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| 1 | Stability analysis of rib pillars in highwall mining under dynamic and static loads in open‑pit coal mine显示文摘The retained coal in the end slope of an open-pit mine can be mined by the highwall mining techniques.However,the instability mechanism of the reserved rib pillar under dynamic loads of mining haul trucks and static loads of the overlying strata is not clear,which restricts the safe and efcient application of highwall mining.In this study,the load-bearing model of the rib pillar in highwall mining was established,the cusp catastrophe theory and the safety coefcient of the rib pillar were considered,and the criterion equations of the rib pillar stability were proposed.Based on the limit equilibrium theory,the limit stress of the rib pillar was analyzed,and the calculation equations of plastic zone width of the rib pillar in highwall mining were obtained.Based on the Winkler foundation beam theory,the elastic foundation beam model composed of the rib pillar and roof under the highwall mining was established,and the calculation equations for the compression of the rib pillar under dynamic and static loads were developed.The results showed that with the increase of the rib pillar width,the total compression of the rib pillar under dynamic and static loads decreases nonlinearly,and the compression of the rib pillar caused by static loads of the overlying strata and trucks has a decisive role.Numerical simulation and theoretical calculation were also performed in this study.In the numerical simulation,the coal seam with a buried depth of 122 m and a thickness of 3 m is mined by highwall mining techniques.According to the established rib pillar instability model of the highwall mining system,it is found that when the mining opening width is 3 m,the reasonable width of the rib pillar is at least 1.3 m,and the safety factor of the rib pillar is 1.3.The numerical simulation results are in good agreement with the results of theoretical calculation,which verifes the feasibility of the theoretical analysis of the rib pillar stability.This research provides a reference for the stability analysis of rib pillars under highwall mining. | Haoshuai Wu Yanlong Chen Haoyan Lv Qihang Xie Yuanguang Chen Jun Gu | 2022 | International Journal of Coal Science & Technology2022，9，3： | 1 |
| 2 | Risk SNP-induced lncRNA-SLCCl drives colorectal cancer through activating glycolysis signaling显示文摘Long non-coding RNAs(lncRNAs)play key roles in colorectal carcinogenesis.Here,we aimed to identify the risk SNP-induced lncRNAs and to investigate their roles in colorectal carcinogenesis.First,we identified rs6695584 as the causative SNP in 1 q41 locus.The A>G mutation of rs6695584 created a protein-binding motif of BATF,altered the enhancer activity,and subsequently activated IncSLCCl expression.Further validation in two independent CRC cohorts confirmed the upregulation of IncSLCCl in CRC tissues,and revealed that increased IncSLCCl expression was associated with poor survival in CRC patients.Mechanistically,lncRNA-SLCCl interacted with AHR and transcriptionally activated HK2 expression,the crucial enzyme in glucose metabolism,thereby driving the glycolysis pathway and accelerating CRC tumor growth.The functional assays revealed that IncSLCCl induced glycolysis activation and tumor growth in CRC mediated by HK2.In addition,HK2 was upregulated in colorectal cancer tissues and positively correlated with IncSLCCl expression and patient survival.Taken together,our findings reveal a risk SNP-mediated oncogene lncRNA-SLCCl promotes CRC through activating the glycolysis pathway. | Tingting Yan Chaoqin Shen Penglei Jiang Chenyang Yu Fangfang Guo Xianglong Tian Xiaoqiang Zhu Shiyuan Lu Bingshe Han Ming Zhong Jinxian Chen Qiang Liu Yingxuan Chen Junfang Zhang Jie Hong Haoyan Chen Jing-Yuan Fang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 3 | Microwave Assisted Hydrothermal Way Towards Highly Crystalized N-Doped Carbon Quantum Dots and Their Oxygen Reduction Performance显示文摘We proposed a green microwave-assisted hydrothermal way to synthesize highly crystalized N-doped carbon quantum dots(N-CQDs).The N-CQDs obtained by this microwave method have good crystalline degree(ID/IG=0.6)and a high molar ratio of N/C(11.1%)comparing with those obtained from traditional top-down method.The experimental results show that glycerine plays a key role ill the fonnation of highly crystalized N-CQDs.The as-prepared N-CQDs have good luminescent property and may be utilized as fluorescent probe to detect ions or mark cells.As the majority of N atoms in the N-CQDs were pyridinic type(64.8%),the as-prepared N-CQDs were used as a catalyst for the oxygen reduction reaction(ORR)electrocatalysis in the anode of the fuel cell(the onset potential is-0.121V),which was a 4e-transfer procedure and the catalyst showed good stability after 100 cycles. | HUANG He LIANG Chen SHA Haoyan YU Ying LOU Yue CHEN Cailing LI Chunguang CHEN Xiaobo SHI Zhan FENG Shouhua | 2019 | Chemical Research in Chinese Universities2019，35，2： | 1 |
| 4 | Deletion of the activating NKG 2C receptor and a functional polymorphism in its ligand HLA ‐E in psoriasis susceptibility显示文摘 | Xue Zeng Haoyan Chen Rashmi Gupta Oscar Paz‐Altschul Anne M. Bowcock Wilson Liao | 2013 | Exp Dermatol2013，，10： | 1 |
| 5 | Short-term variations and influencing factors of suspended sediment concentrations at the Heisha Beach,Guangdong,China显示文摘Knowledge of sediment variation processes is essential to understand the evolution mechanism of beach morphology changes.Thus,a field measurement was conducted at the Heisha Beach,located on the west coast of the Zhujiang River(Pearl River)Estuary,to investigate the short-term variation in suspended sediment concentrations(SSCs)and the relationship between the SSC and turbulent kinetic energy,bottom shear stress(BSS),and relative wave height.Based on extreme event analysis results,extreme events have a greater influence on turbulent kinetic energy than SSC.Although a portion of the turbulent kinetic energy dissipates directly into the water column,it plays an important role in suspended sediment motion.Most of the time,the wave-current interaction is strong enough to drive sediment incipience and resuspension.When combined,the wave-current interaction and wave-induced BSSs have a greater influence on suspended sediment transport and SSC variation than current-induced BSS alone.The relative wave height also has a strong correlation with SSC,indicating that the combined effect of water depth and wave height significantly impacts SSC variation.Water depth is mainly controlled by the tide on the beaches;thus,the effects of tides and waves should be conjunctively considered when analyzing the factors influencing SSC. | Jintang Ou Haoyan Dong Liangwen Jia Xiangxin Luo Zixiao He Kanglin Chen Jing Liu Yitong Lin Mingdong Yu Mingen Liang | 2022 | Acta Oceanologica Sinica2022，41，5： | 0 |
| 6 | Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production显示文摘Dear Editor,The novel COVID-19 coronavirus(SARS-CoV-2)endangers thousands of lives.Recently,nearly 10%COVID-19 patients with symptoms of the digestive tract were subsequently diagnosed in newly discovered SARS-CoV-2 infected cases,1 which indicates that SARSCoV-2 may infect people via digestive systems.The expression profile of angiotensin-converting enzyme homolog 2(ACE2)has been analyzed in gastrointestinal tract using external datasets.Unfortunately,most data of these datasets are not from Asian adults and the expression of other SARS-CoV-2 entry genes have not been detected in human gastrointestinal tract.Therefore,to provide more implications of viral transmission in clinical diagnosis and treatment,it is urgent to explore the expression of SARS-CoV-2 entry genes in the gastrointestinal tract of Asian people.Here,we used single-cell RNA sequencing profiled~27,800 cells of intestinal tissues from six patients with basic intestinal disease of Renji hospital. | Haoyan Chen Tian-Hui Zou Baoqin Xuan Yuqing Yan Tingting Yan Chaoqin Shen Gang Zhao Ying-Xuan Chen Xiao Xiao Jie Hong Jing-Yuan Fang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 7 | Design of phase interface and defect in niobium-nickel oxide for ultrafast Li-ion storage显示文摘Niobium pentoxide(Nb2O5)has attracted much attention in lithium batteries due to its advantages of high operating voltage,large theoretical capacity,environmental friendliness and cost-effectiveness.However,the intrinsic poor electrical conductivity,sluggish kinetics,and large volume changes hinder its electrochemical performance at high power density,making it away from the requirements for practical applications.In this research work,we regulate the electron transport of niobium-nickel oxide(NiNbO)anode material with enhanced structural stability at high power density by constructing the two-phase boundaries between niobium pentoxide(Nb2O5)and nickel niobate(NiNb2O6)through simple solid phase reaction.In addition,the presence of lattice defects in NiNbO-F further speeds up the transport of Li+and promotes the electrochemical reaction kinetics more effectively.The two-phase boundaries and defect modulated anode material displays high Li+diffusion coefficient of 1.63×10^(−10) cm^(2) s^(−1),pretty high initial discharge capacity of 222.8 mAh g^(−1) at 1 C,extraordinary high rate performance(66.7 mAh g^(−1))at an ultrahigh rate(100 C)and ultra-long cycling stability under high rate of 25 C(83.4 mAh g^(−1) after 2000 cycles)with only 0.016%attenuation per cycle.These results demonstrate an effective approach for developing electrode materials that greatly improve rate performance and durability. | Haiting Chen Haoyan Cheng Hangchen Liu Yibo Hu Tongtong Yuan Shuge Dai Meilin Liu Hao Hu | 2023 | Journal of Materials Science & Technology2023，，16： | 0 |
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