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| 1 | Rice DENSE AND ERECT PANICLE 2 is essential for determining panicle outgrowth and elongation显示文摘包括谷物尺寸和圆锥花序形态学,圆锥花序的建筑学直接决定谷物产量。圆锥花序直立,为在中国的北部分完成理想的植物建筑学被选择,引起了米饭 breeders 的增加的注意。这里,稠密、直立的圆锥花序 2 (dep2 ) 异种,显示出稠密、直立的圆锥花序显型,被识别。没有任何已知的功能的领域, DEP2 编码植物特定的蛋白质。表示介绍 DEP2 表明它高度在年轻纸巾被表示,与在年轻圆锥花序的大多数丰富。词法并且表示分析显示在 DEP2 的那个变化主要影响脊柱和主要、第二等的分支的快速的延伸,但是不损害圆锥花序 primordia 的开始或形成。进一步的分析建议在 dep2 的圆锥花序长度的减少被一个缺点在圆锥花序的指数的延伸期间在房间增长引起。尽管有在 dep2 异种的一种更紧缩的植物类型,在谷物生产的重要改变都没在野类型和 dep2 异种之间被发现。因此, DEP2 的学习不仅加强我们圆锥花序建筑学的分子的基因基础的理解而且为米饭繁殖有重要含意。 | Feng Li Wenbo Liu Jiuyou Tang Jinfeng Chen Hongning Tong Bin Hu Chunlai Li Jun Fang Mingsheng Chen Chengcai Chu | 2010 | Cell Research2010，20，7： | 51 |
| 2 | Liuwei Dihuang pill suppresses metastasis by regulating the wnt pathway and disrupting β-catenin/T cell factor interactions in a murine model of triple-negative breast cancer显示文摘OBJECTIVE:To investigate if the Liuwei Dihuang pill(LWDHP)can inhibit metastasis to the liver and lungs in mice bearing triple-negative breast cancer(TNBC),and the molecular mechanism underpinning this action.METHODS:Ninety-nine TNBC bearing-mice were distributed randomly to five groups:control(Con),paclitaxel(PTX),low-dose LWDHP(LLP,2.3 g·kg^-1·d^-1),middle-dose LWDHP(MLP,4.6 g·kg^-1·d^-1)and high-dose LWDHP(HLP,9.2 g·kg^-1·d^-1).The LWDHP were administered(p.o.)to the agonal stage.The morphology of BC cells was observed by hematoxylin&eosin staining.Expression of axin-2,β-catenin,T cell factor(TCF),cyclin-D1 and vascular endothelial growth factor(VEGF)was detected by western blotting or immunofluorescence.β-catenin/TCF-1 interaction was measured using a co-immunoprecipitation assay.RESULTS:After LWDHP treatment,metastasis of BC cells to the lungs and liver was inhibited,expression of axin-2 was increased,expression of TCF-1,β-catenin,cyclin-D1 and VEGF was decreased,andβ-catenin/TCF-1 interaction was disrupted.CONCLUSION:The LWDHP could inhibit metastasis of BC cells to the liver and lungs.The molecular mechanism underlying this action may be regulation of protein expression andβ-catenin/TCF-1 interactions in the Wnt pathway. | Zheng Lixiang Zheng Qing Yu Zhipeng Wang Jian Ren Xiaoying Gong Yan Yang Xue Hunag Ping Weng Meizhi Liu Hongning Liu Haizhou | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 9 |
| 3 | Effect of Liuweidihuang pill and Jinkuishenqi pill on inhibition of spontaneous breast carcinoma growth in mice显示文摘OBJECTIVE: To investigate the preventing and treating action of Liuweidihuang pill(LP) and Jinkuishenqi pill(JP) on spontaneous breast carcinoma in mice.METHODS: A model of spontaneous breast carcinoma was derived from 11.5-month-old female Kunming breeding mice following the delivery of several litters. The mice were randomly divided into five groups: model control group(C),Liuweidihuang pill high-dose group(LH; 4.6 g·kg1·d1),Liuweidihuang pill low-dose group(LL;2.3 g·kg1·d﹣1),Jinkuishenqi pill high-dose group(JH; 4.6 g·kg﹣1·d1) and Jinkuishenqi pill low-dose group(JL;2.3 g·kg﹣1·d﹣1). Cancer tissue volume was measured by water immersion. Histopathology was analyzed by hematoxylin and eosin staining. Vascular endothelial growth factor(VEGF),extracellular signal-regulated kinase(ERK) and cyclin D1 protein expression in cancer tissue was assayed by western blotting.RESULTS: Compared with the control group,cancer tissue volume and weight were lower in the LP and JP groups,and survival time was longer. The expression of VEGF,ERK and Cyclin D1 were inhibited in the LP and JP groups(P < 0.05),and cell differentiation was increased. Tumor weights and volumes and VEGF,ERK and Cyclin D1 expression in LL or LH were significantly lower than in JL and JH(P < 0.01).CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation;moreover,LP was more effective than JP The likely mechanism of action was via inhibition of VEGF,ERK and cyclin D1. | Zheng Lixiang Liu Hongning Gong Yan Meng Xianming Jiang Runde Wang Xiaomin Wang Qiaofeng Wang Yue | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 8 |
| 4 | Big Grain3, encoding a purine permease, regulates grain size via modulating cytokinin transport in rice显示文摘Grain size is an important agronomic trait affecting grain yield,but the underlying molecular mechanisms remain to be elucidated.Here,we isolated a dominant mutant,big grainy(bg3-D),which exhibits a remarkable increase of grain size caused by activation of the PURINE PERMEASE gene,OsPUP4.BC3/OSPUP4 is predominantly expressed in vascular tissues and is specifically suppressed by exogenous cytokinin application.Hormone profiling revealed that the distribution of different cytokinin forms,in roots and shoots of the bg3-D mutant,is altered.Quantitative reverse transcription-PCR(qRT-PCR)analysis indicated that expression of rice cytokinin type-A RESPONSE REGULATOR(OsRR)genes is enhanced in the roots of the bgj-D mutant.These results suggest that OSPUP4 might contribute to the long-distance transport of cytokinin,by reinforcing cytokinin loading into vascular bundle cells.Furthermore,plants overexpressing OsPUP7,the closest homolog of OsPUP4,also exhibited a similar phenotype to the bg3-D mutant.Interestingly,subcellular localization demonstrated that OSPUP4 was localized on the plasma membrane,whereas OSPUP7 was localized to the endoplasmic reticulum.Based on these findings,we propose that OSPUP4 and OSPUP7 function in a linear pathway to direct cytokinin cell-to-cell transport,affecting both its long-distance movement and local allocation. | Yunhua Xiao Dapu Liu Guoxia Zhang Shaopei Gao Linchuan Liu Fan Xu Ronghui Che Yiqin Wang Hongning Tong Chengcai Chu | 2019 | Journal of Integrative Plant Biology2019，61，5： | 7 |
| 5 | Neighbor Detection-Based Spectrum Sensing Algorithm in Distributed Cognitive Radio Networks显示文摘Security issues of spectrum sensing have drawn a lot of attentions in Cognitive radio networks(CRNs).Malicious users can mislead the network to make wrong decision about the states of channels by tampering spectrum sensing data.To defense against Spectrum sensing data falsification(SSDF) attack,we propose a neighbor detection-based spectrum sensing algorithm in distributed CRNs,which can detect attackers with the help of neighbors during spectrum sensing to improve the accuracy of decision making.The proposed scheme can also guarantee the connectivity of the network.Simulation results illustrate that the proposed scheme can defense against SSDF attacks effectively and reach the unified information of spectrum sensing data. | PEI Qingqi LI Hongning LIU Xianjun | 2017 | Chinese Journal of Electronics2017，26，2： | 4 |
| 6 | A cryptic inhibitor of cytokinin phosphorelay controls rice grain size显示文摘Plant hormone cytokinin signals through histidine-aspartic acid(H-D)phosphorelay to regulate plant growth and development.While it is well known that the phosphorelay involves histidine kinases,histidine phosphotransfer proteins(HPs),and response regulators(RRs),how this process is regulated by external components remains unknown.Here we demonstrate that protein phosphatase with kelch-like domains(PPKL1),known as a signaling component of steroid hormone brassinosteroid,is actually a cryptic inhibitor of cytokinin phosphorelay in rice(Oryza sativa).Mutation at a specific amino acid D364 of PPKL1 activates cytokinin response and thus enlarges grain size in a semi-dominant mutant named s48.Overexpression of PPKL1 containing D364,either with the deletion of the phosphatase domain or not,rescues the s48 mutant phenotype.PPKL1 interacts with OsAHP2,one of authentic HPs,and D364 resides in a region resembling the receiver domain of RRs.Accordingly,PPKL1 can utilize D364 to suppress OsAHP2-to-RR phosphorelay,whereas mutation of D364 abolishes the effect.This function of PPKL1 is independent of the phosphatase domain that is required for brassinosteroid signaling.Importantly,editing of the D364-residential region produces a diversity of semi-dominant mutations associated with variously increased grain sizes.Further screening of the edited plants enables the identification of two genotypes that confer significantly improved grain yield.Collectively,our study uncovers a noncanonical cytokinin signaling suppressor and provides a robust tool for seed rational design. | Dapu Liu He Zhao Yunhua Xiao Guoxia Zhang Shouyun Cao Wenchao Yin Yangwen Qian Yanhai Yin Jinsong Zhang Shouyi Chen Chengcai Chu Hongning Tong | 2022 | Molecular Plant2022，15，2： | 3 |
| 7 | Observations and analysis of environment and acoustic field changed by the passage of typhoon Damrey in the Yellow Sea in 2012显示文摘In order to investigate the environment and acoustic filed change induced by typhoon in shallow sea, we conducted two experiments just before and after the passage of typhoon Damrey, which is the strongest to affect the area north of the Yangtze River since 1949, in the Yellow sea in 2012. The data show that the temperature of the whole water column increases dramatically except the sea surface layer after the passage of Damrey while the salinity decreases obviously. The thermocline deepens and weakens, which leads to a change of internal wave activity. The transmission losses(TL) of the two experiments show that the environment change induced by typhoon can increase the TL as large as 8 d B at a distance of 9.2 km and depth of 15 m. The scintillation index(SI) of the sound intensity is simulated to estimate the change of the effect of internal wave activity on acoustic field showing that the SI decreases to a half after the typhoon's passage. The normal mode structures of the two experiments are also significantly different due to the thermocline changes. In addition, the signal arrives earlier after the typhoon's passage due to the water temperature increase. | YANG GuangBing Lü LianGang YUAN YeLi JIANG Ying LIU ZongWei YANG ChunMei LIU HongNing CHEN Zhao | 2015 | Science China Earth Sciences2015，58，12： | 3 |
| 8 | The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice显示文摘Brassinosteroids(BRs)are a class of steroid hormones with great potential for use in crop improvement.De-repression is usually one of the key events in hormone signaling.However,how the stability of GSK2,the central negative regulator of BR signaling in rice(Oryza sativa),is regulated by BRs remains elusive.Here,we identify the U-box ubiquitin ligase TUD1 as a GSK2-interacting protein by yeast two-hybrid screening.We show that TUD1 is able to directly interact with GSK2 and ubiquitinate the protein.Phenotypes of the tud1 mutant are highly similar to those of plants with constitutively activated GSK2.Consistent with this finding,GSK2 protein accumulates in the tud1 mutant compared with the wild type.In addition,inhibition of BR synthesis promotes GSK2 accumulation and suppresses TUD1 stability.By contrast,BRs can induce GSK2 degradation but promote TUD1 accumulation.Furthermore,the GSK2 degradation process is largely impaired in tud1 in response to BR.In conclusion,our study demonstrates the role of TUD1 in BR-induced GSK2 degradation,thereby advancing our understanding of a critical step in the BR signaling pathway of rice. | Dapu Liu Xiaoxing Zhang Qingliang Li Yunhua Xiao Guoxia Zhang Wenchao Yin Mei Niu Wenjing Meng Nana Dong Jihong Liu Yanzhao Yang Qi Xie Chengcai Chu Hongning Tong | 2023 | Plant Communications2023，4，2： | 2 |
| 9 | Brassinosteroid-regulated plant growth and development and gene expression in soybean显示文摘Brassinosteroids(BRs) are endogenous phytohormones that play important roles in regulating plant growth and development.In this study, we evaluated the effects of brassinolide(BL, one of the active BRs) on soybean and identified roles of the hormone in regulating multiple aspects of plant growth and development.BL application promoted hypocotyl and epicotyl elongation in the light but blocked epicotyl elongation in the dark.High levels of castasterone and BL accumulated in light-grown plants.BL disrupted shoot negative gravitropism, whereas gibberellin did not.BL delayed leaf senescence.Transcriptome analysis showed that BL induced cell wall-modifying genes and auxin-associated genes but suppressed a class of WRKY genes involved in senescence and stress responses,showing the complex roles of BRs in multiple biological processes. | Wenchao Yin Nana Dong Mei Niu Xiaoxing Zhang Lulu Li Jun Liu Bin Liu Hongning Tong | 2019 | The Crop Journal2019，7，3： | 2 |
| 10 | Malaria from hyperendemicity to elimination along international borders in Yunnan, China during 2003‒2020: a case study显示文摘Background: Border malaria is one of the most intractable problems hindering malaria elimination worldwide.Movement of both the human population and anopheline mosquitoes infected with Plasmodium spp.can cause cross-border malaria transmission.The Yunnan border area was still hyperendemic for malaria in the early part of this century.The objective of this case study was to analyze the strategies,interventions and impacts of malaria control and elimination in the Yunnan border area.Main text: A total of 10,349 malaria cases and 17.1 per 10,000 person-years of annual parasite incidence(API)were reported in the border area in 2003.Based on natural village-based stratification,integrated interventions,including mass drug administration for radical cures and preventive treatment,clinically presumptive treatment of all febrile patients for malaria and indoor residual spraying or dipping bed nets with insecticides were successfully carried out from 2003 to 2013.The overall API was reduced to 0.6 per 10,000 person-years by 2013,while effective cross-border collaboration interventions dramatically reduced the malaria burden in the neighbouring border areas of Myanmar.From 2014 forward,the comprehensive strategy,including universal coverage of surveillance to detect malaria cases,a rapid response to possible malaria cases and effective border collaboration with neighbouring areas,successfully eliminated malaria and prevented reintroduction of malaria transmission in the Yunnan border area.Conclusions: In Yunnan malaria burden has successfully reduced by dynamically accurate stratification and comprehensive interventions;and then the region achieved elimination and prevented reintroduction of malaria transmission through intensive surveillance,rapid response and border collaboration.Other border areas should perform their own intervention trials to develop their own effective strategy. | Hui Liu Yaowu Zhou Yan Deng Zurui Lin Canglin Zhang Qiyan Chen Chun Wei Kaixia Duan Peng Tian Hongning Zhou Jianwei Xu | 2022 | Infectious Diseases of Poverty2022，11，3： | 1 |
| 11 | Expression of rna-interference/antisense transgenes by the cognate promoters of target genes is a better gene-silencing strategy to study gene functions in rice 显示文摘 | Li J Jiang D Zhou H Li F Yang JW Hongn LF Fu XA Li ZB Liu ZL Li JM Zhuang CX | 2011 | PLoS ONE2011，6，17： | 1 |
| 12 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 13 | Modulus of elasticity of human periodontal ligament by optical measurement and numerical simulation显示文摘 | Liu DongXu Wang HongNing Wang Chun-Ling | 2011 | Angle Orthodontist2011，81，2： | 1 |
| 14 | 蚊肠道共生菌增强伊蚊对蚊媒病毒易感性显示文摘文章简介蚊媒病毒在'宿主-蚊虫'之间传播循环。蚊虫通过吸血获取病毒感染,在这个过程中,蚊虫将血液与病毒一起吸入肠道中。因此,蚊子的肠道组织是病毒首先接触并感染的器官,同时也是抵抗病毒感染的第一道生理屏障,最终决定蚊虫对病毒的易感性。 | 吴葩 Peng Sun Kaixiao Nie Yibin Zhu Mingyu Shi Changguang Xiao Han Liu Qiyong Liu Tongyan Zhao Xiaoguang Chen Hongning Zhou Penghua Wang 程功 | 2020 | 科学新闻2020，，2： | 1 |
| 15 | Triptolide-loaded microemulsion-based hydrogels: physical properties and percutaneous permeability显示文摘Triptolide is a diterpenoid compound that inhibits the inflammation of rheumatoid arthritis(RA).However,the use of triptolide is limited due to its strong gastrointestinal toxicity.The purpose of this work was to develop a transdermal delivery system for triptolide to reduce this toxicity.A microemulsion-based hydrogel(MBH)was prepared from the combination of Gemseal 40-oleic acid as oil phase,Tween 80-labrasol as surfactant,anhydrous ethanol as co-surfactant,water as aqueous phase and Poloxamer 407 as hydrogel matrix.Rheological measurements,environmental scanning electron microscopy(ESEM)and transdermal experiments in vitro were used to characterize triptolide-loaded and blank MBH preparations.The effects of Poloxamer 407 and triptolide on the rheological properties and microstructures of the MBH were determined.Transparent and homogeneous MBH could only be formed when the concentration of Poloxamer 407 in the selected O/W microemulsion was in the range of 14.0–16.0%(w/w).When the concentration of Poloxamer 407 increased,the rheological properties such as the yield stresses(sy),storage and loss moduli(G′,G″)of the formulations increased,and the network structures became more compact.The addition of triptolide did not change the interconnected network structures of the MBH preparations.MBH preparations afford a better sustained release profile when compared to microemulsions,a finding confirmed by an in vitro permeation test in mice.MBH appears to be a promising vehicle for transdermal delivery of triptolide. | Lihua Chen Xiaoting Zhao Jia Cai Yongmei Guan Sen Wang Hongning Liu Weifeng Zhu Junsong Li | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 1 |
| 16 | Discussing the Dietary Regimen and Disease Prevention and its Application as an Anti‑epidemic Measure显示文摘This article discusses the role of dietary regimen in the traditional culture of Chinese medicine according to its origin.Dietary regimen is a technique that inherits the traditional culture of Chinese medicine.Through analysis of the characteristics of the dietary regimen and the discussion of the idea of disease prevention,the application of the dietary regimen in disease prevention is sought.Under the guidance of three key factors,the application of the dietary regimen in disease prevention is mainly manifested in two aspects.First,the dietary regimen can be used to guide the daily reasonable diet to maintain the human body in a balance of Yin and Yang,which could prevent the occurrence of diseases.Second,on the basis of minimizing health loss,it can be used for disease treatment,adjuvant treatment,and rehabilitation.Finally,taking preventive treatment as the guiding ideology,the application of a dietary regimen as an“anti‑epidemic”was briefly discussed. | Jianhe Fang Weifeng Zhu Hongning Liu | 2020 | Chinese Medicine and Culture2020，3，3： | 1 |
| 17 | Simultaneous quantifi cation and evaluate the differences of two skeleton components in raw,salt and wine Angelicae Pubescentis Radix by UPLC-MS/MS in negative/positive modes coupled with chemometrics显示文摘The aim of this study was to establish an ultra-performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry method with positive and negative ion exchange scanning mode for simultaneous quantification of two different skeleton components to reveal the differences among raw and processed Angelicae Pubescentis Radix. The results of methodology showed that each compound had good linearity and recovery rates. And the chemometrics results indicate that there were differences not only in Angelicae Pubescentis Radix samples from different sources but also in raw and processed Angelicae Pubescentis Radix. The results of this study confirm that the method has been successfully applied in simultaneous determination and discovering the difference of two different skeleton components between raw and processed Angelicae Pubescentis Radix for the first time. In short, the method could be an effective tool for detecting the quality of traditional Chinese medicine, and can better reveal the difference between raw and processed Chinese medicine from different sources. | Lin Yang Wanqing Zhang Wen Deng Hui Wang Hongning Liu | 2022 | Journal of Future Foods2022，2，1： | 0 |
| 18 | Sympathetic skin response in patients with myasthenia gravis: A comparative analysis显示文摘BACKGROUND:The examination of sympathetic skin response is an important index for assessing the autonomic nerve function,and patients with myasthenia gravis are always accompanied by dysautonomia. Therefore,it will be important to know whether sympathetic skin response can be used as the index for the clinical evaluation of myasthenia gravis. OBJECTIVE:To investigate the diagnostic value of sympathetic skin response in the damage of autonomic nerve function of patients with myasthenia gravis. DESIGN:A case-controlled comparative observation. SETTING:Department of Neurology and Room of Nerve Electromyogram,the Affiliated Hospital of North Sichuan Medical College. PARTICIPANTS:Thirty outpatients or inpatients with myasthenia gravis were selected from the Department of Neurology,the Affiliated Hospital of North Sichuan Medical College from May 2006 to May 2007,including 9 males and 21 females,aged 8-72 years with a mean age of(28±5) years old. They were all accorded with the diagnostic standards of myasthenia gravis,accompanied by different severity of autonomic nerve symptoms,including poor skin nutrition,sweating of hands and feet,pyknocardia,persistent hypotension,abdominal pain,constipation,etc. They all had not taken any drug affecting the autonomic nerve function before the examination. Informed consents were obtained from all the patients. Meanwhile,30 healthy physical examinees were enrolled as the normal control group,including 10 males and 20 females,aged 10-75 years with a mean age of(31±5) years old. Approval was obtained from the hospital ethic committee. METHODS:After admission,the patients were examined with sympathetic skin response using DANTEC keypoint 2.0 electromyography evoked potential apparatus(Danmark). The changes of the latency and wave amplitude of sympathetic skin response were observed. The subjects in the normal control group were examined with the same methods at physical examination. Abnormality was judged by the disappearance of wave form,latency longer than that in the normal control group by Mean±2.5SD,or wave amplitude lower than the average value in the normal control group by 50%. MAIN OUTCOME MEASURES:The results of the latency and wave amplitude of sympathetic skin response were compared between the patients with myasthenia gravis and normal controls. RESULTS:All the 30 patients with myasthenia gravis and 30 healthy physical examinees were involved in the final analysis of results. There were no significant differences between the left and right upper and lower limbs in both the myasthenia gravis group and normal control group(P > 0.05). In the myasthenia gravis group,the abnormal rate of sympathetic skin response was 37%(11/30),the latency was prolonged and the wave amplitude was decreased as compared with those in the normal control group,and there were significant differences(P < 0.01). CONCLUSION:Sympathetic skin response can be used as an electrophysiological index for judging the damages of autonomic nerve function in patients with myasthenia gravis. | Hongning Zhao Xiaoming Wang Junqiang Zhang Deben Yang Xiaoqiong Zhao Xin Liu HuiHuang Jianxiu Hu | 2007 | Neural Regeneration Research2007，2，11： | 0 |
| 19 | Histological Assessment and Transcriptome Analysis Provide Insights into the Toxic Effects of Perfluorooctanoic Acid to Juvenile Half Smooth Tongue Sole Cynoglossus semilaevis显示文摘Perfluorooctanoic acid(PFOA)is a widespread synthetic persistent organic pollutant that may enrich along the food chain and affect the growth,development,reproduction,and lipid metabolism of aquatic organisms,particularly the benthic organisms.How-ever,the toxic effects of PFOA on the half-smooth tongue sole Cynoglossus semilaevis,a commercial benthic fish in China,have rarely been reported.Because juvenile fish are sensitive to environmental pollutants,in the present study,histological assessment and tran-scriptome sequencing were performed to determine the short-term impact of PFOA on juvenile half-smooth tongue soles.Histologi-cal analysis showed that PFOA exposure caused hepatocyte rupture,intestinal villi breakage,increased goblet cell count,and brain ab-normal.Transcriptome results showed that some interesting signaling pathways,such as glycolysis/gluconeogenesis,PPAR signaling pathway and GABAergic synapse signaling pathway,were enriched after PFOA exposure.In addition,some metabolic,immune and neural genes were differentially expressed,which including ependymin,hbb1-like and gad 1,and they were up-regulated after 14 days of exposure.Transcriptome results also indicated that half-smooth tongue sole might improve energy metabolism in response to PFOA toxicity after 7 days of exposure.These findings provide a basis for studying the ecological effects of PFOA on marine benthic fishes. | ZHAN Min SHI Kunpeng ZHANG Xue FAN Qingxin XU Qian LIU Xinbao LI Zhujun LIU Hongning XIA Yanting SHA Zhenxia | 2023 | Journal of Ocean University of China2023，22，6： | 0 |
| 20 | The divergence of brassinosteroid sensitivity between rice subspecies involves natural variation conferring altered internal auto-binding of OsBSK2显示文摘Japonica/geng and indica/xian are two major rice(Oryza sativa)subspecies with multiple divergent traits,but how these traits are related and interact within each subspecies remains elusive.Brassinosteroids(BRs)are a class of steroid phytohormones that modulate many important agronomic traits in rice.Here,using different physiological assays,we revealed that japonica rice exhibits an overall lower BR sensitivity than indica.Extensive screening of BR signaling genes led to the identification of a set of genes distributed throughout the primary BR signaling pathway with divergent polymorphisms.Among these,we demonstrate that the C38/T variant in BR Signaling Kinase2(OsBSK2),causing the amino acid change P13L,plays a central role in mediating differential BR signaling in japonica and indica rice.OsBSK2in indica plays a greater role in BR signaling than OsB SK2in japonica by affecting the auto-binding and protein accumulation of OsBSK2.Finally,we determined that OsBSK2 is involved in a number of divergent traits in japonica relative to indica rice,including grain shape,tiller number,cold adaptation,and nitrogen-use efficiency.Our study suggests that the natural variation in OsB SK2 plays a key role in the divergence of BR signaling,which underlies multiple divergent traits between japonica and indica. | Wenchao Yin Lulu Li Zhikun Yu Fan Zhang Dapu Liu Hongkai Wu Mei Niu Wenjing Meng Xiaoxing Zhang Nana Dong Yanzhao Yang Jihong Liu Yongqiang Liu Guoxia Zhang Jianlong Xu Shimei Wang Chengcai Chu Qian Qian Hongning Tong | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
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