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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Clinical characteristics and response to tyrosine kinase inhibitors of patients with non-small cell lung cancer harboring uncommon epidermal growth factor receptor mutations显示文摘Objective: To investigate the clinical features of patients with non-small cell lung cancer(NSCLC) harboring uncommon epidermal growth factor receptor(EGFR) mutations, and the treatment outcomes of EGFR tyrosine kinase inhibitors(TKIs) in these patients.Methods: We retrospectively analyzed the data of 128 NSCLC patients pathologically diagnosed with uncommon EGFR mutation in the Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College and Beijing Hospital from January 2010 to December 2015, including 40 advanced patients who received EGFR-TKI.Results: Among the total 128 patients, 11 patients were non-adenocarcinoma, including squamous carcinoma(3.9%), adenosquamous carcinoma(2.3%), large cell carcinoma(0.8%), and composite neuroendocrine carcinoma(1.6%). Single mutations accounted for 75.0%(96/128), including G719X(29.7%), S768I(18.0%), 20 exon insertion(13.3%), L861Q(12.5%), De novo T790M(0.8%), and T725(0.8%). Thirty-two patients harbored complex mutations. Forty advanced patients received EGFR-TKI, the objective response rate(ORR) was 20.0%,the disease control rate(DCR) was 85.0%, and the progression-free survival(PFS) was 6.4 [95% confidence interval(95% CI), 4.8–7.9] months. The exploratory analysis of tumor response and PFS in 33 patients with G719X/S768I/L861 Q subtypes showed that ORR was 21.2%(7/33), the DCR was 93.9%(31/33), and PFS was 7.6(95% CI, 5.8–9.4) months. Patients with exon 20 insertion mutation and De novo T790 M experienced rapid disease progression with PFS no more than 2.7 months.Conclusions: Uncommon EGFR-mutant NSCLCs are heterogeneous, EGFR-TKIs can have different efficacy in this specific subtype, and thus further individual assessment is required for each case. | Yan Zhang Zheng Wang Xuezhi Hao Xingsheng Hu Hongyu Wang Yan Wang Jianming Ying | 2017 | Chinese Journal of Cancer Research2017，29，1： | 19 |
| 3 | Metal Flowing of Involute Spline Cold Roll-beating Forming显示文摘The present research on involute spline cold roll-beating forming is mainly about the principles and motion relations of cold roll-beating,the theory of roller design,and the stress and strain field analysis of cold roll-beating,etc.However,the research on law of metal flow in the forming process of involute spline cold roll-beating is rare.According to the principle of involute spline cold roll-beating,the contact model between the rollers and the spline shaft blank in the process of cold roll-beating forming is established,and the theoretical analysis of metal flow in the cold roll-beating deforming region is proceeded.A finite element model of the spline cold roll-beating process is established,the formation mechanism of the involute spline tooth profile in cold roll-beating forming process is studied,and the node flow tracks of the deformation area are analyzed.The experimental research on the metal flow of cold roll-beating spline is conducted,and the metallographic structure variation,grain characteristics and metal flow line of the different tooth profile area are analyzed.The experimental results show that the particle flow directions of the deformable bodies in cold roll-beating deformation area are determined by the minimum moving resistance.There are five types of metal flow rules of the deforming region in the process of cold roll-beating forming.The characteristics of involute spline cold roll-beating forming are given,and the forming mechanism of involute spline cold roll-beating is revealed.This paper researches the law of metal flow in the forming process of involute spline cold roll-beating,which provides theoretical supports for solving the tooth profile forming quality problem. | CUI Fengkui WANG Xiaoqiang ZHANG Fengshou XU Hongyu QUAN Jianhui LI Yan | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 19 |
| 4 | Two RING-Finger Ubiquitin E3 Ligases Regulate the Degradation of SPX4, An Internal Phosphate Sensor, for Phosphate Homeostasis and Signaling in Rice显示文摘SPX-domain-containing proteins (SPXs) play an important role in inorganic phosphate (Pi) sensing,signaling,and transport in eukaryotes.In plants,SPXs are known to integrate cellular Pi status and negatively regulate the activity of Pi central regulators,the PHOSPATE STARVATION RESPONSE proteins (PHRs).The stability of SPXs,such as SPX4,is reduced under Pi-deficient conditions.However,the mechanisms by which SPXs are degraded remain unclear.In this study,using a yeast-twhybrid screen we iden.tified two RING-finger ubiquitin E3 ligases regulating SPX4 degradation,designated SDEL1 and SDEL2,which were post-transcriptionally induced by Pi starvation.We found that both SDELs were located in the nucleus and cytoplasm,had ubiquitin E3 ligase activity,and directly ubiquitinated the K^213 and K^299 lysine residues in SPX4 to regulate its stability.Furthermore,we found that PHR2,a Pi central regulator in rice,could compete with SDELs by interacting with SPX4 under Pi-sufficient conditions,which protected SPX4 from ubiquitination and degradation.Consistent with the biochemical function of SDEL1 and SDEL2,overexpression of SDEL1 or SDEL2 resulted in Pi overaccumulation and induced Pi-starvation signaling even under Pi-sufficient conditions.Conversely,their loss-of-function mutants displayed decreased Pi accumulation and reduced Pi-starvation signaling.Collectively,our study revealed that SDEL1 and SDEL2 facilitate the degradation of SPX4 to modulate PHR2 activity and regulate Pi homeostasis and Pi signaling in response to external Pi availability in rice. | Wenyuan Ruan Meina Guo Xueqing Wang Zhenhui Guo Zhuang Xu Lei Xu Hongyu Zhao Haiji Sun Chengqi Yan Keke Yi | 2019 | Molecular Plant2019，12，8： | 14 |
| 5 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 6 | Chrysanthemum WRKY15-1 promotes resistance to Puccinia horiana Henn. via the salicylic acid signaling pathway显示文摘Chrysanthemum white rust disease,which is caused by the fungus Puccinia horiana Henn.,severely reduces the ornamental quality and yield chrysanthemum.WRKY transcription factors function in the disease-resistance response in a variety of plants;however,it is unclear whether members of this family improve resistance to white rust disease in chrysanthemum.In this study,using PCR,we isolated a WRKY15 homologous gene,CmWRKY15-1,from the resistant chrysanthemum cultivar C029.Real-time quantitative PCR(RT-qPCR)revealed that CmWRKY15-1 exhibited differential expression patterns between the immune cultivar C029 and the susceptible cultivar Jinba upon P.horiana infection.In addition,salicylic acid(SA)treatment strongly induced CmWRKY15-1 expression.Overexpression of CmWRKY15-1 in the chrysanthemum-susceptible cultivar Jinba increased tolerance to P.horiana infection.Conversely,silencing CmWRKY15-1 via RNA interference(RNAi)in C029 increased sensitivity to P.horiana infection.We also determined that P.horiana infection increased both the endogenous SA content and the expression of salicylic acid biosynthesis genes in CmWRKY15-1-overexpressing plants,whereas CmWRKY15-1 RNAi plants exhibited the opposite effects under the same conditions.Finally,the transcript levels of pathogenesis-related(PR)genes involved in the SA pathway were positively associated with CmWRKY15-1 expression levels.Our results demonstrated that CmWRKY15-1 plays an important role in the resistance of chrysanthemum to P.horiana by influencing SA signaling. | Mengmeng Bi Xueying Li Xin Yan Di Liu Ge Gao Pengfang Zhu Hongyu Mao | 2021 | Horticulture Research2021，8，1： | 9 |
| 7 | Graphene-enabled electrically controlled terahertz meta-lens显示文摘Metasurfaces have become a new photonic structure for providing potential applications to develop integrated devices with small thickness, because they can introduce an abrupt phase change by arrays of scatterers. To be applied more widely, active metasurface devices are highly desired. Here, a tunable terahertz meta-lens whose focal length is able to be electrically tuned by ~4.45λ is demonstrated experimentally. The lens consists of a metallic metasurface and a monolayer graphene. Due to the dependence of the abrupt phase change of the metasurface on the graphene chemical potential, which can be modulated using an applied gate voltage, the focal length is changed from 10.46 to 12.24 mm when the gate voltage increases from 0 to 2.0 V. Experimental results are in good agreement with the theoretical hypothesis. This type of electrically controlled meta-lens could widen the application of terahertz technology. | WEIGUANG LIU BIN HU ZONGDUO HUANG HONGYU GUAN HETING LI XINKE WANG YAN ZHANG HONGXING YIN XIAOLU XIONG JUAN LIU YONGTIAN WANG | 2018 | Photonics Research2018，6，7： | 8 |
| 8 | Phase transformation and microstructure control of Ti_(2)AlNb-based alloys: A review显示文摘In recent years,the Ti_(2) AlNb-based alloys are selected as potential alloys for elevated tempe rature applications to replace conventional Ni-based superalloys owing to their good creep resistance and oxidation resistance which are related to the O precipitates.In this paper,the precipitation mecha nisms of O phase,phase transformation and microstructure control of Ti_(2) AlNb-based alloys are reviewed.Ti_(2) AlNb-based alloys generally consist of B2/β,α_(2),and O phase with different morphologies which are derived from the various heat treatment processes,including equiaxed α_(2)/O particles,bimodal microstructure,and Widmannstatten B2/β+O structures etc.As a newly developed strengthening phase,O precipitates can be precipitated from the B2/β matrix or α_(2) phase directly as well as generated by means of peritectoid reaction of α_(2) phase and bcc matrix.Microstructural control of the Ti_(2) AlNb-based alloys can be implemented by refining the original B2/β grain size and regulating the O precipitates.Multidirectional isothermal forging(MIF) and powder metallurgy technique are two effective methods to refine the original B2/βgrains and the morphology and size of O precipitates can be regulated by adding alloying components and pre-deformation process.Moreover,the phase diagram as well as coarsening behavior of Ti_(2) AlNbbased alloys in ageing process is also reviewed.For the further application of these alloys,more emphasis should be paid on the deep interpolation of microstructure-property relationship and the adoption of advanced manufacturing technology. | Hongyu Zhang Na Yan Hongyan Liang Yongchang Liu | 2021 | Journal of Materials Science & Technology2021，，21： | 7 |
| 9 | BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma显示文摘Background:Long non-codingRNAs(lncRNAs)have been found to be involved in the development of many cancers.In this study,we aimed to identify the molecular mechanisms of lncRNA BAALC antisense RNA 1(BAALC-AS1)in regulating the malignancy of esophageal squamous cell carcinoma(ESCC).Methods:The expression of BAALC-AS1 in cancer patients was analyzed using a tissue microarray.The protein and RNA levels of BAALC-AS1 were determined by Western blotting analysis and quantitative reverse transcription-PCR(RT-qPCR),respectively.The cell proliferation was determined by cell viability assays,bromodeoxyuridine incorporation,and flow cytometry.The relationships among BAALC-AS1,RasGAPSH3 domain-binding protein 2(G3BP2),and c-Myc were determined using RNA immunoprecipitation,RNA pull-down assays,and luciferase assays.Results:The expression of BAALC-AS1 was highly up-regulated and associated with malignant phenotypes in ESCC tissues and cell lines.In vivo and in vitro assays showed that BAALC-AS1 promoted ESCC cell proliferation,migration,and invasion.BAALC-AS1 directly interacted with G3BP2,and thereby inhibited the degradation of c-Myc RNA 3’-UTR by G3BP2,thus leading to the accumulation of c-Myc expression.Additionally,c-Myc acted as a transcription factor that can induce the expression of BAALC-AS1 by directly binding to its promoter region.Conclusions:BAALC-AS1/G3BP2/c-Myc feedback loop plays a critical role in the development of ESCC,which might provide a novel therapeutic target and facilitate the development of new therapeutic strategies for the treatment of ESCC. | Hongyue Zhang Yan Wang Weimin Zhang Qingnan Wu Jiawen Fan Qimin Zhan | 2021 | Cancer Communications2021，41，3： | 7 |
| 10 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 11 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 12 | A Comparison in Laser Precision Drilling of Stainless Steel 304 with Nanosecond and Picosecond Laser Pulses显示文摘Precision drilling with picosecond laser has been advocated to significantly improve the quality of micro-holes with reduced recast layer thickness and almost no heat affected zone.However,a detailed comparison between nanosecond and picosecond laser drilling techniques has rarely been reported in previous research.In the present study,a series of micro-holes are manufactured on stainless steel 304 using a nanosecond and a picosecond laser drilling system,respectively.The quality of the micro-holes,e.g.,recast layer,micro-crack,circularity,and conicity,etc,is evaluated by employing an optical microscope,an optical interferometer,and a scanning electron microscope.Additionally,the micro-structure of the samples between the edges of the micro-holes and the parent material is compared following etching treatment.The researching results show that a great amount of spattering material accumulated at the entrance ends of the nanosecond laser drilled micro-holes.The formation of a recast layer with a thickness of^25μm is detected on the side walls,associated with initiation of micro-cracks.Tapering phenomenon is also observed and the circularity of the micro-holes is rather poor.With regard to the micro-holes drilled by picosecond laser,the entrance ends,the exit ends,and the side walls are quite smooth without accumulation of spattering material,formation of recast layer and micro-cracks.The circularity of the micro-holes is fairly good without observation of tapering phenomenon.Furthermore,there is no obvious difference as for the micro-structure between the edges of the micro-holes and the parent material.This study proposes a picosecond laser helical drilling technique which can be used for effective manufacturing of high quality micro-holes. | ZHANG Hongyu DI Jianke ZHOU Ming YAN Yu | 2014 | Chinese Journal of Mechanical Engineering2014，27，5： | 5 |
| 13 | Kelly sideband suppression and wavelength tuning of a conventional soliton in a Tm-doped hybrid mode-locked fiber laser with an all-fiber Lyot filter显示文摘We demonstrate a stable conventional soliton in a Tm-doped hybrid mode-locked fiber laser by employing a homemade all-fiber Lyot filter(AFLF) and a single-wall carbon nanotube. The AFLF, designed by sandwiching a piece of polarization-maintained fiber(PMF) with two 45° tilted fiber gratings inscribed by a UV laser in PMF with a phase-mask scanning technique, shows large filter depth of ~9 d B and small insertion loss of ~0.8 dB. By optimizing the free spectral range of the AFLF, the Kelly sidebands of a conventional soliton centered at1966.4 nm can be dramatically suppressed without impairing the main shape of the soliton spectrum. It gives the pulse duration of 1.18 ps and bandwidth of 3.8 nm. By adjusting the temperature of the PMF of the AFLF from 7°C to 60°C, wavelength tunable soliton pulses ranging from 1971.62 nm to 1952.63 nm are also obtained.The generated soliton pulses can be precisely tuned between 1971.62 nm and 1952.63 nm by controlling the temperature of the AFLF. | JIANFENG LI YAZHOU WANG HONGYU LUO YONG LIU ZHIJUN YAN ZHONGYUAN SUN LIN ZHANG | 2019 | Photonics Research2019，7，2： | 5 |
| 14 | 中国加入《1992年设立国际油污损害赔偿基金国际公约》的前景分析显示文摘中国船舶油污损害赔偿基金管理委员会自2015年成立后,已经受理了9起船舶油污损害案件,该基金的成立对我国船舶油污损害的补偿起到了显著的积极作用。但是,对于重大石油污染事件而言,该基金在赔偿范围、赔偿限额、赔付实践等方面均存在明显不足。相比较而言,国际油污损害赔偿基金在这方面的补偿能力较高。然而,基于我国当时的国情,我国仅加入了《1992年国际油污损害赔偿民事责任公约》,而《1992年设立国际油污损害赔偿基金国际公约》仅适用于中国香港地区。鉴于我国自2010年起已迈入中等收入国家行列,清污水平提高和船舶油污评价体系逐步完善,与此同时,随着海运业的发展,我国面临的船舶油污损害风险也越来越大,本文认为我国加入《1992年设立国际油污损害赔偿基金国际公约》的条件已经成熟。 | 郝会娟 ZENG Yan(译) XIE Hongyue(译) | 2019 | 中华海洋法学评论2019，15，2： | 4 |
| 15 | Recent Progress on Al_(2)O_(3)-C Refractories with Low/ultra-low Carbon Content:A Review显示文摘This work intends to provide a comprehensive review on the development of Al_(2)O_(3)-C refractories with low/ultra-low carbon content.It covers three parts:carbon materials,microstructure optimization of the refractory matrix by ceramic phases,and application of metal Al as raw material.Carbon black,expanded graphite,and ultrafine microcrystalline graphite,as price-competitive carbon materials,can be chosen to prepare the low-carbon Al_(2)O_(3)-C refractories after some special treatment.Ni/Co/Fe-catalyzed phenolic resin contributes to improving the properties of the low-carbon Al_(2)O_(3)-C refractories.The performance deterioration of the low-carbon Al_(2)O_(3)-C refractories can also be improved by in-situ formed or pre-synthesized ceramic phases.Metal Al,characterized by plasticity forming,acceleration of sintering,oxidation resistance,and high reactivity,can be used as raw materials to completely replace graphite,and the prepared resin bonded Al-Al_(2)O_(3)based refractories are one novel development direction of the ultra-low carbon Al_(2)O_(3)-C refractories. | ZHAO Chenrui YAN Mingwei LI Hongyu NIU Zhiwang LIANG Baoqing SHANG Junli | 2022 | China's Refractories2022，31，1： | 4 |
| 16 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 17 | Distribution and characteristics of telocytes as nurse cells in the architectural organization of engineered heart tissues显示文摘Interstitial Cajal-like cells are a distinct type of interstitial cell with a wide distribution in mammalian organs and tissues,and have been given the name'telocytes'.Recent studies have demonstrated the potential roles of telocytes in heart development,renewal,and repair.However,further research on the functions of telocytes is limited by the complicated in vivo environment.This study was designed to construct engineered heart tissue(EHT)as a three-dimensional model in vitro to better understand the role of telocytes in the architectural organization of the myocardium.EHTs were constructed by seeding neonatal cardiomyocytes in collagen/Matrigel scaffolds followed by culture under persistent static stretch.Telocytes in EHTs were identified by histology,toluidine blue staining,immunofluorescence,and transmission electron microscopy.The results from histology and toluidine blue staining demonstrated widespread putative telocytes with compact toluidine blue-stained nuclei,which were located around cardiomyocytes.Prolongations from the cell bodies showed a characteristic dichotomous branching pattern and formed networks in EHTs.Immunofluorescence revealed positive staining of telocytes for CD34 and vimentin with typical moniliform prolongations.A series of electron microscopy images further showed that typical telocytes embraced the cardiomyocytes with their long prolongations and exhibited a marked appearance of nursing cardiomyocytes during the construction of EHTs.This finding highlights the great importance of telocytes in the architectural organization of EHTs.It also suggests that EHT is an appropriate physical and pathological model system in vitro to study the roles of telocytes during heart development and regeneration. | ZHOU Jin WANG Yan ZHU Ping SUN HongYu MOU YongChao DUAN CuiMi YAO AnNing LV ShuangHong WANG ChangYong | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 18 | HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia显示文摘Dear Editor,β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin: HbA1 (~97%), HbA2 (~2%) and HbF (~1%). HbA1 (α2β2) is composed of two a-globin and two β-globi n sub units en coded by HBA and HBB, respectively;HbF (α2β2)is made up of two α-globin subunits and two β-globin sub units en coded by HBG. Mutations in the coding region or regulatory region of HBB are involved in β-thalassemia pathogenesis. Except for some rare dominant mutations, most HBB mutations are recessive (Origa, 2017). Depending on the mutation type, the β-globin level will either be reduced or completely depleted, resulting in α-globin accumulation and precipitation. These α-globin precipitates lead to red blood cell death, resulting in anemia and tissue damage, and even death in thalassemia major patients. Blood transfusions can help slow disease progression but lead to iron overload, ultimately resulting in iron toxicity. Bone marrow transfer is the only cure in the clinic and is available only to a small percentage of patients with human leukocyte antigervmatched donors. Recently, gene therapy and gene editing therapy have shown great promise in curing β-thalassemia (Glaser et al., 2015;Thompson et al., 2018). However, no appropriate animal models are available for evaluating the safety and efficacy of such advanced therapeutic strategies in vivo.β-thalassemia mice are the sole animal model available for research. However, substantial differences have been reported between the types and expressi on patter ns of human and mouse globins (McColl and Vadolas, 2016). Moreover, mice contain no fetal globin gene equivalent, and homozygous mutations of HBB in mouse for early models of β-thalassemia major or Cooley anemia are all embryonic lethal (Huo et al., 2009). Recently, significant phenotype and physiology differences have been reported between SIRT6- null mice and the non-human primate model (Zhang et al., 2018). Thus, an appropriate non-human primate model is needed for human β-thalassemia studies and treatments. | Yan Huang Chenhui Ding Puping Liang Duanduan Li Yu Tang Wei Meng Hongwei Sun Hongyu Lu Yu Chen Xueying Chen Qunshan Huang Jianpei Fang Canquan Zhou Shihua Yang Junjiu Huang | 2019 | Protein & Cell2019，10，7： | 4 |
| 19 | Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images显示文摘The size and shape of the foveal avascular zone(FAZ)have a strong positive correlation with several vision-threatening ret inovascular diseases.The identification,segmentation and analysis of FAZ are of great significance to clinical diagnosis and treatment.We presented an adaptive watershed algorithm to automatically extract F AZ from retinal optical coherence tomography angiography(OCTA)images.For the traditional watershed algorithm,'over-segmentation'is the most common problem.FAZ is often incorrectly divided into multiple regions by redundant'dams'.This paper analyzed the relationship between the'dams'length and the maximum inscribed circle radius of FAZ,and proposed an adaptive watershed algorithm to solve the problem of'over-segmentation'.Here,132 healthy retinal images and 50 diabetic retinopathy(DR)images were used to verify the accuracy and stability of the algorithm.Three ophthal-mologists were invited to make quan titative and qualitative evaluations on the segmentation results of this algorithm.The quantitative evaluation results show that the correlation coffi-cients between the automatic and manual segmentation results are 0.945(in healthy subjects)and 0.927(in DR patients),respectively.For qualitative evaluation,the percentages of'perfect segmentation'(score of 3)and'good segmentation'(score of 2)are 99.4%(in healthy subjects)and 98.7%(in DR patients),respectively.This work promotes the application of watershed algorithm in FAZ segmentation,making it a useful tool for analyzing and diagnosing eye diseases. | Jian Liu Shixin Yan Nan Lu Dongni Yang Chunhui Fan Hongyu Lv Shuanglian Wang in Zhu Yuqian Zhao Yi Wang Zhenhe Ma Yao Yu | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 3 |
| 20 | Isolation, Identification and Pathogenicity Analysis of Streptococcus suis Type 2显示文摘[Objectives]This study aimed to investigate the pathogenicity,growth characteristics and drug resistance of Streptococcus suis type 2.[Methods]Bacterial isolation and identification,biochemical experiments,determination of growth curve and correlation curve between OD 600 values and viable counts,drug susceptibility tests,pathogenicity analysis,and histopathological observations were carried out.[Results]The Streptococcus strain isolated from infected pigs was identified as Streptococcus suis type 2,which was named TA01 strain.TA01 strain reached the growth peak at 6-8 h post-incubation,and viable counts gradually declined after 8 h of incubation.The correlation equation between OD 600 values and viable counts is y=24.659 x-1.076 1,R^2=0.996 7.TA01 strain was sensitive to penicillin,erythromycin,florfenicol and oxacillin,and resistant to ciprofloxacin,polymyxin B and clindamycin.According to the results of pathogenicity analysis,all the mice in 3.6×10^9 cfu/mouse group died within 48,and these dead mice exhibited acute pyaemia septica.Based on the Reed-Muench formula,it was calculated that LD 50 of TA01 strain was 1.137×10^8 cfu/mouse.Pathological examination showed obvious blue-stained bacteria clusters,accompanied by neutrophil infiltration.[Conclusions]TA01 strain was a virulent strain of Streptococcus suis type 2.Compared with Streptococcus strains which were isolated and reported in China,TA01 strain exhibited strong virulence and rapid proliferation. | Zicheng MA Yan LI Jinyuan GU Tao PENG Zhaohu LIU Hongyu WANG Fanliang MENG Fangkun WANG Sidang LIU | 2019 | Agricultural Biotechnology2019，8，4： | 3 |
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