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| 1 | Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis显示文摘间充质的干细胞(MSC ) 试验性地被使用了对待煽动性的混乱,部分由于他们的抑制免疫力的性质。尽管 interleukin-1β(IL-1β) 是最重要的煽动性的调停人之一,成长证据显示那 IL-1β发信号得到 MSC 的抑制免疫力的性质。然而,它仍然保持不清楚怎么 IL-1β发信号完成这项活动。这里,我们集中于 IL-1β 的治疗学的功效;在葡聚糖硫酸盐钠(决策支持系统) 的告知的 MSC 劝诱了大肠炎模型,除了加重的机制。我们首先发现了那 IL-1β没有在 vitro 的任何看得见的显型变化,告知的 MSC 显著地稀释了导致决策支持系统的鼠科的大肠炎的发展。而且, IL-1β告知的 MSC 通过提高 cyclooxygenase-2 (COX-2 ) 在怒气和 mesenteric 淋巴节点(MLN ) 调制了有免疫力的房间的平衡, IL-6 和 IL-8 表示并且影响腹巨噬细胞的极化。重要地, IL-1β告知的 MSC 拥有了一个提高的能力经由 chemokine 受体类型 4 的 upregulation (CXCR4 ) 移居到内脏的煽动性的地点表示。在摘要, IL-1β告知的 MSC 在对待导致决策支持系统的大肠炎改进了功效,它部分至少取决于他们的增加的抑制免疫力的能力和提高的迁居能力。 | Hongye Fan Guangfeng Zhao Liu Liu Fei Liu Wei Gong Xianqin Liu Liu Yang Jianjun Wang Yayi Hou | 2012 | Cellular & Molecular Immunology2012，9，6： | 21 |
| 2 | 17β-estradiol contributes to the accumulationof myeloid-derived suppressor cells in bloodby promoting TNF-αsecretion显示文摘雌激素被影响有免疫力的房间的发展和激活强烈在有免疫力的回答处于性差别含有。最近的研究显示出那导出 myeloid 的 suppressor 房间(MDSC ) ,源于 CD11b + 在病理学的条件下面的 Gr-1 + myeloid 房间,在 modulating 免疫者回答起重要作用。然而,它仍然是未知的 MDSC 上的雌激素的效果。在现在的学习,我们在调整 MDSC 的累积上调查了雌激素的效果和机制。与有全身的豺狼座 erythematosus (SLE ) 的男病人相比,有 SLE 的女病人在浆液在外部血 mononuclear 房间和肿瘤坏死因素(TNF-) 的高水平显示出 MDSC 的更高的频率,这被发现。尤其是,在有 SLE 的女病人的浆液的 estradiol 水平断然与 MDSC 的频率被相关。而且, 17-estradiol 能支持 TNF -- 在由增加 CD11b + Gr-1 + 房间。而且, 17-estradiol 在 vivo 支持了 TNF- 的分泌物,它贡献了 CD11b + Gr-1 + 房间。另外,雌老鼠显示出 CD11b + Gr-1 + 房间和更高的 TNF- 比匹配年龄的雄的老鼠在血铺平。这些数据显示 17-estradiol 由支持 TNF- 分泌物在血贡献 MDSC 的累积,它增加 CD11b + Gr-1 + 房间。我们的调查结果在发炎和自体免疫的疾病的流行提供新卓见进性差别的机制。 | Guanjun Dong Ming You Hongye Fan Jianjian Ji Liang Ding Pengfei Li Yayi Hou | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 11 |
| 3 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 4 | Computer-aided ionic liquid design for alkane/cycloalkane extractive distillation process显示文摘A computer-aided ionic liquid design(CAILD) study is presented for the frequently encountered alkane/cycloalkane separations in petrochemical industry. Exhaustive experimental data are first collected to extend the UNIFAC-IL model for this system, where the proximity effect in alkanes and cycloalkanes is considered specifically by defining distinct groups. The thermodynamic performances of a large number of ILs for 4 different alkane/cycloalkane systems are then compared to select a representative example of such separations. By applying n-heptane/methylcyclohexane extractive distillation as a case study, the CAILD task is cast as a mixed-integer nonlinear programming(MINLP) problem based on the obtained task-specific UNIFAC-IL model and two semi-empirical models for IL physical properties. The top 5 IL candidates determined by solving the MINLP problem are subsequently introduced into Aspen Plus for process simulation and economic analysis, which finally identify 1-hexadecyl-methylpiperidinium tricyanomethane([C_(16)MPip][C(CN)_3]) as the best entrainer for this separation. | Zhen Song Xinxin Li He Chao Fan Mo Teng Zhou Hongye Cheng Lifang Chen Zhiwen Qi | 2019 | Green Energy & Environment2019，4，2： | 6 |
| 5 | Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 B 房间 hyperreactivity 描绘的自体免疫的疾病。像使用费的受体 7 (TLR7 ) 表明小径反常地在 SLE B 房间被激活。CyclinD3 (CCND3 ) 在 B 房间增长,开发,和区别起一个重要作用。尽管以前的研究为自发的幼芽的中心的发展集中了于 TLR7 的 B 房间内在的角色,在 SLE B 房间的 CCND3 上的 TLR7 的影响仍然不是清楚的。这里,我们使用了介绍薄片的 B 房间并且发现 CCND3 与 SLE 有关并且显著地在 SLE B 房间提高了。而且,我们决定 CCND3 的表示水平更高,当 miR-15b 与正常题目相比在从 SLE 病人和 B6.MRL-Faslpr/J 豺狼座老鼠的 B 房间是显著地更低的时。而且,我们证明 TLR7 的激活戏剧性地增加了 CCND3 表示,但是显著地减少了在在 vitro 的 B 房间的 miR-15b 并且我们鉴别 CCND3 是 miR-15b 的一个直接目标。为了推进,证实我们的结果,我们由谈论地对待 C57BL/6 (B6 ) 建立了另一个豺狼座模型有为 8 个星期的 TLR-7 收缩筋 imiquimod (IMQ ) 的老鼠根据以前描述的协议。Expectedly,有 IMQ 的热门治疗显著地也增加了 CCND3 并且减少在 B6 老鼠的 B 房间的 miR-15b。一起拿,我们的结果鉴别 TLR7 的激活在 B cells; 经由 miR-15b 的 downregulation 增加了 CCND3 表示;因此,这些调查结果建议那外来的导致因素的 CCND3 表情可以在 SLE 贡献 B 房间的反常。 | Deshan Ren Fei Liu Guanjun Dong Ming You Jianjian Ji Yahong Huang Yayi Hou Hongye Fan | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 6 | mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus显示文摘 | Xiaojing Li Xuefang Zhang Yuchen Pan Guoping Shi Jing Ren Hongye Fan Huan Dou Yayi Hou | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 4 |
| 7 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，： | 1 |
| 8 | Progesterone Enhances Immunoregulatory Activity of Human Mesenchymal Stem Cells Via PGE 2 and IL ‐6显示文摘 | Xiaoyin Zhao Liu Liu Dan Liu Hongye Fan Yaping Wang Yali Hu Yayi Hou | 2012 | Am J Reprod Immunol2012，，4： | 1 |
| 9 | Preparation of WO3 thin films by dip film-drawing for photoelectrochemical performance显示文摘Here we report the WO3 thin films on F-doped SnO2 conducting glass (FTO) substrates which were prepared by using dip film-drawing method. Dip film-drawing was a simple, convenient, economical method and in largescale to prepare photoanodes for future applications. The FTO substrates were dipped in tungstic acid solution then film-drawn included 3, 6, 9, 12 and 15 times for prepared different thicknesses of WO3 thin film photoanodes. Then the photoa no des were employed as the electrodes in photoelectrochemical property Keywords: WO3 thin films Dip film-drawing Photoelectrochemical Thicknesses Large-scale measurements, which include scan linear sweep, repeated on/off illumination cycles, electrochemical impedanee spectroscopy and incident phot on to current conversion efficiency, respectively. The results showed that the WO3 thin films dipped 9 times with 175 nm thicknesses had the best photoelectrochemical performance of 0.067 mA·cm^-2 at 1.23 V versus RHE. | Dongbo Xu Lili Li Weiqiang Fan Fagen Wang Hongye Bai Baodong Mao Weidong Shi | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 1 |
| 10 | Decreased CDld level is associated with CD86 over-expression in B cells from systemic lupus erythematosus显示文摘 | Fei Liu Jianjian Ji Xiujun Li Xiaojing Li Jingjing Xu Huimin Yue Shuli Zhao Hongye Fan Yayi Hog | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 1 |
| 11 | Application of an amphipathic molecule at the NiO_(x)/perovskite interface for improving the efficiency and long-term stability of the inverted perovskite solar cells显示文摘The presence of defects and detrimental reactions at NiO_(x)/perovskite interface extremely limit the efficiency performance and long-term stability of the perovskite solar cells(PSCs) based on NiO_(x).Herein,an amphipathic molecule Triton X100(Triton) is modified on the NiO_(x)surface.The hydrophilic chain of Triton as a Lewis base additive can coordinate with the Ni3+on the NiO_(x)surface which can passivate the interfacial defects and hinder the detrimental reactions at the NiO_(x)/perovskite interface.Additionally,the hydrophobic chain of Triton protrudes from the NiO_(x)surface to prevent moisture from penetrating into the NiO_(x)/perovskite interface.Consequently,the NiO_(x)/Triton-based devices(MAPbI3as absorbing layer) show superior moisture and thermal stability,retaining 88.4% and 64.3% of the initial power conversion efficiency after storage in air(40%-50% relative humidity(RH)) at 25 ℃ for 1070 h and in N2at 85℃ for 800 h,respectively.Moreover,the efficiency increases from 17.59% to 19.89% because of the passivation defect and enhanced hole-extraction capability.Besides,the NiO_(x)/Triton-based PSCs with Cs_(0.05)(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))3perovskite as the light-absorbing layer also exhibits better moisture and thermal stability compared to the control devices,indicating the viability of our strategies.Of particular note,a champion PCE of 22.35% and 20.46% was achieved for small-area(0.1 cm^(2)) and large-area(1.2 cm^(2)) NiO_(x)/Triton-based devices,respectively. | Guibin Shen Hongye Dong Fan Yang Xin Ren Ng Xin Li Fen Lin Cheng Mu | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 12 | TLR7, a third signal for the robust generation of spontaneous germinal center B cells in systemic lupus erythematosus显示文摘Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the loss of tolerance to self-nuclear antigens,in which altered B-cell signaling shows an essential role.1 The clonal expansion and antigen-based affinity maturation of B cells primarily occurs at germinal centers(GCs).2 Significantly,recent studies have demonstrated that the robust activity of GCs and the breach of tolerance to self-nuclear antigens are associated with the pathogenesis of SLE. | Hongye Fan Deshan Ren Yayi Hou | 2018 | Cellular & Molecular Immunology2018，15，3： | 0 |
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