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| 1 | Simultaneously Improving Mechanical Properties and Stress Corrosion Cracking Resistance of High-Strength Low-Alloy Steel via Finish Rolling within Non-recrystallization Temperature显示文摘The effect of hot rolling process on microstructure evolution,mechanical properties and stress corrosion cracking(SCC)resistance of high-strength low-alloy(HSLA)steels was investigated by varying the finish rolling temperature(FRT)and total rolling reduction.The results revealed granular bainite with large equiaxed grains was obtained by a total rolling reduction of60%with the FRT of 950℃(within recrystallization temperature T_(r)).The larger grain size and much less grain boundaries should account for the relatively lower strength and SCC resistance.A larger rolling reduction of 80% under the same FRT resulted in the formation of massive martensite-austenite(M/A)constituents and resultant low ductility and SCC resistance.In contrast,a good combination of strength,ductility and SCC resistance was obtained via 80% rolling reduction with the FRT of 860℃(within non-recrystallization temperature T_(nr)),probably because of the fine grain size and M/A constituents,as well as a high density of grain boundary network. | Hongchi Ma Baijie Zhao Yi Fan Kui Xiao Jinbin Zhao Xuequn Cheng Xiaogang Li | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，4： | 4 |
| 2 | Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells显示文摘 | Dali Zhao Bo Zhai Changjun He Gang Tan Xian Jiang Shangha Pan Xuesong Dong Zheng Wei Lixin Ma Haiquan Qiao Hongchi Jiang Xueying Sun | 2014 | Cellular Signalling2014，，： | 1 |
| 3 | Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells显示文摘 | Dali Zhao Bo Zhai Changjun He Gang Tan Xian Jiang Shangha Pan Xuesong Dong Zheng Wei Lixin Ma Haiquan Qiao Hongchi Jiang Xueying Sun | 2014 | Cellular Signalling2014，，： | 1 |
| 4 | Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy显示文摘 | Lixin Ma Liqiong Luo Haiquan Qiao Xuesong Dong Shangha Pan Hongchi Jiang Geoffrey W. Krissansen Xueying Sun | 2006 | Journal of Hepatology2006，，： | 1 |
| 5 | Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: Role of Akt and nuclear factor-κB显示文摘 | Yong Ma Jizhou Wang Lianxin Liu Huaqiang Zhu Xiaoning Chen Shangha Pan Xueying Sun Hongchi Jiang | 2010 | Cancer Letters2010，，1： | 1 |
| 6 | Yes-associated protein contributes to magnesium alloy-derivedinflammation in endothelial cells显示文摘Magnesium alloy(Mg alloy)has attracted massive attention in the potential applications of cardiovascular stents because of its good biocompatibility and degradability.However,whether and how the Mg alloy induces inflammation in endothelial cells remains unclear.In the present work,we investigated the activation of Yes-associated protein(YAP)upon Mg alloy stimuli and unveiled the transcriptional function in Mg alloy-induced inflammation.Quantitative RT–PCR,western blotting and immunofluorescence staining showed that Mg alloy inhibited the Hippo pathway to facilitate nuclear shuttling and activation of YAP in human coronary artery endothelial cells(HCAECs).Chromatin immunoprecipitation followed sequencing was carried out to explore the transcriptional function of YAP in Mg alloy-derived inflammation.This led to the observation that nuclear YAP further bonded to the promoter region of inflammation transcription factors and co-transcription factors.This binding event activated their transcription and modified mRNA methylation of inflammation-related genes through regulating the expression of N6-methyladenosine modulators(METTL3,METTL14,FTO and WTAP).This then promoted inflammation-related gene expression and aggravated inflammation in HCAECs.In YAP deficiency cells,Mg alloy-induced inflammation was reduced.Collectively,our data suggest that YAP contributes to the Mg alloy-derived inflammation in HCAECs and may provide a potential therapeutic target that alleviates inflammation after Mg alloy stent implantation. | Hongchi Yu Zhe Hou Nuoya Chen Rifang Luo Li Yang Michael Miao Xiaoyi Ma Lifeng Zhou Fugui He Yang Shen Xiaoheng Liu Yunbing Wang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 7 | The biological responses and mechanisms of endothelial cells to magnesium alloy显示文摘Due to its good biocompatibility and degradability,magnesium alloy(Mg alloy)has shown great promise in cardiovascular stent applications.Rapid stent re-endothelialization is derived from migrated and adhered endothelial cells(ECs),which is an effective way to reduce late thrombosis and inhibit hyperplasia.However,fundamental questions regarding Mg alloy affecting migration and adhesion of ECs are not fully understood.Here,we evaluated the effects of Mg alloy on the ECs proliferation,adhesion and migration.A global gene expression profiling of ECs co-culturing with Mg alloy was conducted,and the adhesion-and migration-related genes were examined.We found that Mg alloy had no adverse effects on ECs viability but significantly affected ECs migration and adhesion.Co-cultured with Mg alloy extract,ECs showed contractive adhesion morphology and decreased motility,which was supported by the down-regulation of adhesion-related genes(Paxillin and Vinculin)and migration-related genes(RAC 1,Rho A and CDC 42).Accordingly,the re-endothelialization of Mg alloy stent was inhibited in vivo.Our results may provide new inspiration for improving the broad application of Mg alloy stents. | Zhe Hou Maolong Xiang Nuoya Chen Xiao Cai Bo Zhang Rifang Luo Li Yang Xiaoyi Ma Lifeng Zhou Fugui He Hongchi Yu Yunbing Wang | 2021 | Regenerative Biomaterials2021，8，3： | 0 |
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