|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetlands: A case study in the Yellow River wetland in China显示文摘Riparian wetland is the major transition zone of matter, energy and information transfer between aquatic and terrestrial ecosystems and has important functions of water purification and non-point pollution control. Using the field experiment method and an isotope tracing technique, the agricultural non-point nitrogen pollution control function of dierent vegetation types in riparian wetland was studied in the Kouma Section of the Yellow River. The results showed that the retention of agricultural non-point nitrogen pollution by riparian wetland soil occurs mainly in top 0-10 cm layer. The amount of nitrogen retained by surface soils associated with three types of vegetation are 0.045 mg/g for Phragmites communis Trin Linn, 0.036 mg/g for Scirpus triqueter Linn, and 0.032 mg/g for Typha angustifolia Linn, which account for 59.21%, 56.25%, and 56.14% of the total nitrogen interception, respectively. Exogenous nitrogen in 0-10 cm soil layer changes more quickly than in other layers. One month after adding K15NO3 to the tested vegetation, nitrogen content was 77.78% for P. communis Trin, 68.75% for T. angustifolia, and 8.33% for S. triqueter in the surface soil. After three months, nitrogen content was 93.33% for P. communis Trin, 72.22% for S. triqueter, and 37.50% for T. Angustifolia. There are large dierences among vegetation communities respecting to purification of agricultural non-point nitrogen pollution. The nitrogen uptake amount decreases in the sequence: new shoots of P. communis Trin (9.731 mg/g) > old P. communis Trin (4.939 mg/g) > S. triqueter (0.620 mg/g) > T. angustifolia (0.186 mg/g). Observations indicated that the presence of riparian wetlands as buers on and adjacent to stream banks could be recommended to control agricultural non-point pollution. | ZHAO Tongqian XU Huashan HE Yuxiao TAI Chao MENG Hongqi ZENG Fanfu XING Menglin | 2009 | Journal of Environmental Sciences2009，21，7： | 29 |
| 2 | 高白细胞性急性白血病 244 例临床分析显示文摘为了解高白细胞性急性白血病(HAL)的临床规律和预后因素。对244例HAL和同期非HAL进行回顾性对照分析。结果显示:发现HAL构成比为8.5%,HAL中急性淋巴细胞白血病(ALL)较多,在急性髓细胞白血病(AML)中M5占的比例最多,为40.5%。HAL发病时肝、脾、淋巴结肿大,DIC,中枢神经系统白血病(CNSL)较非HAL为多。完全缓解(CR)率为41.4%,低于非HAL的54.2%,早期病死率是23.8%。早期死亡的主要原因是颅内出血,占50%。早期死亡的高危因素有发病时Hb≤40g/L,血小板≤30×109/L,DIC,感染,CNSL。结果显示:HAL完全缓解率低,早期死亡率高,预后差,特别是HAL-AML的早期死亡率明显高于HAL-ALL,要重视其早期处理。 | Shanghai Leukemia Cooperation Group Wang Xiaoqin, Lin Guowei, Wang Jun, et al. Shanghai Huashan Hospital, Shanghai 200040 | 1997 | 中华内科杂志1997，36，8： | 27 |
| 3 | A HEMODYNAMIC MODEL AND A MATHEMATICAL METHOD TO CALCULATE THE DYNAMICS INDEX FOR CEREBRAL CIRCULATION显示文摘The dynamics indexes,playing an important role in the cerebral circulation,will be changed significantly compared with their normal range in many cerebrovascular disease.The geometrical parameters of cerebrovascular may be detected by DSA or MRA scan,but the hemodynamic parameters,such as,blood flow,artery resistance and compliance must be calculated by building hemodynamics model. The cerebral circular system that has four entrances for blood flow(two carotid and two vertebral arteries)and three communicating arteries is much different from the systematic ststem which has only one entrance,ic.,the aortic.The purpose of this study is to set up a hemodynamics model with lumped parameters to describe the cerebral circulation.From this model,we get its governing equations and present a new method to calculate the hemodynamics indexes in clinical application. | Ding Guang-hongDepartment of Applied Mechanics, Fudan University, Shanghai 200433, P. R. ChinaLu Chuan-zhenDepartment of Neurology, Huashan Hospital, Institute of Neurology, Shanghai MedicalUniversity, Shanghai 200040, P.R.ChinaYao Wei, Wang Yan-boDepartment of Applied Mechanics, Fudan University, Shanghai 200433, P. R. ChinaCheng Shao-HuaDepartment of Neurology, Huashan Hospital, Institute of Neurology, Shanghai MedicalUniversity, Shanghai 200040, P.R.ChinaCheng JinDepartment of Applied Mechanics, Fudan University, Shanghai 200433, P. R. ChinaGao Jian, Wang Xiao-dongBeijing 305 Hospital, Beijing 100017, P.R.China | 1997 | Journal of Hydrodynamics1997，9，4： | 17 |
| 4 | Postreperfusion syndrome during orthotopic liver transplantation:a single-center experience显示文摘BACKGROUND: Marked hemodynamic alteration, commonly referred to as postreperfusion syndrome (PRS), often occurs after revascularization of the donor organ during orthotopic liver transplantation (OLT) and is associated with poor outcomes. This study aimed to investigate the incidence, predictive factors and clinical outcomes of PRS in Chinese patients following OLT at a liver transplantation center in China. METHODS: Over a 5-year period, 330 consecutive patients who had undergone OLT for hepatocellular carcinoma or cirrhosis were included in this retrospective study. PRS was defined as a >30% decrease in the mean arterial pressure compared with that before revascularization for more than 1 minute during the first 5 minutes of graft reperfusion. The patients were divided into 2 groups according to the development of PRS: group 1 (patients with PRS, n=56) and group 2 (patients without PRS, n=274). The demographic characteristics, operative and postoperative courses, and outcomes of the patients were analyzed using SPSS version 18.0. RESULTS: Multivariate regression analysis showed that left ventricular diastolic dysfunction determined by echocardiography and prolonged cold ischemia time were the independent risk factors for PRS. More patients in group 1 showed postoperative renal dysfunction than those in group 2 (19.23% vs 8.4%). Moreover, patients in group 1 also had higher intraoperative (7.14% vs 0%) and postoperative mortalities (26.92% vs 12.04%).CONCLUSION: Left ventricular diastolic dysfunction and prolonged cold ischemia time contribute to a high incidence of PRS, which is associated with adverse outcomes in Chinese patients following OLT. | Zhen-Dong Xu, Hai-Tao Xu, Hong-Bin Yuan, Hao Zhang, Rui-Hua Ji, Zui Zou, Zhi-Ren Fu and Xue-Yin Shi Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China Department of Anesthesiology Organ Transplantation Center , Changzheng Hospital, Second Military Medical University, Shanghai 200003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 15 |
| 5 | Toll-like receptor 3(TLR3)regulation mechanisms and roles in antiviral innate immune responses显示文摘Toll-like receptor 3(TLR3)is a member of the TLR family,mediating the transcriptional induction of type I interferons(IFNs),proinflammatory cytokines,and chemokines,thereby collectively establishing an antiviral host response.Studies have shown that unlike other TLR family members,TLR3 is the only RNA sensor that is utterly dependent on the Tollinterleukin-1 receptor(TIR)-domain-containing adaptor-inducing IFN-β(TRIF).However,the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear.In this review,we focus on recent advances in understanding the antiviral mechanism of the TRIF pathway and describe the essential characteristics of TLR3 and its antiviral effects.Advancing our understanding of TLR3 may contribute to disease diagnosis and could foster the development of novel treatments for viral diseases. | Yujuan CHEN Junhong LIN Yao ZHAO Xianping MA Huashan YI | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，8： | 11 |
| 6 | Different Hydrocarbon Accumulation Histories in the Kelasu-Yiqikelike Structural Belt of the Kuqa Foreland Basin显示文摘Kuqa 低岬盆是气体支配的重要的含石油的盆。Kela-2 大天然气水库和 Yinan-2, Dabei-1, Tuzi 和 Dina-11 煤气的水库在盆被发现了直到礼品。在 Kelasu 区域和 Yinan 区域的天然气从甲烷和乙烷碳同位素显示的不同来源岩石被产生。前者从侏罗记和三叠纪的来源岩石被导出,当后者主要从侏罗记时。在盆基于它的多级式的进化和重叠和强烈构造转变,控告历史的烃能被划分成早、中间的喜玛拉雅的烃累积和晚喜玛拉雅的再分配和重新丰富。更重的碳同位素作文和 C1/C14 的高天然气比率显示在早喜玛拉雅的阶段的积累的天然气被破坏,现在的套住的天然气主要在中间、迟了的喜玛拉雅的阶段被控告。在 Kelasu 和 Yinan 区域生产的油的比较和对比显示在上述二个区域控告历史的烃是复杂的并且应该被多级式的烃移植和累积描绘。 | WANG Zhaoming LONG Huashan | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 9 |
| 7 | Analysis of gene expression profiles in pancreatic carcinoma by using cDNA microarray显示文摘OBJECTIVES: To survey the gene expression profiles in pancreatic carcinoma by using cDNA microarrayand detect target genes for further study.METHODS: Three mixed samples from 2 cases of normal pancreatic tissue and 4 cases ofmoderate-differentiated pancreatic carcinoma were studied by means of cDNA microarray consisting of18 000 genes.RESULTS: 1484 and 1353 different expressed genes were observed in two cancer samples respectively.We identified 455 genes altered with the same tendency in both samples, including 102 up-regulated and353 down-regulated genes. There were 274 known genes and 181 unknown genes; 27.8% and 52.0%genes respectively had an expression level in cancer that was 2-fold higher or lower than that in normalsamples. Tumor suppressor genes, growth factors and receptor genes, signal conduction genes,transcription factor genes were identified.CONCLUSIONS: cDNA microarray is an efficient and high-throughout method to investigate geneexpression profiles in pancreatic carcinoma. MBD1, EDG1 and gene hypermethylation mechanism wouldplay an important role in the pathogenesis of pancreatic carcinoma. | Xian-Jun Yu Jiang Long De-Liang Fu Qun-Hua Zhang Quan-Xin Ni the Center for Pancreatic Cancer, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，3： | 8 |
| 8 | Relationships Between River Water Quality and Landscape Factors in Haihe River Basin, China: Implications for Environmental Management显示文摘River water plays a key role in human health, and in social and economic development, and is often affected by both natural factors and human activities. An in-depth understanding of the role of these factors can help in developing an effective catchment management strategy to protect precious water resources. This study analyzed river water quality, patterns of terrestrial and riparian ecosystems, intensity of agricultural activities, industrial structure, and spatial distribution of pollutant emissions in the Haihe River Basin in China for the year of 2010, identifying the variables that have the greatest impact on river water quality. The area percentage of farmland in study area, the percentage of natural vegetation cover in the 1000-m riparian zone, rural population density, industrial Gross Domestic Product(GDP)/km^2, and industrial amino nitrogen emissions were all significantly correlated with river water quality(P < 0.05). Farming had the largest impact on river water quality, explaining 43.0% of the water quality variance, followed by the coverage of natural vegetation in the 1000-m riparian zone, which explained 36.2% of the water quality variance. Industrial amino nitrogen emissions intensity and rural population density explained 31.6% and 31.4% of the water quality variance, respectively, while industrial GDP/km^2 explained 26.6%. Together, these five indicators explained 67.3% of the total variance in water quality. Consequently, water environmental management of the Haihe River Basin should focus on adjusting agricultural activities, conserving riparian vegetation, and reducing industrial pollutant emissions by optimizing industrial structure. The results demonstrate how human activities drive the spatial pattern changes of river water quality, and they can provide reference for developing land use guidelines and for prioritizing management practices to maintain stream water quality in a large river basin. | XU Huashan ZHENG Hua CHEN Xiaoshu REN Yufen OUYANG Zhiyun | 2016 | Chinese Geographical Science2016，26，2： | 4 |
| 9 | Geochemistry of the Batang Group in the Zhaokalong Area, Yushu, Qinghai: Implications for the Late Triassic Tectonism in the Northern Sanjiang Region, China显示文摘The Batang Group in the Zhaokalong area not only hosts an important Fe-Cu polymetallic deposit but also reveal important insights for the Late Triassic tectonism in the northern Sanjiang region. In order to delineate the tectonic setting and evolutionary process of the paleo arc-basin system, geochemical studies on the Batang Group strata have been carried out. The results suggest that andesite in the Zhaokalong area mainly belongs to the tholeiite series and is characterized by obvious fractionation of LREE and HREE, enrichment in LILE and depletion in HFSE, and a distinctly elevated δ^(34)SCDT average of 10.5‰. The sandstone is classified as lithic sandstone, which is also characterized by obvious fractionation of LREE and HREE, as well as weak negative Ce and Eu anomalies. The limestone displays positive Eu anomalies, with δ^(13)CPDB ranging from-1.3‰ to 4.4‰ and δ^(18) OSMOW ranging from 14.6‰ to 22.5‰. These results indicate that the andesite has a dual signature of both arc andesite and rift volcanic rocks, whereas the sandstone may be formed in an active continental margin, and the limestone could be deposited in a weak oxidizing shallow sea. The sandstone in the Zhaokalong area represents sedimentation in a platform slope facies, corresponding to the main stage of the Jinshajing oceanic basin subduction during the middle period of Late Triassic. The continental arc volcanic activity resulted from subsequent strengthened subduction, forming the andesite in the North Qiangtang backarc basin. Afterwards, the limestone was formed after the cessation of magmatic activity. The information gleaned from the Batang Group strata helped constrain the evolution of the paleo-Jomda island arc and Jinshajiang oceanic subduction in the Late Triassic. | LI Huan XI Xiaoshuang SUN Huashan KONG Hua WU Qianhong WU Chengming Jillian Aira S.GABO-RATIO | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 3 |
| 10 | Exhumation history of the Jiaodong and its adjacent areas since the Late Cretaceous:Constraints from low temperature thermochronology显示文摘The thermal history of the Jiaodong region and adjacent provinces(Shandong and northern Jiangsu) have been extensively studied,particularly by apatite fission track(AFT) dating.However,the AFT ages from surface outcrops range broadly and do not show an apparent relationship between age and elevation.This work provides a multiple low temperature thermochronological dataset including zircon and apatite(U-Th)/He ages(ZHe and AHe),and AFT ages from a 1000-m-deep borehole at the Jiaojia goldneld in the northwest of Jiaodong Peninsula.ZHe,AFT and AHe ages range from-100-70,-85-50and-65-50 Ma,respectively.These data conform to the principles of age vs.closure temperature and age vs.elevation and thus can be employed to estimate the exhumation history.Based on the density histogram of fission track length calculation,thermal history modeling,and previously published AFT ages from the Chinese Continental Science Drill program,this work concludes that compared to the AFT ages from surface outcrops,the low temperature thermochronological ages from the boreholes show a better relationship between age,elevation and closure temperature,and the age becomes younger with increasing depth.In addition,the exhumation history in the Jiaodong and adjacent areas can be divided into two distinct stages:a short,rapid tectonic exhumation(~100-95 Ma) and a long,slow exhumation since 95 Ma.The rate and amount of tectonic exhumation since 95 Ma are inferred as ~30 m Ma^(-1) and ~3 km,respectively. | SUN HuaShan LI Huan LIU Liu CHEN QiaoMei YANG Hui WU Pan | 2017 | Science China Earth Sciences2017，60，3： | 3 |
| 11 | Effects of Panax notoginseng saponins on hydrogen peroxide-induced apoptosis in cultured rabbit bone marrow stromal cells显示文摘Objective To investigate the effects of Panax notoginseng saponins(PNS)on hydrogen peroxide(H2O2)-induced apoptosis in cultured rabbit bone marrow stromal cells(BMSCs).Methods BMSCs from 3-month-old New Zealand rabbits were isolated and cultured by the density gradient centrifugation combined with adherent method.The cultured BMSCs were divided into three groups:normal control,H2O2 treatment(100μmol/L),and PNS pretreatment(0.1g/L).Intracellular reactive oxygen species(ROS)levels as the index of oxidative stress were measured by using 2'7'-dichlorodihydrofluorescein diacetate.Flow cytometry was used to observe the apoptosis of BMSCs by staining with annexinV-FITC/PI.The protein expression of Bax in BMSCs was analyzed by Western blotting.Activity of caspase-3 enzyme was measured by spectrofluorometry.Results Pretreatment with PNS significantly decreased intracellular ROS level induced by H2O2(P<0.01).PNS markedly attenuated H2O2-induced apoptosis rate from 38.68% to 19.24%(P<0.01).PNS reversed H2O2-induced augmentation of Bax expression.Furthermore,PNS markedly reduced the altered in activity of caspase-3 enzyme induced by H2O2(P<0.01).Conclusion PNS has a protective effect on hydrogen peroxide-induced apoptosis in cultured rabbit BMSCs by scavenging ROS and decreasing Bax expression and caspase-3 activity. | Hui Qiang1,2,Guang-Sheng Wang3,Chen Zhang1,Zhi-Bin Shi1,Li-Hong Fan1,Kun-Zheng Wang1 1.Department of Orthopedics,the Second Affiliated Hospital,Medical School of Xi’an Jiaotong University,Xi’an 710004 2.Department of Orthopedics,Shaanxi Province People’s Hospital,Xi’an 710068 3.Department of Orthopedics,Huashan Hospital,Baoji 721000,China. | 2010 | Journal of Pharmaceutical Analysis2010，22，1： | 3 |
| 12 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 13 | Theory of high-density low-cross-talk waveguide superlattices显示文摘Waveguide superlattices, a special type of waveguide arrays, can be designed to achieve very low cross talk at submicrometer/subwavelength pitches. The theoretical framework and design rationales for such waveguide superlattices will be presented in depth. Waveguide sidewall roughness can help to deter the coherent coupling between identical waveguides in nearby supercells, but it also induces random fluctuation of transmission.Statistical behavior of the transmission due to roughness in a waveguide superlattice is systematically treated.Complex transmission characteristics due to spectral oscillation and random roughness will be presented, and their evolution with the superlattice length will be analyzed. | Nan Yang Huashan Yang Hengrun Hu Rui Zhu Shining Chen Hongguo Zhang Wei Jiang | 2016 | Photonics Research2016，4，6： | 2 |
| 14 | Preparation of composite adsorbent of sawdust and CaCl_2 by carbonization method for creating pore显示文摘To solve the problem of swelling and agglomeration of CaCl 2 during the process of ammonia adsorption and improve the performance of mass transfer,we present a new method for the preparation of adsorbent.The CaCl 2 is first immerged into sawdust by soaking method,then the composite adsorbent is prepared by carbonizing the mixture of CaCl 2 and sawdust.The SEM image and elements analysis indicated that the new adsorbent has high porosity and uniform distribution of CaCl 2 due to carbonization under temperature of 700°C.The performance testing of ammonia adsorption showed that under the conditions of evaporation temperature of 5°C and condensation temperature of 40°C,the ammonia uptake reaches 0.204,0.253 and 0.285 kg/kg,the specific cooling power(SCP) is 868.96,540.02 and 405.16 W/kg,and the average adsorption rate is 6.79×10 4,4.22×10 4 and 3.17×10 4 kg/kg/s when the adsorption time is 5,10 and 15 min,respectively.The problems of swelling and agglomeration of CaCl 2 are solved. | BU XianBiao WANG LingBao LI HuaShan LU ZhenNeng | 2012 | Science China(Technological Sciences)2012，55，9： | 2 |
| 15 | Neodymium-doped Yttrium Aluminum Garnet Transparent Laser Ceramics Prepared by Co-precipitation Method显示文摘Transparent polycrystalline neodymium-doped yttrium aluminum garnet ceramics (Nd∶YAG) with better chemical stability, excellent optical and high temperature mechanical property is becoming a new laser host material. The Nd∶YAG precursor powders with loosely dispersed, slightly agglomerated and YAG cubic crystal phase were synthesized at 1100 ℃ by the co-precipitation method combined with the reverse strike, using Nd2O3, Y2O3, Al(NO3)3·9H2O and NH4HCO3 as raw materials, (NH4)2SO4 as electrical stabilizer, TEOS as sintering additive. The Nd∶YAG transparent ceramics were fabricated after being sintered at 1700 ℃ in vacuum for 5 h. The Nd∶YAG ceramic materials were characterized by the TG-DTA, XRD, FT-IR, TEM, FT-PL and FEG-ESEM. The results show that the precursor powders are amorphous at 800 ℃, the large amount YAlO3(YAP) and tiny amout Y3Al5O 12(YAG) appear when the calcination temperature is 890 ℃ and the YAP hexagonal crystal phase transforms to YAG cubic crystal phase at 1012 ℃. There are agglomerations in the precursor powders resulting from the high calcination temperature and the agglomerates link together, but as a whole the particles distribute homogeneously. The lasing wavelength of (Nd 0.01Y 0.99)3Al5O 12 transparent ceramics is 1.065 μm and there exists a slight red-shift compared to the single crystal with the same chemical composition. With the optical wavelength increasing, the transmittance of (Nd 0.01Y 0.99)3Al5O 12 raises gradually and the optical transmittance is about 45% in the visible light and 58% in the infrared light. | Su Chunhui Song Qiong Zhang Huashan Zhang Hongbo Hou Zhaoxia Shao Jing | 2006 | Journal of Rare Earths2006，24，1： | 2 |
| 16 | Study on crystallization and microstructure of Li_2O-Al_2O_3-SiO_2 glass ceramics显示文摘 | Zhaoxia Hou Yongming Zhang Huashan Zhang Hongbo Zhang Jing Shao Chunhui Su | 2006 | Journal of University of Science and Technology Beijing2006，13，6： | 2 |
| 17 | 灾害后响应献血号召的初次献血者保留显示文摘2008年5月12日,一次严重的地震袭击了中国四川。许多人为灾区第1次献血,这样的行为使我们不禁发问,这些初次献血者能否在将来成为重复献血者?有文献报道,一般来说灾难(如9·11事件对于美国)和事故对于献血行为有短期的促进作用,而这种刺激确实对于血液供给也是短期的。献血者,尤其是初次献血者,不能意识到我们需要重复的献血去持续不断的补充血液供应。 | 文秀琼 黄毅 李聚林 姚富柱 吕运来 铁木尔 美黑丽 王憬惺 HuaShan | 2012 | 中国输血杂志2012，25，10： | 2 |
| 18 | Targeted therapy for head and neck cancer:signaling pathways and clinical studies显示文摘Head and neck cancer(HNC)is malignant,genetically complex and difficult to treat and is the sixth most frequent cancer,with tobacco,alcohol and human papillomavirus being major risk factors.Based on epigenetic data,HNC is remarkably heterogeneous,and treatment remains challenging.There is a lack of significant improvement in survival and quality of life in patients with HNC.Over half of HNC patients experience locoregional recurrence or distal metastasis despite the current multiple traditional therapeutic strategies and immunotherapy.In addition,resistance to chemotherapy,radiotherapy and some targeted therapies is common.Therefore,it is urgent to explore more effective and tolerable targeted therapies to improve the clinical outcomes of HNC patients.Recent targeted therapy studies have focused on identifying promising biomarkers and developing more effective targeted therapies.A well understanding of the pathogenesis of HNC contributes to learning more about its inner association,which provides novel insight into the development of small molecule inhibitors.In this review,we summarized the vital signaling pathways and discussed the current potential therapeutic targets against critical molecules in HNC,as well as presenting preclinical animal models and ongoing or completed clinical studies about targeted therapy,which may contribute to a more favorable prognosis of HNC.Targeted therapy in combination with other therapies and its limitations were also discussed. | Qingfang Li Yan Tie Aqu Alu Xuelei Ma Huashan Shi | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 2 |
| 19 | Time-optimal and Jerk-continuous Trajectory Planning for Robot Manipulators with Kinematic Constraints显示文摘 | Liu Huashan Lai Xiaobo Wu Wenxiang | 2013 | Robotics and Computer Integrated Manufacturing2013，29，2： | 1 |
| 20 | Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection显示文摘The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants.In Chengdu,China,an infection wave was predominantly induced by the BA.5 subvariant.It is crucial to determine whether the hybrid anti-SARS-CoV-2 immunity following BA.5 infection. | Jingyun Yang Weiqi Hong Hong Lei Cai He Wenwen Lei Yanan Zhou Tingmei Zhao Aqu Alu Xuelei Ma Jiong Li Li Yang Zhenling Wang Wei Wang Guangwen Lu Guobo Shen Shuaiyao Lu Guizhen Wu Huashan Shi Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员