|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adakitic rocks and destruction of the North China Craton:Evidence from experimental petrology and geochemistry显示文摘The general temporal-spatial consistency for the formation of adakitic rocks and lithospheric thinning in northern China provide a window to examine the processes and mechanism for the destruction of the North China Craton.With experimental petrology data,this paper demonstrates that the adakitic rocks in northern China are the products of partial melting of middle-to high-potassic metabasalts at the base of the lower continent crust.Based on the TiO2 solubility model,many adakitic rocks in Dabie,Jiaodong and the northern part of the craton appear to have been saturated with TiO2.This indicates the presence of a Ti-rich accessory phase in their source regions.This phase must be rutile based on the decreasing Nb/La with increasing La/Yb in the adakitic rocks.The adakitic magmas were,thus,derived from a depth of more than 50 km,based on pressures (higher than 1.5 GPa) for the stability of rutile in a metabasalt system.Because present-day crustal thickness is generally only 35 km,we suggest that the destruction of the North China Craton may have led to at least 15 km of thinning or delamination of the crust. | XIONG XiaoLin LIU XingCheng ZHU ZhiMin LI Yuan XIAO Wan Sheng SONG MaoShuang ZHANG Sheng WU JinHua | 2011 | Science China Earth Sciences2011，54，6： | 34 |
| 2 | Atmospheric lead pollution in fine particulate matter in Shanghai, China显示文摘The Pb-monitoring program was extended for 6 years from 2002 to 2007 at 17 representative urban sites (6 traffic, 5 industrial, and 6 residential sites), and 3 suburban sites to assess the lead pollution in fine particulate matter (PM2.5) after phasing out leaded gasoline in Shanghai. Compared with Pb levels reported in other places, the Pb pollution in Shanghai is still serious after phasing out leaded gasoline, which remains at high concentration range (213–176 ng/m3) in PM2.5 in winter. Significant spatial variation of Pb concentrations and strong seasonal variation of higher Pb concentration in winter than that in summer were detected. The size distribution of Pb in particulate matter has a unimodal mode that peaks at approximately 0.154–1.59 μm particle diameter, indicating that Pb is mainly concentrated in fine fraction. Lead in the fine fraction is enriched by a factor of 103–104 relative to Pb abundance in crust. Eight categories of Pb pollution sources were identified in the PM2.5 in the winter of 2007 in Shanghai. The important emission sources among them are vehicle exhaust derived from combustion of unleaded gasoline, metallurgic industry emission, and coal combustion emission. | LI Xiaolin ZHANG Yuanxun TAN Mingguang LIU Jiangfeng BAO Liangman ZHANG Guilin LI Yan IIDA Atsuo | 2009 | Journal of Environmental Sciences2009，21，8： | 20 |
| 3 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 4 | Coherent beam combining of high powerfiber lasers: Progress and prospect显示文摘The recent research progress of coherent beam combining of high power fiber lasers is reviewed. Key technologies like coherently combinable fiber laser, phase control of multiple beams and beam tilling are specially analyzed. Prospects for single coherently combinable high power fiber amplifier, beam tilling and target-in-the-loop control for propagation in real atmosphere are presented. | LIU ZeJin ZHOU Pu XU XiaoJun WANG XiaoLin MA YanXing | 2013 | Science China(Technological Sciences)2013，56，7： | 16 |
| 5 | 1.3 kW monolithic linearly polarized single-mode master oscillator power amplifier and strategies for mitigating mode instabilities显示文摘We report on the high-power amplification of a 1064 nm linearly polarized laser in an all-fiber polarizationmaintained master oscillator power amplifier,which can operate at an output power level of 1.3 kW.The beam quality(M^2) was measured to be <1.2 at full power operation.The polarization extinction rate of the fiber amplifier was measured to be above 94% before mode instabilities(MIs) set in,which reduced to about 90% after the onset of MI.The power scaling capability of strategies for suppressing MI is analyzed based on a semianalytical model,the theoretical results of which agree with the experimental results.It shows that mitigating MI by coiling the gain fiber is an effective and practical method in standard double-cladding large mode area fiber,and,by tight coiling of the gain fiber to the radius of 5.5 cm,the MI threshold can be increased to three times higher than that without coiling or loose coiling.Experimental studies have been carried out to verify the idea,which has proved that MI was suppressed successfully in the amplifier by proper coiling. | Rumao Tao Pengfei Ma Xiaolin Wang Pu Zhou Zejin Liu | 2015 | Photonics Research2015，3，3： | 15 |
| 6 | Identification of mecciRNAs and their roles in the mitochondrial entry of proteins显示文摘Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus. | Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan | 2020 | Science China(Life Sciences)2020，63，10： | 15 |
| 7 | Factors predicting sensory and motor recovery after the repair of upper limb peripheral nerve injuries显示文摘OBJECTIVE: To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES: The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a publication date between 1 January 1990 and 16 February 2011. STUDY SELECTION: The following types of article were selected:(1) clinical trials describing the repair of median, ulnar, radial, and digital nerve injuries published in English; and(2) studies that reported sufficient patient information, including age, mechanism of injury, nerve injured, injury location, defect length, repair time, repair method, and repair materials. SPSS 13.0 software was used to perform univariate and multivariate logistic regression analyses and to investigate the patient and intervention factors associated with outcomes. MAIN OUTCOME MEASURES: Sensory function was assessed using the Mackinnon-Dellon scale and motor function was assessed using the manual muscle test. Satisfactory motor recovery was defined as grade M4 or M5, and satisfactory sensory recovery was defined as grade S3+ or S4.RESULTS: Seventy-one articles were included in this study. Univariate and multivariate logistic regression analyses showed that repair time, repair materials, and nerve injured were independent predictors of outcome after the repair of nerve injuries(P < 0.05), and that the nerve injured was the main factor affecting the rate of good to excellent recovery. CONCLUSION: Predictors of outcome after the repair of peripheral nerve injuries include age, gender, repair time, repair materials, nerve injured, defect length, and duration of follow-up. | Bo He Zhaowei Zhu Qingtang Zhu Xiang Zhou Canbin Zheng Pengliang Li Shuang Zhu Xiaolin Liu Jiakai Zhu | 2014 | Neural Regeneration Research2014，9，6： | 12 |
| 8 | Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared显示文摘Single-walled carbon nanotubes(SWNTs)with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity.Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs.Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor(EGFR)on LS174T colon cancer cells from cell culture to in vivo tumor growth.This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared(NIR)region under a single laser excitation.Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low,smooth autofluorescence background of biological species. | Zhuang Liu Scott Tabakman Sarah Sherlock Xiaolin Li Zhuo Chen Kaili Jiang Shoushan Fan Hongjie Dai | 2010 | Nano Research2010，3，3： | 11 |
| 9 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 10 | Patterns of platinum-group elements in mantle peridotite, granulite xenoliths and basalt in Hannuoba显示文摘Neutron activation analysis after preconcentration of nickel sulfide fire assay was used in measurement of Ru, Ph, Pd, Os, Ir, Pt (i.e. PGE elements) and Au concentrations for basalt, mantle and granulite xenoliths in Hannuoba. The chondrite- and primitive mantle-normalized PGE patterns generally exhibit flat (for Iherzolite), negative slope (for harzburgite), | CHU Xuelei, LI Xiaolin, XU Jiuhua and LIU Jianming1. The Research Center of Mineral Resources Exploration , Chinese Academy of Sciences , Beijing 100101, China 2. Institute of Geology , Chinese Academy of Sciences , Beijing 100029, China 3. Institute of High Energy Physics , Chinese Academy of Sciences , Beijing 100817 , China 4. Beijing University of Science and Engineering , Beijing 100083, China Corresponding author | 1999 | Chinese Science Bulletin1999，44，18： | 10 |
| 11 | Structure of the receptor-activated human TRPC6 and TRPC3 ion channels显示文摘TRPC6 和 TRPC3 是属于正规短暂受体潜力(TRPC ) 的家庭的激活受体的 nonselective 阳离子隧道隧道。他们被 diacylglycerol 激活,一个类脂化合物秒送信人。TRPC6 和 TRPC3 涉及许多生理的过程并且在人的基因疾病含有。这里我们在场在有最新识别的高亲密关系的禁止者 BTDM 的建筑群的人的 TRPC6 homotetramer 的结构由单个粒子的 cryo 电子显微镜学解决了到 3.8?分辨率。我们也在 4.4 点介绍人的 TRPC3 的结构吗?分辨率。这些结构显示出塑造钟的 cytosolic 层在保持 transmembrane 层的二层的体系结构。包括 N 终端 ankyrin 重复和 C 终端卷卷, cytosolic 领域的广泛的内部子单元的相互作用贡献 tetramer 集会。高亲密关系的禁止者 BTDM 在 S5-S6 毛孔领域和电压之间挤像传感器的领域禁止隧道开。我们的结构揭开 TRPC 隧道的分子的建筑学并且为理解这些隧道的机制提供一个结构的基础。 | Qinglin Tang Wenjun Guo Li Zheng Jing-Xiang Wu Meng Liu Xindi Zhou Xiaolin Zhang Lei Chen | 2018 | Cell Research2018，28，7： | 10 |
| 12 | Thermodynamic conditions of framework grain dissolution of clastic rocks and its application in Kela 2 gas field显示文摘Feldspar and clastic debris are the most important constituent framework grains of sedimentary clastic rocks and their chemical dissolution plays an essential role in the formation and evolution of the secondary pore in the reservoir rocks. On the basis of thermodynamic phase equilibrium, this study investigates the chemical equilibrium relationships between fluid and various plagioclase and K-feldspar in diagenesis of the sediments, particularly, the impact of temperature and fluid compositions (pH, activity of K+, Na+, Ca2+ and so on) on precipitation and dissolution equilibria of feldspars. Feldspar is extremely easily dissolved in the acid pore water with a low salinity when temperature decreases. The dissolution of anorthite end-member of plagioclase is related to the Ca content of the mineral and the fluid, higher Ca either in the mineral or in the fluid, easier dissolution of the feldspar. Moreover, the dissolution of albite end-member of plagioclase is related to Na of both the mineral and fluid, lower Na out of both the mineral and fluid, easier dissolution of the mineral. Similarly, lower-K fluid is more powerful to dissolve K-feldspar than the higher. The anorthite component of plagioclase is most easily dissolved in ground water-rock system, the albite is the secondary, and K-feldspar is the most stable. Selective dissolution of plagioclase occurs in diagenesis because of the plagioclase solid solution that is mainly composed of albite and anorthite end-members, Ca-rich part of which is preferentially dissolved by the pore water, in contrast to the Na-rich parts. Based on investigation of reservoir quality, secondary pore, dissolution structures of feldspar, clay minerals and ground water chemistry of the Kela 2 gas field of Kuqa Depression in the Tarim basin of Western China, we discovered that the secondary pore is very well developed in the highest quality section of the reservoir, and the plagioclase of which was obviously selectively dissolved, in contrast to the overgrowth of K-feldspar. Chemistry of the ground water out of the highest quality section of the reservoir is consistent with the complete dissolution field of anorthite, partial dissolution field of albite component of plagioclase, and the precipitation of K-feldspar on the temperature-logK phase equilibrium diagram drawn from this study. The thermodynamic modeling calculation gave us an insight into formation of the secondary pore within the reservoir, and the dissolution of plagioclase an important cause of the secondary pore. It is assumed that the solvent to dissolve the plagioclase frame grains originated from the origin-enriched compacted fluid acids out of the mudstone buried beneath the top of geopressured zones in the Kuqa Depression. | LAI Xingyun, YU Bingsong, CHEN Junyuan, CHEN Xiaolin, LIU Jianqing, MEI Mingxiang, JING Weiguang & CHENG Suhua School of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083, China Key Laboratory of Lithospheric Tectonics, Deep-level Process and Exploration of Ministry of Education, Beijing 100083, China | 2005 | Science China Earth Sciences2005，48，1： | 9 |
| 13 | Experimental investigation of boundary layer transition over a delta wing at Mach number 6显示文摘An experimental study on the boundary layer transition over a delta wing was carried out at Mach number 6 in a quiet wind tunnel.The Nano-tracer-based Planar Laser Scattering(NPLS)and Temperature-Sensitive Paints(TSP)techniques were used to measure the fine flow field structure and the wall Stanton number of the delta wing.The influence of factors such as the angle of attack and the Reynolds number was studied.The following results were obtained.The boundary layer transition between the leading edge and the centerline was dominated by the crossflow instability.At the location of the initial appearance of the traveling crossflow waves,the Stanton number began to rise.The Stanton number reached a maximum when the crossflow waves were broken up to turbulence.Increasing the angle of attack increased the spanwise pressure gradient at the windward side of the delta wing,thereby increasing the crossflow instability and advancing the boundary layer transition front.However,increasing the angle of attack caused the transition front to move backward at the leeward side.In addition,the sensitivity of the boundary layer transition to the Reynolds number varied with the angle of attack and the region. | Haibo NIU Shihe YI Xiaolin LIU Xiaoge LU Dundian GANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 9 |
| 14 | All-fiberized and narrow-linewidth 5 kW power-level fiber amplifier based on a bidirectional pumping configuration显示文摘In this paper,an all-fiberized and narrow-linewidth 5 kW power-level fiber amplifier is presented.The laser is achieved based on the master oscillator power amplification configuration,in which the phase-modulated single-frequency laser is applied as the seed laser and a bidirectional pumping configuration is applied in the power amplifier.The stimulated Brillouin scattering,stimulated Raman scattering,and transverse mode instability effects are all effectively suppressed in the experiment.Consequently,the output power is scaled up to 4.92 kW with a slope efficiency of as high as approximately 80%.The 3-dB spectral width is about 0.59 nm,and the beam quality is measured to be M^(2)~1.22 at maximum output power.Furthermore,we have also conducted a detailed spectral analysis on the spectral width of the signal laser,which reveals that the spectral wing broadening phenomenon could lead to the obvious decrease of the spectral purity at certain output power.Overall,this work could provide a reference for obtaining and optimizing high-power narrow-linewidth fiber lasers. | Pengfei Ma Hu Xiao Wei Liu Hanwei Zhang Xiaolin Wang Jinyong Leng Pu Zhou | 2021 | High Power Laser Science and Engineering2021，9，3： | 9 |
| 15 | Expression of neurocan mRNA and ultrastructure of brain tissue after cerebral ischemia and reperfusion in stroke-prone renovascular hypertensive rats treated by electroacupuncture显示文摘We established a stroke-prone renovascular hypertensive rat model by bilateral constriction of the renal artery with sliver loop clips. After ten weeks, middle cerebral artery occlusion was induced for 2 hours. The rats then received electro-acupuncture at Baihui (DU 20) and Dazhui (DU 14) after onset of ischemia for 30 days. In situ hybridization study showed that electroacupuncture significantly reduced the number of neurocan mRNA-positive cells in the ischemic penumbra and hippocampal tissues of rats. Electron microscopy results demonstrated that the structure of neurons and blood vessels in the ischemic tissues were restored with electroacupuncture. Overall, these data suggest that electroacupuncture may protect neurons against ischemic reperfusion injury in stroke-prone renovascular hypertensive rats, which may be regulated by downregulation of expression of nerve inhibitory factor neurocan mRNA. | Feng Tan Saiying Wan Haike Wu Qiwen HUO Jinliang Wang Wenlin Chen Meifeng Fang Xiaolin Liu Xuewen Wang Jingbo Sun | 2011 | Neural Regeneration Research2011，6，36： | 8 |
| 16 | Glycerol aerobic oxidation to glyceric acid over Pt/hydrotalcite catalysts at room temperature显示文摘Glycerol(GLY) aerobic oxidation in an aqueous solution is one of the most prospective pathways in biomass transformation, where the supported catalysts based on noble metals(mainly Au, Pd, Pt) are most commonly employed. Herein, Pt nanoparticles supported on rehydrated MgxAl1-hydrotalcite(denoted as re-MgxAl1-LDH-Pt) were prepared via impregnation-reduction method followed by an in situ rehydration process, which showed high activity and selectivity towards GLY oxidation to produce glyceric acid(GLYA) at room temperature. The metal-support interfacial structure and catalyst basicity were modulated by changing the Mg/Al molar ratio of the hydrotalcite precursor, and the optimal performance was achieved on re-Mg6Al1-LDH-Pt with a GLY conversion of 87.6% and a GLYA yield of 58.6%, which exceeded the traditional activated carbon and oxide supports. A combinative study on structural characterizations(XANES, CO-FTIR spectra, and benzoic acid titration) proves that a higher Mg/Al molar ratio promotes the formation of positively charged Ptd+species at metal-support interface, which accelerates bond cleavage of a-C–H and improves catalytic activity. Moreover, a higher Mg/Al molar ratio provides a stronger basicity of support that contributes to the oxidation of terminal-hydroxyl and thus enhances the selectivity of GLYA. This catalyst with tunable metal-support interaction shows prospective applications toward transformation of biomass-based polyols. | Junbo Zhang Xiaolin Li Ming Xu Yusen Yang Yinwen Li Ning Liu Xiaoyu Meng Lifang Chen Shuxian Shi Min Wei | 2019 | Science Bulletin2019，64，23： | 8 |
| 17 | Endostatin enhances antitumor effect of tumor antigen-pulsed dendritic cell therapy in mouse xenograft model of lung carcinoma显示文摘Objective: To investigate the antitumor effect of endostatin combined with tumor antigen-pulsed dendritic cell(DC)-T cell therapy on lung cancer.Methods: Transplanted Lewis lung cancer(LLC) models of C57BL/6 mice were established by subcutaneous injection of LLC cells in left extremity axillary. Tumor antigen-pulsed DC-T cells from spleen cells and bone of mice were cultured in vitro. Tumor-bearing mice were randomly divided into three groups, including DCT+endostatin group, DC-T group, and phosphate-buffered saline(PBS) control group. Microvessel density(MVD) of tumor tissue in tumor-bearing mice was determined by immunohistochemistry(IHC). The expressions of vascular endothelial growth factor(VEGF) and hypoxia-inducible factor-1α(HIF-1α) were determined by Western blotting and IHC staining. The proportions of CD8+ T cells, mature dendritic cells(m DC), tumor-associated macrophages [TAM(M1/M2)], and myeloid-derived suppressor cells(MDSC) in suspended cells of tumor tissue were determined by flow cytometry. The expressions of interleukin(IL)-6, IL-10, IL-17, transforming growth factor-β(TGF-β) and interferon-γ(IFN-γ) in suspended cells of tumor tissue were detected by enzyme-linked immune sorbent assay(ELISA).Results: DC-T cells combined with endostatin remarkably suppressed tumor growth. MVD of mice in DCT+endostatin group was significantly lower than that of the control group and DC-T monotherapy group. The expressions of VEGF, IL-6 and IL-17 in tumors were markedly decreased, but IFN-γ and HIF-1α increased after treating with DC-T cells combined with endostatin, compared to control group and DC-T group. In the DCT+endostatin group, the proportions of MDSC and TAM(M2 type) were significantly decreased, m DC and TAM(M1 type) were up-regulated, and CD8+ T cells were recruited to infiltrate tumors, in contrast to PBS control and DC-T monotherapy. DC-T cells combined with endostatin potently reduced the expressions of IL-6, IL-10, TGF-β and IL-17 in tumor tissue, and enhanced the expression of IFN-γ.Conclusions: The study indicated the synergic antitumor effects between endostatin and tumor antigen-pulsed DC-T cells, which may be a prospective therapy strategy to achieve potent antitumor effects on lung cancer. | ring Liang Xiaolin Liu Qi Xie Guoling Chen Xingyu Li Yanrui Jia Beibei Yin Xun Qu Yan Li | 2016 | Chinese Journal of Cancer Research2016，28，4： | 8 |
| 18 | MicroRNAs are involved in the development and progression of gastric cancer显示文摘MicroRNAs (miRNAs) are recognized as an essential component of the RNA family, exerting multiple and intricate biological functions, particularly in the process of tumorigenesis, proliferation, and metastatic progression. MiRNAs are altered in gastric cancer (GC), showing activity as both tumor suppressors and oncogenes, although their true roles have not been fully understood. This review will focus upon the recent advances of miRNA studies related to the regulatory mechanisms of gastric tumor cell proliferation, apoptosis, and cell cycle. We hope to provide an in-depth insight into the mechanistic role of miRNAs in GC development and progression. In particular, we summarize the latest studies relevant to miRNAs’ impact upon the epithelial- mesenchymal transition, tumor microenvironment, and chemoresistance in GC cells. We expect to elucidate the molecular mechanisms involving miRNAs for better understanding the etiology of GC, and facilitating the development of new treatment regimens for the treatment of GC. | Xiaolin Liu Ruixia Ma Bin Yi Adam I.Riker Yaguang Xi | 2021 | Acta Pharmacologica Sinica2021，42，7： | 8 |
| 19 | Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study显示文摘OBJECTIVE:To observe the efficacy of a traditional Chinese medicine,Shenzhuo formula,on patients with diabetic kidney disease(DKD).METHODS:Eighty-eight outpatients with DKD were enrolled.Changes in estimated glomerular filtration rate(eGFR),creatinine clearance,serum creatinine,blood-urea-nitrogen,albuminuria,glycosylated hemoglobin(Hb_(A1C)),blood pressure,and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1,3,6,9,12,and 18 months.RESULTS:Compared with the baseline amounts,serum creatinine decreased,and eGFR and creatinine clearance increased,significantly after intervention for 1,3,6,9,12,and 18 months(all P < 0.05).Mean eGFR increased by 2.11 mL/min per 1.73 m7 y after18-month treatment.Urinary protein at 24 h decreased significantly after 1,3,9,and 12 months(P < 0.05).Hb_(A1C) decreased significantly(P < 0.05) after 3,6,9,12,and 18 months,and systolic blood pressure decreased significantly(P < 0.05) after 1,3,and 6 months.Total cholesterol decreased significantly(P < 0.05) after 1,3,6,and 18 months.Triglyceride and low-density lipoprotein-cholesterol decreased significantly(P < 0.05) after 1 and 3 months.CONCLUSION:Shenzhuo formula can improve eGFR and possibly slow DKD progression.Shenzhuo formula can also lower Hb_(A1C),lipid levels and blood pressure. | Tian Jiaxing Zhao Linhua Zhou Qiang Liu Wenke Chen Xinyan Lian Fengmei Tong Xiaolin | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 8 |
| 20 | Adsorption-energy-based activity descriptors for electrocatalysts in energy storage applications显示文摘Energy storage technologies, such as fuel cells, ammonia production and lithium–air batteries, are important strategies for addressing the global challenge of energy crisis and environmental pollution.Taking overpotential as a direct criterion, we illustrate in theory and experiment that the adsorption energies of charged species such as Li^++e^-and H^++e^-are a central parameter to describe catalytic activities related to electricity-in/electricity-out efficiencies. The essence of catalytic activity is revealed to relate with electronic coupling between catalysts and charged species. Based on adsorption energy, some activity descriptors such as d-band center, e_g-electron number and charge-transfer capacity are further defined by electronic properties of catalysts that directly affect interaction between catalysts and charged species. The present review is helpful for understanding the catalytic mechanisms of these electrocatalytic reactions and developing accurate catalytic descriptors, which can be employed to screen high-activity catalysts in future high-throughput calculations and experiments. | Youwei Wang Wujie Qiu Erhong Song Feng Gu Zhihui Zheng Xiaolin Zhao Yingqin Zhao Jianjun Liu Wenqing Zhang | 2018 | National Science Review2018，5，3： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员