 in high temperature hydrogenated water显示文摘The influence of temperature on the corrosion behavior of Alloy 690 is evaluated using potentiodynamic polarization curves,electrochemical impedance spectra(EIS),scanning electron microscopy(SEM),Xray photoelectron spectroscopy(XPS) and transmission electron microscopy(TEM).The corrosion rate of Alloy 690 reaches a local maximum at 250?C.The kinetic control step of the growth of oxide film changes from the diffusion process of aqueous-phase ions to the growth of Cr-rich barrier layer in the temperature range of 200–300?C.A modified double-layer model is proposed to describe the effect of temperature on the structure and composition of the oxide film. | Jiazhen Wang Jianqiu Wang Hongliang Ming Zhiming Zhang En-Hou Han | 2018 | Journal of Materials Science & Technology2018，34，8： | 1 |
| 11 | Regulating the nanoscale intimacy of metal and acidic sites in Ru/γ-Al_(2)O_(3)for the selective conversions of lignin-derived phenols to jet fuels显示文摘Catalytic hydrodeoxygenation(HDO)of biomass-derived oxy-compounds to advanced hydrocarbon fuels usually requires bifunctional catalysts containing metals and acidic sites.The appropriate tuning of metal and/or acidic active sites at interfaces of bifunctional catalysts can significantly improve catalyst activity and product selectivity.Here,4-trifuoromethyl salicylic acid(TFMSA),as a hydrothermal stable organic acid,was employed to tailor the bifunctional interface of Ru/γ-Al_(2)O_(3)to enhance the catalytic performance on converting lignin-derived phenols to jet fuel range cycloalkanes.More than 80%phenol was converted into cyclohexane at 230°C for 1 h over Ru/γ-Al_(2)O_(3)modified by TFMSA,which was about three times higher than that over unmodified Ru/γ-Al_(2)O_(3).X-ray diffraction(XRD),Transmission electron microscope(TEM),H2 chemisorption,and energy dispersive X-ray spectroscopy(EDS)elemental mapping results indicated that Ru nanoparticles and TFMSA were well distributed onγ-Al_(2)O_(3),and a nanoscale intimacy between Ru and TFMSA was reached.Meanwhile,Fourier transform infrared spectroscopy after pyridine adsorption(Py-FT-IR)analysis proved that Brønsted acidic sites on the catalytic interfaces of TFMSA modified Ru/γ-Al_(2)O_(3)had been improved.Moreover,the kinetic and density functional theory(DFT)results suggested that the synergistic effects of adjacent Ru nanoparticles and acidic sites were crutial for promoting the rate-limiting conversion step of phenol HDO to cyclohexane. | Shanshuai Chen Weichen Wang Xue Li Puxiang Yan Wanying Han Tian Sheng Tiansheng Deng Wanbin Zhu Hongliang Wang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 12 | Alkylation of Benzene with 1--Dodecene in Ionic Liquids ^+ Al2Cl6X-(R= butyl, octyl and dodecyl; X=chlorine, bromine and iodine)显示文摘 | XIN Hongliang WU Qin HAN Minghan | 2005 | Appl Catal A2005，292，： | 1 |
| 13 | Param-eter identifications for a rotor system based on its finiteelement model and with varying speeds 显示文摘 | Han Qinkai Yao Hongliang Wen Bangchun | 2008 | Advancesin Vibration Engineering2008，7，： | 1 |
| 14 | Increasing Lump Ores Proportion in Blast Furnace Based on the High- Temperature Interactivity of Iron Bearing Materials显示文摘 | Wu Shengli Han Hongliang Xu Haifa | 2010 | ISIJ International2010，50，5： | 1 |
| 15 | Increasing lump ores proportion in blast furnace based on the high-temperature interactivity of iron beating materials显示文摘 | WU Shengli HAN Hongliang XU Haifa | 2010 | ISIJ international2010，50，5： | 1 |
| 16 | Highly effective use of Australian Pilbara blend lump ore in a blast furnace显示文摘 | WU Shengli HAN Hongliang LIU Xinliang | 2010 | Revue de M6tallurgie2010，107，5： | 1 |
| 17 | Computational identification of microRNAs and their targets in wheat (Triticum aestivum L.)显示文摘microRNAs (miRNAs) are a class of endogenous, non-coding, short (~21 nt) RNAs directly involved in regulating gene expression at the post-transcriptional level. Previous reports have noted that plant miRNAs in the plant kingdom are highly conserved, which provides the foundation for identification of conserved miRNAs in other plant species through homology alignment. Conserved miRNAs in wheat are identified using EST (Expressed Sequence Tags) and GSS analysis. All previously known miRNAs in other plant species were blasted against wheat EST and GSS sequences to select novel miRNAs in wheat by a series of filtering criteria. From a total of 37 conserved miRNAs belonging to 18 miRNA families 10 conserved miRNAs comprising 4 families were reported in wheat. MiR395 is found to be a special family, because three members belonging to the same miR395 family are clustered together, similar to animal miRNAs. MiRNA targets are transcription factors involved in wheat growth and development, metabolism,and stress responses. | HAN YouSheng, LUAN FuLei, ZHU HongLiang, SHAO Yi, CHEN AnJun, LU ChengWen, LUO YunBo & ZHU BenZhong Laboratory of Fruit Biotechnology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China | 2009 | Science China(Life Sciences)2009，52，11： | 1 |
| 18 | Responses of rice and winter wheat to free-air CO2 enrichment (China FACE) at rice/wheat rotation system显示文摘 | Hongliang Ma Jianguo Zhu Zubin Xie Gang Liu Qing Zeng Yong Han | 2007 | Plant and Soil (-)2007，，1： | 1 |
| 19 | High-precision stress determination in photoelasticity显示文摘Stress separation is usually achieved by solving differential equations of equilibrium after parameter determination from isochromatics and isoclinics.The numerical error resulting from the stress determination is a main concern as it is always a function of parameters in discretization.To improve the accuracy of stress calculation,a novel meshless barycentric rational interpolation collocation method(BRICM)is proposed.The derivatives of the shear stress on the calculation path are determined by using the differential matrix which converts the differential form of the equations of equilibrium into a series of algebraic equations.The advantage of the proposed method is that the auxiliary lines,grids,and error accumulation which are commonly used in traditional shear difference methods(SDMs)are not required.Simulation and experimental results indicate that the proposed meshless method is able to provide high computational accuracy in the full-field stress determination. | Zikang XU Yongsheng HAN Hongliang SHAO Zhilong SU Ge HE Dongsheng ZHANG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，4： | 1 |
| 20 | High effective utilization of iron-containing dust and sludge in sintering process 显示文摘 | Han Hongliang Duan Dongping Feng Gensheng | 2011 | Metalurgia International2011，16，12： | 1 |
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