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| 1 | A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer显示文摘Objective: This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods: Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen(oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals) for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant treatment.Results: All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients(91.3%) had reductions in tumor volume after neoadjuvant treatment, and 13 patients(56.5%) had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete response.Conclusions: Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer. | Haitao Zhou Yan Song Jun Jiang Haitao Niu Hong Zhao Jianwei Liang Hao Su Zheng Wang Zhixiang Zhou Jing Huang | 2016 | Chinese Journal of Cancer Research2016，28，6： | 18 |
| 2 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 3 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 4 | Recent Advances in Visible-Light-Driven Photoelectrochemical Water Splitting: Catalyst Nanostructures and Reaction Systems显示文摘Photoelectrochemical(PEC) water splitting using solar energy has attracted great attention for generation of renewable hydrogen with less carbon footprint, while there are enormous challenges that still remain for improving solar energy water splitting efficiency, due to limited light harvesting, energy loss associated to fast recombination of photogenerated charge carriers, as well as electrode degradation. This overview focuses on the recent development about catalyst nanomaterials and nanostructures in different PEC water splitting systems. As photoanode, Au nanoparticle-decorated TiO_2 nanowire electrodes exhibited enhanced photoactivity in both the UV and the visible regions due to surface plasmon resonance of Au and showed the largest photocurrent generation of up to 710 nm. Pt/Cd S/CGSe electrodes were developed as photocathode. With the role of p–n heterojunction, the photoelectrode showed high stability and evolved hydrogen continuously for more than 10 days. Further, in the Z-scheme system(Bi_2S_3/TNA as photoanode and Pt/Si PVC as photocathode at the same time), a self-bias(open-circuit voltage Voc= 0.766 V) was formed between two photoelectrodes, which could facilitate photogenerated charge transfers and enhance the photoelectrochemical performance, and which might provide new hints for PEC water splitting. Meanwhile, the existing problems and prospective solutions have also been reviewed. | Xiaoping Chen Zhixiang Zhang Lina Chi Aathira Krishnadas Nair Wenfeng Shangguan Zheng Jiang | 2016 | Nano-Micro Letters2016，8，1： | 3 |
| 5 | Surgical Management and Prognostic Factors of Hilar Cholangiocarcinoma: Experience with 115 Cases in China显示文摘 | Liu Yubin PhD Fang Chihua PhD Jian Zhixiang MM Ou Jinrui BA Liu Zixian BA Zheng Jianghua BA Lin Ye MD Jin Haosheng MD Lu Chaomin PhD | 2008 | Annals of Surgical Oncology2008，，8： | 2 |
| 6 | Genetic and Phylogenetic Characterization of a Chikungunya Virus Imported into Shenzhen, China显示文摘Dear Editor,Chikungunya virus(CHIKV)is a mosquito-borne virus belonging to the family Togaviridae,genus Alphavirus,and was first isolated in Tanzania in the 1950s(Silva and Dermody 2017;Weaver and Lecuit 2015).Human infections with CHIKV typically result in a rapid-onset febrile disease,with symptoms that include fever,headache,rash,severe joint and muscle pain,as well as prolonged periods of disability in some patients(Weaver and Lecuit 2015;Silva and Dermody 2017). | Yang Yang Zhixiang Xu Haixia Zheng Jingdong Song Ying Wu Zhou Tong Jing Yuan Gary Wong William J.Liu Yuhai Bi Yingxia Liu George F.Gao | 2020 | Virologica Sinica2020，35，1： | 2 |
| 7 | Concise route to prepared graphene-CNTs nanocomposite supported Pt nanoparticles and used as new electrode material for electrochemical sensing 显示文摘 | Zheng Zhixiang Du Yong ling Wang Zaihua | 2012 | Journal of Molecular Catalysis A Chemical2012，，： | 1 |
| 8 | Concise route to prepared graphene-CNTs nanocomposite supported Pt nanoparticles and used as new electrode material for electrochemical sensing 显示文摘 | Zheng Zhixiang Du Yong ling Wang Zaihua | 2012 | Journal of Molecular Catalysis A: Chemical2012，，： | 1 |
| 9 | Facile method to prepare Pdf graphene-polyaniline nanocomposite and used as new electrode material for electrochemical sen?sing显示文摘 | Zheng Zhixiang Du Yongling Feng Qingliang et a1 | 2012 | J Molecular Cataly A: Chem2012，，： | 1 |
| 10 | Pt/graphene-CNTs nanoeomposite based electrochemical sensors for the determination of endocrine disruption bisphenol A in thermal printing papper 显示文摘 | Zheng Zhixiang Du Yong ling Wang Zaihua | 2013 | Analyst2013，138，69： | 1 |
| 11 | Concise route to prepared graphene-CNTs nanocomposite supported Pt nanoparticles and used as new electrode material for electrochemical sensing 显示文摘 | ZHENG Zhixiang DU Yongling WANG Zaihua | 2012 | Journal of Molecular Catalysis A: Chemical2012，，363364： | 1 |
| 12 | Pt/graphene-CNTs nanocomposite based electrochemical sensors for the determination of endocrine disruptionbisphenol A in thermal printing pappers显示文摘 | ZHENG Zhixiang DU Yongling WANG Zaihua | 2013 | Analyst2013，138，： | 1 |
| 13 | Preparation of surface-silvered graphene-CNTs polyimide hybrid films: processing, morphology and properties 显示文摘 | ZHENG Zhixiang WANG Zaihua FENG Qingliang | 2013 | Materials Chemistry and Physics2013，138，： | 1 |
| 14 | Pressureless infiltration of liquid aluminum alloy into SiC preforms to form near net-shape SiC/Al composites 显示文摘 | Liu Jun Zheng Zhixiang Wang Jianmin | 2008 | Journal of Alloys and Compounds2008，465，12： | 1 |
| 15 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 16 | 显示文摘 | Liu Junwu Zheng Zhixiang Wang Jianmin | 2008 | Journal of Alloys and Compounds2008，465，12： | 1 |
| 17 | Low-cost polymer acceptors with noncovalently fused-ring backbones for efficient all-polymer solar cells显示文摘The polymerization of fused-ring acceptors(FRAs) to afford their corresponding polymeric acceptors for high-performance all-polymer solar cells(all-PSCs) has achieved remarkable progress in the past few years.However,due to the high degree of synthetic complexity for the monomer,the high-cost of these polymeric acceptors may limit their commercial applications.Thus,it is urgent to develop inexpensive and high-performance polymeric acceptors for all-PSCs.Herein,two novel polymeric acceptors(PBTzO and PBTzO-2F) have been designed and synthesized by copolymerization of noncovalently fused ring acceptors(NFRAs),which were employed in all-PSCs for the first time.Upon introducing the “noncovalently conformational locks(NoCLs)” in the backbone and selective fluorination of the end-group,photophysical and electrical properties,and solidstate packing properties of the NFRAs have been rationally tuned.As a result,the PBDB-T:PBTzO-2F based devices presented an excellent power conversion efficiency(PCE) of 11.04%,much higher than that of PBTzO based ones due to the increased charge generation and extraction,improved hole transfer and carrier mobilities,and reduced energy loss.More importantly,PBTzO-2F exhibited a much lower synthetic complexity(SC) index and higher figure-of-merit(FOM) values than the high-performance fused-ring acceptor based polymer acceptors(FRA-PAs) due to the simpler structures and more effective synthesis.This contribution provided a novel idea to achieve low-cost and high-performance all-PSCs. | Xiaobin Gu Yanan Wei Xingzheng Liu Na Yu Laiyang Li Ziyang Han Jinhua Gao Congqi Li Zhixiang Wei Zheng Tang Xin Zhang Hui Huang | 2022 | Science China Chemistry2022，65，5： | 1 |
| 18 | Biosynthesis of salicylic acid in plants显示文摘 | CHEN Zhixiang ZHENG Zuyu HUANG Junli | 2009 | Plant Signal Behav2009，4，6： | 1 |
| 19 | Realizing transmitted metasurface cloak by a tandem neural network显示文摘Being invisible at will has been a long-standing dream for centuries, epitomized by numerous legends;humans have never stopped their exploration steps to realize this dream. Recent years have witnessed a breakthrough in this search due to the advent of transformation optics, metamaterials, and metasurfaces. However, the previous metasurface cloaks typically work in a reflection manner that relies on a high-reflection background, thus limiting the applications. Here, we propose an easy yet viable approach to realize the transmitted metasurface cloak, just composed of two planar metasurfaces to hide an object inside, such as a cat. To tackle the hard-to-converge issue caused by the nonuniqueness phenomenon, we deploy a tandem neural network(T-NN) to efficiently streamline the inverse design. Once pretrained, the T-NN can work for a customer-desired electromagnetic response in one single forward computation, saving a great amount of time. Our work opens a new avenue to realize a transparent invisibility cloak, and the tandem-NN can also inspire the inverse design of other metamaterials and photonics. | ZHENG ZHEN CHAO QIAN YUETIAN JIA ZHIXIANG FAN RAN HAO TONG CAI BIN ZHENG HONGSHENG CHEN ERPING LI | 2021 | Photonics Research2021，9，5： | 1 |
| 20 | Fabrication and Characterization of 3D Graded PDMS Scaffolds Using Vacuum-Assisted Resin Transfer Moulding显示文摘Graded porous scaffold can be applied to study the interactions between cells and scaffold with different pore sizes. Polydimethylsiloxane(PDMS) scaffold with an axial pore size grade was successfully manufactured via vacuum-assisted resin transfer moulding(VARTM) and particle leaching technologies. The properties of graded PDMS scaffolds, including porosity, water absorption, interconnectivity, compression modulus, as well as compression strength were investigated. The results showed that the smaller the size of the NaCl particles is, the higher the porosity and water absorption of graded PDMS scaffolds would be. The graded PDMS scaffold fabricated had a compressive modulus and a compressive strength of 19.69±1.42 kPa and 4.76±0.22 kPa, respectively. Moreover, the graded chitosan(CS)-coated PDMS scaffolds were prepared by using dip-coating technique under low vacuum and their hydrophilicity was examined. It is found that the water contact angle(WCA) will decrease with an increase in the CS solution concentration and the coating time, which indicates that CS-coated PDMS scaffolds exhibit noticeable hydrophilicity compared with graded PDMS scaffold. | 司军辉 LIN Jiahe ZHENG Zifeng CUI Zhixiang WANG Qianting | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 1 |
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