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| 1 | RANKL,a necessary chance for clinical application to osteoporosis and cancer-related bone diseases显示文摘Osteoporosis is a common bone disease characterized by reduced bone and increased risk of fracture. In postmenopausal women, osteoporosis results from bone loss attributable to estrogen deficiency. Osteoclast differentiation and activation is mediated by receptor activator of nuclear factor-κB ligand(RANKL), its receptor receptor activator of nuclear factor-κB(RANK), and a decoy receptor for RANKL, osteoprotegerin(OPG). The OPG/RANKL/RANK system plays a pivotal role in osteoclast biology. Currently, a fully human antiRANKL monoclonal antibody named denosumab is being clinically used for the treatment of osteoporosis and cancer-related bone disorders. This review describes recent advances in RANKL-related research, a story from bench to bedside. First, the discovery of the key factors, OPG/RANKL/RANK, revealed the molecular mechanism of osteoclastogenesis. Second, we established three animal models:(1) a novel and rapid bone loss model by administration of glutathione-S transferase-RANKL fusion protein to mice;(2) a novel mouse model of hypercalcemia with anorexia by overexpression of soluble RANKL using an adenovirus vector; and(3) a novel mouse model of osteopetrosis by administration of a denosumab-like anti-mouse RANKL neutralizing monoclonal antibody. Lastly, anti-human RANKL monoclonal antibody has been successfully applied to the treatment of osteoporosis and cancer-related bone disorders in many countries. This is a real example of applying basic science to clinical practice. | Hisataka Yasuda | 2013 | World Journal of Orthopedics2013，4，4： | 22 |
| 2 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 2 |
| 3 | Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation: a propensity score-based cohort analysis显示文摘 | Shinpei Doi Ichiro Yasuda Tsuyoshi Mukai Takuji Iwashita Shinya Uemura Takahiro Yamauchi Masanori Nakashima Seiji Adachi Masahito Shimizu Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2013 | Journal of Gastroenterology2013，，9： | 2 |
| 4 | Metallic stents are more efficacious than plastic stents in unresectable malignant hilar biliary strictures: a randomized controlled trial显示文摘 | Tsuyoshi Mukai Ichiro Yasuda Masanori Nakashima Shinpei Doi Takuji Iwashita Keisuke Iwata Tomohiro Kato Eiichi Tomita Hisataka Moriwaki | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，2： | 2 |
| 5 | Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG):A mechanism by which OPG/OCIF Inhibits osteoclastogenesis in vitro显示文摘 | Hisataka Yasuda Nobuyuka Shima Nobuyuka Nakagawa | 1998 | Endocrinology1998，139，3： | 1 |
| 6 | Intrahepatic cholangiocarcinoma arising 10 years after the excision of congenital extrahepatic biliary dilation显示文摘 | Naoe Goto Ichiro Yasuda Takahiro Uematsu Nobuhiro Kanemura Shinji Takai Kazuki Ando Tomohiro Kato Shinji Osada Hiroshi Takao Shigetoyo Saji Kuniyasu Shimokawa Hisataka Moriwaki | 2001 | Journal of Gastroenterology2001，，12： | 1 |
| 7 | Endoscopic Ultrasound-Guided Antegrade Treatments for Biliary Disorders in Patients with Surgically Altered Anatomy显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Shinya Uemura Masatoshi Mabuchi Mitsuru Okuno Tsuyoshi Mukai Takao Itoi Hisataka Moriwaki | 2013 | Digestive Diseases and Sciences2013，，8： | 1 |
| 8 | Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL显示文摘 | Hisataka Yasuda Nobuyuki Shima Nobuaki Nakagawa | 1998 | PNAS1998，95，7： | 1 |
| 9 | Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin(OPG):A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro显示文摘 | Nobuyuki Shima Nobuaki Nakagawa | 1999 | Endocrinology1999，39，3： | 1 |
| 10 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 1 |
| 11 | Regulation of RANKL‐induced osteoclastogenesis by TGF‐β through molecular interaction between Smad3 and Traf6显示文摘 | Tetsuro Yasui Yuho Kadono Masaki Nakamura Yasushi Oshima Takumi Matsumoto Hironari Masuda Jun Hirose Yasunori Omata Hisataka Yasuda Takeshi Imamura Kozo Nakamura Sakae Tanaka | 2011 | J Bone Miner Res2011，，7： | 1 |
| 12 | Needle tract implantation on the esophageal wall after EUS-guided FNA of metastatic mediastinal lymphadenopathy显示文摘 | Shinpei Doi Ichiro Yasuda Takuji Iwashita Takashi Ibuka Hideki Fukushima Hiroshi Araki Yoshinobu Hirose Hisataka Moriwaki | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 13 | Intrahepatic cholangiocarcinoma arising 10 years after the excision of congenital extrahepatic biliary dilation显示文摘 | Naoe Goto Ichiro Yasuda Takahiro Uematsu Nobuhiro Kanemura Shinji Takai Kazuki Ando Tomohiro Kato Shinji Osada Hiroshi Takao Shigetoyo Saji Kuniyasu Shimokawa Hisataka Moriwaki | 2001 | Journal of Gastroenterology2001，，12： | 1 |
| 14 | Preventive Effects of Curcumin on the Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Male C57BL/KsJ-db/db Obese Mice显示文摘 | Masaya Kubota Masahito Shimizu Hiroyasu Sakai Yoichi Yasuda Daishi Terakura Atsushi Baba Tomohiko Ohno Hisashi Tsurumi Takuji Tanaka Hisataka Moriwaki | 2012 | Nutrition and Cancer2012，，1： | 1 |
| 15 | Liver acid sphingomyelinase inhibits growth of metastatic colon cancer显示文摘 | Osawa Yosuke Suetsugu Atsushi Matsushima-Nishiwaki Rie Yasuda Ichiro Saibara Toshiji Moriwaki Hisataka Seishima Mitsuru Kozawa Osamu | 2013 | Journal of Clinical Investigation2013，，2： | 1 |
| 16 | Renin–angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ- db/db obese mice显示文摘 | Masaya Kubota Masahito Shimizu Hiroyasu Sakai Yoichi Yasuda Tomohiko Ohno Takahiro Kochi Hisashi Tsurumi Takuji Tanaka Hisataka Moriwaki | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 1 |
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