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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008,18,4: | 64 |
| 2 | Depletion and dysfunction of Vy,2Vo2 T cells in HIV disease: mechanisms, impacts and therapeutic implications显示文摘有人的免疫不全病毒(HIV ) 的感染在 γ 之中破坏平衡; δT 房间子集,与增加 Vδ 1 +房间和传播 Vδ 的实质的弄空; 2 +房间。弄空是在 CD4 否定的 Vδ 的 HIV 的间接效果; 2 个房间,但是为 Vγ 识别的 phosphoantigen 应答的 subpopulations 是特定的; 2-J γ 1.2 (也叫的 Vγ 9-J γ P ) T 房间受体重新整理。房间损失和恢复的程度与临床的地位仔细有关,与功能的 Vδ 的高水平;在病毒控制器(当 antiretroviral 治疗不在时的无法发现的 viremia ) 在场的 2 个房间。我们为 Vδ 考察机制和临床的后果;在 HIV 的 2 房间弄空疾病。我们探讨的问题调停 HIV 的 Vδ尽管有是感染的间接效果, 2 房间弄空是为这个病毒的有免疫力的避免策略的重要部分。为 Vδ 的重要角色;作为受动器和有免疫力的管理者, 2 个房间识别 HIV 影响的关键机制并且显示出在 Vδ 之间的强壮的关系; 2 房间损失和免疫不全疾病。这块场地基于指向 Vδ 向有免疫力的治疗正在移动; 2 个房间和我们现在有清楚的球门和期望指导 interventional 临床的选拔赛。 | Haishan Li Suchita Chaudry Bhawna Poonia Yiming Shao C David Pauza | 2013 | Cellular & Molecular Immunology2013,10,1: | 9 |
| 3 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012,22,1: | 7 |
| 4 | WELDING BETWEEN HIGH MANGANESE STEEL AND HIGH CARBON STEEL显示文摘Manuscript received 30 July 1999 Abstract The shielded metal arc welding (SMAW) of a manganese steel part as a crossing of railway track to a carbon steel part as the rails of the railroad is the welding of dissimilar steel. It are was known that it is not possible to the the rail of railroad directly to the cross- ing of railway track made from a steel containing about 14% of manganese (wt. ) because of so many differences between the two kinds of steels such as composition, microstructure,mechanical properties and weldability.A method was used to solve the problem by presetting an intermediate layer on each side of the joint and other special procedures were used.The result of test indicated that a good weld joint was obtained. | M. H. Guo,D. C. Shao, Z. G Dong and J. C Yang National Key Laboratory Advanced Welding Production Technology, Harbin institute of Technology, Harbin 150001, China | 2000 | Acta Metallurgica Sinica(English Letters)2000,13,1: | 2 |
| 5 | 冠状动脉内皮功能障碍患者胆固醇流出异常,高密度脂蛋白颗粒物浓度降低显示文摘冠状动脉内皮功能障碍(endothelial dysfunction,ED)是动脉粥样硬化早期标志,增加心血管事件发生风险。该研究假设胆固醇流出容量和高密度脂蛋白颗粒浓度(high-density lipoprotein particle concentration,HDL-PIMA)较高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)更能预测ED。 | 刘莉 叶鹏 Monette JS Hutchins PM Ronsein GE Wimberger J Irwin AD Tang C Sara JD Shao B Vaisar T Lerman A Heinecke JW | 2016 | 中华高血压杂志2016,24,6: | 2 |
| 6 | P-order metric UWB receiver structures with superior performance显示文摘 | BEAULIEU N C SHAO H FIORINA J | 2008 | IEEE Transactions on Communications2008,56,10: | 1 |
| 7 | Semi-wild wheat from Xi zang(Tibet)显示文摘 | Shao Q Q Li Ch S Basang C R | 1980 | Acta Genet Sin1980,7,2: | 1 |
| 8 | Treatment of brewery wastewater using anaerobic sequencing batch reactor 显示文摘 | SHAO X W PENG D C TENG Z H | 2008 | Bioresource Technology2008,99,: | 1 |
| 9 | On the Marcinkiewicz integral with variable kernels显示文摘 | DING Y LIN C C SHAO S L | 2004 | Indiana Univ Math J2004,53,: | 1 |
| 10 | Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis显示文摘 | Ma T Kang C Shao H | 2006 | Eur Surg Res2006,38,5: | 1 |
| 11 | Signal processing with fractional low order moments:stable processes and their application显示文摘 | Shao M Nikias C L | 1993 | Proceedings of the IEEE1993,81,7: | 1 |
| 12 | Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes 显示文摘 | VANDEN HOEK TL SHAO Z LI C | 1997 | J Mol Cell Cardiol1997,29,9: | 1 |
| 13 | Whole exon 5 and intron 5 replaced byRHCEin DVa(Hus) 显示文摘 | Shao C Xiong W Wang W | 2004 | J Hum Genet2004,49,2: | 1 |
| 14 | Cobra cardiotoxin-induced cell death in fetal rat cardiomycoytes and cortical neurons:different pathway butsimilar cell surface target显示文摘 | Chia HW Robert M Shao C L | 2006 | Toxlcon2006,,46: | 1 |
| 15 | Two new flavonoid alkaloids from Senecio argunensis 显示文摘 | Li N Shao L Zhang C F | 2008 | J Asian Nat Prod Res2008,10,12: | 1 |
| 16 | Quantitative evaluation of precipitates in an A1-Zn-Mg-Cu alloy after isothermal aging 显示文摘 | DU Z W SUN Z M SHAO B L ZHOU T T CHEN C Q | 2006 | Materials Characterization2006,56,: | 1 |
| 17 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012,54,4: | 1 |
| 18 | Activation of a single-chamber solid oxide fuel cell by a simple catalyst-assisted in-situ process显示文摘 | ZHANG C M SUN L L RAN R SHAO Z P | 2009 | Electrochem Commun2009,11,8: | 1 |
| 19 | Sensitive and rapid detection of the new Delhi metallo-beta- lactamase gene by loop-mediated isothermal amplification 显示文摘 | Liu W Zou D Li Y Wang X He X Wei X Shao C Li X Shang W Yu K Liu D Li Y Guo J Yin Z Yuan J | 2012 | J Clin Microbiol2012,50,5: | 1 |
| 20 | Water-dichloromethane interface controlled synthesis of hierarchical rutile TiO2 superstuctures and their photocatalytic properties显示文摘 | Wang C Shao C Zhang X | | 0,,15: | 1 |