|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | An analytical solution for thermally fully developed combined pressure-electroosmotically driven flow in microchannels显示文摘 | Azad Qazi Zade Manzari Mehrdad T Hannani Siamak K | 2007 | Int J Heat Mass Transfer2007，50，56： | 1 |
| 3 | Harnessing gammadelta T cells in anticancer immunotherapy显示文摘 | Hannani D Ma Y Yamazaki T | 2012 | Trends lmmunol2012，33，5： | 1 |
| 4 | Minimally oxidized low density lipoproteins induces tissue factor expression in cultured human endothelial cells 显示文摘 | Drake IA Hannani K Fei HH | 1991 | Am J Pathol1991，138，3： | 1 |
| 5 | Genetic loci influencing natural variations in femoral bone mor- phometry in mice显示文摘 | Drake T A Hannani K Ka bo J M | 2001 | J Orthop Res2001，19，4： | 1 |
| 6 | Harnessing γTδ cells in anticancer immunotherapy 显示文摘 | Hannani D Ma Y Yamazaki T | 2012 | Trends hnmunol2012，33，5： | 1 |
| 7 | Harnessing γ/Tδ cells in anticancer immunotherapy 显示文摘 | Hannani D Ma Y Yamazaki T | 2012 | Trends Immunol2012，33，5： | 1 |
| 8 | Prerequisites for the antitumor vaccine-like effect of chemotherapy and radiotherapy显示文摘 | Hannani D Sistiqu A Kepp O | 2011 | Cancer J2011，17，5： | 1 |
| 9 | Photochemotherapy in- duces the apoptosis of monocytes without impairing their function 显示文摘 | Hannani D Gabert F Laurin D | 2010 | Transplantation2010，89，5： | 1 |
| 10 | Photochemotherapy in- duces the apoptosis of monocytes without impairing their function 显示文摘 | Hannani D Gabert F Laurin D | 2010 | Transplantation2010，89，5： | 1 |
| 11 | Mechanisms of load transfer in the cadaver forearm: role of the interosseous mem- brane 显示文摘 | Markolf K L Dunbar A K Hannani K | 2000 | J Hand Surg Am2000，25，4： | 1 |
| 12 | Large eddy simulation of heavy-particle transport in turbulent channel flow 显示文摘 | Amiri A E Hannani S K Mashayek F | 2007 | Numerical Heat Transfer Part B: Fundamentals2007，50，4： | 1 |
| 13 | Mechanisms of load transfer in the ca- daver forearm:role of the interosseous membrane 显示文摘 | Markolf KL Dunbar AM Hannani K | 2000 | J Hand Surg (Am)2000，25，4： | 1 |
| 14 | Second Law Based Modeling to Optimum Design of High Capacity Pulse Tube Refrigerators显示文摘 | Jafarian A Saidi M H Hannani S K | 2008 | International Journal of Refrigeration2008，，： | 1 |
| 15 | Harnessing γδ T cells in anticancer immunotherapy显示文摘 | Dalil Hannani Yuting Ma Takahiro Yamazaki Julie Déchanet-Merville Guido Kroemer Laurence Zitvogel | 2012 | Trends in Immunology2012，，5： | 1 |
| 16 | Mechanisms of load transfer in the cadaver forearm: role of the interosseous membrane显示文摘 | Markolf KL Dunbar AK Hannani K | 2000 | J Hand Surg[hm]2000，25，4： | 1 |
| 17 | Prerequisites for the antitumor vaccine-like effect of chemotherapy and radiotherapy显示文摘 | Hannani D Sistigu A Kepp O | 2011 | Cancer J2011，17，5： | 1 |
| 18 | 显示文摘 | Hannani A | 1998 | Trans Inst Met Finish1998，76，3： | 1 |
| 19 | A fully explicit three-step SPH algorithm for simulation of non-Newtonian fluid flow 显示文摘 | Hosseini S Manzari M Hannani S | 2007 | International Journal of Numerical Methods for Heat & Fluid Flow2007，17，7： | 1 |
| 20 | Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells显示文摘 | Yuting Ma Sandy Adjemian Stephen R. Mattarollo Takahiro Yamazaki Laetitia Aymeric Heng Yang Jo?o Paulo Portela Catani Dalil Hannani Helene Duret Kim Steegh Isabelle Martins Frederic Schlemmer Micka?l Michaud Oliver Kepp Abdul Qader Sukkurwala Laurie Menge | 2013 | Immunity2013，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员