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| 1 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 2 | Deep carbon cycles constrained by a large-scale mantle Mg isotope anomaly in eastern China显示文摘Although deep carbon recycling plays an important role in the atmospheric CO_2 budget and climate changes through geological time,the precise mechanisms remain poorly understood.Since recycled sedimentary carbonate through plate subduction is the main light-δ^(26)Mg reservoir within deep-Earth,Mg isotope variation in mantle-derived melts provides a novel perspective when investigating deep carbon cycling.Here,we show that the Late Cretaceous and Cenozoic continental basalts from 13 regions covering the whole of eastern China have low δ^(26)Mg isotopic compositions,while the Early Cretaceous basalts from the same area and the island arc basalts from circum-Paciic subduction zones have mantle-like or heavy Mg isotopic characteristics.hus,a large-scale mantle low δ^(26)Mg anomaly in eastern China has been delineated,suggesting the contribution of sedimentary carbonates recycled into the upper mantle,but limited into the lower mantle.his large-scale spatial and temporal variation of Mg isotopes in the mantle places severe constraints on deep carbon recycling via oceanic subduction. | Shu-Guang Li Wei Yang Shah Ke Xunan Meng Hengci Tian Lijuan Xu Yongsheng He Jian Huang Xuan-Ce Wang Qunke Xia Weidong Sun Xiaoyong Yang Zhong-Yuan Ren Haiquan Wei Yongsheng Liu Fancong Meng Jun Yan | 2017 | National Science Review2017，4，1： | 23 |
| 3 | Zircon U-Pb geochronology of the volcanic rocks from Fanchang-Ningwu volcanic basins in the Lower Yangtze region and its geological implications显示文摘The latest eruptions in two important Mesozoic volcanic basins of Fanchang and Ningwu located in the middle-lower reaches of the Yangtze River formed the bimodal volcanic rocks of the Kedoushan Formation and ultrapotassic volcanic rocks of the Niangniangshan Formation, respectively. The repre-sentative volcanic rocks of the two Formations were selected for LA-ICPMS zircon U-Pb dating. The results indicate that there exist a large amount of magmatic zircons as indicated by high Th/U ratios in these volcanic rocks. The weighted mean age of 21 analyses is 130.7±1.1 Ma for the Kedoushan Formation, and that of 20 analyses is 130.6±1.1 Ma for the Niangniangshan Formation. These U-Pb ages are interpreted to represent the formation times of the volcanic rocks. In combination with other known geochronological data for Mesozoic volcanic rocks from the Lower Yangtze region, it is proposed that the latest volcanic activations in the Jinniu, Luzong, Fanchang and Ningwu volcanic basins probably came to end prior to ca. 128 Ma. There is no significant time interval between the early and later volcanic activities in the Luzong and Ningwu basins, suggesting a short duration of volcanic activities and thus implying the onset of an extensional tectonic setting at about 130 Ma in the Lower Yangtze region. Integrated studies reveal that the Early Cretaceous magmatic activities and their geochronological framework in the Lower Yangtze region are a response to progressively dynamic deep processes that started with the transformation of tectonic setting from compression to extension, followed by delaminating of the lower part of the thickened lithosphere, lithospheric thinning, asthenosphere upwelling, and crust-mantle interaction. | YAN Jun LIU HaiQuan SONG ChuanZhong XU XiSheng AN YaJun LIU Jia DAI LiQun | 2009 | Chinese Science Bulletin2009，54，16： | 20 |
| 4 | Progress in Nanocellulose Preparation and Application显示文摘Nanocellulose is a biodegradable, renewable, nonmeltable polymeric material that is insoluble in most solvents due to hydrogen bonding and crystallinity. Nanocellulose has attracted considerable attention in recent decades owing to its environmental friendliness, wide availability, good biocompatibility, high crystallinity, and high Young's modulus. This review presents the recent achievements in preparation and applications of nanocellulose, including a discussion of the advantages and disadvantages of various preparation methods and a summary of the applications of nanocellulose in composite materials research. Finally, we examine the mounting evidence of more widespread potential applications of nanocellulose. | HaiQuan Mao YongYang Gong YuanLi Liu ShiQi Wang LinLin Du Chun Wei | 2017 | Paper And Biomaterials2017，2，4： | 19 |
| 5 | Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers显示文摘 | Li, Fei Feng, Yan Fang, Rong Fang, Zhaoyuan Xia, Jufeng Han, Xiangkun Liu, Xin-Yuan Chen, Haiquan Liu, Hongyan Ji, Hongbin | 2012 | Cell Research2012，22，5： | 11 |
| 6 | Differentiation of adipose-derived stem cells toward nucleus pulposuslike cells induced by hypoxia and a three-dimensional chitosan-alginate gel scaffold in vitro显示文摘 | Zhang Zhicheng Li Fang Tian Haiquan Guan Kai Zhao Guangmin Shan Jianlin Ren Dajiang | 2014 | Chinese Medical Journal2014，，2： | 10 |
| 7 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 8 | Earth observation satellite scheduling for emergency tasks显示文摘The earth observation satellites(EOSs)scheduling problem for emergency tasks often presents many challenges.For example,the scheduling calculation should be completed in seconds,the scheduled task rate is supposed to be as high as possible,the disturbance measure of the scheme should be as low as possible,which may lead to the loss of important observation opportunities and data transmission delays.Existing scheduling algorithms are not designed for these requirements.Consequently,we propose a rolling horizon strategy(RHS)based on event triggering as well as a heuristic algorithm based on direct insertion,shifting,backtracking,deletion,and reinsertion(ISBDR).In the RHS,the driven scheduling mode based on the emergency task arrival and control station time window events are designed to transform the long-term,large-scale problem into a short-term,small-scale problem,which can improve the schedulability of the original scheduling scheme and emergency response sensitivity.In the ISBDR algorithm,the shifting rule with breadth search capability and backtracking rule with depth search capability are established to realize the rapid adjustment of the original plan and improve the overall benefit of the plan and early completion of emergency tasks.Simultaneously,two heuristic factors,namely the emergency task urgency degree and task conflict degree,are constructed to improve the emergency task scheduling guidance and algorithm efficiency.Finally,we conduct extensive experiments by means of simulations to compare the algorithms based on ISBDR and direct insertion,shifting,deletion,and reinsertion(ISDR).The results demonstrate that the proposed algorithm can improve the timeliness of emergency tasks and scheduling performance,and decrease the disturbance measure of the scheme,therefore,it is more suitable for emergency task scheduling. | SUN Haiquan XIA Wei HU Xiaoxuan XU Chongyan | 2019 | Journal of Systems Engineering and Electronics2019，30，5： | 8 |
| 9 | Characterization of integrons and novel cassette arrays in bacteria from clinical isloates in China,2000-2014显示文摘Rapid dissemination of antibiotic resistance genes among bacterial isolates is an increasing problem in China.Integron,a conserved DNA sequence,which is carried on episomal genetic structures,plays a very important role in development of antibiotic resistance.This systematic analysis was based on MEDLINE and EMBASE databases.We summarized the distribution and proportion of different types of gene cassette arrays of integrons(including class 1,2,3 and atypical class 1 integron) from clinical bacteria isolates in China.Fifty-six literatures were included in this study.Most of the strains were Gram-negative bacteria(94.1%,7,364/7,822) while only 5.9% strains were Grampositive bacteria.Class 1 integrons were detected in 54.2%(3956/7295) Gram-negative strains.aadA2 was the most popular gene cassette array detected from 60 Gram-positive bacteria while dfrA17-aadA5 were detected in 426 Gramnegative bacteria.This study identified 12 novel gene cassette arrays which have not been previously found in any species.All the novel gene cassette arrays were detected from Gram-negative bacteria.A regional characteristic of distribution of integrons was presented in this study.The results highlight a need for continuous surveillance of integrons and provide a guide for future research on integron-mediated bacteria resistance. | Wenying Xia Ting Xu Tingting Qin Pengpeng Liu Yun Liu Haiquan Kang Bing Gu Ping Ma | 2016 | The Journal of Biomedical Research2016，30，4： | 5 |
| 10 | Late Carboniferous to early Permian sedimentaryetectonic evolution of the north of Alxa, Inner Mongolia, China: Evidence from the Amushan Formation显示文摘The late Paleozoic evolution of the Wulijishanhen(WSH)-Shangdan(SD) area near to the Chaganchulu Ophiolite belt is reinterpreted. Analysis of the upper Carboniferous to lower Permian sedimentary sequence, biological associations, detrital materials, sandstone geochemistry and volcanic rocks indicates that the SD area was an epicontinental sea and rift during the late Paleozoic rather than a large-scale ocean undergoing spreading and closure. This study reveals that the actual evolution of the study area is from the late Carboniferous to the early Permian. The fusulinids Triticites sp. and Pseudoschwagerina sp.in the limestones demonstrate that the Amushan Formation develops during the late Carboniferous to the early Permian. The limestones at the base of the SD section indicate that it is a stable carbonate platform environment, the volcanic rocks in the middle of the sequence support a rift tectonic background, and the overlying conglomerates and sandstones are characteristic of an epicontinental sea or marine molasse setting. The rift volcanism made the differences in the fossil content of the SD and WSH sections and led to two sections expose different levels within the Amushan Formation and different process of tectonic evolution. Moreover, the geochemical characteristics and detrital materials of the sandstones show that the provenance and formation of the sandstones were related to the setting of active continental margin. The quartz-feldspar-lithic fragments distribution diagram indicates that the material source for the sandstones was a recycled orogenic belt. Thus, the source area of the sandstones may have been an active continental margin before the late Carboniferouseearly Permian. The characteristics of the regional tectonic evolution of the area indicate that the region may form a small part of the Gobie Tianshan rift of southern Mongolia. | Haiquan Yin Hongrui Zhou Weijie Zhang Xiaoming Zheng Shengyu Wang | 2016 | Geoscience Frontiers2016，7，5： | 5 |
| 11 | Preparation and electrochemical characterization of ultrathin WO3-x/C nanosheets as anode materials in lithium ion batteries显示文摘 | Keyan Bao Wutao Mao Guangyin Liu Liqun Ye Haiquan Xie Shufang Ji Dingsheng Wang Chen Chen Yadong Li | 2017 | Nano Research2017，10，6： | 4 |
| 12 | Multibeam water column data research in the Taixinan Basin:Implications for the potential occurrence of natural gas hydrate显示文摘A multi beam sonar survey is carried out in the continental slope of the Taixinan Basin to obtain submarine topographic and water column data. The data are processed to obtain water column images. Anomalous water column images, displaying plume characteristics, are found in gas hydrate enriched areas in the Taixinan Basin.This indicates the presence of natural gas resources in the Taixinan Basin. The multibeam sonar system is shown to provide an accurate and effective approach for detecting sub-sea gas hydrate. | Yilan Chen Jisheng Ding Haiquan Zhang Qiuhua Tang Xinghua Zhou Xiaoyu Liu | 2019 | Acta Oceanologica Sinica2019，38，5： | 4 |
| 13 | Recent Geochemical Variation of the Hot-Spring Gases from the Tianchi Volcano, Changbai Mountains, Northeast China显示文摘Recent fluid monitoring work shows that the contents of mantle-derived CO_2,He and CH_4 increased anomalously in 2002 and 2003. The 3He/4He ratio of the deep-fault-type Jinjiang hot springs increased highly anomalously in 2003, and then decreased in 2004. The 3He/4He ratio from the thermal-reservoir-type Changbaijulong hot springs increased slowly in 2003, and the increase continued in 2004. The mantle-derived He content of the He released from the Changbaijulong springs increased obviously in 2004. The anomaly of the released gases and the isotopic He was consistent with the trends of seismic activities in the Tianchi volcanic area between 2002 and 2004. The abnormal release of the Jinjiang hot springs apparently decreased after the seismic activities ceased in the second half of 2004, while the abnormal release from the Changbaijulong increased significantly after these seismic activities. It shows that the abnormal release of magmas-derived gases from the thermal-reservoir-type springs lags behind that of the deep-fault-type springs. These characteristics may be of great significance for identifying deep magmatic activity and predicting volcanic earthquakes in the future. | Gao Ling Wei Haiquan Shangguan Zhiguan Wu Chengzhi | 2007 | Earthquake Research in China2007，21，2： | 4 |
| 14 | Scalable and Identifier/Locator-Splitting Routing Protocol for Mobile Ad Hoc Networks显示文摘In the traditional Internet Protocol (IP) architecture, there is an overload of IP semantic problems. Existing solutions focused mainly on the infrastructure for the fixed network, and there is a lack of support for Mobile Ad Hoc Networks (MANETs). To improve scalability. a routing protocol for MANETs is presented based on a locator named Tree-structure Locator Distance Vector (TLDV). The hard core of this routing method is the identifier/locator split by the Distributed Hash Table (DHT) method, which provides a scalable routing service. The node locator indicates its relative location in the network and should be updated whenever topology changes. Locator space is organized as a tree-structure, and the basic routing operation of the TLDV protocol is presented. TLDV protocol is compared to some classical routing protocols for MANETs on the NS2 platform. Results show that TLDV has better scalability. | Wang Haiquan Chen Meng Hu Junshun Xia Chunhe | 2012 | China Communications2012，9，1： | 3 |
| 15 | A MIMO system with finite-bit feedback based on fixed constellations显示文摘In this paper,a MIMO system with finite-bit feedback based on fixed constellations is considered.Based on performance analysis of the system,an optimal operating system with maximum-likelihood decoding is demonstrated.Surprisingly,this operation reveals that the optimal way for the system to transmit signals needs to invoke the multimode scheme.We propose designing criteria for this scheme and methods for pre-codebooks,and a method to determine the number of modes for any specific channel.Furthermore,to reduce encoding complexity at the receiver side,we also develop a fast encoding algorithm.Theoretical analysis and simulations show that the proposed systems offer considerable gain over existing systems.Moreover,these systems also have much lower encoding complexity.Indeed,for the case of a MIMO system with two pairs of transmitting and receiving antennas,a properly designed system with a transmission rate of 8 bits per channel use and with 6-bit feedback can provide about a 1.5 dB performance gain over a beamforming system. | WANG HaiQuan ZHAO ZhiJin | 2013 | Science China(Information Sciences)2013，56，6： | 3 |
| 16 | Nanostructured SnO_2 photoanode-based dye-sensitized solar cells显示文摘This review focuses on recent developments in the nanostructured SnO2 photoanodes for dye-sensitized solar cells(DSSCs)applications.Carefully designed and fabricated nanostructured SnO2films are advantageous for effective improvement in performance of DSSCs.Nanocrystals can offer a large surface area for dye adsorption;nanowires are able to provide a direct transfer pathway for the rapid collection of photogenerated electrons;the mesoporous,monodisperse beads with a submicrometer-sized diameter ensure a large specific surface area for dye adsorption and simultaneously promote light scattering;the surface modification of SnO2by other oxides may improve the photovoltage and photocurrent,hence resulting in the higher power conversion efficiency of SnO2-based DSSCs. | Zhengdao Li Yong Zhou Ruzhong Sun Yan Xiong Haiquan Xie Zhigang Zou | 2014 | Chinese Science Bulletin2014，59，18： | 3 |
| 17 | Dicarboxylate CaC8H4O4 as a high-performance anode for Li-ion batteries显示文摘当前,许多器官的材料正在被看作电极材料并且显示好电气化学的行为。然而,与器官的电极的宽使用有关的最关键的问题由于他们在电解质的高溶解度是他们的低热稳定性和差的骑车性能。集中于最常规的羧化物之一器官的材料,也就是锂 terephthalate 李<潜水艇class=“ a-plus-plus ”> 2 C <潜水艇class=“ a-plus-plus ”> 8 H <潜水艇class=“ a-plus-plus ”> 4 O <潜水艇class=“ a-plus-plus ”> 4 ,我们经由修改它的分子的结构处理这些典型劣势由阳离子替换。 CaC <潜水艇class=“ a-plus-plus ”> 8 H <潜水艇class=“ a-plus-plus ”> 4 O <潜水艇class=“ a-plus-plus ”> 4 和艾尔<潜水艇class=“ a-plus-plus ”> 2 (C 8 H <潜水艇class=“ a-plus-plus “> 4 O <潜水艇class=” a-plus-plus “> 4 ) 3 经由灵巧的阳离子交换反应被准备。这些, CaC < 潜水艇 class= “ a-plus-plus ” > 8 H < 潜水艇 class= “ a-plus-plus ” > 4 O < 潜水艇 class= “ a-plus-plus ” > 4 与热稳定性介绍最好骑车的表演直到 | Liping Wang Haiquan Zhang Chengxu Mou Qianling Cui Qijiu Deng Jing Xue Xinyi Dai Jingze Li | 2015 | Nano Research2015，8，2： | 3 |
| 18 | Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression显示文摘Objective:To explore the molecular mechanisms of antitumor properties of triptolide,a bioactive component isolated from the Chinese herb Tripterygium wolfordii Hook F.Methods:Human fibrosarcoma HT-1080 cells were treated with different doses of triptolide for 72 h.Then the expression and activity of matrix metalloproteinase(MMP)-2 and -9 were measured and the invasiveness of triptolide-treated HT-1080 cells was compared with that of anti-MMP-9- treated HT-1080 cells.Results:18 nmol/L triptolide inhibited the gene expression and activity of MMP-9,but not those of MMP-2,in HT-1080 cells.In addition,both 18 nmol/L triptolide and 3μg/mL anti-MMP-9 significantly reduced the invasive potential of HT-1080 cells,by about 50%and 35%, respectively,compared with the control.Whereas there was no significant difference between the effect of 18 nmol/L triptolide and that of anti-MMP-9 on invasive potential of HT-1080 cells. Conclusions:These data suggest that triptolide inhibits tumor cell invasion partly by reducing MMP-9 gene expression and activity. | Shengbo Yang Can Gu Guiying Zhang Jian Kang Haiquan Wen QianJin Lu Jinhua Huang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 3 |
| 19 | Copeptin in the assessment of acute lung injury and cardiogenic pulmonary edema显示文摘 | Qionghua Lin Fengming Fu Haiquan Chen Biao Zhu | 2012 | Respiratory Medicine2012，，9： | 2 |
| 20 | Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques显示文摘Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential immunization.The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type. | Wei Deng Qi Lv Fengdi Li Jiangning Liu Zhiqi Song Feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing Jia Kai Gao Jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
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