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| 1 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 2 | Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry显示文摘 | Atsushi Nashimoto Kohei Akazawa Yoh Isobe Isao Miyashiro Hitoshi Katai Yasuhiro Kodera Shunichi Tsujitani Yasuyuki Seto Hiroshi Furukawa Ichiro Oda Hiroyuki Ono Satoshi Tanabe Michio Kaminishi | 2013 | Gastric Cancer2013，，1： | 6 |
| 3 | High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302显示文摘 | Isao Miyashiro Masahiro Hiratsuka Mitsuru Sasako Takeshi Sano Junki Mizusawa Kenichi Nakamura Atsushi Nashimoto Akira Tsuburaya Norimasa Fukushima | 2014 | Gastric Cancer2014，，2： | 5 |
| 4 | Clinical features and outcomes of delayed perforation after endoscopic submucosal dissection for early gastric cancer显示文摘 | N. Hanaoka N. Uedo R. Ishihara K. Higashino Y. Takeuchi T. Inoue R. Chatani M. Hanafusa Y. Tsujii H. Kanzaki N. Kawada H. Iishi M. Tatsuta Y. Tomita I. Miyashiro M. Yano | 2010 | Endoscopy2010，，12： | 3 |
| 5 | Phase II trial of S-1 for neoadjuvant chemotherapy against scirrhous gastric cancer (JCOG 0002)显示文摘 | Taira Kinoshita Mitsuru Sasako Takeshi Sano Hitoshi Katai Hiroshi Furukawa Akira Tsuburaya Isao Miyashiro Masahide Kaji Motoki Ninomiya | 2009 | Gastric Cancer2009，，1： | 3 |
| 6 | Successful embolization assisted by covered stents for a pseudoaneurysm following pancreatic surgery显示文摘Delayed intra-abdominal hemorrhage after pancreatic surgery is a potentially lethal complication.Transarterial coil embolization and/or the placing of an endovascular stent are minimally invasive and effective procedures.An artery that is extensively eroded and rendered friable due to operative skeletonization or postoperative inflammation sometimes contributes to delayed intra-abdominal hemorrhage or rebleeding after coil embolization.This report presents a case of successful management of postoperative hemorrhage in a-74-year-old Japanese male.He experienced bleeding from a pseudoaneurysm of the brittle hepatic artery following total pancreatectomy.Initially the pseudoaneurysm was successfully treated with covered coronary stent-grafts,but rebleeding occurred 1 mo later due to the brittleness of the artery.Rebleeding was definitively managed by the complete packing of the stent by coil embolization.He remains stable at 18 mo following the f inal embolization.A stent graft can be used for protecting a brittle artery to avoid injury by coil embolization. | Koji Tanaka Hiroaki Ohigashi Hidenori Takahashi Kunihito Gotoh Terumasa Yamada Isao Miyashiro Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，9： | 2 |
| 7 | Screening, isolation, and some properties of microbial cell flocculants显示文摘 | Nakamura J Miyashiro S Hirose Y | 1976 | Agr Biol Chem1976，40，2： | 2 |
| 8 | Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients显示文摘 | Koshi Kumagai Noriko Yamamoto Isao Miyashiro Yasuhiko Tomita Hitoshi Katai Ryoji Kushima Hitoshi Tsuda Yuko Kitagawa Hiroya Takeuchi Makio Mukai Masayuki Mano Hidetaka Mochizuki Yo Kato Nariaki Matsuura Takeshi Sano | 2014 | Gastric Cancer2014，，2： | 2 |
| 9 | Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study显示文摘 | Toru Masuzawa Shuji Takiguchi Motohiro Hirao Hiroshi Imamura Yutaka Kimura Junya Fujita Isao Miyashiro Shigeyuki Tamura Masahiro Hiratsuka Kenji Kobayashi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2014 | World Journal of Surgery2014，，5： | 2 |
| 10 | Survival benefit of bursectomy in patients with resectable gastric cancer: interim analysis results of a randomized controlled trial显示文摘 | Junya Fujita Yukinori Kurokawa Tomoyuki Sugimoto Isao Miyashiro Shohei Iijima Yutaka Kimura Shuji Takiguchi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2012 | Gastric Cancer2012，，1： | 2 |
| 11 | Application of sentinel node biopsy to gastric cancer surgery显示文摘 | Masahiro Hiratsuka Isao Miyashiro Osamu Ishikawa Hiroshi Furukawa Kazuyoshi Motomura Hiroaki Ohigashi Masao Kameyama Yo Sasaki Toshiyuki Kabuto Shingo Ishiguro Shingi Imaoka Hiroki Koyama | 2001 | Surgery2001，，3： | 2 |
| 12 | Flow-ioduced vascular remodeling in the rat carotid artery diminishes with age 显示文摘 | Miyashiro JK Poppa V Berk BC | 1997 | Circ Res1997，81，3： | 1 |
| 13 | Inhibition of human immunodeficiency virus type 1 reverse transcriptase and ribonuclease H activities by constituents of Juglans mandshurica显示文摘 | MIN B S NAKAMURA N MIYASHIRO H KIM Y H HATTPRI M | 2000 | Chem Pharm Bull2000，48，2： | 1 |
| 14 | 显示文摘 | NAKAMURA J MIYASHIRO S HIROSE Y | 1976 | Agric Biol Chem1976，40，2： | 1 |
| 15 | Randomized Clinical Tri- al of Adjuvant Chemotherapy with Intraperitoneal and Intravenous Dis- plation Followed by Oral Fluorouracil (UFT) in Serosa-positive Gas- tric Cancer Versus Curative Resection alone: Final Results of the Ja- pan Clinical Oncology Group Trial JCOG9206 - 2 显示文摘 | Miyashiro I Furukawa H Sasako M | 2011 | Gastric Canc-er2011，14，3： | 1 |
| 16 | Detection of sentinel node in gastric cancer surgery by indocyanine green fluorescence imaging : comparison with infrared imaging 显示文摘 | Miyashiro I Miyoshi N Hiratsuka M | 2008 | Ann Surg Oncol2008，15，6： | 1 |
| 17 | Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity显示文摘 | MA CM NAKAMURA N MIYASHIRO H | 2002 | Phytother Res2002，16，2： | 1 |
| 18 | Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase显示文摘 | MIN B S MIYASHIRO H HATTORI M | 2002 | Phytother Res2002，16，： | 1 |
| 19 | Screening, isolation and some properties of microbial cell flocculants显示文摘 | Nakamura J Miyashiro S Hirose Y | 1976 | Agric Bial Chem1976，40，2： | 1 |
| 20 | Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease显示文摘 | MIN BS NAKAMURA N MIYASHIRO H | 1998 | Chem Pharm Bull (Tokyo)1998，46，10： | 1 |
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