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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 4 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 5 | Energetics of charged point defects in rutile TiO2 by density functional theory显示文摘 | LI X FINNIS M W HE J BEHERA R K PHILLPOT S R SINNOTT S B DICKEY E C | 2009 | Acta Materialia2009，57，： | 1 |
| 6 | Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy显示文摘 | Hinton DR Spee C He S Weitz S Usinger W LaBree L | 2004 | Diabetes Care2004，27，3： | 1 |
| 7 | An innovative design for using flexible printed coils for magnetostrictive-based longitudinal guided wave sensors in steel strand inspection显示文摘 | Tse P W Liu X C Liu Z H Wu B He C F Wang XJ | 2011 | Smart Materials and Structures2011，20，05： | 1 |
| 8 | China's regional difference of water resource use efficiency and influencing factors显示文摘 | Qian W J He C F | 2011 | China Population Resources and Environment2011，21，2： | 1 |
| 9 | Trace mercury(II)detection and separation in serum and water samplesusing a reusable bifunctional fluorescent sensor显示文摘 | He C Zhu W Xu Y Chen T Qian X | 2009 | Ana-lytica Chimica Acta2009，651，2： | 1 |
| 10 | Sensitive and rapid detection of the new Delhi metallo-beta- lactamase gene by loop-mediated isothermal amplification 显示文摘 | Liu W Zou D Li Y Wang X He X Wei X Shao C Li X Shang W Yu K Liu D Li Y Guo J Yin Z Yuan J | 2012 | J Clin Microbiol2012，50，5： | 1 |
| 11 | Nickel-catalyzed oxidative coupling reactions of two different terminal alkynes using 02 as the oxidant at room temperature : facile syntheses of unsymmetrie 1, 3-diynes 显示文摘 | Yin W He C Chen M | 2009 | Org Lett2009，11，3： | 1 |
| 12 | Microstructures and proper- ties of SnZn lead-free solder joints bearing La for electronic pack- aging显示文摘 | Zhang L Han J G He C W | 2012 | IEEE Transactions on Electron Devices2012，59，12： | 1 |
| 13 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 14 | The mechanism of starch granule reacted with OSA by phase transition catalyst in aqueous medium显示文摘 | WANG C HE X W HUANG Q | 2013 | Food Chemistry2013，141，4： | 1 |
| 15 | 2007b Mechanism of heterogeneous reaction of carbonyl sulfide on magnesium oxide 显示文摘 | Liu Y C He H Xu W Q | 2007 | J Phys Chem (A)2007，111，： | 1 |
| 16 | Study on molecular epidemiology of Streptococcus suis type 2显示文摘 | He K W Ni Y X Wang J C | 2002 | Chinese Journal of Zoonoses2002，18，5： | 1 |
| 17 | New proxy multisignature scheme显示文摘 | HSU C WU T HE W | 2005 | Applied Mathematics and Computation2005，162，3： | 1 |
| 18 | A processing-induced clay dispersion and its effect on the structure and properties of polyamide 6 显示文摘 | Liu T J Tjiu W C He C | 2004 | Polym Int2004，53，4： | 1 |
| 19 | A continuum model for size-dependent deformation of elastic films of nanoscale thickness显示文摘 | He L H Lim C W Wu B S | 2004 | International Journal of Solids and Structures2004，41，： | 1 |
| 20 | Novel KOH electrolyte for one-step electrochemical synthesis of high purity solid K2FeO4:Comparison with NaOH 显示文摘 | He W C Wang J M Shao H B | 2005 | Electrochemistry Communications2005，7，6： | 1 |
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