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1最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL 2014神经病学与神经康复学杂志2014,11,3:31
2The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells显示文摘Liu X Wu JY Zhou F Sun XL Yao HH Yang Y Ding JH Hu G 2006中国生物学文摘2006,20,10:11
3Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats显示文摘Yang Y Liu X Long Y Wang F Ding JH Liu SY Sun YH Yao HH Wang H Wu J Hu G 2006中国生物学文摘2006,20,10:4
4胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
5Insights into human CD34(+) hematopoietic stem/progenitor cells through a systematically proteomic survey coupled with transcriptome显示文摘Liu F Lu J Fan HH Wang ZQ Cui SJ Zhang GA Chi M Zhang X Yang PY Chen Z Han ZG 2006中国生物学文摘2006,20,5:2
6A comparative pilot study of low intensity laser versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus显示文摘Jajarm HH Falaki F Mahdavi O 0,,06:1
7Mortality of patients with mood disorders:follow - up over 34-38 years显示文摘Angst F Stassen HH Clayton PJ 0,,2:1
8Management of im- ported malaria in Europe 显示文摘Askling HH Bruneel F Burehard G 2012Malar J2012,11,:1
9Inhibition of c-FLIP expression by miR-512-3p contributes to Taxol-induced apoptosis in hepatocellular carcinoma cells 显示文摘Chen F Zhu HH Zhou LF 2010Oncol Rep2010,23,5:1
10Inhibition of tissue factor signaling suppresses tumor growth显示文摘Versteeg HH Schaffner F Kerver M 2008Blood2008,111,1:1
11Tissue distribution and residues of clenbuterol, salbutamol, and terbutaline in tissues of treated broiler chickens 显示文摘Malucelli A Ellendorff F Meyer HH 1994J Anim Sci1994,72,:1
12Inhibition of tissue factor signaling suppresses tumor growth显示文摘Versteeg HH Schaffner F Kerver M 0,,01:1
13Long-term followup after electrocautery transurethral resection of the prostate forbenign prostatic hyperplasia显示文摘KALLENBERG F HOSSACK TA WOO HH 2011Adv Urol2011,22,3:1
14Destrin deletion enhances the bone loss in hindlimb suspended mice显示文摘Shuang F Sun Y Yang HH 2013Eur J Appl Physiol2013,113,2:1
15Aliskiren combined with losartan in type 2 diabetes and nephropathy 显示文摘Parving HH Persson F Lewis JB 2008N Engl J Med2008,358,23:1
16Long-term followup after electrocautery transurethral resection of the prostate for benign prostatic hyperplasia显示文摘Kallenberg F Hossack TA Woo HH 0,,:1
17Aliskiren combined with losartan in type 2 diabetes and nephropathy显示文摘PARVING HH PERSSON F LEWIS JB 2008N Engl J Med2008,358,23:1
18The combination of aliskiren, a direct renin inhibitor, and losartan in patients with type 2 diabetes and nephropathy显示文摘Parring HH Persson F Lewis JB 2008New Engl J Med2008,358,23:1
19Aliskiren combined with losartan in type 2 diabetes and nephropathy显示文摘Parving HH Persson F Lewis JB 2008N Engl J Med2008,358,23:1
20Relationship between postoperative recurrence rale and eosinophil density of nasal polyps 显示文摘Tosun F Arslan HH Ka slioglu Y 2010Ann Otol Rhinol Laryngol2010,119,7:1
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