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| 1 | Improving the performance of solid oxide electrolysis cell with gold nanoparticles-modified LSM-YSZ anode显示文摘Gold, as the common current collector in solid oxide electrolysis cell(SOEC), is traditionally considered to be inert for oxygen evolution reaction at the anode of SOEC. Herein, gold nanoparticles were loaded onto conventional strontium doped lanthanum manganite-yttria stabilized zirconia(LSM-YSZ) anode, which evidently improved the performance of oxygen evolution reaction at 800 °C. The current densities at 1.2 V and 1.4 V increased by 60.0% and 46.9%, respectively, after loading gold nanoparticles onto the LSM-YSZ anode. Physicochemical characterizations and electrochemical measurements suggested that the improved SOEC performance was attributed to the accelerated electron transfer of elementary process in anodic polarization reaction and the newly generated triple phase boundaries in gold nanoparticles-loaded LSMYSZ anode. | Yuefeng Song Xiaomin Zhang Yingjie Zhou Houfu Lv Qingxue Liu Weicheng Feng Guoxiong Wang Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 2 | Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs显示文摘An in vitro blood-brain barrier(BBB) model is critical for enabling rapid screening of the BBB permeability of the drugs targeting on the central nervous system.Though many models have been developed, their reproducibility and renewability remain a challenge. Furthermore, drug transport data from many of the models do not correlate well with the data for in vivo BBB drug transport.Induced-pluripotent stem cell(i PSC) technology provides reproducible cell resources for in vitro BBB modeling.Here, we generated a human in vitro BBB model by differentiating the human i PSC(hi PSC) line GM25256 into brain endothelial-type cells. The model displayed BBB characteristics including tight junction proteins(ZO-1,claudin-5, and occludin) and endothelial markers(von Willebrand factor and Ulex), as well as high transendothelial electrical resistance(TEER)(1560 X.cm2±230 X.cm2) and c-GTPase activity. Co-culture with primary rat astrocytes significantly increased the TEER of the model(2970 X.cm2 to 4185 X.cm2). RNAseq analysis confirmed the expression of key BBB-related genes in the hi PSC-derived endothelial cells in comparison with primary human brain microvascular endothelial cells,including P-glycoprotein(Pgp) and breast cancer resistant protein(BCRP). Drug transport assays for nine CNS compounds showed that the permeability of non-Pgp/BCRP and Pgp/BCRP substrates across the model was strongly correlated with rodent in situ brain perfusion data for these compounds(R2= 0.982 and R2= 0.9973,respectively), demonstrating the functionality of the drug transporters in the model. Thus, this model may be used to rapidly screen CNS compounds, to predict the in vivo BBB permeability of these compounds and to study the biology of the BBB. | Yuan Li Xueying Sun Houfu Liu Liang Huang Guofeng Meng Yu Ding Wenji Su Jiaqi Lu Sophie Gong Georg C.Terstappen Ru Zhang Wandong Zhang | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 3 | Infiltration of Ce0.8Gd0.2O1.9 nanoparticles on Sr2Fe1.5Mo0.5O6-δ cathode for CO2 electroreduction in solid oxide electrolysis cell显示文摘Solid oxide electrolysis cell(SOEC) can electrochemically convert CO2 to CO at the gas-solid interface with a high current density and Faradaic efficiency, which has attracted increasing attentions in recent years.Exploring efficient catalyst for electrochemical CO2 reduction reaction(CO2 RR) at the cathode is a grand challenge for the research and development of SOEC. Sr2Fe1.5Mo0.5O6-δ(SFM) is one kind of promising cathode materials for SOEC, but suffers from insufficient activity for CO2 RR. Herein, Gd0.2Ce0.8O1.9(GDC)nanoparticles were infiltrated onto the SFM surface to construct a composite GDC-SFM cathode and improve the CO2 RR performance in SOEC. The current density over the GDC infiltrated SFM cathode with a GDC loading of 12.8 wt% reaches 0.446 A cm-2 at 1.6 V and 800 °C, which is much higher than that over the SFM cathode(0.283 A cm-2). Temperature-programmed desorption of CO2 measurements suggest that the infiltration of GDC nanoparticles significantly increases the density of surface active sites and three phase boundaries(TPBs), which are beneficial for CO2 adsorption and subsequent conversion. Electrochemical impedance spectroscopy results indicate that the polarization resistance of 12.8 wt% GDCSFM cathode was obviously decreased from 0.46 to 0.30 cm^2 after the infiltration of GDC nanoparticles. | Houfu Lv Yingjie Zhou Xiaomin Zhang Yuefeng Song Qingxue Liu Guoxiong Wang Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，8： | 3 |
| 4 | A turn-on fluorescent probe for Au^(3+) based on rodamine derivative and its bioimaging application显示文摘A new fluorescent probe RY was synthesized for the detection of Au3+ions based on a rhodamine B derivative.The fluorescent probe showed good selectivity and sensitivity to Au3+ions.Obvious color and fluorescence changes could be observed with the naked eye while the fluorescent probe reacted with the Au3+ions.The detection limit of the probe was determined to be 36 ppb by the fluorescence titration.The excellent linear relationship suggests that the probe is potentially useful for quantitative detection of Au3+in vitro.We also demonstrated its bioimaging application in both living cells and mice.This was the first time that a fluorescent probe was successfully applied to imaging Au3+in living animals. | SONG FengLing NING HouFu SHE HaiYing WANG JingYun PENG XiaoJun | 2014 | Science China Chemistry2014，57，7： | 3 |
| 5 | High-tempera-ture liquid-liquid structure transition in liquid Sn-Bi alloys:experimental evidence by electrical resistivity method显示文摘 | Li Xianfen Zu Fangqiu Ding Houfu | 2006 | Physics Letters A2006，354，4： | 1 |
| 6 | Reduced thermal boundary conductance in GaN-based electronic devices introduced by metal bonding layer显示文摘Achieving high interface thermal conductance is one of the biggest challenges in the nanoscale heat transport of GaN-based devices such as light emitting diodes(LEDs),and high electron mobility transistors(HEMTs).In this work,we experimentally measured thermal boundary conductance(TBC)at interfaces between GaN and the substrates with AuSn alloy as a commonly-used adhesive layer by time-domain thermoreflectance(TDTR).We find that the TBCs of GaN/Ti/AuSn/Ti/Si,GaN/Ti/AuSn/Ti/SiC,and GaN/Ti/AuSn/Ti/diamond,are 16.5,14.8,and 13.2 MW·m^(-2)·K^(-1)at room temperature,respectively.Our measured results show that the TBC of GaN/Ti/AuSn/Ti/SiC interface is inferior to the TBC of pristine GaN/SiC interface,due to the large mismatch of phonon modes between AuSn/Ti and substrates,shown as the difference of Debye temperature of two materials.Overall,we measured the TBC at interface between GaN and thermal conductive substrates,and provided a guideline for designing the interface between GaN and substrate at HEMT from a thermal management point of view. | Susu Yang Houfu Song Yan Peng Lu Zhao Yuzhen Tong Feiyu Kang Mingsheng Xu Bo Sun Xinqiang Wang | 2021 | Nano Research2021，14，10： | 1 |
| 7 | Influence of Impact Energy on Impact Corrosion-abrasion of High Manganese Steel显示文摘 | Xiaodong Du Houfu Ding Kai | 2007 | Journal of Wuhan University of Technology2007，22，3： | 1 |
| 8 | High-temperature liquid-liquid structure transition in liquid Sn-Bi alloys: expefimental evidence by electrical resistively method 显示文摘 | Li Xianfen Zu Fangqiu Ding Houfu | 2006 | Physics Letters A2006，354，4： | 1 |
| 9 | Effect of component and microstrueture on impact wear property and mechanism of steels in corrosive condition 显示文摘 | DING Houfu CUI Fangming DU Xiaodong | 2006 | Materials Science and Engineering: A2006，421，12： | 1 |
| 10 | A study of the solid state reaction betweensilicon carbide and iron显示文摘 | TANG Wenming ZHENG Zhixiang DING Houfu | 2002 | Mater Chem Phys2002，74，： | 1 |
| 11 | Numerical simulation of materials-oriented ultra-precision diamond cutting:review and outlook显示文摘Ultra-precision diamond cutting is a promising machining technique for realizing ultra-smooth surface of different kinds of materials.While fundamental understanding of the impact of workpiece material properties on cutting mechanisms is crucial for promoting the capability of the machining technique,numerical simulation methods at different length and time scales act as important supplements to experimental investigations.In this work,we present a compact review on recent advancements in the numerical simulations of material-oriented diamond cutting,in which representative machining phenomena are systematically summarized and discussed by multiscale simulations such as molecular dynamics simulation and finite element simulation:the anisotropy cutting behavior of polycrystalline material,the thermo-mechanical coupling tool-chip friction states,the synergetic cutting responses of individual phase in composite materials,and the impact of various external energetic fields on cutting processes.In particular,the novel physics-based numerical models,which involve the high precision constitutive law associated with heterogeneous deformation behavior,the thermo-mechanical coupling algorithm associated with tool-chip friction,the configurations of individual phases in line with real microstructural characteristics of composite materials,and the integration of external energetic fields into cutting models,are highlighted.Finally,insights into the future development of advanced numerical simulation techniques for diamond cutting of advanced structured materials are also provided.The aspects reported in this review present guidelines for the numerical simulations of ultra-precision mechanical machining responses for a variety of materials. | Liang Zhao Junjie Zhang Jianguo Zhang Houfu Dai Alexander Hartmaier Tao Sun | 2023 | International Journal of Extreme Manufacturing2023，5，2： | 1 |
| 12 | In situ electrochemical reconstruction of Sr_(2)Fe_(1.45)Ir_(0.05)Mo_(0.5)O_(6-δ)perovskite cathode for CO_(2)electrolysis in solid oxide electrolysis cells显示文摘Solid oxide electrolysis cells provide a practical solution for the direct conversion of CO_(2)to other chemicals(i.e.CO),however,an in-depth mechanistic understanding of the dynamic reconstruction of active sites for perovskite cathodes during CO_(2)electrolysis remains a great challenge.Herein,we identify that iridium-doped Sr_(2)Fe_(1.45)Ir_(0.05)Mo_(0.5)O_(6-δ)(SFIrM)perovskite displays a dynamic electrochemical reconstruction feature during CO_(2)electrolysis with abundant exsolution of highly dispersed IrFe alloy nanoparticles on the SFIrM surface.The in situ reconstructed IrFe@SFIrM interfaces deliver a current density of 1.46 A cm^(−2)while maintaining over 99%CO Faradaic efficiency,representing a 25.8%improvement compared with the Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)counterpart.In situ electrochemical spectroscopy measurements and density functional theory calculations suggest that the improved CO_(2)electrolysis activity originates from the facilitated formation of carbonate intermediates at the IrFe@SFIrM interfaces.Our work may open the possibility of using an in situ electrochemical poling method for CO_(2)electrolysis in practice. | Yuxiang Shen Tianfu Liu Rongtan Li Houfu Lv Na Ta Xiaomin Zhang Yuefeng Song Qingxue Liu Weicheng Feng Guoxiong Wang Xinhe Bao | 2023 | National Science Review2023，10，9： | 0 |
| 13 | Study on Microstructure and Thermal Stability Behavior of Rapidly Solidified Al-Fe-Ce Alloy显示文摘Rapidly solidified Al 8Fe 4Ce alloy was prepared by melt spinning.As quenched and as annealed microstructures were studied by TEM and energy dispersive spectrum analysis.The microhardness of the alloy at different annealing temperature was measured.The results obtained indicated that as quenched microstructure varied with different cooling rates.The microstructure annealed at 300℃ was much the same as that of the as quenched.The dispersed phases at grain boundary of the microstructure annealed at 400℃ became coarsening.After annealing at 450℃ for 2 hours,the primary phase and the intercellular dispersed phases,metastable phase Al 6Fe and Al 20 Fe 5Ce respectively,coarsened further.The soften temperature was deduced at over 300℃ by measuring microhardness. | Chen Yiqing,Su Yong,Ding Houfu and Zheng Yuchun (Department of Materials Science & Technology,Hefei University of Technology,Hefei 230009) | 2000 | Rare Metals2000，19，3： | 0 |
| 14 | Characteristics of atmospheric boundary layer structure and its influencing factors under different sea and land positions in Europe显示文摘This study identifies quantitatively the dominant contributions of meteorological factors on the development of the boundary layer heights(BLH)in the European region,based on 32 years(1990-2021)of radiosonde observations.The spatial variability of the BLH is further discussed by location,by classifying recording stations as inland,coastal,or bay.We find that the BLH in Europe varies considerably from day to night and with the seasons.Nighttime BLH is higher in winter and lower in summer,with the highest BLH recorded at coastal stations.Daytime BLH at coastal stations shows a bimodal structure with peaks in spring and autumn;at inland and bay stations,daytime BLH is lower in winter and higher in summer.The daily amplitudes of BLH at the inland and bay stations are stronger than those at coastal stations.Based on our multiple linear regression analysis and our decoupling analysis of temperature and specific humidity,we report that the development of the nighttime BLH at all types of stations is strongly dominated by the variations of surface wind speed(and,at coastal stations,wind directions).The main contributors to daytime BLH are the near-surface temperature variability at most coastal and inland stations,and,at most bay stations,the variation of the near-surface specific humidity. | YeHui Zhang XinPeng Yong HouFu Zhou HaiYang Gao Na Yang | 2023 | Earth and Planetary Physics2023，7，2： | 0 |
| 15 | In-situ exsolution of cobalt nanoparticles from La_(0.5)Sr_(0.5)Fe_(0.8)Co_(0.2)O_(3-δ) cathode for enhanced CO_(2) electrolysis performance显示文摘Solid oxide electrolysis cell(SOEC)is a promising technology for CO_(2) conversion and renewable energy storage with high efficiency.It is highly desirable to develop catalytically active cathodes for CO_(2) electrolysis.Herein,cathode materials with different structural stabilities are designed by Nb substitution on La_(0.5)Sr_(0.5)Fe_(0.8)Co_(0.2)O_(3-δ)(LSFC82)to obtain La_(0.5)Sr_(0.5)Fe_(0.7)Co_(0.2)Nb_(0.1)O_(3-δ)(LSFCN721)and La_(0.5)Sr_(0.5)Fe_(0.8)Co_(0.1)Nb_(0.1)O_(3-δ)(LSFCN811),respectively.LSFC82-Sm_(0.2)Ce_(0.8)O_(2-δ)(SDC)cathode with inferior structural stability(ability to maintain the structure)shows desirable CO_(2) electrolysis performance with the generated current density of 1.80 A cm^(-2)2 at 1.6 V and stable performance during 110 h operation at 1.2 V and 800℃.However,LSFC82 particles are collapsed into pieces after stability test with the generation of Co nanoparticles simultaneously.The frameworks of LSFCN721 and LSFCN811 particles maintain well because of the high-valent niobium,but Co exsolution,ox-ygen vacancy content and the corresponding CO_(2) electrolysis performance are restricted.This work confirms that Co nanoparticles can be exsolved from LSFC82-SDC cathode during CO_(2) electrolysis,providing references for constructing metallic nanoparticles decorated-perovskite cathodes for SOECs. | Jingwei Li Qingxue Liu Yuefeng Song Houfu Lv Weicheng Feng Yuxiang Shen Chengzhi Guan Xiaomin Zhang Guoxiong Wang | 2022 | Green Chemical Engineering2022，3，3： | 0 |
| 16 | Interferon-γ induces immunosuppression in salivary adenoid cystic carcinoma by regulating programmed death ligand 1 secretion显示文摘Interferon-γ(IFN-γ), a key effector molecule in anti-tumor immune response, has been well documented to correlate with the intratumoral infiltration of immune cells. Of interest, however, a high level of IFN-γ has been reported in salivary adenoid cystic carcinoma(SACC), which is actually a type of immunologically cold cancer with few infiltrated immune cells. Investigating the functional significance of IFN-γ in SACC would help to explain such a paradoxical phenomenon. In the present study, we revealed that,compared to oral squamous cell carcinoma cells(a type of immunologically hot cancer), SACC cells were less sensitive to the growthinhibition effect of IFN-γ. Moreover, the migration and invasion abilities of SACC cells were obviously enhanced upon IFN-γ treatment.In addition, our results revealed that exposure to IFN-γ significantly up-regulated the level of programmed death ligand 1(PD-L1) on SACC cell-derived small extracellular vesicles(s EVs), which subsequently induced the apoptosis of CD8+T cells through antagonizing PD-1. Importantly, it was also found that SACC patients with higher levels of plasma IFN-γ also had higher levels of circulating s EVs that carried PD-L1 on their surface. Our study unveils a mechanism that IFN-γ induces immunosuppression in SACC via s EV PD-L1,which would account for the scarce immune cell infiltration and insensitivity to immunotherapy. | Qiuyun Fu Xingchi Liu Houfu Xia Yicun Li Zili Yu Bing Liu Xuepeng Xiong Gang Chen | 2022 | International Journal of Oral Science2022，14，4： | 0 |
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