|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Routing for predictable Multi-Layered Satellite Networks显示文摘Multi-Layered Satellite Network(MLSN),especially LEO/MEO satellite network,consisting of low and medium earth orbit satellites,is capable of providing higher coverage and better service than single-layered one.Its performance in deployment,however,is mainly encumbered by obsolete routing protocols and algorithms.This paper takes the predictability of satellite movements into consideration,based on which a novel routing protocol Predictable Satellite Network Routing Protocol(PSNRP)—is proposed.In this protocol,every topology change due to satellite movement is either described as a predictable or an unpredictable change.On the basis of PSNRP,we import a heuristic routing algorithm for satisfying Quality-of-Service(QoS)requirements from network users,which is convinced as a Non-deterministic Polynomial Complete problem.The QoS requirements in this paper mainly refer to end-to-end delay,bandwidth and package loss rate.In addition to obtaining better routing performance,PSNRP successfully allocates calculation tasks evenly among all nodes,separates user data from protocol control data and achieves stronger robustness against satellite failures and link congestions.The superiority of our routing scheme is proved by simulation results. | LIU HeYu SUN FuChun | 2013 | Science China(Information Sciences)2013，56，11： | 5 |
| 2 | Fish forewarning of comprehensive toxicity in water environment based on Bayesian sequential method显示文摘Environmental impact of pollutants can be analyzed effectively by acquiring fish behavioral signals in water with biological behavior sensors. However, a variety of factors, such as the complexity of biological organisms themselves, the device error and the environmental noise, may compromise the accuracy and timeliness of model predictions. The current methods lack prior knowledge about the fish behavioral signals corresponding to characteristic pollutants, and in the event of a pollutant invasion, the fish behavioral signals are poorly discriminated. Therefore, we propose a novel method based on Bayesian sequential,which utilizes multi-channel prior knowledge to calculate the outlier sequence based on wavelet feature followed by calculating the anomaly probability of observed values. Furthermore, the relationship between the anomaly probability and toxicity is analyzed in order to achieve forewarning effectively. At last, our algorithm for fish toxicity detection is verified by integrating the data on laboratory acceptance of characteristic pollutants. The results show that only one false positive occurred in the six experiments, the present algorithm is effective in suppressing false positives and negatives, which increases the reliability of toxicity detections, and thereby has certain applicability and universality in engineering applications. | Kaifeng Rao Li Tang Xin Zhang Heyu Xiang Liang Tang Yong Liu Wei Wang Jie Jiang Mei Ma Yiping Xu Zijian Wang | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 3 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 4 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://links.lww.com7CM9/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 5 | LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells显示文摘We recently demonstrated that leukocyte Ig-like receptor 4(LILRB4)expressed by monocytic acute myeloid leukemia(AML)cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular domain.The cytoplasmic domain of LILRB4 contains three immunoreceptor tyrosine-based inhibitory motifs(ITIMs);the tyrosines at positions 360,412,and 442 are phosphorylation sites.Here,we analyzed how the ITIMs of LILRB4 in AML cells mediate its function.Our in vitro and in vivo data show that Y412 and Y442,but not Y360,of LILRB4 are required for T-cell inhibition,and all three ITIMs are needed for leukemia cell infiltration.We constructed chimeric proteins containing the extracellular domain of LILRB4 and the intracellular domain of LILRB1 and vice versa.The intracellular domain of LILRB4,but not that of LILRB1,mediates T-cell suppression and AML cell migration.Our studies thus defined the unique signaling roles of LILRB4 ITIMs in AML cells. | Zunling Li Mi Deng Fangfang Huang Changzhu Jin Shuang Sun Heyu Chen Xiaoye Liu Licai He Ali HSadek Cheng Cheng Zhang | 2020 | Cellular & Molecular Immunology2020，17，3： | 1 |
| 6 | Virtual Strategy QoS routing in satellite networks显示文摘Satellite network users want to unify different satellites to enhance the quality-of-service(Qo S)stability of the satellite networks and select feasible paths through different networks to feed different applications. Unfortunately, the state of affairs is that different applications need to use several different application programming interfaces and to design different protocols on how and when to use a specific network. This is troublesome and error-prone as the application programming interfaces vary a lot. In this paper, we design a Virtual Strategy in satellite network based on which a Qo S routing service scheme is then proposed. We analyze why applications should use and benefit from Virtual Strategy. This Virtual Strategy is a middleware solution that enables seamless usage of services from different satellite network parts. And then, the supporting Qo S routing solution enables the committed Qo S services over Virtual Strategy. Finally, we provide a comparison between the previous satellite networks and our work. The simulation results show that our Virtual Strategy Qo S routing scheme demonstrates dominated performances under complex architecture. | Heyu LIU Fuchun SUN Shaoqing WANG | 2016 | Science China(Information Sciences)2016，59，9： | 1 |
| 7 | Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII^(hi) neutrophils显示文摘Breast cancer can metastasize to various organs,including the lungs.The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer.Infection with pathogens such as viruses and bacteria can alter the immune status of the lung.However,the effect of chronic inflammation caused by bacteria on the formation of a premetastatic niche within the lung is unclear,and the contribution of specific immune mediators to tumor metastasis also remains largely undetermined.Here,we used a mouse model revealing that chronic pulmonary bacterial infection augmented breast cancer lung metastasis by recruiting a distinct subtype of tumor-infiltrating MHCII^(hi) neutrophils into the lung,which exhibit cancer-promoting properties.Functionally,MHCII^(hi) neutrophils enhanced the lung metastasis of breast cancer in a cell-intrinsic manner.Furthermore,we identified CCL2 from lung tissues as an important environmental signal to recruit and maintain MHCII^(hi) neutrophils.Our findings clearly link bacterial-immune crosstalk to breast cancer lung metastasis and define MHCII^(hi) neutrophils as the principal mediator between chronic infection and tumor metastasis. | Teng Ma Yu Tang Taolin Wang Yang Yang Yige Zhang Ruihuan Wang Yongxin Zhang Yi Li Mingbo Wu Miao Tang Xueli Hu Chaoyu Zou Yuan Ren Huan Liu Qianhua Zhang Heyue Li Min Wu Jing Li Xikun Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 8 | Segregation of Re at theγ/γ'boundary of Ni-based single crystal superalloys revealed by first-principles calculations based Monte-Carlo simulations显示文摘Nickel-based single crystal superalloys have been widely used in aero-engines and gas turbine engines.To improve the creep resistance,rhenium is often added to the alloys.However,it is not yet fully under-stood how the added Re elements distribute in the alloys and how the microstructure evolves with the addition of Re.Here,we performed extensive first-principles calculations based Monte-Carlo simulated annealing of Ni-Al-Re ternary alloys with different Re concentrations ranging from 0.5 at.%to 6.0 at.%.The results demonstrate that with the decreasing temperature,most of Re atoms stay in theγphase,while a few of Re atoms stay in theγ'phase and tend to occupy the Al positions.At low temperatures,the Re atoms segregate at theγ/γ'boundary,in good agreement with experiment.We find that the disorder-order transition temperature of the Ni-Al-Re ternary alloys increases with the Re concentration due to the Re-enhanced Al-Al ordering tendency.In addition,we observe that at low temperatures the Re segregation at theγ/γ'boundary promotes the formation of Ni 4 Re-or Ni 8 Re-like local structures as the Re concentration is over 2 at.%.The formation of a large amount of these local structures consumes the Re atoms in solid solutions,and thus from the solid-solution strengthening point of view,this would have a negative influence on the creep resistance of the superalloys.This work provides important atomistic insights on the Re distribution and its effects on the stability of superalloys. | Heyu Zhu Jiantao Wang Lei Wang Yongpeng Shi Mingfeng Liu Jiangxu Li Yun Chen Yingche Ma Peitao Liu Xing-Qiu Chen | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 9 | Correction to: LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells显示文摘In this article,published online on 7 November 2019,there was an unintended error during image processing of Fig.1a and Fig.6c leading to wrong pictures to appear.These pictures have now been replaced with the appropriate pictures that were generated for this experiment.The corrected Fig.1 and Fig.6 are shown here.The conclusion made from the experiments remains unaltered.The inconvenience caused by this error is deeply regretted. | Zunling Li Mi Deng Fangfang Huang Changzhu Jin Shuang Sun Heyu Chen Xiaoye Liu Licai He Ali H.Sadek Cheng Cheng Zhang | 2020 | Cellular & Molecular Immunology2020，17，3： | 0 |
| 10 | AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation显示文摘Bone metastasis of cancer cells leads to severe pain by disrupting bone structure and inducing central sensitization.Neuroinflammation in the spinal cord plays a decisive role in the maintenance and development of pain.In the current study,male Sprague-Dawley(SD)rats are used to establish a cancer-induced bone pain(CIBP)model by intratibial injection of MRMT-1 rat breast carcinoma cells.Morphological and behavioral analyses verify the establishment of the CIBP model,which represents bone destruction,spontaneous pain and mechanical hyperalgesia in CIBP rats.Activation of astrocytes marked by upregulated glial fibrillary acidic protein(GFAP)and enhanced production of the proinflammatory cytokine interleukin-1β(IL-1β)are accompanied by increased inflammatory infiltration in the spinal cord of CIBP rats.Furthermore,activation of the NOD-like receptor pyrin domain-containing protein 3(NLRP3)inflammasome is consistent with increased neuroinflammation.Adenosine monophosphateactivated protein kinase(AMPK)activation is involved in attenuating inflammatory pain and neuropathic pain.Intrathecal injection of the AMPK activator AICAR in the lumbar spinal cord reduces dynamin-related protein 1(Drp1)GTPase activity and suppresses NLRP3 inflammasome activation.This effect consequently alleviates pain behaviors in CIBP rats.Cell research on C6 rat glioma cells indicates that AICAR treatment restores IL-1β-induced impairment of mitochondrial membrane potential and elevation of mitochondrial reactive oxygen species(ROS).In summary,our findings indicate that AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation in the spinal cord. | Heyu Yang Yujia Wang Shuqing Zhen Banghua Wang Ming Jiao Ling Liu Dai Li Haili Zhu Min Xie | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 11 | Ab initio Molecular Dynamics Study of Local Atomic Structure Evolution of U–Zr Alloy Melts upon Solidification显示文摘We study the local atomic structure evolution of UZr and UZr_(2) alloy melts upon solidification through ab initio molecular dynamics simulations.This is achieved by analyzing in detail the temperature dependence of structure factors,pair correlation functions,the bond angle distributions,Honeycutt-Anderson index and Voronoi tessellation analysis as well as local bond orientation order parameters.We observe that as the temperature decreases the pair correlation functions and structure factors become more structured with clear distinctions at the liquid–solid phase transition temperature.The Honeycutt-Anderson indices and Voronoi tessellation analysis indicate that the liquid phase is predominantly comprised of the icosahedra-like local structures,whose fraction increases with decreasing temperature up to the transition temperature and then abruptly drops at the transition temperature,whereas the bcc-like local atomic structures dominate during the solidification process.Furthermore,the bond orientation order analyses with\({\overline{w}}_{6}\)–\({\overline{q}}_{6}\)correlation map and bond angle distribution imply that the local structures mainly consist of the bcc-type during the solidification below the transition temperature.All the analyses are consistent with each other,showing a first-order liquid to solid phase transition for both UZr and UZr_(2) solid solutions,which only differ in different predicted transition temperatures.This work provides a comprehensive insight into the detailed local structure evolution during the solidification of the U–Zr alloy melts at the atomic level.Similar strategies used here can be extended to studying the liquid–solid phase transition in other alloy systems. | Mingfeng Liu Jiantao Wang Yongpeng Shi Heyu Zhu Yan Sun Peitao Liu Xing-Qiu Chen | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员