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| 1 | Prophylactic lateral pelvic lymph node dissection in stage Ⅳ low rectal cancer显示文摘AIM To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage Ⅳ low rectal cancer.METHODS We selected 71 consecutive stage Ⅳ low rectal cancer patients who underwent primary tumor resection,and enrolled 50 of these 71 patients without clinical LPLN metastasis.The patients had distant metastasis such as liver,lung,peritoneum,and paraaortic LN.Clinical LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography scan.All patients underwent primary tumor resection,27 patients underwent total mesorectal excision(TME) with LPLND(LPLND group),and 23 patients underwent only TME(TME group).Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group.R0 resection of both primary and metastatic sites was achieved in 20 of 50 patients.We evaluated possible prognostic factors for 5-year overall survival (OS),and compared 5-year cumulative local recurrence between the LPLND and TME groups.RESULTS For OS,univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%,P = 0.523); multivariate analysis revealed that R0 resection was an independent prognostic factor.Regarding cumulative local recurrence,the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%,P = 0.833).CONCLUSION Prophylactic LPLND shows no oncological benefits in patients with Stage Ⅳ low rectal cancer without clinical LPLN metastasis. | Hiroshi Tamura Yoshifumi Shimada Hitoshi Kameyama Ryoma Yagi Yosuke Tajima Takuma Okamura Mae Nakano Masato Nakano Masayuki Nagahashi Jun Sakata Takashi Kobayashi Shin-ichi Kosugi Hitoshi Nogami Satoshi Maruyama Yasumasa Takii Toshifumi Wakai | 2017 | World Journal of Clinical Oncology2017，8，5： | 4 |
| 2 | Reversed portal flow: Clinical influence on the long-term outcomes in cirrhosis显示文摘AIM: To elucidate the natural history and the longitudinal outcomes in cirrhotic patients with non-forward portal flow(NFPF).METHODS: The present retrospective study consisted of 222 cirrhotic patients(120 males and 102 females; age, 61.7 ± 11.1 years). The portal hemodynamics were evaluated at baseline and during the observation period using both pulsed and color Doppler ultrasonography. The diameter(mm), flow direction, mean flow velocity(cm/s), and mean flow volume(m L/min) were assessed at the portal trunk, the splenic vein, the superior mesenteric vein, and the collateral vessels. The average values from 2 to 4 measurements were used for the data analysis. The portal flow direction was defined as follows: forward portal flow(FPF) for continuous hepatopetal flow; bidirectional flow for to-and-fro flow; and reversed flow for continuous hepatofugal flow. The bidirectional flow and the reversed flow were classified as NFPF in this study. The clinical findings and prognosis were compared between the patients with FPF and those with NFPF. The median follow-up period was 40.9 mo(range, 0.3-156.5 mo).RESULTS: Twenty-four patients(10.8%) demonstrated NFPF, accompanied by lower albumin level, worse ChildPugh scores, and model for end-stage liver disease scores. The portal hemodynamic features in the patients with NFPF were smaller diameter of the portal trunk;presence of short gastric vein, splenorenal shunt, or inferior mesenteric vein; and advanced collateral vessels(diameter > 8.7 mm, flow velocity > 10.2 cm/s, and flow volume > 310 m L/min). The cumulative incidence rates of NFPF were 6.5% at 1 year, 14.5% at 3 years, and 23.1% at 5 years. The collateral vessels characterized by flow velocity > 9.5 cm/s and those located at the splenic hilum were significant predictive factors for developing NFPF. The cumulative survival rate was significantly lower in the patients with NFPF(72.2% at 1 year, 38.5% at 3 years, 38.5% at 5 years) than in those with forward portal flow(84.0% at 1 year, 67.8% at 3 years, 54.3% at 5 years, P = 0.0123) using the Child-Pugh B and C classifications.CONCLUSION: NFPF has a significant negative effect on the prognosis of patients with worse liver function reserve, suggesting the need for careful management. | Takayuki Kondo Hitoshi Maruyama Tadashi Sekimoto Taro Shimada Masanori Takahashi Osamu Yokosuka | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 3 | Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma显示文摘 | Shunsuke Kondo Hidenori Ojima Hitoshi Tsuda Jun Hashimoto Chigusa Morizane Masafumi Ikeda Hideki Ueno Kenji Tamura Kazuaki Shimada Yae Kanai Takuji Okusaka | 2013 | International Journal of Clinical Oncology2013，，2： | 2 |
| 4 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 5 | Risk Factors and Management of Bile Leakage after Hepatic Resection显示文摘 | Yasuhiko Nagano M.D. Ph.D. Shinji Togo M.D. Ph.D. Kuniya Tanaka M.D. Ph.D. Hidenori Masui M.D. Ph.D. Itaru Endo M.D. Ph.D. Hitoshi Sekido M.D. Ph.D. Kaoru Nagahori M.D. Ph.D. Hiroshi Shimada M.D. Ph.D | 2003 | World Journal of Surgery2003，，6： | 2 |
| 6 | β‐amyloid in lewy body disease is related to Alzheimer’s disease‐like atrophy显示文摘 | Hitoshi Shimada Hitoshi Shinotoh Shigeki Hirano Michie Miyoshi Koichi Sato Noriko Tanaka Tsuneyoshi Ota Kiyoshi Fukushi Toshiaki Irie Hiroshi Ito Makoto Higuchi Satoshi Kuwabara Tetsuya Suhara | 2012 | Mov Disord2012，，： | 1 |
| 7 | Retroportal Hepaticojejunostomy for Extended Resection of Hilar Bile Ducts显示文摘 | Itaru Endo Mitsutaka Sugita Hideki Masunari Kenichi Yoshida Kazuhisa Takeda Hitoshi Sekido Shinji Togo Hiroshi Shimada | 2008 | Journal of Gastrointestinal Surgery2008，，5： | 1 |
| 8 | Outcome after simultaneous colorectal and hepatic resection for colorectal cancer with synchronous metastases显示文摘 | Kuniya Tanaka Hiroshi Shimada Kenichi Matsuo Yasuhiko Nagano Itaru Endo Hitoshi Sekido Shinji Togo | 2004 | Surgery2004，，3： | 1 |
| 9 | Prognostic Significance of the Number of Positive Lymph Nodes in Gallbladder Cancer显示文摘 | Itaru Endo Hiroshi Shimada Mikiko Tanabe Yoshiro Fujii Kazuhisa Takeda Daisuke Morioka Kuniya Tanaka Hitoshi Sekido Shinji Togo | 2006 | Journal of Gastrointestinal Surgery2006，，7： | 1 |
| 10 | Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor显示文摘 | Kazutaka Kikuta Daisuke Kubota Tsuyoshi Saito Hajime Orita Akihiko Yoshida Hitoshi Tsuda Yoshiyuki Suehara Hitoshi Katai Yasuhiro Shimada Yoshiaki Toyama Koichi Sato Takashi Yao Kazuo Kaneko Yasuo Beppu Yasufumi Murakami Akira Kawai Tadashi Kondo | 2011 | Journal of Proteomics2011，，4： | 1 |
| 11 | Usefulness of granular BCAA after hepatectomy for liver cancer complicated with liver cirrhosis显示文摘 | Shinji Togo Kuniya Tanaka Daisuke Morioka Mitsutaka Sugita Michio Ueda Yasuhiko Miura Toru Kubota Yasuhiko Nagano Kenichi Matsuo Itaru Endo Hitoshi Sekido Hiroshi Shimada | 2005 | Nutrition2005，，4： | 1 |
| 12 | Early Statin Treatment in Patients With Acute Coronary Syndrome: Demonstration of the Beneficial Effect on Atherosclerotic Lesions by Serial Volumetric Intravascular Ultrasound Analysis During Half a Year After Coronary Event: The ESTABLISH Study显示文摘 | Shinya Okazaki Takayuki Yokoyama Katsumi Miyauchi Kazunori Shimada Takeshi Kurata Hitoshi Sato Hiroyuki Daida | 2004 | Circulation2004，，9： | 1 |
| 13 | Risk Factors and Management of Bile Leakage after Hepatic Resection显示文摘 | Yasuhiko Nagano M.D. Ph.D. Shinji Togo M.D. Ph.D. Kuniya Tanaka M.D. Ph.D. Hidenori Masui M.D. Ph.D. Itaru Endo M.D. Ph.D. Hitoshi Sekido M.D. Ph.D. Kaoru Nagahori M.D. Ph.D. Hiroshi Shimada M.D. Ph.D | 2003 | World Journal of Surgery2003，，6： | 1 |
| 14 | Is parenchyma-preserving hepatectomy a noble option in the surgical treatment for high-risk patients with hilar bile duct cancer?显示文摘 | Hiroshi Shimada Itaru Endo Mitsutaka Sugita Hideki Masunari Yoshiro Fujii Kuniya Tanaka Hitoshi Sekido Shinji Togo | 2003 | Langenbeck’s Archives of Surgery2003，，1： | 1 |
| 15 | Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer显示文摘 | Takako Eguchi Nakajima Yasuhide Yamada Tetsutaro Hamano Koh Furuta Takuji Gotoda Hitoshi Katai Ken Kato Tetsuya Hamaguchi Yasuhiro Shimada | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 16 | Emergency anticoagulation treatment for cirrhosis patients with portal vein thrombosis and acute variceal bleeding显示文摘 | Hitoshi Maruyama Masanori Takahashi Taro Shimada Osamu Yokosuka | 2012 | Scandinavian Journal of Gastroenterology2012，，6： | 1 |
| 17 | Anisakidosis: a cause of intestinal obstruction from eating sushi显示文摘 | Kazuaki Takabe Shigeo Ohki Osamu Kunihiro Takeshi Sakashita Itaru Endo Yasushi Ichikawa Hitoshi Sekido Teruaki Amano Yukio Nakatani Keiichiro Suzuki Hiroshi Shimada | 1998 | The American Journal of Gastroenterology1998，，7： | 1 |
| 18 | Usefulness of granular BCAA after hepatectomy for liver cancer complicated with liver cirrhosis显示文摘 | Shinji Togo Kuniya Tanaka Daisuke Morioka Mitsutaka Sugita Michio Ueda Yasuhiko Miura Toru Kubota Yasuhiko Nagano Kenichi Matsuo Itaru Endo Hitoshi Sekido Hiroshi Shimada | 2005 | Nutrition2005，，4： | 1 |
| 19 | Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture显示文摘 | Hitoshi Yaoita Hideo Orimo Yasumasa Shirai Takashi Shimada | 2000 | Journal of Bone and Mineral Metabolism2000，，2： | 1 |
| 20 | Risk Factors and Management of Bile Leakage after Hepatic Resection显示文摘 | Yasuhiko Nagano Shinji Togo Kuniya Tanaka Hidenori Masui Itaru Endo Hitoshi Sekido Kaoru Nagahori Hiroshi Shimada | 2003 | World Journal of Surgery2003，，6： | 1 |
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