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| 1 | One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients显示文摘The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. | Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai | 2016 | Science China(Life Sciences)2016，59，7： | 18 |
| 2 | Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine显示文摘Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future. | Sufang Han Zhifeng Xiao Xing Li Huan Zhao Bin Wang Zhixue Qiu Zhi Li Xin Mei Bai Xu Caixia Fan Bing Chen Jin Han Yanzheng Gu Huilin Yang Qin Shi Jianwu Dai | 2018 | Science China(Life Sciences)2018，61，1： | 15 |
| 3 | Study on Multiple Electromagnetic Continuous Casting of Aluminum Alloy显示文摘与高质量获得半固体艾尔合金营舍,调查被在连续的扔从一个铜模子的外面强加一个多重磁场执行。为处理的半固体金属(SSM ) 设计的 AISi6Mg2 合金连续地在各种各样的条件下面通过一张沉没入口嘴被扔。新月运动,温度分发和营舍质量上的多重磁场的效果被检验。试验性的结果证明那新月骚乱引起了由电磁激动人心能有效地被控制,半固体艾尔合金营舍的表面质量极大地被改进,并且越过营舍的横向的节的一致地好的、球状的微观结构被优化多重磁场的分发完成。 | Zhifeng ZHANG Jun XUN Likai SHI | 2006 | Journal of Materials Science & Technology2006，22，4： | 13 |
| 4 | Seasonal variations in the occurrence and distribution of estrogens and pharmaceuticals in the Zhangweinanyun River System显示文摘The report describes the use of solid-phase extraction(SPE)and LC/MS/MS to investigate the occurrence and distribution of 4 estrogens(estrone,17 β-estradiol,estriol,and 17 α-ethynylestradiol)and 3 anti-inflammatories(ibuprofen,ketoprofen and naproxen)in the Zhangweinanyun River System(China).Relatively higher concentrations were observed for estrone,17 α-ethynylestradiol,and ketoprofen in the Wei Canal than in the Wei River and in the Zhangweixin River.The study suggested that there is a potential ecological risk of male fish feminization from estrogens in the Zhangweinanyun River System. | CAO JinLing SHI JiangHong HAN Rui LI YingXia YANG ZhiFeng | 2010 | Chinese Science Bulletin2010，55，27： | 13 |
| 5 | Numerical simulation on electromagnetic field,flow field and temperature field in semisolid slurry preparation by A-EMS显示文摘A two-dimensional computational model coupling an annular electromagnetic stirring(A-EMS) with a macroscopic heat and fluid flow analysis in Al-alloys semisolid slurry preparation was developed.The dynamic evolutions of the electromagnetic field,flow field,and temperature field were presented successfully by commercial software ANSYS 10.0 with corresponding experimental verification.A horizontally rotational electromagnetic field and,thereby,a more intensive velocity field were uniformly distributed in the stirred melt even at commercial frequency,and thus,a lower temperature difference in the stirred melt and subsequent uniformly fine microstructures were obtained compared with the normal electromagnetic stirring.The simulation results were in good agreement with experimental ones. | ZHANG Zhifeng,CHEN Xingrun,XU Jun,and SHI Likai National Engineering & Technology Research Center for Nonferrous Metal Matrix Composites,General Research Institute for Nonferrous Metals,Beijing 100088,China | 2010 | Rare Metals2010，29，6： | 13 |
| 6 | Annular electromagnetic stirring——a new method for the production of semi-solid A357 aluminum alloy slurry显示文摘A new method for producing semisolid slurry,annular electromagnetic stirring(AEMS),to refine and spheroidize grains was exploited.Experimental work was undertaken to investigate the effects of cooling rate,stirring power and stirring time on the solidification behavior of A357 alloy using A-EMS.It was found that increasing the cooling rate and stirring power gave rise to substantial grain refinement,which could be attributed to the increase of effective nucleation rate caused by the extremely uniform temperature and composition fields in the bulk liquid during the initial stage of solidification.Results showed that a fully grain refined spherical structure could be obtained using proper processing conditions within 10s. | Guanglei ZHU Jun XU Zhifeng ZHANG Yuelong BAI Likai SHI | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，6： | 11 |
| 7 | In-situ fabrication of PtSe2/GaN heterojunction for self-powered deep ultraviolet photodetector with ultrahigh current on/off ratio and detectivity显示文摘The research of ultraviolet photodetectors(UV PDs)have been attracting extensive attention,due to their important applications in many areas.In this study,PtSe2/GaN heterojunction is in-situ fabricated by synthesis of large-area vertically standing two-dimensional(2D)PtSe2 film on n-GaN substrate.The PtSe2/GaN heterojunction device demonstrates excellent photoresponse properties under illumination by deep UV light of 265 nm at zero bias voltage.Further analysis reveals that a high responsivity of 193 mA·W^-1,an ultrahigh specific detectivity of 3.8 × 10^14 Jones,linear dynamic range of 155d B and current on/off ratio of^10^8,as well as fast response speeds of 45/102μs were obtained at zero bias voltage.Moreover,this device response quickly to the pulse laser of 266 nm with a rise time of 172 ns.Such high-performanee PtSe2/GaN heteroj u nction UV PD demonstrated in this work is far superior to previously reported results,suggesting that it has great potential for deep UV detection. | Ranran Zhuo Longhui Zeng Huiyu Yuan Di Wu Yuange Wang Zhifeng Shi Tingting Xu Yongtao Tian Xinjian Li Yuen Hong Tsang | 2019 | Nano Research2019，12，1： | 11 |
| 8 | Modeling the impacts of drying trend scenarios on land systems in northern China using an integrated SD and CA model显示文摘Climate-induced drought has exerted obvious impacts on land systems in northern China.Although recent reports by the Intergovernmental Panel on Climate Change(IPCC) have suggested a high possibility of climate-induced drought in northern China,the potential impacts of such drying trends on land systems are still unclear.Land use models are powerful tools for assessing the impacts of future climate change.In this study,we first developed a land use scenario dynamic model(iLUSD) by integrating system dynamics and cellular automata.Then,we designed three drying trend scenarios(reversed drying trend,gradual drying trend,and acceleration of drying trend) for the next 25 years based on the IPCC emission scenarios and considering regional climatic predictions in northern China.Finally,the impacts of drying trend scenarios on the land system were simulated and compared.An accuracy assessment with historic data covering 2000 to 2005 indicated that the developed model is competent and reliable for understanding complex changes in the land use system.The results showed that water resources varied from 441.64 to 330.71 billion m3 among different drying trend scenarios,suggesting that future drying trends will have a significant influence on water resource and socioeconomic development.Under the pressures of climate change,water scarcity,and socioeconomic development,the ecotone(i.e.,transition zone between cropping area and nomadic area) in northern China will become increasingly vulnerable and hotspots for land-use change.Urban land and grassland would have the most prominent response to the drying trends.Urban land will expand around major metropolitan areas and the conflict between urban and cultivated land will become more severe.The results also show that previous ecological control measures adopted by the government in these areas will play an important role in rehabilitating the environment.In order to achieve a sustainable development in northern China,issues need to be addressed such as how to arrange land use structure and patterns rationally,and how to adapt to the pressures of climate change and socioeconomic development together. | HUANG QingXu HE ChunYang LIU ZhiFeng SHI PeiJun | 2014 | Science China Earth Sciences2014，57，4： | 10 |
| 9 | Metal halide perovskite nanocrystals and their applications in optoelectronic devices显示文摘In recent years, metal halide perovskite nanocrystals (NCs) have been favored by manyresearchers due to their unique properties including long carrier diffusion length, highcarrier mobility, tunable emission wavelength, and narrow full width at half maximum,making them great application potentials in optoelectronic devices. The photoluminescencequantum yields of perovskite NCs are nearly 100%, and the device efficiencyof perovskite NC-based light-emitting diodes (LEDs) has been improvedsignificantly from below 0.1% to over 20%. In addition, perovskite NC-based solarcells and photodetectors have also developed rapidly in recent years. Here, we summarizethe synthesis and the basic optoelectronic properties of metal halide perovskiteNCs and introduce their applications in LEDs, solar cells, and photodetectors. | Po Lu Min Lu Hua Wang Ning Sui Zhifeng Shi William W.Yu Yu Zhang | 2019 | InfoMat2019，1，4： | 7 |
| 10 | The tectonic differences between the east and the west in the deep-water area of the northern South China Sea显示文摘The deep-water area of the northern South China Sea, which has active and complicated tectonics, is rich in natural gas and gas hydrate. While the tectonic characteristics is different obviously between the east and the west because of the special tectonic position and tectonic evolution process. In terms of submarine geomorphology,the eastern shelf-slope structure in Pearl River Mouth Basin is characterized by having wide sub-basins and narrow intervening highs, whereas the western(Qiongdongnan Basin) structure is characterized by narrow subbasins and wide uplift. As to the structural features, the deep-water sags in the east are all structurally halfgrabens, controlled by a series of south-dipping normal faults. While the west sags are mainly characterised by graben structures with faulting in both the south and north. With regards to the tectonic evolution, the east began neotectonic activity when the post-rifting stage had completed at the end of the Middle Miocene. In the Baiyun Sag, tectonic activity became strong and was characterised by rapid subsidence and obvious faulting. Whereas in the west, neotectonic activity began at the end of the Late Miocene with rapid deposition and weak fault activity. | XIA Zhongyu WAN Zhifeng WANG Xianqing SHI Qiuhua CAI Song XIA Bin | 2016 | Acta Oceanologica Sinica2016，35，1： | 4 |
| 11 | The enhanced protective effects of salvianic acid A: A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier显示文摘Ischemic stroke is the leading cause of disability and death worldwide. Currently, the only proven treatment for ischemic stroke is restoring the cerebral blood supply. In addition, some of the tissue is damaged during the subsequent reperfusion because of the overproduction of reactive oxygen species (ROS). Furthermore, antioxidant therapies have shown promise in preclinical studies for the treatment of ischemia-reperfusion injury. However, their therapeutic efficacy has been limited because of their low bioavailability in brain. To resolve this issue, we synthesized ROS-responsive, fan-shaped dendrimer nanoparticles (NPs) and conjugated them with a blood-brain barrier (BBB)-targeting peptide, COG1410, and salvianic acid A (SA), which is an effective antioxidant in ischemic stroke. The BBB targeting peptide acts as a ligand of the nanocarrier system and penetrates the BBB through the endocytosis of the ligand receptor. The results showed that T-SA-NPs not only target and accumulate in the infarct area, they also reduce over 2 times of the infarct area and reverse the behavioral deficits in MCAO mice, which illustrates that these NPs have an effective therapeutic effect on the ischemic stroke. In addition, these NPs had no toxicity in any organs of the body. Importantly, the present study provides an alternative strategy for delivering antioxidants to the brain and achieving targeted therapy of ischemic stroke. | Yaru Li Xiaojie Zhang Zhifeng Qi Xueling Guo Xiaopeng Liu Wenjuan Shi Yang Liu Libo Du | 2020 | Nano Research2020，13，10： | 4 |
| 12 | Highly sensitive solar-blind deep ultraviolet photodetector based on graphene/PtSe_(2)/β-Ga_(2)O_(3)2D/3D Schottky junction with ultrafast speed显示文摘There is an emerging need for high-sensitivity solar-blind deep ultraviolet(DUV)photodetectors with an ultra-fast response speed.Although nanoscale devices based on Ga_(2)O_(3)nanostructures have been developed,their practical applications are greatly limited by their slow response speed as well as low specific detectivity.Here,the successful fabrication of two-/three-dimensional(2D/3D)graphene(Gr)/PtSe2/β-Ga_(2)O_(3)Schottky junction devices for high-sensitivity solar-blind DUV photodetectors is demonstrated.Benefitting from the high-quality 2D/3D Schottky junction,the vertically stacked structure,and the superior-quality transparent graphene electrode for effective carrier collection,the photodetector is highly sensitive to DUV light illumination and achieves a high responsivity of 76.2 mA/W,a large on/off current ratio of~105,along with an ultra-high ultraviolet(UV)/visible rejection ratio of 1.8×104.More importantly,it has an ultra-fast response time of 12µs and a remarkable specific detectivity of~1013 Jones.Finally,an excellent DUV imaging capability has been identified based on the Gr/PtSe2/β-Ga_(2)O_(3)Schottky junction photodetector,demonstrating its great potential application in DUV imaging systems. | Di Wu Zhihui Zhao Wei Lu Lukas Rogée Longhui Zeng Pei Lin Zhifeng Shi Yongtao Tian Xinjian Li Yuen Hong Tsang | 2021 | Nano Research2021，14，6： | 4 |
| 13 | Recent Advances and Opportunities of Lead-Free Perovskite Nanocrystal for Optoelectronic Application显示文摘Metal halide perovskite nanocrystals(NCs),as a new class of light-emitting and light-harvesting materials,have recently attracted intensive attention for an impressive variety of optoelectronic applications.However,the lead toxicity and poor stability of such materials severely restrict their practical applications and future commercialization.Lead-free perovskite NCs and their derivatives,designed by the reasonable chemical substitution of Pb with other nontoxic elements,are recently booming as an attractive alternative to lead-based counterparts.In this review,we firstly present a comprehensive overview of currently explored lead-free perovskite NCs with an emphasis on their design routes,morphologies,optoelectronic properties,and environmental stability issues.Then,we discuss the preliminary achievements of lead-free perovskite NCs in versatile optoelectronic applications,such as light-emitting devices,solar cells,photodetectors,and photocatalysis.We finish this review with a critical outlook into the currently existing challenges and possible development opportunities of this rapidly evolving field. | Fei Zhang Zhuangzhuang Ma Zhifeng Shi Xu Chen Di Wu Xinjian Li Chongxin Shan | 2021 | Energy Material Advances2021，，1： | 3 |
| 14 | Joint Design of Coalition Formation and Semi-Blind Channel Estimation in Fog Radio Access Networks显示文摘Coordinated signal processing can obtain a huge transmission gain for Fog Radio Access Networks(F-RANs).However,integrating into large scale,it will lead to high computation complexity in channel estimation and spectral efficiency loss in transmission performance.Thus,a joint cluster formation and channel estimation scheme is proposed in this paper.Considering research remote radio heads(RRHs)centred serving scheme,a coalition game is formulated in order to maximize the spectral efficiency of cooperative RRHs under the conditions of balancing the data rate and the cost of channel estimation.As the cost influences to the necessary consumption of training length and estimation error.Particularly,an iterative semi-blind channel estimation and symbol detection approach is designed by expectation maximization algorithm,where the channel estimation process is initialized by subspace method with lower pilot length.Finally,the simulation results show that a stable cluster formation is established by our proposed coalition game method and it outperforms compared with full coordinated schemes. | Zhifeng Wang Feifan Yang Shi Yan Saleemullah Memon Zhongyuan Zhao Chunjing Hu | 2019 | China Communications2019，16，11： | 3 |
| 15 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 16 | Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold显示文摘Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. | Fengwu Tang Jiaguang Tang Yannan Zhao Jiaojiao Zhang Zhifeng Xiao Bing Chen Guang Han Na Yin Xianfeng Jiang Changyu Zhao Shixiang Cheng Ziqiang Wang Yumei Chen Qiaoling Chen Keran Song Zhiwei Zhang Junjie Niu Lingjun Wang Qin Shi Liang Chen Huilin Yang Shuxun Hou Sai Zhang Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，5： | 3 |
| 17 | Solubility of ammonium paratungstate in the system NH_3·H_2O·H_2O显示文摘The equilibrium solubilities of 5(NH4)O@ 12WO3 @ 5H2O (APT@ 5H2O) were determined at the terminal ammoniaconcentration of 2 mol/L at 87-95℃. Experimental data were regressed. The linear functional relation between the solubilityof APT@ 5H2O and the temperature (t / ℃) is given as y = - 588.08 + 7.28t. The solubility of the species as a function of theterminal ammonia concentration (x / mol@ L-1) is also achieved: y = 36.76 + 18.86x. The solubility of APT@ 5H2O producedby ion-exchange method in China is much lower, which is due to much lower silica, much higher NH4C1, and a smallamount of APT@ 7H2O with low solubility in the APT crystals. APT@ 7H2O forms because of a large amount of NH4Cl andthe low activity of water in the crystallization. | WAN Linsheng, XU Zhifeng, and SHI ZhonglingFaculty of Materials and Chemical Engineering, Southern Institute of Metallurgy, Ganzhou 341000, China | 2003 | Rare Metals2003，22，1： | 3 |
| 18 | Effect of pulsatile perfusion during cardiopulmonary bypass in terms of radial artery sphygmogram显示文摘OBJECTIVE: To investigate a quantitative method for using radial artery pulse waveforms to assess the effect of pulsatile flow during cardiopulmonary bypass(CPB).METHODS: A total of 34 adults with heart disease who underwent open-heart surgery between April2010 and January 2011 were randomized into a pulsatile perfusion group(n=17) and a non-pulsatile perfusion group(n=17). Radial arterial pulse waveforms of pulsatile and non-pulsatile perfusion patients were observed and compared before and during CPB.RESULTS: No pulse waveform could be detected at patients' radial artery in both groups when the aorta was cross-clamped. Pulse waveforms could be detected at pulsatile perfusion patients' radial artery, but could not be detected at non-pulsatile perfusion patients' radial artery during CPB. Additionally, patients' pulse waveforms during pulsatile perfusion were lower than those before the operation.CONCLUSION: Our findings indicate that radial artery sphygmogram can be used as a valid indicator to evaluate the effectiveness of pulsatile perfusion during CPB. | Zhifeng Zhang Jiatuo Xu Enyuan Zhu Qi Zhang Lu Yu Yongbing Qiu Jianguo Tang Zhaofu Fei Xin Li Liping Tu Chouping Han Ying Liu Zhen Guo Changle Zhou Meiyu Shi Yingxin Qian Yimin Bao Xinming Ji | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
| 19 | 3D-printed bioactive ceramic scaffolds with biomimetic micro/nano-HAp surfaces mediated cell fate and promoted bone augmentation of the bone-implant interface in vivo显示文摘Calcium phosphate bio-ceramics are osteo-conductive,but it remains a challenge to promote the induction of bone augmentation and capillary formation.The surface micro/nano-topography of materials can be recognized by cells and then the cell fate are mediated.Traditional regulation methods of carving surface structures on bio-ceramics employ mineral reagents and organic additives,which might introduce impurity phases and affect the biological results.In a previous study,a facile and novel method was utilized with ultrapure water as the unique reagent for hydrothermal treatment,and a uniform hydroxyapatite(HAp)surface layer was constructed on composite ceramics(β-TCP/CaSiO_(3))in situ.Further combined with 3D printing technology,biomimetic hierarchical structure scaffolds were fabricated with interconnected porous composite ceramic scaffolds as the architecture and micro/nano-rod hybrid HAp as the surface layer.The obtained HAp surface layer favoured cell adhesion,alleviated the cytotoxicity of precursor scaffolds,and upregulated the cellular differentiation of mBMSCs and gene expression of HUVECs in vitro.In vivo studies showed that capillary formation,bone augmentation and new bone matrix formation were upregulated after the HAp surface layer was obtained,and the results confirmed that the fabricated biomimetic hierarchical structure scaffold could be an effective candidate for bone regeneration. | Xiao Liu Yali Miao Haifeng Liang Jingjing Diao Lijing Hao Zhifeng Shi Naru Zhao Yingjun Wang | 2022 | Bioactive Materials2022，7，6： | 2 |
| 20 | Polymer nanoparticles with dendrimer-Ag shell and its application in catalysis显示文摘Polymer nanoparticles with dendrimer-Ag shell were prepared and their application in catalytic reduction of 4-nitrophenol(4-NP) was investigated.Cross-linked polystyrene(PS) microspheres were prepared through dispersion copolymerization of styrene,acrylic acid and crosslinking monomer 1,2-divinylbenzene.PS microspheres with average size of 450 nm and narrow size distribution were used as support for the immobilization of dendrimer-Ag shell.The polyamidoamine(PAMAM) dendrimer shell was successively grafted onto the surface of PS microspheres through repetitive Michael addition reaction of methyl acrylate(MA) and amidation of the obtained esters with large excess of ethylenediamine(EDA).Silver nanoparticles were formed directly inside the PAMAM shell through reduction with NaBH_4.The resulting PS@PAMAM-Ag nanoparticles were packed in a stainless steel column and used successfully for catalytic reduction of 4-NP.This technique for packing catalytic polymer particles in a column could improve the efficiency of using the metal catalyst and the tedious separation in catalytic reaction. | Gaofei Dang Yan Shi Zhifeng Fu Wantai Yang | 2013 | Particuology2013，11，3： | 2 |
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