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| 1 | Full-color micro-LED display with high color stability using semipolar(20-21) InGaN LEDs and quantum-dot photoresist显示文摘Red-green-blue(RGB)full-color micro light-emitting diodes(μ-LEDs)fabricated from semipolar(20-21)wafers,with a quantum-dot photoresist color-conversion layer,were demonstrated.The semipolar(20-21)In Ga N/Ga Nμ-LEDs were fabricated on large(4 in.)patterned sapphire substrates by orientation-controlled epitaxy.The semipolarμ-LEDs showed a 3.2 nm peak wavelength shift and a 14.7%efficiency droop under 200 A∕cm2injected current density,indicating significant amelioration of the quantum-confined Stark effect.Because of the semipolarμ-LEDs’emission-wavelength stability,the RGB pixel showed little color shift with current density and achieved a wide color gamut(114.4%NTSC space and 85.4%Rec.2020). | SUNG-WEN HUANG CHEN YU-MING HUANG KONTHOUJAM JAMES SINGH YU-CHIEN HSU FANG-JYUN LIOU JIE SONG JOOWON CHOI PO-TSUNG LEE CHIEN-CHUNG LIN ZHONG CHEN JUNG HAN TINGZHU WU HAO-CHUNG KUO | 2020 | Photonics Research2020，8，5： | 12 |
| 2 | Spectral tomographic imaging with aplanatic metalens显示文摘Tomography is an informative imaging modality that is usually implemented by mechanical scanning,owing to the limited depth-of-field(DOF)in conventional systems.However,recent imaging systems are working towards more compact and stable architectures;therefore,developing nonmotion tomography is highly desirable.Here,we propose a metalens-based spectral imaging system with an aplanatic GaN metalens(NA=0.78),in which large chromatic dispersion is used to access spectral focus tuning and optical zooming in the visible spectrum.After the function of wavelength-switched tomography was confirmed on cascaded samples,this aplanatic metalens is utilized to image microscopic frog egg cells and shows excellent tomographic images with distinct DOF features of the cell membrane and nucleus.Our approach makes good use of the large diffractive dispersion of the metalens and develops a new imaging technique that advances recent informative optical devices. | Chen Chen Wange Song Jia-Wern Chen Jung-Hsi Wang Yu Han Chen Beibei Xu Mu-Ku Chen Hanmeng Li Bin Fang Ji Chen Hsin Yu Kuo Shuming Wang Din Ping Tsai Shining Zhu Tao Li | 2019 | Light(Science & Applications)2019，8，1： | 12 |
| 3 | Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG显示文摘 | Wen-Ying Liao Chih-Chuang Liaw Yuan-Chao Huang Hsin-Ying Han Hung-Wei Hsu Shiaw-Min Hwang Sheng-Chu Kuo Chia-Ning Shen Hui-Fen Liao | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 4 | Thermal Insulation Materials of Alumina Based Porous Ceramics显示文摘Significant energy saving effects can be made through the improvement of furnace refractories,especially the thermal insulation refractories. In this study,the preparation and the application of different alumina based porous ceramics were briefly introduced. Alumina based porous ceramics were prepared combined foaming method with gelcasting,sol- gel process or cement curing process. The influences of different preparation methods on the sintering shrinkage, porosity, phase composition, microstructure, compressive strength and thermal conductivity were discussed. Alumina based porous ceramics with relatively high strength and low thermal conductivity could be obtained through the above mentioned methods. Compared with the traditional lining materials,about 40% energy could be saved when they were used as the furnace wall. | YUAN Bo CHEN Kuo HAN Jianshen DONG Binbin WANG Gang LI Hongxia | 2015 | China's Refractories2015，24，3： | 2 |
| 5 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 6 | The Notch pathway attenuates burn-induced acute lung injury in rats by repressing reactive oxygen species显示文摘Background:Acute lung injury(ALI)is a common complication following severe burns.The underlying mechanisms of ALI are incompletely understood;thus,available treatments are not sufficient to repair the lung tissue after ALI.Methods:To investigate the relationship between the Notch pathway and burn-induced lung injury,we established a rat burn injury model by scalding and verified lung injury via lung injury evaluations,including hematoxylin and eosin(H&E)staining,lung injury scoring,bronchoalveolar lavage fluid and wet/dry ratio analyses,myeloperoxidase immunohistochemical staining and reac-tive oxygen species(ROS)accumulation analysis.To explore whether burn injury affects Notch1 expression,we detected the expression of Notch1 and Hes1 after burn injury.Then,we extracted pulmonary microvascular endothelial cells(PMVECs)and conducted Notch pathway inhibition and activation experiments,via aγ-secretase inhibitor(GSI)and OP9-DLL1 coculture,respectively,to verify the regulatory effect of the Notch pathway on ROS accumulation and apoptosis in burn-serum-stimulated PMVECs.To investigate the regulatory effect of the Notch pathway on ROS accumulation,we detected the expression of oxidative-stress-related molecules such as superoxide dismutase,nicotinamide adenine dinucleotide phosphate(NADPH)oxidase(NOX)2,NOX4 and cleaved caspase-3.NOX4-specific small interfering RNA(siRNA)and the inhibitor GKT137831 were used to verify the regulatory effect of the Notch pathway on ROS via NOX4.Results:We successfully established a burn model and revealed that lung injury,excessive ROS accumulation and an inflammatory response occurred.Notch1 detection showed that the expression of Notch1 was significantly increased after burn injury.In PMVECs challenged with burn serum,ROS and cell death were elevated.Moreover,when the Notch pathway was suppressed by GSI,ROS and cell apoptosis levels were significantly increased.Conversely,these parameters were reduced when the Notch pathway was activated by OP9-DLL1.Mechanistically,the inhibition of NOX4 by siRNA and GKT137831 showed that the Notch pathway reduced ROS production and cell apoptosis by downregulating the expression of NOX4 in PMVECs.Conclusions:The Notch pathway reduced ROS production and apoptosis by downregulating the expression of NOX4 in burn-stimulated PMVECs.The Notch-NOX4 pathway may be a novel therapeutic target to treat burn-induced ALI. | Weixia Cai Kuo Shen Peng Ji Yanhui Jia Shichao Han Wanfu Zhang Xiaolong Hu Xuekang Yang Juntao Han Dahai Hu | 2022 | Burns & Trauma2022，10，1： | 2 |
| 7 | Perihepatic nodes detected by point-of-care ultrasound in acute hepatitis and acute-on-chronic liver disease显示文摘AIM: To study the manifestations of perihepatic lymph nodes during the episode of acute hepatitis flare by point-of-care ultrasonography.METHODS: One hundred and seventy-six patients with an episode of acute hepatitis flare(ALT value > 5 × upper normal limit) were enrolled retrospectively. Diagnosis of etiology of the acute hepatitis flare was based on chart records and serological and virological assays. The patients were categorized into two groups(viral origin and non-viral origin) and further defined into ten subgroups according to the etiologies. An ultrasonograpy was performed within 2 h to 72 h(median, 8 h). The maximum size of each noticeable lymph node was measured. Correlation between clinical parameters and nodal manifestations was analyzed RESULTS: Enlarged lymph nodes(width ≥ 5mm)were noticeable in 110(62.5%) patients, mostly in acute on chronic hepatitis B(54.5%). The viral group had a higher prevalence rate(89/110 = 80.9%) and larger nodal size(median, 7 mm) than those of the non-viral group(21/66 = 31.8%; median, 0 mm)(P < 0.001 for both). Meanwhile, there were significant differences in the nodal size between acute and chronic viral groups(P < 0.01), and between acute hepatitis A and non-hepatitis A viral groups(P < 0.001). In logistical regression analysis, the nodal width still showed strong significance in multivariate analysis(P < 0.0001) to stratify the two groups. The area under the curve of ROC was 0.805, with a sensitivity of 80.9%, a specificity of 68.2%, positive predictive value of 80.92%, negative predictive value of 68.18%, and an accuracy of 76.14%. CONCLUSION: Point-of-care ultrasonography to detect perihepatic nodal change is valuable for clarifying the etiologies in an episode of acute hepatitis flare. | I Che Feng Szu Jen Wang Ming Jen Sheu Lok-Beng Koay Ching Yih Lin Chung Han Ho Chi Shu Sun Hsing Tao Kuo | 2015 | World Journal of Gastroenterology2015，21，44： | 2 |
| 8 | Mechanical pain sensitivity of deep tissues in children--possible develop- ment of myofascial trigger points in children 显示文摘 | Han TI Hong CZ Kuo FC | 2012 | BMC Musculoskelet Disord2012，13，4： | 1 |
| 9 | Application of resist-profile-aware source optimization in 28 nm full chip optical proximity correction显示文摘As technology node shrinks, aggressive design rules for contact and other back end of line(BEOL)layers continue to drive the need for more effective full chip patterning optimization. Resist top loss is one of the major challenges for 28 nm and below technology nodes, which can lead to post-etch hotspots that are difficult to predict and eventually degrade the process window significantly. To tackle this problem, we used an advanced programmable illuminator(FlexRay) and Tachyon SMO(Source Mask Optimization) platform to make resistaware source optimization possible, and it is proved to greatly improve the imaging contrast, enhance focus and exposure latitude, and minimize resist top loss thus improving the yield. | Jun Zhu David Wei Zhang Chinte Kuo Qing Wang Fang Wei Chenming Zhang Han Chen Daquan He Stephen D.Hsu | 2017 | Journal of Semiconductors2017，38，7： | 1 |
| 10 | A hybrid of genetic algorithm and particle swarm optimization for solving bi-level linear programming problem - A case study on supply chain model 显示文摘 | KUO R J HAN Y S | 2011 | Applied Mathematical Modelling2011，35，8： | 1 |
| 11 | Improvement in uniformity of emission by ZrO2 nano-particles for white LEDs显示文摘 | Hsin-Chu Chen Kuo-Ju Chen Chien-Chung Lin Chao-Hsun Wang Hau-Vei Han Hsin-Han Tsai Hsuan-Ting Kuo Shih-Hsuan Chien Min-Hsiung Shih Hao-Chung Kuo | 2012 | Nanotechnology2012，，26： | 1 |
| 12 | Regulation of CD28 expression on umbilical cord blood and adult peripheral blood CD8+ T ceils by interleukin(IL )-15/IL-21 显示文摘 | Yu Han Chen Ming Ling Kuo Po-Jen Cheng | 2012 | Cytokine2012，58，1： | 1 |
| 13 | Predictors of in‐hospital mortality after acute variceal bleeding in patients with hepatocellular carcinoma and concurrent main portal vein thrombosis显示文摘 | Ming‐Lun Han Chieh‐Chang Chen Shih‐Hao Kuo Wen‐Feng Hsu Jyh‐Ming Liou Ming‐Shiang Wu Hsiu‐Po Wang | 2014 | J Gastroenterol Hepatol2014，，2： | 1 |
| 14 | A Hybrid of Genetic Algorithm and Particle Swarm Optimization for Solving Bi-Level Linear Programming Problem -A Case Study on Supply Chain Model显示文摘 | Kuo R J Han Y S | 2011 | Applied Mathematical Modelling2011，35，8： | 1 |
| 15 | Semicontinu- ous microcosm study of aerobic cometabolism of trichlor- eoethylene using toluene 显示文摘 | Han Y L Tom Kuo T M C Tseng I C | 2007 | Journal of Hazardours Mate- rials2007，148，3： | 1 |
| 16 | Pilot studies for in-situ aerobic cometabolism of trichloroethylene using toluene-vapor as the primary substrate 显示文摘 | Tom Kuo M C Liang K F Han Y L | 2004 | Water Research2004，38，： | 1 |
| 17 | 查看详情显示文摘 | Chen Y W Han P Y Zhang X C Kuo M L Lin S Y | | 0，，： | 1 |
| 18 | Pilot studies for in- situ aerobic cometabolism of trichloroethylene using toluene- vapor as the primary substrate显示文摘 | M C Tom Kuo K F Liang Y L Han | 2004 | Water Research2004，38，： | 1 |
| 19 | Lower urinary tract symptoms in women with irritable bowel syndrome显示文摘 | Ya‐JunGuo Chen‐HsunHo Shyh‐ChyanChen Shun‐ShuangYang Han‐MoChiu Kuo‐HowHuang | 2010 | International Journal of Urology2010，，2： | 1 |
| 20 | Variation in the use of intraoper-ative cholangiography during cholecystectomy 显示文摘 | Sheffield KM Han Y Kuo YF | 2012 | J Am Coll Surg2012，214，4： | 1 |
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