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| 1 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 2 | Use of artificial neural networks for modelling cyanobacteria Anabaena spp. in the River Murray, South Australia显示文摘 | Holger R Maier Graeme C Dandy Michael D Burch | 1998 | Ecological Modelling1998，，2： | 2 |
| 3 | Application of partial mutual information variable selection to ANN forecasting of water quality in water distribution systems 显示文摘 | Robert J M Graeme C D Holger R M | 2008 | Environmental Modelling & Software2008，3，8： | 1 |
| 4 | Percutaneous left ventricular assist devices in acute myocardial infarction complicated by cardiogenic shock显示文摘 | HOLGER T SMALI ING R W SCHUI ER G C | 2007 | Eur HeartJ2007，17，： | 1 |
| 5 | Real-Time Video Abstraction显示文摘 | Holger Winnemoller Seven C Olsen Bruce Gooch | 2006 | ACM Transactions on Graphics2006，25，3： | 1 |
| 6 | Quantum-chemical Study of the Structure, Vibrations and Sill Bond Properties of Disilylamine , NH( SiH3 ) 2 显示文摘 | Holger F Donald C Mckean D C | 2002 | Mol Biomol Spectrosc (S0739-1102)2002，58，： | 1 |
| 7 | Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis显示文摘 | Heiko Mahrholdt Anja Wagner Claudia C. Deluigi Eva Kispert Stefan Hager Gabriel Meinhardt Holger Vogelsberg Peter Fritz Juergen Dippon C Thomas Bock Karin Klingel Reinhard Kandolf Udo Sechtem | 2006 | Circulation2006，，15： | 1 |
| 8 | Transition Metal Complexes of Boron-synthesis,Structure and Reactivity显示文摘 | HOLGER B MIRIAM C | 2001 | Coordination Chemistry Reviews2001，223，1： | 1 |
| 9 | A fuzzy reinforce- ment learning approach for self-optimization of coverage in LTE networks 显示文摘 | Rouzbeh R Siegfried K Holger C | 2010 | Bell Labs Technical Journal2010，15，3： | 1 |
| 10 | IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells显示文摘 | Stefan Pflanz Jackie C Timans Jeanne Cheung Rency Rosales Holger Kanzler Jonathan Gilbert Linda Hibbert Tatyana Churakova Marilyn Travis Elena Vaisberg Wendy M Blumenschein Jeanine D Mattson Janet L Wagner Wayne To Sandra Zurawski Terrill K McClanahan Dan | 2002 | Immunity2002，，6： | 1 |
| 11 | Polymer microfabrication technologies for microfluidic systems显示文摘 | B Holger C G/irtner | 2008 | Anal Bioanal Chem2008，390，1： | 1 |
| 12 | Impacts of the Madden-Julian Oscillation on Australian Rainfall and Circulation显示文摘 | Wheeler Matthew C Hendon Harry H Cleland Sam Meinke Holger Donald Alexis | 2009 | Journal of Climate2009，，： | 1 |
| 13 | The Use of Artificial Neural Networks for the Prediction of Water Quality Parameters显示文摘 | Holger R Maier Graeme C Dandy | 1996 | Water Resources Research1996，32，4： | 1 |
| 14 | An exceptional red shift of emission maxima upon fluorine substitution 显示文摘 | Frederik C Krebs Holger Spanggaard | 2002 | Organic Chemistry2002，67，： | 1 |
| 15 | An exceptional red shift of emission maxima upon fluorine substitution显示文摘 | Frederik C K Holger S | 2002 | J Org Chem2002，67，5： | 1 |
| 16 | Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis显示文摘 | Heiko Mahrholdt Anja Wagner Claudia C. Deluigi Eva Kispert Stefan Hager Gabriel Meinhardt Holger Vogelsberg Peter Fritz Juergen Dippon C Thomas Bock Karin Klingel Reinhard Kandolf Udo Sechtem | 2006 | Circulation2006，，： | 1 |
| 17 | Reliability- Based Approach to Multicriteria Decision Analysis for Water Resources显示文摘 | Kylie M H Holger R M Chris B C | 2004 | Water Resources Planning and Management2004，130，6： | 1 |
| 18 | McKean,Ivy T,Quantum-chemical study of the structure,vibrations and SiH bond properties of disilylamine,NH(SiH3)2显示文摘 | Holger F Donald C | 2002 | Mol Biomol Spectro2002，58，： | 1 |
| 19 | Synthesis structure and reactions of thiocarbonic acid derivatives new pentathiodipercarbonates and the first trisulfide显示文摘 | Holger C Hansen Alexander senning Rita G Hazell | 1985 | Tetrahed1985，41，22： | 1 |
| 20 | An exceptional red shift of emission maxima upon fluorine substitution显示文摘 | Frederik C K Holger S | 2002 | Organic Chemistry2002，67，： | 1 |
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