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| 1 | CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDACl-associated repression of C/EBPα显示文摘 | Dahu Li HengZhu Chao Liang Wenbo Li Guichun Xing Lanzhi Ma Lujing Ding Yi Zhang Fuchu He Lingqiang Zhang | 2014 | Journal of Molecular Cell Biology2014，8，5： | 4 |
| 2 | The C-Terminal Portion of the Nucleocapsid Protein Demonstrates SARS-CoV Antigenicity显示文摘In order to develop clinical diagnostic tools for rapid detection of SARS-CoV (severe acute respiratory syndrome-associated coronavirus) and to identify candidate proteins for vaccine development, the C-terminal portion of the nucleocapsid (NC)gene was amplified using RT-PCR from the SARS-CoV genome, cloned into a yeast expression vector (pEGH), and expressed as a glutathione S-transferase (GST) and Hisx6 double-tagged fusion protein under the control of an inducible promoter.Western analysis on the purified protein confirmed the expression and purification of the NC fusion proteins from yeast. To determine its antigenicity, the fusion protein was challenged with serum samples from SARS patients and normal controls.The NC fusion protein demonstrated high antigenicity with high specificity, and therefore, it should have great potential in designing clinical diagnostic tools and provide useful information for vaccine development. | GuozhenLiu ShaohuiHu YongwuHu PengChen JianningYin JieWen JingqiangWang LiangLin JinxiuLiu BoYou YeYin ShutingLi HaoWang YanRen JiaJi XiaoqianZhao YongqiaoSun XiaoweiZhang JianqiuFang JianWang SiqiLiu JunYu HengZhu HuanmingYang | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 4 |
| 3 | Construction of a recombinant lentivirus containing human microRNA-7-3 and its inhibitory effects on glioma proliferation显示文摘In the present study, we constructed a lentivirus, FIV-CMV-GFP-miR-7-3, containing the microRNA-7-3 gene and the green fluorescent protein gene, and used it to transfect human glioma U251 cells. Fluorescence microscopy showed that 80% of U251 cells expressed green fluorescence. Real-time reverse transcription PCR showed that microRNA-7-3 RNA expression in U251 cells was significantly increased. Proliferation was slowed in transfected U251 cells, and most cells were in the G 1 phase of the cell cycle. In addition, the expression of the serine/threonine protein kinase 2 was decreased. Results suggested that transfection with a lentivirus carrying microRNA-7-3 can effectively suppress epidermal growth factor receptor pathway activity in U251 cells, arrest cell cycle transition from G 1 phase to S phase and inhibit glioma cell growth. | Lun Dong Chongxu Han Hengzhu Zhang Xuewen Gu Jian Li Yongkang Wu Xiaodong Wang | 2012 | Neural Regeneration Research2012，7，27： | 3 |
| 4 | Ultrafast polarization-dependent all-optical switching of germanium-based metaphotonic devices显示文摘Metamaterials play an important role in the modulation of amplitude and group delay in the terahertz(THz)regime on account of their optical properties,which are rare in natural materials.Here an ultrafast anisotropic switch of the plasmon-induced transparency(PIT)effect is experimentally and numerically demonstrated by metamaterial devices composed of two pairs of planar split-ring resonators and a pair of closed-ring resonators.By integration with a germanium(Ge)film,a recovery time of 3 ps and a decay constant of 785 fs are realized in the metadevice.Stimulated by the exterior optical pump,the PIT windows at different frequencies are switched off with an excellent property of slow light for vertical and horizontal THz polarizations,realizing an astonishing modulation depth as high as 99.06%.This work provides a new platform for ultrafast anisotropic metadevices tunable for amplitude and group delay. | HAO SUN YUZE HU YUHUA TANG JIE YOU JUNHU ZHOU HENGZHU LIU XIN ZHENG | 2020 | Photonics Research2020，8，3： | 3 |
| 5 | FOPWA: An Optimized Parallel Algorithm of Watershed Transform for Image Segmentation显示文摘 | Haifang Zhou Xuejun Yang Hengzhu Liu Yu rang | 2006 | 通讯和计算机(中英文版)2006，3，1： | 1 |
| 6 | 1例促甲状腺激素型垂体瘤的综合治疗(英文)显示文摘Thyroid-stimulating hormone(TSH)-secreting pituitary adenoma is a rare type in all pituitary tumors.Recently we treated a TSH-secreting pituitary tumor in our hospital.The patient had been treated for hyperthyroidism,in which methimazole had been prescribed for 10 years,but the symptoms had not been alleviated.MRI imaging demonstrated the typical features of a sellar tumor,and the diameter was approximately 2.7 cm.Based on the laboratory studies:T3 at 6.27 nmol/L,T4 at 260.10 nmol/L,FT3 at 17.22 pmol/L,FT4 at 76.06 pmol/L,TSH at 9.93 Mu/L,the patient was diagnosed with a TSH-secreting pituitary tumor and central hyperthyroidism.After the patient was given octreotide for one week,he received resection of tumor via single-nostril transsphenoidal approach.After discharge,the patient received the radiation therapy two courses about 20 days.Through the comprehensive treatment of surgery,radiotherapy and drugs,the patient received a satisfactory result. | Hengzhu Zhang Xiaodong Wang Xian Zhang Yongkang Wu Lun Dong Lei She | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，8： | 1 |
| 7 | Nitric oxide-mediated immunosuppressive effect of Human amniotic membrane-derived mesenchymal stem cells on the viability and migration of microglia显示文摘 | Ke Yan Run Zhang Lei Chen Fanfan Chen Yi Liu Lingmei Peng Haitao Sun Weiyi Huang Chengmei Sun Bingke Lv Feng Li Yingqian Cai Yanping Tang Yuxi Zou Mouxuan Du Lingsha Qin Hengzhu Zhang Xiaodan Jiang | 2014 | Brain Research2014，，： | 1 |
| 8 | Microsurgical experience with keyhole operations on intracranial aneurysms显示文摘 | Qing Lan Zhigang Gong Dezhi Kang Hengzhu Zhang Zhiyuan Qian Jian Chen Qiang Huang | 2006 | Surgical Neurology2006，，： | 1 |
| 9 | Review of insulin-like growth factor 1 signaling pathway and its role in protection against brain diseases显示文摘Insulin-like growth factor 1(IGF-1) is a pluripotent growth factor,with multiple functions in the peripheral and central nervous systems. Increasing evidence suggests that IGF-1 fine-tunes the development of the central nervous system,ensuring proper neuronal differentiation,maturation,and connectivity. It supports neuronal survival and axon growth,and acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by the IGF-1 signaling pathway. Recent studies have proposed the modulation of the members of the IGF-1/IGF-1 signaling pathway as treatment for neuropathologies. In this study,we introduce the structure of IGF-1/2 and its receptors,with the intra-cellular interactions. Further,we review the therapeutic effects of IGF-1 in different models of brain diseases,via activation of different cellular mechanisms. | Min Wei Lun Dong Hengzhu Zhang Zhenfei Teng Xiaodong Wang Zhengcun Yan Lei She Yuping Li Xingdong Wang | 2017 | Translational Neuroscience and Clinics2017，3，4： | 0 |
| 10 | Microsurgical Resection of Pituitary Adenoma via Single-Nostril Transsphenoidal Approach显示文摘OBJECTIVE To explore the methods and experience of thesingle-nostril transsphenoidal approach for treating pituitaryadenomas.METHODS We retrospectively analyzed 46 patients whohad pituitary tumors and received surgery via the singlenostriltranssphenoidal approach and observed the effects andcomplications of surgery. The specific surgical methods are: a nasalspeculum is inserted slowly through the right nostril towards theanterior wall of the sphenoid sinus. A 1.5 cm incision is made intothe nasal mucosa in the right nasal cavity at the level of the middlenasal turbinate. By fracturing the bony septum, a space is formedbetween the bilateral nasal mucosa and the bony septum of thesphenoid sinus. Then, the inside of the sphenoid sinus is exposed.The remaining part of the bony septum, the anterior sphenoidsinus wall, and the sphenoid mucosa are gradually removed. Theanterior sphenoidotomy is less than 1.5 cm wide. After confirmingthe tumor by dural puncture, a cross incision of the dura is made,and the tumor is slowly removed by curette. The sella is usuallycollapsed and visible after the total tumor removal. When thetumor is resected satisfactorily, gelatin sponges are placed into theoperative cavity to stop bleeding.RESULTS Postoperative MRI scans revealed that among the 46cases, total resection of the tumor was achieved in 34 cases andsubtotal in 12. No deaths or disability occurred, and the hormonelevels of almost all patients improved. Signs of diabetes insipidusoccurred in 17, electrolyte disturbances in 5, and there were noreports of postoperative cerebrospinal fluid rhinorrhea.CONCLUSION The direct single nostril transsphenoidalapproach of continuous improvement has the advantages ofa convenient approach, simplified operation, safety and highefficiency. | Hengzhu Zhang Xian Zhang Hongmei Du Yongkang Wu Lun Dun Lei She Xiaodong Wang Xueqiang Shi Cunlin Xu | 2009 | Clinical oncology and cancer resexreh2009，6，6： | 0 |
| 11 | Dual-Issue CGRA for DAG Acceleration显示文摘 | Li Zhou Jianfeng Zhang Hengzhu Liu | 2018 | 国际计算机前沿大会会议论文集2018，，1： | 0 |
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