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| 1 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 2 | The roles of Kruppel-like factor6and peroxisome proliferator-activated receptor-gamma in theregulation of macrophage inflammatory protein-3alpha at earlyonset of diabetes显示文摘 | Qi W Holian J Tan CY | 2011 | Int J Biochem Cell Biol2011，43，3： | 1 |
| 3 | Resveratrol inhibits the proliferation of normal human keratinocytes in vitro 显示文摘 | HOLIAN O WALTER R J | 2001 | Cell Biochem2001，81，36： | 1 |
| 4 | Silica binding and toxicity in alveolar macrophages 显示文摘 | Hamihon R F Jr Thakur S A Holian A | 2008 | Free Radic Biol Med2008，44，7： | 1 |
| 5 | Role of Kruppel-like factor 6 in transforming growth factor-betal-induced epithelial-mesenchymal transition of proximal tubule cells 显示文摘 | Holian J Qi W Kelly D J | 2008 | Am J Physiol Renal Physiol2008，295，5： | 1 |
| 6 | Role of lysosomes in silica-induced inflammasome activation and inflammation in absence ofMARCO 显示文摘 | Biswas R Hamilton R F Jr Holian A | 2014 | J Immunol Res2014，，30： | 1 |
| 7 | Silica binding and toxicity in alveolar macrophages显示文摘 | Hamilton RF Thakur SA Holian A | | 0，，： | 1 |
| 8 | Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung显示文摘 | Davis DW Weidner DA Holian A | 2000 | J Exp Med2000，192，6： | 1 |
| 9 | Nitric oxide-dependent activation of p53 supprcsses blcomycin-included oppoptosis in the lung 显示文摘 | Cpavis D W Weider D A Holian A | 2000 | T EXP Med2000，192，6： | 1 |
| 10 | Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells显示文摘 | Qi W Chen X Holian J | 2006 | Am J Physiol2006，291，： | 1 |
| 11 | Plasticity induced by shock waves in nonequilibrium molecular-dynamics simulations显示文摘 | Holian B L Lomdahl P S | 1998 | Science1998，280，5372： | 1 |
| 12 | Silica binding and toxicity in alveolar macrophages 显示文摘 | Raymond F Thakur S Holian A | 2008 | Free Rad Biol Med2008，44，7： | 1 |
| 13 | Role of kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells显示文摘 | Holian J Qi W Kelly D J | 2008 | Am J Physiol Renal Physiol2008，29，5： | 1 |
| 14 | Silica binding and toxicity in alveolar macmphages显示文摘 | HAMILTON R F Jr THAKUR S A HOLIAN A | 2008 | Free Radic Biol Med2008，44，7： | 1 |
| 15 | Transcription factors Kruppel-likefactor 6 and peroxisome proliferator-activated receptor-{gamma}mediate high glucose-induced thioredoxin-interacting protein显示文摘 | Qi W Chen X Holian J | 2009 | AmJ Pathol2009，175，5： | 1 |
| 16 | Fracture simulations using large-scale moleeular dynamics显示文摘 | HOLIAN B RAVELO R | 1995 | Physical Review B1995，51，11： | 1 |
| 17 | Urban particle-induced apoptosis and phenotype shifts in human alveolar macrophages 显示文摘 | Holian A Hamilton Jr RF Morandi MT | 1998 | Environ Health Persp1998，106，3： | 1 |
| 18 | Transcription factors Krtippel-like factor 6 and peroxisome proliferator-activa- ted receptor- / gamma } mediate high glucose-induced thi- oredoxin-interacting protein 显示文摘 | Qi w Chen X Holian J | 2009 | Am J Pathol2009，175，5： | 1 |
| 19 | Hoover NPT Dynam- ics for Systems Varying in Shape and Size 显示文摘 | Melchionna S Ciccotti G Holian B | 1993 | Molecular Physics1993，78，53： | 1 |
| 20 | Role of Krtippel-like fac-tor 6 in transforming growth factor betal induced epithe- lial-mesenchymal transition of proximal tubule cells 显示文摘 | Holian J Qi w Kelly D J | 2008 | Am J Physiol Renal Physio12008，295，5： | 1 |
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