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| 1 | Two centuries of April-July temperature change in southeastern China and its influence on grain productivity显示文摘China is a traditional agriculture based country and one main region for crop production is southeastern China where temperature is a dominant climate variable affecting agriculture. Temperature and social disturbances both influence crop production, yet distinguishing their relative impacts is difficult due to a lack of reliable, high-resolution historical climatic records before the very recent period. Here we present the first tree-ring based warm-season temperature reconstruction for southeastern China, a core region of the East Asian monsoon, for the past 227 years. The reconstruction target was April-July mean temperature, and our model explained 60.6% of the observed temperature variance during 1953–2012.Spatial correlation analysis showed that the reconstruction is representative of April-July temperature change over most of eastern China. The reconstructed temperature series agrees well with China-scale(heavily weighted in eastern China) agricultural production index values quite well at decadal timescales.The impacts of social upheavals on food production, such as those in the period 1920–1949, were confirmed after climatic influences were excluded. Our study should help distinguish the influence of social disturbance and warm-season temperature on grain productivity in the core agricultural region of China during the past two centuries. | Jiangfeng Shi Jinbao Li David D.Zhang Jingyun Zheng Shiyuan Shi Quansheng Ge Harry F.Lee Yesi Zhao Jie Zhang Huayu Lu | 2017 | Science Bulletin2017，62，1： | 6 |
| 2 | Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells显示文摘OBJECTIVE To investigate the role of connexin proteins(Cx),which form gap junctions(GJ),in progression and chemotherapeutic sensitivity of cervical cancer(CaC x).METHODS We analyze the expression of Cx26,Cx30,Cx32 and Cx43 in human specimens consisting of:Normal cervix(n=78),CaCx FIGO stageⅠ(n=148),CaCx FIGO stageⅡ(n=165).In CaCx cell lines,Hela-Cx32(induced expression by doxycycline),C-33A(endogenously express Cx32)and si Ha(transiently transfected plasmid with Cx32),we detected the role of Cx32 against tostreptonigrin/cisplatin-induced apopotosisin presence or absence of functional GJ through using GJ inhibitors or low density cultural.Furtherly,we observed the relativity of Cx32 and EGFR expression in human specimens.Also,we detected the role of EGFR signaling pathway in the process of Cx32 anti-apoptosis through suppressed EGFR expression by inhibitors or si RNA sequences in cell lines.RESULTS We firstly demonstrated the expression of Cx32 was highly upregulated and accumulated in cytoplasm in the CaCx specimens,and the degree of upregulation correlated with advanced FIGO stages.Thus,in three human cervical cell lines,Cx32 was shown to suppress apoptosis when GJ formation is inhibited.No matter in cases of CaCx or cell lines,Cx32 expression was highly correlated with expression of EGFR and the EGFR pathway is an essential component of the Cx32-induced anti-apoptotic effect.CONCLUSION Cx32,traditionally tumor suppressive protein,was shown to be tumor protective against chemotherapy through EGFR pathway in a GJ-independent way. | Yi-fan ZHAO Yong-chang LAI Hui GE Yun-quan GUO Xue FENG Jia SONG Qin WANG Li-xia FAN Andrew L HARRIS Xi-yan WANG Liang TAO | 2017 | 中国药理学与毒理学杂志2017，31，10： | 3 |
| 3 | HIV peev counseling and the development ofhope:perspectives from peer counselors and peer counseling recip-ients显示文摘 | Harris GE Lavsen D | 2007 | AIDS Patient Care STDS2007，21，11： | 1 |
| 4 | Treatment outcome in psychiatric inpatients: the discriminative value of self-esteem显示文摘 | Talbot F Harris GE French DJ | 2009 | Int J Psychiatry Med2009，39，3： | 1 |
| 5 | Defective Interplay of Activators and Repressors with TFIIH in Xeroderma Pigmentosum显示文摘 | Juhong Liu Sasha Akoulitchev Achim Weber Hui Ge Sergei Chuikov Daniel Libutti Xin W Wang Joan Weliky Conaway Curtis C Harris Ronald C Conaway Danny Reinberg David Levens | 2001 | Cell2001，，3： | 1 |
| 6 | The activation function-1 domain of Nur77/NR4A1 mediates trans-activation,cell specificity,and coactivator recruitment显示文摘 | Wansa KD Harris JM Muscat GE | 2002 | J Biol Chem2002，277，33： | 1 |
| 7 | 显示文摘 | Ge J J Hou H Q Graham M J Greiner A Reneker D Harris F W Cheng S Z | 2004 | JACS2004，126，15： | 1 |
| 8 | Comparison of NTP historical control tumor incidence rates infemale Harlan Sprague Dawley and Fischer 344/N Rats 显示文摘 | Dinse GE Peddada SD Harris SF | 2010 | Toxicol Pathol2010，38，5： | 1 |
| 9 | Liquid crystalline and monot ropic phase behaviors of 2,3,6,7,10,11-hexa (4-octyloxybenzoyloxy) triphenylene discotic molecules显示文摘 | Tang BY Ge J J Zhang A Calhoun B Chu P Wang H Shen Z Harris F W Cheng S Z D | | 0，，01： | 1 |
| 10 | Adaptive Neural Network Control of Robotic Manipulators显示文摘 | Ge S S Lee T H Harris C J | 1998 | London:World Scientific1998，，： | 1 |
| 11 | The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment显示文摘 | Wansa KD Harris JM Muscat GE | 2002 | J Biol Chem2002，277，33： | 1 |
| 12 | Physical fitness and blood pressure in school children显示文摘 | Fraser GE Phillips RL Harris R | | 0，，： | 1 |
| 13 | Adaptive Neural Network Control of Robotic Manipulators 显示文摘 | Ge S S Lee T H Harris C J | 1997 | World IEEE Transactions on Industrial Electronics (S0278-0046)1997，44，6： | 1 |
| 14 | Stmctm'e/function analysis of a dUTPase: Catalytic mechanism of a potential chemotherapeutic target显示文摘 | Harris JM Mclntosh EM Muscat GE | 1999 | J Mol Biol1999，288，2： | 1 |
| 15 | Pharmacokinetics of flunixin meglumine in the cow显示文摘 | Hardee GE Smith JA Harris SJ | 1985 | Res Vet Sci1985，39，1： | 1 |
| 16 | Nitric oxide is a key component in inflammation-accelerated tumorigenesis 显示文摘 | Hussain SP He P Subleski J Hofseth LJ Trivers GE Mechanic L Hofseth AB Bernard M Schwank J Nguyen G Mathe E Djurickovic D Haines D Weiss J Back T Gruys E Laubach VE Wiltrout RH Harris CC | 2008 | Cancer Res2008，68，17： | 1 |
| 17 | Strong quantum-confined Stark effect in germanium quantum-well structures on silicon显示文摘 | Kuo Y H Lee Y K Ge Y Ren S Roth J E Kamins T I Miller D A B Harris J S | | 0，，7063： | 1 |
| 18 | Quantum-confined stark effect in Ge/SiGe quantum wells on Si for optical modulators显示文摘 | Kuo Y H Lee Y K Ge Y S Ren S Roth J E Kamins T I Miller D A B Harris J S | | 0，，06： | 1 |
| 19 | Comparison of renal function after endovascular aneurysm repair with different transrenally fixated endografts显示文摘 | Forbes TL Harding GE Lawlor DK Derose G Harris KA | | 0，，： | 1 |
| 20 | Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease显示文摘 | Harris MA Pluhar GE | 2008 | J Nutr Biochem2008，19，2： | 1 |
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