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| 1 | Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition显示文摘改变的新陈代谢是癌症房间的特点之一。戊糖磷酸盐小径(PPP ) 是细胞的新陈代谢的一个基本部件。Glucose-6-phosphate 脱氢酶(G6PD ) , PPP 的限制率的酶,在许多癌症被提高并且由通过 PPP 生产 ribose-5-phosphate 和 NADPH 贡献肿瘤生长。然而,在 hepatocellular 的 G6PD 的角色癌(HCC ) 转移和在 HCC 前进和预后的 G6PD 的临床的意义一直不是很好坚定的。在这研究,由从 HCC 病人和 HCC 房间线调查织物样品,我们发现那提高的 G6PD 表情显著地与 HCC 转移和差的预后被联系 HCC,和那 G6PD 击倒在 vitro 禁止 HCC 房间线的增长,移植和侵略。进一步的研究表明 G6PD 由通过信号变换器的激活和抄写 3 的使活跃之物(STAT3 ) 导致上皮间充质的转变贡献 HCC 移植和 hepatocellular 癌房间的侵略小径。我们的调查结果建议那指向的 G6PD 能为转移干预开创可能性并且为 HCC 改进病人结果。 | Ming Lu Lu Lu Qiongzhu Dong Guangyang Yu Jinhong Chen Lunxiu Qin Lianxin Wang Wenwei Zhu Huliang Jia | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 10 |
| 2 | Management and outcome of pelvic fractures in elderly patients: a retrospective study of 40 cases显示文摘 | Dong Jinlei Hao Wei Wang Bomin Wang Lubo Li Lianxin Mu Weidong Yang Yongliang Xin Maoyuan Wang Fu Zhou Dongsheng | 2014 | Chinese Medical Journal2014，，15： | 8 |
| 3 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 4 | Postmarketing studies on safety of Dengfeng~ shenmai injection显示文摘OBJECTIVE: To systematically research the postmarketing safety of Dengfeng shenmai injection, identify potential risk factors, and ensure its clinical safety. METHODS: We investigated a comprehensive series of studies on the production process, quality standards, pharmacology, postmarketing clinical studies, and safety evaluation of Shenmai injection, including literature analysis of adverse drug reaction(ADR) case analysis and systematic review. Data from the hospital information system(HIS) and spontaneous reporting system(SRS) were also analyzed. RESULTS: The approximate dosage leading to death in dogs is 45.0-67.5 g raw drug/kg and the toxic reactions are restlessness, skin irritation, salivation, and vomiting. The results of chronic toxicity tests in mice and dogs, and the other tests such as 6-month toxicity, drug safety, genetic toxicity, and reproductive toxicity of rats and dogs, were positive or qualified. Patient ADR history and ADR family history were closely associated with itching based on the data analysis from SRS. There was no damage to renal function from Shenmai injection use at a dosage and a treatment course outside the recommended dosage and treatment course as specified based on data analysis from HIS. The most common ADR from Shenmai injection are difficulty breathing, facial flushing, nausea, vomiting, chest tightness, skin itching, rash, and back pain. CONCLUSION: This study includes complete information on Shenmai injection ADR incidence rate. We found that Shenmai injection is safe and this study can provide clinical, research, and production institutions with an objective, reliable, and scientific basis for use of Shenmai injection. | Lianxin Wang Wen Zhang Yanming Xie Yang Bai Mulan Wang Qinghua Ai | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 3 |
| 5 | Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma显示文摘 | Tongsen Zheng Xuehui Hong Jiabei Wang Tiemin Pei Yingjian Liang Dalong Yin Ruipeng Song Xuan Song Zhaoyang Lu Shuyi Qi Jiaren Liu Boshi Sun Changming Xie Shangha Pan Yuejin Li Xiaohe Luo Shuai Li Xiang Fang Nishant Bhatta Hongchi Jiang Lianxin Liu | 2014 | Hepatology2014，，： | 2 |
| 6 | An ensemble estimation of impact times and strength of Fukushima nuclear pollution to the east coast of China and the west coast of America显示文摘Based on the statistics of all surface drifting buoys of 1978-2011 and Lagrangian tracers simulated from high quality ocean reanalysis currents,the impact times and strength of Fukushima nuclear pollution to the east coast of China and the west coast of America have been estimated.Under the circumstances of the radioactive pollutants drifting in the ocean surface,preliminary research results show that while the tracers took about 4 years to reach the west coast of USA,there are two types of tracers to carry out Fukushima nuclear pollutants to reach the east coast of China,corresponding to 1.5-year recirculation gyre transport and 3.5-year subtropical circulation transport.The distributions of the impact strength at these time scales are given according to the variation of relative number concentration with time combined with the decaying rate of radioactive matter.For example,starting from 1% at 1.5-year,of the initial level at the originating area of Fukushima nuclear pollution,the impact strength of Cesium-137 in the South China Sea continuously increases up to 3% by 4 years,while the impact strength of Cesium-137 in the west coast of America is as high as 4% due to the role of strong Kuroshio-extension currents as a major transport mechanism of nuclear pollutants for that area. | HAN GuiJun LI Wei FU HongLi ZHANG XueFeng WANG XiDong WU XinRong ZHANG LianXin | 2013 | Science China Earth Sciences2013，56，8： | 2 |
| 7 | Seasonal changes in the effects of free-air CO 2 enrichment (FACE) on dry matter production and distribution of rice ( Oryza sativa L.)显示文摘 | Lianxin Yang Jianye Huang Hongjie Yang Guichun Dong Gang Liu Jianguo Zhu Yulong Wang | 2005 | Field Crops Research2005，，1： | 2 |
| 8 | A variational successive corrections approach for the sea ice concentration analysis显示文摘The sea ice concentration observation from satellite remote sensing includes the spatial multi-scale information.However,traditional data assimilation methods cannot better extract the valuable information due to the complicated variability of the sea ice concentration in the marginal ice zone.A successive corrections analysis using variational optimization method,called spatial multi-scale recursive filter(SMRF),has been designed in this paper to extract multi-scale information resolved by sea ice observations.It is a combination of successive correction methods(SCM)and minimization algorithms,in which various observational scales,from longer to shorter wavelengths,can be extracted successively.As a variational objective analysis scheme,it gains the advantage over the conventional approaches that analyze all scales resolved by observations at one time,and also,the specification of parameters is more convenient.Results of single-observation experiment demonstrate that the SMRF scheme possesses a good ability in propagating observational signals.Further,it shows a superior performance in extracting multi-scale information in a two-dimensional sea ice concentration(SIC)experiment with the real observations from Special Sensor Microwave/Imager SIC(SSMI). | Xuefeng Zhang Lu Yang Hongli Fu Dong Li Zheqi Shen Lianxin Zhang Xuhui Hu | 2020 | Acta Oceanologica Sinica2020，39，9： | 1 |
| 9 | Yield formation of CO 2 -enriched inter-subspecific hybrid rice cultivar Liangyoupeijiu under fully open-air field condition in a warm sub-tropical climate显示文摘 | Lianxin Yang Hongjiang Liu Yunxia Wang Jianguo Zhu Jianye Huang Gang Liu Guichun Dong Yulong Wang | 2008 | Agriculture Ecosystems and Environment2008，，1： | 1 |
| 10 | Experiments on the Huanan placer gold deposit,Heilongjiang with the magnetic prospecting method显示文摘 | WANG LIANXIN HAN DEBO | 1997 | Mineral Resources and Geology1997，11，1： | 1 |
| 11 | Yield formation of CO 2 -enriched hybrid rice cultivar Shanyou 63 under fully open-air field conditions显示文摘 | Hongjiang Liu Lianxin Yang Yulong Wang Jianye Huang Jianguo Zhu Wang Yunxia Guichun Dong Gang Liu | 2008 | Field Crops Research2008，，1： | 1 |
| 12 | The impact of free-air CO 2 enrichment (FACE) and nitrogen supply on grain quality of rice显示文摘 | Lianxin Yang Yulong Wang Guichun Dong Hui Gu Jianye Huang Jianguo Zhu Hongjian Yang Gang Liu Yong Han | 2007 | Field Crops Research2007，，2： | 1 |
| 13 | Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCoV-2),a novel coronavirus that causes Coronavirus Disease 2019(COVID-19)(Yang and Wang,2020),has spread to more than 200 countries and infected more than 9,000,000 people as of Jun 2020.Tens of thousands of patients with COVID-19 have recovered and been discharged from hospital.However,there are reports of recovered patients who subsequently tested positive for SARSCoV-2 after discharge(re-detectable positive,RP)(An et al.,2020;Lan et al.,2020),and this has led to increasing focus on the mechanism(s)underlying RP. | Wanyin Tao Xiaofang Wang Guorong Zhang Meng Guo Huan Ma Dan Zhao Yong Sun Jun He Lianxin Liu Kaiguang Zhang Yucai Wang Jianping Weng Xiaoling Ma Tengchuan Jin Shu Zhu | 2021 | Protein & Cell2021，12，3： | 1 |
| 14 | The effect of (Li,Ce) and (K,Ce) doping in Aurivillius phase material CaBi 4 Ti 4 O 15显示文摘 | Haixue Yan Zhen Zhang Weimin Zhu Lianxin He Youhua Yu Chengen Li Jiaguang Zhou | 2004 | Materials Research Bulletin2004，，9： | 1 |
| 15 | The impact of atmospheric CO 2 concentration enrichment on rice quality – A research review显示文摘 | Yunxia Wang Michael Frei Qiling Song Lianxin Yang | 2011 | Acta Ecologica Sinica2011，，6： | 1 |
| 16 | The impact of free-air CO 2 enrichment (FACE) and nitrogen supply on grain quality of rice显示文摘 | Lianxin Yang Yulong Wang Guichun Dong Hui Gu Jianye Huang Jianguo Zhu Hongjian Yang Gang Liu Yong Han | 2007 | Field Crops Research2007，，2： | 1 |
| 17 | Effects of yeast polysaccharide on growth and flavonoid accumulation in fagopyrum tataricum sprout cultures显示文摘 | Zhao Gang Zhao Jianglin Peng Lianxin | 2012 | Molecules2012，17，11： | 1 |
| 18 | 2009-18年西北太平洋区域海洋再分析CORA1.0产品研制及检验显示文摘在51年(1958-2008)西北太平洋区域海洋再分析CORA1.0产品的基础上,改进了模式配置和同化方法,研制了2009-18年的CORA产品并对其进行以下检验:(1)温盐和海表高度异常均方根误差分布检验;(2) 35°N处温度断面分布检验;(3)再分析流场和表漂浮标轨迹对比检验.结果显示,2009-18年的CORA产品可以再现海洋要素长时间序列,时空多尺度的变化特征,为研究特征海洋现象和过程提供背景信息. | Guofang Chao Xinrong Wu Lianxin Zhang Hongli Fu Kexiu Liu Guijun Han | 2021 | Atmospheric and Oceanic Science Letters2021，14，5： | 1 |
| 19 | Regional var-iations in ore composition and fluid features of massive sulphide deposits in South China:Implications for genetic modelling显示文摘 | Gu Lianxin Hu Wenxuan He Jinxiang | 2000 | Episodes2000，23，2： | 1 |
| 20 | Statistical characteristics and mechanisms of mesoscale eddies in the North Indian Ocean显示文摘The statistical characteristics and mechanisms of mesoscale eddies in the North Indian Ocean are investigated by adopting multi-sensor satellite data from 1993 to 2019.In the Arabian Sea(AS),seasonal variation of eddy characteristics is remarkable,while the intraseasonal variability caused by planetary waves is crucial in the Bay of Bengal(BOB).Seasonal variation of the eddy kinetic energy(EKE)is distinct along the west boundary of AS,especially in the Somali Current region.In the BOB,larger EKE occurs at the northwest basin from March to May,to the east of Sri Lanka from June to September,and along the east coast of India from November to December.The wind stress work(WW)is further studied to figure out the direct influence of wind forcing on EKE.The WW exerts positive effects on EKE along the west boundary of AS and in the south of India/Sri Lanka during the two monsoon seasons.Besides,the WW also has impact on EKE along the east coast of India in November and December.Eventually,we investigate the characteristics and the driving mechanisms of long lifespan eddies.In the AS,long lifespan anti-cyclonic eddies(AEs)mainly generate in the Socotra,the West Indian Coastal Current and the East Arabian Current regions,while cyclonic eddies(CEs)are concentrated in the northwest region.In the BOB,long lifespan AEs mostly form near the west of Myanmar,while CEs are accumulated at the north and northwest basin.The instabilities caused by Rossby waves,coastal Kelvin waves,seasonal currents,together with wind stress forcing exert enormous efforts on the generation and evolution of these eddies. | Chunjian Sun Xidong Wang Anmin Zhang Lianxin Zhang Caixia Shao Guosong Wang | 2022 | Acta Oceanologica Sinica2022，41，5： | 1 |
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