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| 1 | Volume fractal dimension of soil particles and relationships with soil physical-chemical properties and plant species diversity in an alpine grassland under different disturbance degrees显示文摘Fractal geometry is an important method in soil science,and many studies have used fractal theory to examine soil properties and the relationships with other eco-environmental factors.However,there have been few studies examining soil particle volume fractal dimension in alpine grasslands.To study the volume fractal dimension of soil particles(D) and its relationships with soil salt,soil nutrient and plant species diversity,we conducted an experiment on an alpine grassland under different disturbance degrees:non-disturbance(N 0),light disturbance(L),moderate disturbance(M) and heavy disturbance(H).The results showed that(1) Ds varied from 2.573 to 2.635 among the different disturbance degrees and increased with increasing degrees of disturbance.(2) Shannon-Wiener diversity index,Pielou's evenness index and Margalef richness index reached their highest values at the M degree,indicating that moderate disturbance is beneficial to the increase of plant species diversity.(3) In the L and M degrees,there was a significant positive correlation between D and clay content and a significant negative correlation between D and soil organic matter(SOM).In the H degree,D was significantly and positively correlated with total salt(TS).The results suggested that to a certain extent,D can be used to characterize the uniformity of soil texture in addition to soil fertility characteristics.(4) For the L degree,there was a significant negative correlation between D and the Shannon-Wiener diversity index;while for the M degree,there was a significant negative correlation between D and Pielou's evenness index. | YanYan LIU YanMing GONG Xin WANG YuKun HU | 2013 | Journal of Arid Land2013，5，4： | 18 |
| 2 | Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers显示文摘Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler(LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5.81 μm and a fine particle fraction of 46.71%, suitable for pulmonary delivery. The uptake of curcumin liposomes by human lung cancer A549 cells was markedly greater and faster than that of free curcumin. The high cytotoxicity on A549 cells and the low cytotoxicity of curcumin liposomes on normal human bronchial BEAS-2B epithelial cells yielded a high selection index partly due to increased cell apoptosis. Curcumin powders, LCDs and gemcitabine were directly sprayed into the lungs of rats with lung cancer through the trachea. LCDs showed higher anticancer effects than the other two medications with regard to pathology and the expression of many cancer-related markers including VEGF, malondialdehyde, TNF-α, caspase-3 and BCL-2. LCDs are a promising medication for inhalation treatment of lung cancer with high therapeutic efficiency. | Tongtong Zhang Yanming Chen Yuanyuan Ge Yuzhen Hu Miao Li Yiguang Jin | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 12 |
| 3 | Fluxes of methane,carbon dioxide and nitrous oxide in an alpine wetland and an alpine grassland of the Tianshan Mountains,China显示文摘Methane(CH4), carbon dioxide(CO2) and nitrous oxide(N2O) are known to be major greenhouse gases that contribute to global warming. To identify the flux dynamics of these greenhouse gases is, therefore, of great significance. In this paper, we conducted a comparative study on an alpine grassland and alpine wetland at the Bayinbuluk Grassland Eco-system Research Station, Chinese Academy of Sciences. By using opaque, static, manual stainless steel chambers and gas chromatography, we measured the fluxes of CH4, N2O and CO2 from the grassland and wetland through an in situ monitoring study from May 2010 to October 2012. The mean flux rates of CH4, N2O and CO2 for the experimental alpine wetland in the growing season(from May to October) were estimated at 322.4 μg/(m2?h), 16.7 μg/(m2?h) and 76.7 mg/(m2?h), respectively; and the values for the alpine grassland were –88.2 μg/(m2?h), 12.7 μg/(m2?h), 57.3 mg/(m2?h), respectively. The gas fluxes showed large seasonal and annual variations, suggesting weak fluxes in the non-growing season. The relationships between these gas fluxes and environmental factors were analyzed for the two alpine ecosystems. The results showed that air temperature, precipitation, soil temperature and soil moisture can greatly influence the fluxes of CH4, N2O and CO2, but the alpine grassland and alpine wetland showed different feedback mechanisms under the same climate and environmental conditions. | GuiXiang HE KaiHui LI XueJun LIU YanMing GONG YuKun HU | 2014 | Journal of Arid Land2014，6，6： | 7 |
| 4 | Carbon Storage and Vertical Distribution in Three Shrubland Communities in Gurbantünggüt Desert,Uygur AutonomousRegion of Xinjiang,Northwest China显示文摘This study was carried out in the Gurbantünggüt Desert,Uygur Autonomous Region of Xinjiang,Northwest China in August,2009.To quantify the storage,contribution and vertical distribution patterns of plant biomass carbon (PBC)and soil organic carbon(SOC)in the study area,we investigated the carbon concentrations and its vertical distribution in three different desert shrubland communities dominated by Reaumuria soongorica,Haloxylon ammodendron+R.soongorica and Tamarix ramosissima+R.soongorica,respectively.We analyzed vertical distribution of root biomass carbon and soil carbon contents by excavating soil profiles for each dominated community.The results show that SOC is considerably the larger carbon pool in the soil layers of 1.0-3.0 m(the mean value of three shrubland communities is 38.46%)and 3.0-5.0 m(the mean value is 40.24%).In contrast,70.74%of belowground biomass carbon storage in 0-1.0 m layer,and its content decrease with increasing soil depth.The Haloxylon ammodendron+R. soongorica shrubland community has the highest belowground biomass carbon among three selected communities. This study highlights the importance of SOC stored in deep soil layers(lower than 3.0 m from the surface)in arid shrubland communities in the global carbon balance.In addition,it provides the data support for revealing deep soil solid carbon potential,and offers scientific basis for the further research in the carbon cycle of terrestrial ecosystem. | GONG Yanming HU Yukun FANG Fei LIU Yanyan LI Kaihui ZHANG Guangming | 2012 | Chinese Geographical Science2012，22，5： | 6 |
| 5 | Characterization of miRNomes in Acute and Chronic Myeloid Leukemia Cell Lines显示文摘Myeloid leukemias are highly diverse diseases and have been shown to be associated with microRNA(miRNA) expression aberrations. The present study involved an in-depth miRNome analysis of two human acute myeloid leukemia(AML) cell lines, HL-60 and THP-1, and one human chronic myeloid leukemia(CML) cell line, K562, via massively parallel signature sequencing. mRNA expression profiles of these cell lines that were established previously in our lab facilitated an integrative analysis of miRNA and mRNA expression patterns. miRNA expression profiling followed by differential expression analysis and target prediction suggested numerous miRNA signatures in AML and CML cell lines. Some miRNAs may act as either tumor suppressors or oncomiRs in AML and CML by targeting key genes in AML and CML pathways. Expression patterns of cell type-specific miRNAs could partially reflect the characteristics of K562, HL-60 and THP-1 cell lines, such as actin filament-based processes, responsiveness to stimulus and phagocytic activity. miRNAs may also regulate myeloid differentiation, since they usually suppress differentiation regulators. Our study provides a resource to further investigate the employment of miRNAs in human leukemia subtyping, leukemogenesis and myeloid development. In addition, the distinctive miRNA signatures may be potential candidates for the clinical diagnosis, prognosis and treatment of myeloid leukemias. | Qian Xiong Yadong Yang Hai Wang Jie Li Shaobin Wang Yanming Li Yaran Yang Kan Cai Xiuyan Ruan Jiangwei Yan Songnian Hu Xiangdong Fang | 2014 | Genomics, Proteomics & Bioinformatics2014，12，2： | 6 |
| 6 | Research progress in protein post-translational modification显示文摘Protein post-translational modification plays an important role in organism. It makes the protein obtain more complicated structures, perfect functions, more accurate regulations and more spe-cific operations. The most common protein post- translational modifications include ubiquitylation, phosphorylation, glycosylation, lipodation, methyla-tion, and acetylation and so on. Ubiquitylation plays an essential role in cellular functions such as cellular differentiation, apoptosis, DNA repair, antigen proc-essing, and stress response. Phosphorylation is re-lated to physiological and pathological processes including cellular signal conduction, nervous activity, muscle contraction and proliferation, development and differentiation of cells. Protein glycosylation is of great importance for many cell processes like im-munoprotection, virus replication, cell growth, and occurrence of inflammation and so on. Lipodation is vital to signal conduction. Histone methylation and acetylation are responsible for transcription regula-tion. In vivo, different post-translational modifications do not occur isolatedly, but influence each other’s function and cooperate with each other. Under-standing what influences the post-translational modi-fications will help to uncover cellular processes and protein network in molecular level and finally direct more precise drug design targeting molecules. Post-translational modification mimics are set to dominate the next wave of protein therapeutics and become powerful medicinal tools in the 21st century. | HU Jia GUO Yanting LI Yanme | 2006 | Chinese Science Bulletin2006，51，6： | 4 |
| 7 | A Modified Enrichment Method to Construct Microsatellite Library from Plateau Pika Genome(Ochotona curzoniae)显示文摘A microsatellite-enriched library of plateau pika(Ochotona curzoniae) was constructed according to the strong affinity between biotin and streptavidin.Firstly,genomic DNA was fragmented by ultrasonication,which is a major improvement over traditional methods.Linker-ligated DNA fragments were hybridized with biotinylated microsatellite probes,and then were subjected to streptavidin-coated magnetic beads.PCR amplification was performed to obtain double-stranded DNA fragments containing microsatellites.Ligation and transformation were carried out by using the pGEM-T Vector System I and Escherichia coli DH10B competent cells.Sequencing results showed that 80.2% of clones contained microsatellite repeat motif.Several modifications make this protocol time-efficient and technically easier than the traditional ones;particularly,composition and relative abundance of microsatellite repeats in plateau pika genome were truly represented through the optimized PCR conditions.This method has also been successfully applied to construct microsatellite-enriched genomic libraries of Chinese hamster(Cricetulus griseus) and small abalone [Haliotis diversicolor(Reeve)] with high rates of positive clones,demonstrating its feasibility and stability. | Jianing Geng Kexin Li Yanming Zhang Songnian Hu | 2010 | Genomics, Proteomics & Bioinformatics2010，8，1： | 4 |
| 8 | Plant diversity-productivity patterns in the alpine steppe environment of the Central Tianshan Mountains显示文摘The biodiversity-productivity relationship is an important topic in the research of bio- diversity and ecosystem function. The plant diversity-productivity pattern is commonly unimodal and positively correlated. This paper researches the characteristics of plant diversity-productivity patterns in the Bayanbuluk alpine steppe in the central Tianshan Mountains, Xinjiang, China, and analyzes the effects of environmental factors on the distribution of plant communities, species composition, plant diversity and productivity in the steppe. The results show a positive correlation between plant diversity and productivity. DCCA (detrended canonical correspondence analysis) ordination reveals a significant relationship between the effects of air temperature, soil moisture content, available soil nitrogen, relative humidity and pH value on the distribution and composition of plant communities. There are significant correlations between the soil moisture content, relative humidity, pH value, air temperature and species richness and the aboveground biomass of Gramineae and Cyperaceae, and also significant correlations between the relative humidity, pH values and the total aboveground biomass of plant communities. | Hu, YuKun Li, KaiHui Gong, YanMing Yin, Wei | 2009 | Journal of Arid Land2009，1，1： | 3 |
| 9 | Lanthanide complexes mediated coordinative chain transfer polymerization of conjugated dienes显示文摘Tremendous advances has been witnessed in the past few years in the lanthanide complexes mediated coordinative chain transfer polymerization(CCTP) of conjugated dienes. CCTP features catalyst economy, well-controlling over both microstructure and architecture of the resulting polymers, and accessibility for novel(co)polymers. This review highlights the recent progresses made in the field of CCTP of dienes. After a brief introduction, the body of this review is divided into three parts:(1) principle of CCTP;(2) coordinative chain transfer homopolymerization of dienes;(3) coordinative chain transfer copolymerization of dienes.At the end, we present some challenges remaining in this area and our personal opinion regarding where this field should continue to develop. CCTP represents a novel strategy to prepare polydiene synthetic rubbers with controlled high molecular weight and narrow molecular weight distribution, which has reached the practical industrial application level, demonstrating a great potential in industrialization. | WANG Feng LIU Heng HU YanMing ZHANG XueQuan | 2018 | Science China(Technological Sciences)2018，61，9： | 2 |
| 10 | DEFORMATION MEASUREMENT USING DUAL-FREQUENCY PROJECTION GRATING PHASE-SHIFT PROFILOMETRY显示文摘当一个使变形的目标有时, 2 蟺阶段歧义问题在阶段测量是很重要的一从飞机大排水量。双频率的设计栅栏阶段 -- 变的 profilometry (PSP ) 能被用来解决如此的一个问题。在测量,二合适 -- 选择频率栅栏被利用综合在一个主要阶段范围保证计算阶段的一个相等的波长栅栏。因此,错误与常规阶段由阶段 unwrapping 过程引起了重建算法能被消除。最后,有大塑料变丑的一个标本的试验性的结果被给证明建议方法是有效的处理阶段断绝。 | Yanming Chen Yuming He Eryi Hu Hongmao Zhu | 2008 | Acta Mechanica Solida Sinica2008，21，2： | 2 |
| 11 | Inter-and intra-specific phenotypic variation of ecological stoichiometric traits in a mixed-oak secondary forest in China显示文摘Ecological stoichiometry provides a framework for the balance and flow of elements between organisms and ecosystems.Elemental phenotypes have an important influence on the environmental adaptation and ecological evolution of plants.There have been few reports on inter-and intra-specific phenotypic variations of ecological stoichiometric traits for congeneric species in a mixed forest although such variations are well-documented at the species level at global,regional and local scales.In this study,total carbon(TC),nitrogen(TN),phosphorus(TP)and potassium(TK)were measured in leaves and the elemental phenotypes were statistically analyzed in four species of oaks—Quercus fabri,Q.serrata var.glandulifera,Q.acutissima and Q.variabilis—in a mixed-oak secondary forest in Yushan,Jiangsu,China.The average element concentrations in the four oak species were not relatively higher than previously reported for oaks from world and Chinese flora.Ecological stoichiometry traits were correlated with tree height and diameter at breast height,indicating that phosphorous and potassium were positively correlated with tree size,while carbon was negatively correlated,especially the relationship between oak growth and total carbon or total phosphorus was obvious,and the study concluded that this was because plant growth depended on phosphorus storage and had opposite effects on leaf carbon accumulation.Based on tree plasticity index and the coefficient of variation,there was medium variation in element concentrations.The plasticity index of total carbon levels was the lowest,and that of potassium the highest.Principal component analysis and cluster analysis showed that the intra-specific variation among the four oak species was higher than inter-specific variation.From the perspective of nutrient supply and ecological adaptation,this study creates a foundation for the management of secondary oak forest stands. | Yueyao Feng Xuan Li Biyao Zhou Rong Hu Huanchao Zhang Jiading Yang Yanming Fang | 2021 | Journal of Forestry Research2021，32，6： | 2 |
| 12 | Effects of crystal growth conditions on morphology of crystalline syndiotactic 1, 2-polybutadiene 显示文摘 | Chen Ye Yang Decai Hu Yanming | 2004 | Crystal Growth and Design2004，4，1： | 1 |
| 13 | Morphology and Properties of PP In-reactor Alloys Prepared with a MgCl2/TiCl4/Diisobutyl Phthalate/Phosphate Tris-methylphenyl Ester Catalyst System显示文摘 | ZHANG Chunyu DONG Bo ZHANG Hexin HU Yanming ZHANG Xuequan | 2018 | Chemical Research in Chinese Universities2018，34，1： | 1 |
| 14 | Controlling coal fires using the three-phase foam and water mist techniques in the Anjialing Open Pit Mine, China显示文摘 | Zhenlu Shao Deming Wang Yanming Wang Xiaoxing Zhong Xiaofei Tang Xiangming Hu | 2015 | Natural Hazards2015，，2： | 1 |
| 15 | Lentivirus‐Mediated RNAi Knockdown of NUPR1 Inhibits Human Nonsmall Cell Lung Cancer Growth In Vitro and In Vivo显示文摘 | Xiaotong Guo Wei Wang Jing Hu Kejian Feng Yanming Pan Linyou Zhang Yukuan Feng | 2012 | Anat Rec2012，，12： | 1 |
| 16 | Complication following gastric pull-up reconstruction for advanced hypopharyngeal or cervical esophageal carcinoma: a 20-year review in a Chinese institute显示文摘 | He Shuangba Sun Jingwu Wang Yinfeng Hu Yanming Lv Qiuping Li Xianguang Xu Weiqing Wang Shengjun Yu Zhenkun | 2011 | American Journal of Otolaryngology--Head and Neck Medicine and Surgery2011，，4： | 1 |
| 17 | microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C显示文摘 | Jing Hu Yongxia Cheng Yuezhen Li Zaishun Jin Yanming Pan Guibo Liu Songbin Fu Yafang Zhang Kejian Feng Yukuan Feng | 2014 | European Journal of Cancer2014，，13： | 1 |
| 18 | 'One-pot' ran dom terpolymerization of styrene, isoprene and butadiene with Nd-based catalyst 显示文摘 | Li Tingting Hu Yanming Zhang Hongxia | 2013 | Journal of Applied PoLymer Science2013，130，3： | 1 |
| 19 | Microstructure Evolution of T91 Heat-Resistant Steels after Long-Time Aging显示文摘To investigate the evolution of microstructure damage degree and the precipitated phases of heat-resistant metal in power plant under high temperature and stress environment, the high-temperature aging tests were conducted to investigate the aging behavior of T91 steel at different temperatures and stress. The optical microscopy, scanning electron microscopy, and transmission electron microscopy were used to investigate the structure and precipitated phases, the results showed that the orientation characteristics of tempered martensite was dispersed, and the grain size is obviously increased. The density of dislocation decreased with increasing temperature and stress. The important strengthening phase of M23C6 (M=Fe, Cr) was coarsened by the diffusion of main alloying elements Cr, while the smaller size MX (M=Nb,V; X=C, N) phase distributed in the grain is relatively stable in the aging. | WAN Qiang HU Wenlong LI Zhenggang CHEN Yanming YANG Bing | 2013 | Wuhan University Journal of Natural Sciences2013，18，1： | 1 |
| 20 | Disclination and molecular director studies on bowlic columnar nematic phase using mosaic-like morphologydecoration method显示文摘Two bowlic cyclotriveratrylene CTV-1 and CTV-2, with different peripheral groups of -OCH3 and -OCH2CH3 for CTV-1 and -OCH3 and -OCH2COOCH3 for CTV-2, respectively, were synthesized by typical trimerization via a multistep sequence from vanillin. Both bowlic CTV molecules were thermotropic liquid crystals, and presented typical grainy textures of the nematic phase and homogeneous texture of the single domain nematic phase. It is of interest to observe the regular and beautiful mosaic-like morphologies after cooling from liquid crystalline phases, which appeared and vanished repeatedly in several circles of cooling and heating. The size of each mosaic was several dozens of micron. In nature, the mosaic-like morphologies are the optical pattern of cracks formed by the shrinking, due to the crystallization of frozen texture of nematic phases. By means of scanning electron microscopy, the mosaic-like morphologies were observed to consist of lamellae, and each mosaic is a rectangular multi-layer lamella, which is composed of packed single-layered lamellae. The fibrils in the diameter of about 1 μm were observed, which are the structural units of lamellae and would be the bundles of the bowlic molecular columns. The mosaic-like morphologies decorate the bowlic molecular columnar nematic phase, therefore, a novel mosaic-like morphologies decoration method was applied to reveal the director distribution of several kinds of point disclinations, such as s = +1(δ =0°and δ =90°) and s = ±1/2, and Nèel domain walls. It was shown that the bowlic molecular columnar nematic phase behaved as normal nematic phases; however, the basic structural units ordered were the bowlic molecular column or the bundles of bowlic molecular column (i.e. fibrils), but not the bowlic molecules themselves. The bowlic molecular columns acted as the rod-like molecules in a normal nematic phase. Therefore, a new term BCN (bowlic columnar nematic phase) is used to describe the anomalous nematic phase in this paper. | DONG YanMing CHEN DanMei ZENG ErMan HU XiaoLan ZENG ZhiQun | 2009 | Science China Chemistry2009，52，7： | 1 |
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