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| 1 | Signaling Mechanisms in Pattern-Triggered Immunity (PTI)显示文摘在自然,植物常常不得不面对病原体攻击。然而,植物疾病很少由于主人植物拥有的有效免疫系统发生。病原体被开始所谓的被触发模式的豁免 PTI 和被触发受动器的豁免 ETI 的二个不同识别系统察觉,哪个被通常排斥病原体攻击的一套导致的辩护伴随。这里,我们讨论表明发生在 PTI 期间的小径的复杂网络,集中于激活 mitogen 的蛋白质 kinases 的参与。 | Jean Bigeard Jean Colcombet Heribert Hirt | 2015 | Molecular Plant2015，8，4： | 42 |
| 2 | A Major Role of the MEKK1-MKK1/2-MPK4 Pathway in ROS Signalling显示文摘 | Andrea Pitzschke Armin Djamei Frederique Bitton Heribert Hirt | 2009 | Molecular Plant2009，2，1： | 22 |
| 3 | Rhizosphere Microbes as Essential Partners for Plant Stress Tolerance显示文摘Ever since plants colonized land,they evolved mechanisms to respond to changing environmental conditions and settle in extreme habitats.Recent studies show that several plant species require microbial associations for stress tolerance and survival.Although many plants lack the adaptive capability to adapt to stress conditions,the ability of a variety of plants to adapt to stress conditions often appears to depend on their association with certain microbes,raising a number of questions:What distinguishes the microbes and plants that can adapt to extreme environmental conditions? Can all plants improve stress tolerance when associated with appropriate microbial partners? Answers to these questions should modify our concepts of plant physiology and could lead to new ways towards a sustainable agriculture. | Axel de Zelicourt Mohamed AI-Yousif Heribert Hirt | 2013 | Molecular Plant2013，6，2： | 12 |
| 4 | Histological grading and staging of chronic hepatitis显示文摘 | Kamal Ishak Amelia Baptista Leonardo Bianchi Francesco Callea Jan De Groote Fred Gudat Helmut Denk Valeer Desmet Gerhard Korb Roderick N.M. MacSween M.James Phillips Bernard G. Portmann Hemming Poulsen Peter J. Scheuer Martin Schmid Heribert Thaler | 1995 | Journal of Hepatology1995，，6： | 4 |
| 5 | Histological grading and staging of chronic hepatitis显示文摘 | Kamal Ishak Amelia Baptista Leonardo Bianchi Francesco Callea Jan De Groote Fred Gudat Helmut Denk Valeer Desmet Gerhard Korb Roderick N.M. MacSween M.James Phillips Bernard G. Portmann Hemming Poulsen Peter J. Scheuer Martin Schmid Heribert Thaler | 1995 | Journal of Hepatology1995，，6： | 4 |
| 6 | Salmonella enterica Flagellin Is Recognized via FLS2 and Activates PAMP-Triggered Immunity in Arabidopsis thaliana显示文摘有沙门氏菌 enterica 的感染属于食物中毒和感染的水果的最突出的原因,蔬菜代表重要向量 forsalmonellosis。最近的证据显示植物认出 S。enterica 和加薪防卫回答。尽管如此,控制 S 的相互作用的分子的机制。有植物的 enterica 大部分仍然是不清楚的。这里,我们从 S 显示出那 flagellin。enterica 在 Arabidopsis thaliana 代表一个突出的联系病原体的分子的模式(PAMP ) ,它由受体 kinase FLS2 经由 flg22 领域的识别导致被触发 PAMP 的免疫(PTI ) 。Arabidopsis fls2 异种表演不过减少了没废除的 PTI 激活,显示植物也依靠另外的 S 的识别。enterica PAMP。有趣地, S。enterica 类型 III 分泌物系统(T3SS ) 异种 prgH 在 Arabidopsis 比野类型的细菌导致了更强壮的防卫基因表示,建议 T3SS 受动器涉及防卫抑制。而且,我们观察那 S。enterica 紧张在 flg22 epitope 显示出变化,它与减少的导致 PTI 活动导致蛋白质。总的来说, theseresults 表演那 S。enterica 在 Arabidopsis 激活 PTI 并且建议那,以便完成植物殖民, S。enterica 发展了策略避免或压制 PTI.Key 词: | Ana Victoria Garcia Amelie Charrier Adam Schikora Jean Bigeard Stephanie Pateyron Marie-Ludivine de Tauzia-Moreau Alexandre Evrard Axel Mithofer Marie Laure Martin-Magniette Isabelle Virlogeux-Payant Heribert Hirt | 2014 | Molecular Plant2014，7，4： | 3 |
| 7 | Dupilumab治疗常年性变应性鼻炎并发哮喘患者的疗效和安全性显示文摘背景Dupilumab是一种抗IL-4受体α亚基的抗体,可以阻断IL-4/IL-13的信号转导。IL-4/IL-13是2型/Th2型免疫疾病(如特应性/过敏性疾病)的关键驱动因子。一项重要的2b期临床研究(NCT01854047)显示,在使用了中高剂量吸入激素联合长效β2受体激动剂(ICS/LABA)后仍控制不佳的持续性哮喘患者中,dupilumab可减少哮喘重度急性发作,改善患者的肺功能和生活质量,且耐受性良好。目的探讨在哮喘并发常年性变应性鼻炎(PAR)患者中,dupilumab对SNOT-22的总分及其中变应性鼻炎(AR)相关症状评分的影响。方法对2b临床研究中每2周(q2w) 200 mg和300 mg dupilumab治疗后的数据进行析因分析。这两种剂量的dupilumab目前正在3期临床研究(NCT02414854)中进行验证。PAR定义为:在研究开始时,患者出现对典型的常年性抗原产生特异性应答(Ig E≥0. 35 Ku/L)。结果总共241例(61%)患者患有PAR。与安慰剂相比,每两周300 mg dupilumab显著改善了在哮喘并发PAR的患者中SNOT-22的总分(最小二乘平均差,-5. 98; 95%CI,-10. 45~-1. 5; P=0. 009)和4项AR相关症状的评分(鼻塞,-0. 60; 95%CI,-0. 96~-0. 25;流鼻涕,-0. 67; 95%CI,-1. 04~-0. 31;打喷嚏,-0. 55; 95%CI,-0. 89~-0. 21;鼻后分泌物,-0. 49;95%CI,-0. 83~-0. 16; 4项评分都P <0. 01);每两周200 mg dupilumab治疗减少了并发PAR的患者的SNOT-22总分(-1. 82; 95%CI,-6. 46~2. 83; P=0. 443)和AR相关的症状评分,但与安慰剂相比无统计学差异。在无PAR的哮喘患者中,dupilumab与安慰剂治疗这些评分无差异。结论每两周300 mg dupilumab治疗显著改善了在控制不佳的持续性哮喘并发PAR患者中的AR相关的鼻部症状。 | Steven F.Weinstein Rohit Katial Shyamalie Jayawardena Gianluca Pirozzi Heribert Staudinger Laurent Eckert Vijay N.Joish Nikhil Amin Jaman Maroni Paul Rowe Neil M.H.Graham Ariel Teper 黄庭萱(翻译) 刘春涛(审校) | 2018 | 中华临床免疫和变态反应杂志2018，12，5： | 2 |
| 8 | Activation of mitogen activated protein kinases via complement receptor type 2显示文摘Background Complement receptor type 2 (CR2) is the receptor for C3d and C3dg and for Epstein Barr virus The aim of our study was to explore whether CR2 can independently mediate the activation of mitogen activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK), and to highlight the molecular mechanism of CD 4 + cell deletion in AIDS Methods HOS cells (HOS CR2) and HOS CD4 cells (HOS CD4CR2) stably expressing CR2 were established and then identified by FACS and Western blotting Activation and blocking tests of MAPKs were assessed by Western blot Cell proliferation was determined using Cell Titer 96 Aqueous One Solution Reagent Results FACS results showed that the positive rates of HOS CR2 and HOS CD4CR2 cells were greater than 96%, and Western blot showed that the CR2 expression levels on HOS CR2 and HOS CD4CR2 cells were high Activation and blocking tests of MAPKs (ERK, JNK, and p38MAPK) were carried out in HOS CR2, HOS CD4, and HOS CD4CR2 cells The activation of MAPKs in HOS CR2 cells stimulated with PMA (100 ng/ml) and NHS (10%) was identical The activation of MAPKs increased at 5 minutes, reached a peak at 10 minutes, and decreased to baseline within 30 minutes, all in a time dependent manner; the activation of MAPKs was blocked by anti CR2 McAb, PD98059 (inhibitor of ERK), and Wortmanin (inhibitor of PI 3K), respectively In HOS CD4 cells, MAPKs were activated by HIV gp160 In HOS CD4CR2 cells, MAPK activation was induced by HIV gp160, 10% NHS, and HIV gp160+10%NHS; phosphorylation of p38MAPK was dramatically induced by HIV gp160+NHS, and lasted for 1 hour The cell proliferation results showed that HIV gp160 inhibited the proliferation of HOS CD4 and HOS CD4CR2 cells ( P <0 01) and that NHS enhanced the effect of HIV gp160 ( P <0 01) Conclusions The activation of MAPKs is independently mediated by CR2 and that anti CR2 McAb, PD98059, and Wortmanin block the activation of MAPKs, respectively The results of the signal transduction and cell proliferation assays of HOS CD4CR2 cells show that CR2 plays a role in the pathogenesis of HIV infection, especially in the inhibition of CD 4 + cell | 罗敏华 陈明亮 Heribert Stoiber Manfred P Dierich | 2004 | Chinese Medical Journal2004，17，12： | 2 |
| 9 | Are scarce products always more attractive? The interaction of different types of scarcity signals with products’ suitability for conspicuous consumption显示文摘 | Heribert Gierl Verena Huettl | 2010 | International Journal of Research in Marketing2010，，3： | 2 |
| 10 | Simulating surface- plant-air interactions inside urban environments with a three dimensional numerical model 显示文摘 | Michael Bruse Fleer Heribert | 1998 | Environmental Modelling & Software1998，13，34： | 1 |
| 11 | Diabetics with acute coro- nary syndrome: advances, challenges, and uncertainties 显示文摘 | PETER W R HERIBERT S | 2010 | Eur Heart J2010，31，： | 1 |
| 12 | Assimilation and metabolism of formaldehyde by leaves appear unlikely to be of value for indoor air purification 显示文摘 | Heribert Schmitz Ute Hilgers Manfred Weidner | 2000 | New Phytologist2000，147，2： | 1 |
| 13 | Phenol-induced membrane changes in free and immobilized Escherichia coli显示文摘 | Heribert Keweloh Gerd Weyrauch Hans-Jürgen Rehm | 1990 | Applied Microbiology and Biotechnology1990，，1： | 1 |
| 14 | Design, synthesis, physical and chemical characterisation, and biological interactions of lectin-targeted latex nanoparticles bearing Gd–DTPA chelates: an exploration of magnetic resonance molecular imaging (MRMI)显示文摘 | Irena Paschkunova-Martic Christian Kremser Klaudia Mistlberger Nadezhda Shcherbakova Hermann Dietrich Heribert Talasz Yiping Zou Beate Hugl Markus Galanski Elisabeth S?lder Kristian Pfaller Isabella H?liner Wolfgang Buchberger Bernhard Keppler Paul Debbag | 2005 | Histochemistry and Cell Biology2005，，3： | 1 |
| 15 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 16 | Microvascular obstruction in patients with non-ST-elevation myocardial infarction: a contrast-enhanced cardiac magnetic resonance study显示文摘 | Elena Guerra Martin Hadamitzky Gjin Ndrepepa Corinna Bauer Tareq Ibrahim Ilka Ott Karl-Ludwig Laugwitz Heribert Schunkert Adnan Kastrati | 2014 | The International Journal of Cardiovascular Imaging2014，，： | 1 |
| 17 | New amphiphilic poly(butadiene)-graft-poly(ethylene oxide)s显示文摘 | Heribert Echer Reimund Stadler | 1995 | Polymer International1995，38，： | 1 |
| 18 | Genetics and heritability of coronary artery disease and myocardial infarction显示文摘 | Dr. Bj?rn Mayer MD Jeanette Erdmann PhD Heribert Schunkert MD | 2007 | Clinical Research in Cardiology2007，，1： | 1 |
| 19 | Developments in soil microbiology since the mid 1960s显示文摘 | Heribert Insam | 2001 | Geoderma2001，100，： | 1 |
| 20 | The International Monetary Fund and the World Bank:In need of a betterperformance?显示文摘 | Heribert Dieter | 2004 | Asia Europe Journal2004，，2： | 1 |
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