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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Occurrence and assessment of veterinary antibiotics in swine manures:A case study in East China显示文摘We investigated the occurrence of 14 selected antibiotics including five therapeutic classes of tetracyclines,sulfonamides,macrolides,fluoroquinolones and chloramphenicols in manures collected from four swine farms of different sizes in eastern China.Tetracyclines(tetracycline,oxytetracycline,chlortetracycline,and doxycycline) and sulfadiazine were the most prominent contaminants in the manure samples,with maximum concentrations reaching 98.2 × 10 3,354.0 × 10 3,139.4 × 10 3,37.2× 10 3,and 7.1× 10 3 μg/kg,respectively.The occurrence of these compounds was dependent on breeding scale,animal type,and breeding season.Manure storage and vermiculture were not able to effectively deplete the heavier contaminants(tetracyclines and sulfadiazine),resulting in high levels of these chemicals remaining in manures.Therefore,the occurrence of these antibiotics in agricultural soils(0.1-205.1 μg/kg) collected from four types of agricultural land(pear orchard,tea plantation,bamboo forest,and paddy field) near the studied farms,was a reflection of manure application.However,the extremely high concentrations of antibiotics in manures were unlikely from feed consumption,but from other direct forms of medicine application. | CHEN YongShan ZHANG HaiBo LUO YongMing SONG Jing | 2012 | Chinese Science Bulletin2012，57，6： | 29 |
| 3 | An experimental investigation on the mechanism of fluid flow through single rough fracture of rock显示文摘The structure of fractures in nature rock appears irregular and induces complicated seepage flow behavior.The mechanism and quantitative description of fluid flow through rock fractures is a difficult subject that has been greatly concerned in the fields of geotechnical,mining,geological,and petroleum engineering.In order to probe the mechanism of fluid flow and the effects of rough structures,we conducted a few laboratory tests of fluid flow through single rough fractures,in which the Weierstrass-Mandelbrot fractal function and PMMA material were employed to produce the fracture models with various fractal roughnesses.A high-speed video camera was employed to record the fluid flow through the entire single rough fracture with a constant hydraulic pressure.The properties of fluid flow varying with the fracture roughness and the influences of the rough structure were analyzed.The components of flow resistance of a single rough fracture were discussed.A fractal model was proposed to relate the fluid resistance to the fracture roughness.A fractal equivalent permeability coefficient of a single rough fracture was formulated.This study aims to provide an experimental basis and reference for better understanding and quantitatively relating the fluid flow properties to the structures of rock fractures. | JU Yang ZHANG QinGang YANG YongMing XIE HePing GAO Feng WANG HuiJie | 2013 | Science China(Technological Sciences)2013，56，8： | 28 |
| 4 | Reactive adsorption of thiophene on Ni/ZnO adsorbent:Effect of ZnO textural structure on the desulfurization activity显示文摘To better understand the nature of reactive adsorption of thiophene on Ni/ZnO adsorbent,the effect of ZnO textural structure on the desulfurization activity was investigated.ZnO materials were synthesized by low-temperature solid-state reaction and the corresponding Ni/ZnO adsorbents were prepared by incipient impregnation method.The analysis results showed that the crystalline sizes of ZnO as-synthesized as well as the BET surface areas varied obviously with the calcination temperature.The activity evaluations indicated that the Ni/ZnO adsorbents prepared with ZnO possessed a favorable textural structure as active component exhibited good activity of removing thiophene.The evolutions of the main crystalline phases of Ni/ZnO adsorbents before and after reaction confirmed that ZnO played a crucial role in taking up S element and converting it into ZnS in the reactive adsorption process.It was concluded that ZnO with larger surface area and smaller crystal particles resulted in better desulfurization activity,which may be the main reason for the different activities of the Ni/ZnO adsorbents prepared with ZnO calcined at different temperatures. | Jingcheng Zhang Yunqi Liu Shuang Tian Yongming Chai Chenguang Liu | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 13 |
| 5 | Occurrence and distribution of antibiotic resistance genes in the sediments of the East China Sea bays显示文摘The coastal area of the East China Sea has experienced rapid urbanization and industrialization in China since 1980 s, resulting in severe pollution of its environments.Antibiotic resistance genes(ARGs) are regarded as a kind of emerging pollutant with potential high risk. The sediment samples were collected from Hangzhou Bay(HB),Xiangshan Bay(XB), and Taizhou Bay(TB) to investigate the spatial occurrence and distribution of 27 ARGs and class I integron–integrase gene(intI1) in the coastal area of the East China Sea. The PCR results showed the frequent presence of 11 ARGs and intI1 in the sediments of the three bays. The qPCR results further showed that sulfonamide resistance was the most prevalent ARG type and antibiotic target replacement and protection were the most important resistance mechanisms in the sediments. Regarding the subtype of ARGs, sulI, tetW, and dfrA13 were the most abundant ARGs, in which sulI was higher in TB(based on both the absolute and relative abundances) and dfrA13 was higher in HB(based on the relative abundances). The network analysis revealed that intI1 had significant correlations with tetC, sulI, sulII, and blaPSE-1. Oil was the key connected factor, which had positive connections with sulI, sulII, and blaPSE-1. In addition, the joint effect of heavy metals and nutrients & organic pollutants might be crucial for the fate of ARGs in the coastal sediments. | Jiayu Chen Zhiguo Su Tianjiao Dai Bei Huang Qinglin Mu Yongming Zhang Donghui Wen | 2019 | Journal of Environmental Sciences2019，31，7： | 13 |
| 6 | Predicting As,Cd and Pb uptake by rice and vegetables using field data from China显示文摘Plant uptake factor(PUF),single-variable regression of natural log-transformed concentrations in rice grain/vegetables versus natural log-transformed concentrations in soil and multiple-variable regression with soil concentrations and pH,was derived,validated and compared based on the paired crop and soil data collected from studies regarding As,Cd and Pb contaminated croplands in China.Results showed that the median value of PUF did not present deterministic prediction.But after natural logarithm transformation,the PUF followed Gaussian distribution which could be useful in risk assessment.The single-variable regression models were significant for As,Cd and Pb uptake both by rice and vegetables;however,the standard errors of all the regressions were comparatively large.Soil pH as a variable was generally significant but it only contributed positively to model fit for Cd uptake.After model comparison and selection,the upper 95% prediction limits of the multiple regression model for Cd uptake by rice was recommended to calculate screening value of Cd for paddy soil based on the limit for Cd concentration in rice grain. | Hongzhen Zhang Yongming Luo Jing Song Haibo Zhang Jiaqi Xia Qiguo Zhao | 2011 | Journal of Environmental Sciences2011，23，1： | 12 |
| 7 | A Novel Single-Nucleotide Mutation in a CLAVATA3 Gene Homolog Controls a Multilocular Silique Trait in Brassica rapa L.显示文摘 | Chuchuan Fan, Yudi Wu, Qingyong Yang, Yang Yang, Qingwei Meng, Keqiao Zhang, Jinguo Li, Jinfang Wang Yongming Zhou | 2014 | Molecular Plant2014，7，12： | 12 |
| 8 | Prevalent intrinsic emission from nonaromatic amino acids and poly(amino acids)显示文摘Nonaromatic amino acids are generally believed to be nonemissive, owing to their lack of apparently remarkable conjugation within individual molecules. Here we report the intrinsic visible emission of nonaromatic amino acids and poly(amino acids) in concentrated solutions and solid powders. This unique and widespread luminescent characteristic can be well rationalized by the clustering-triggered emission(CTE) mechanism, namely the clustering of nonconventional chromophores(i.e. amino, carbonyl,and hydroxyl) and subsequent electron cloud overlap with simultaneous conformation rigidification. Such CTE mechanism is further supported by the single crystal structure analysis, from which 3 D through space electronic communications are uncovered.Besides prompt fluorescence, room temperature phosphorescence(RTP) is also detected from the solids. Moreover, persistent RTP is observed in the powders of exampled poly(amino acids) of ε-poly-L-lysine(.-PLL) after ceasing UV irradiation. These results not only illustrate the feasibility of employing the building blocks of nonaromatic amino acids in the exploration of new luminescent biomolecules, but also provide significant implications for the emissions of peptides and proteins at aggregated or crystalline states. Meanwhile, they may also shed lights on further understanding of autofluorescence from biological systems. | Xiaohong Chen Weijian Luo Huili Ma Qian Peng Wang Zhang Yuan Yongming Zhang | 2018 | Science China Chemistry2018，61，3： | 8 |
| 9 | Room temperature phosphorescence from natural products: Crystallization matters显示文摘Efficient room temperature phosphorescence is observed in natural compounds and polymers such as starch, cellulose, bovine serum albumin (BSA), and some other carbohydrates. Whereas being practically nonluminescent in solutions and TLC plates, they emit bright phosphorescence in the crystalline states with lifetime up to microseconds, exhibiting crystallization-induced phosphorescence (CIP) characteristics. The CIP of these natural products without any conventional chromophores offers a new platform for the exploration of conceptually novel luminogens. | GONG YongYang TAN YeQiang MEI Ju ZHANG YiRen YUAN WangZhang ZHANG YongMing SUN JingZhi TANG Ben Zhong | 2013 | Science China Chemistry2013，56，9： | 8 |
| 10 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 11 | Adsorption and desorption characteristics of diphenylarsenicals in two contrasting soils显示文摘Diphenylarsinic acid(DPAA) is formed during the leakage of aromatic arsenic chemical weapons in soils,is persistent in nature,and results in arsenic contamination in the field.The adsorption and desorption characteristics of DPAA were investigated in two typical Chinese soils,an Acrisol(a variable-charge soil) and a Phaeozem(a constant-charge soil).Their thermodynamics and some of the factors influencing them(i.e.,initial pH value,ionic strength and phosphate) were also evaluated using the batch method in order to understand the environmental fate of DPAA in soils.The results indicate that Acrisol had a stronger adsorption capacity for DPAA than Phaeozem.Soil DPAA adsorption was a spontaneous and endothermic process and the amount of DPAA adsorbed was affected significantly by variation in soil pH and phosphate.In contrast,soil organic matter and ionic strength had no significant effect on adsorption.This suggests that DPAA adsorption may be due to specific adsorption on soil mineral surfaces.Therefore,monitoring the fate of DPAA in soils is recommended in areas contaminated by leakage from chemical weapons. | Anan Wang Shixin Li Ying Teng Wuxin Liu Longhua Wu Haibo Zhang Yujuan Huang Yongming Luo Peter Christie | 2013 | Journal of Environmental Sciences2013，25，6： | 8 |
| 12 | Synergistic effect of ozonation and ionizing radiation for PVA decomposition显示文摘Ozonation and ionizing radiation are both advanced oxidation processes(AOPs) without chemical addition and secondary pollution. Also, the two processes' efficiency is determined by different p H conditions, which creates more possibilities for their combination. Importantly,the combined process of ozonation and ionizing radiation could be suitable for treating wastewaters with extreme p H values, i.e., textile wastewater. To find synergistic effects, the combined process of ozonation and ionizing radiation mineralization was investigated for degradation of polyvinyl alcohol(PVA) at different p H levels. A synergistic effect was found at initial p H in the range 3.0–9.4. When the initial p H was 3.0, the combined process of ozonation and ionizing radiation gave a PVA mineralization degree of 17%. This was 2.7 times the sum achieved by the two individual processes, and factors of 2.1 and 1.7 were achieved at initial p H of7.0 and 9.4, respectively. The combined process of ozonation and ionizing radiation was demonstrated to be a feasible strategy for treatment of PVA-containing wastewater. | Weihua Sun Lujun Chen Yongming Zhang Jianlong Wang | 2015 | Journal of Environmental Sciences2015，27，8： | 7 |
| 13 | IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling显示文摘Interleukin-17 (IL-17 或 IL-17A ) 生产是 TH17 房间的一个特点,贡献多重自体免疫、煽动性的疾病的致病的 CD4+ T 淋巴细胞的一个新唯一的系。IL-17 受体(IL-17R 或 IL-17RA ) 为 IL-17 生物活动是必要的。新兴的数据建议 heteromeric 或 homomeric 受体建筑群的形成为 IL-17 发信号被要求。这里,我们证明孤儿受体 IL-17RD (Sef,类似的表示到 FGF 基因或 IL-17RLM ) 被联系并且有 IL-17R 的 colocalized。重要地, IL-17RD 调停 IL-17 发信号,用一个酶记者评估了由 24p3 的本国的倡导者开车, IL-17 目标基因。另外,主导否定地缺乏细胞内部的领域的 IL-17RD 异种压制 IL-17R-mediated IL-17 发信号。而且,象 IL-17R 一样的 IL-17RD 与 TRAF6 被联系,一个 IL-17R 下游的分子。这些结果显示 IL-17RD 是表明建筑群的 IL-17 受体的部分,因此为通过 heteromeric 或 homomeric 受体建筑群发信号的 IL-17 提供新奇证据。 | Zhili Rong Anan Wang Zhiyong Li Yongming Ren Long Cheng Yinghua Li Yinyin Wang Fangli Ren Xiaoning Zhang Jim Hu Zhijie Chang | 2009 | Cell Research2009，19，2： | 6 |
| 14 | Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury显示文摘In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast-induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression. | Jian Huo Jiachuan Liu Jinbiao Wang Yongming Zhang Chunlin Wang Yanyan Yang WenjiangSun Shaonian Xu | 2012 | Neural Regeneration Research2012，7，22： | 6 |
| 15 | Crystallization-induced phosphorescence of benzils at room temperature显示文摘Efficient room temperature phosphorescence (RTP) is rarely observed in pure organic luminogens. However, we have newly observed that benzil and its derivatives are nonluminescent in solvents and thin layer chromatography (TLC) plates, but become highly phosphorescent in crystal state at room temperature, exhibiting typical crystallization-induced phosphorescence (CIP) characteristics. The CIP phenomenon is ascribed to the restriction of intramolecular rotations in crystals owing to effective intermolecular interactions. Such intermolecular interactions greatly rigidify the molecular conformation and significantly decrease the nonradiative deactivation channels of the triplet excitons, thus giving boosted phosphorescent emission at room temperature. | GONG YongYang TAN YeQiang LI Hong ZHANG YiRen YUAN WangZhang ZHANG YongMing SUN JingZhi TANG Ben Zhong | 2013 | Science China Chemistry2013，56，9： | 6 |
| 16 | Genome-and transcriptome-wide association studies provide insights into the genetic basis of natural variation of seed oil content in Brassica napus显示文摘Seed oil content(SOC)is a highly important and complex trait in oil crops.Here,we decipher the genetic basis of natural variation in SOC of Brassica napus by genome-and transcriptome-wide association studies using 505 inbred lines.We mapped reliable quantitative trait loci(QTLs)that control SOC in eight environments,evaluated the effect of each QTL on SOC,and analyzed selection in QTL regions during breeding.Six-hundred and ninety-two genes and four gene modules significantly associated with SOC were identified by analyzing population transcriptomes from seeds.A gene prioritization framework,POCKET(prioritizing the candidate genes by incorporating information on knowledge-based gene sets,effects of variants,genome-wide association studies,and transcriptome-wide association studies),was implemented to determine the causal genes in the QTL regions based on multi-omic datasets.A pair of homologous genes,BnPMT6s,in two QTLs were identified and experimentally demonstrated to negatively regulate SOC.This study provides rich genetic resources for improving SOC and valuable insights toward understanding the complex machinery that directs oil accumulation in the seeds of B.napus and other oil crops. | Shan Tang Hu Zhao Shaoping Lu Liangqian Yu Guofang Zhang Yuting Zhang Qing-Yong Yang Yongming Zhou Xuemin Wang Wei Ma Weibo Xie Liang Guo | 2021 | Molecular Plant2021，14，3： | 6 |
| 17 | Outage Probability Minimization for Low-Altitude UAV-Enabled Full-Duplex Mobile Relaying Systems显示文摘In this paper, a novel unmanned aerial vehicle(UAV)-enabled full duplex decode-and-forward(DF) technique is used in mobile relaying system. Compared with conventional static relaying, mobile relaying provides more degree of freedom for experiencing better channel conditions and further improving the system reliable performance. The source and relay transmit power as well as relay trajectory are jointly optimized for sum outage probability minimization in mobile relaying system. Due to the non-convex nature of the original problem, block coordinate decent optimization techniques are employed to decompose it into two sub-problems, which leads to an efficient iterative algorithm. Specifically, for the pre-determined relay trajectory, the optimal transmit power of source and relay are obtained by solving Karush-Kuhn-Tucker(KKT) conditions. For the given source/relay power allocation, the optimal UAV trajectory is obtained by solving dual problem. Based on the two steps, an iterative algorithm is proposed to jointly optimize source/relay power allocation and UAV trajectory alternately. Numerical results show the performance gain of our proposed scheme. | Meng Hua Yi Wang Zhengming Zhang Chunguo Li Yongming Huang Luxi Yang | 2018 | China Communications2018，15，5： | 5 |
| 18 | Construction and Expression of a Single Chain Antibody Mimicing Human Ovarian Cancer Antigen CA125显示文摘为癌症的有免疫力的治疗的一个概念包含抗原的正式就职模仿抗体对肿瘤房间触发有免疫力的反应。对为肿瘤抗原特定的抗体的抗原绑定地点指导的 Anti-idiotypic 抗体可以机能上地并且甚至在结构上模仿抗原并且导致 anti-anti-idiotypic 免疫者反应。Monoclonal 抗体 WJ02 是如此的 anti-idiotypic 抗体之一,它包含 CA125 的内部图象。以便改进 mAb WJ02 的 immunospecificity,我们在 Vl-linker-Vh 取向构造了 mAb WJ02 的单个链。scFv-WJ02 能在 recombinant Pichia pastoris 系统被表示并且藏匿。有 30 kD 的分子的重量的分泌 scFv 蛋白质保留了 mAb WJ02 的生物活动,它被直接有约束力的试金和抑制实验证明。我们的结果显示 scFv-WJ02 能对卵巢的癌症为 idiotypic 治疗被用作一个可能的工具,它可能提高消除 mAb WJ02 导致的 nonspecific 回答的可能性。 | Aidong Li Zheng Li Yinghong Wang Yongming Zhang Jie Ma | 2006 | Cellular & Molecular Immunology2006，3，1： | 5 |
| 19 | Effect of Yb^(3+) concentration on the structures and upconversion luminescence properties of Y_2O_3:Er^(3+) ultrafine phosphors显示文摘Y2O3:Er3+ ultrafine phosphors with a varying Yb3+ ion concentration were prepared by a urea homogeneous precipitation method. The results of XRD show that all the samples are of a pure cubic structure and the average crystallite sizes can be calculated as 45, 34, and 28 nm for Y2O3:Er3+ ultrafine phosphors with Yb3+ ion concentrations of 0, 10%, and 20%, respec- tively. The lattice constant and cell volume of the ultrafine phosphors decrease with enhancing Yb3+ ion concentration. The upconversion luminescence spectra of all the samples were studied under 980 nm laser excitation. The strong green and red upconversion emission were observed, and attributed to the 2H11/2 → 4I15/2, 4S3/2 → 4I15/2 and 4F9/2 → 4I15/2 transitions of Er3+, respectively. The intensity of red emission increases with increasing Yb3+ ion concentration. The effect of Yb3+ ion concentra- tion on the structures and upconversion luminescence mechanism were discussed. | ZHANG Yongming LI Yanhong ZHANG Yang HONG Guangyan YU Yingning | 2008 | Rare Metals2008，27，6： | 4 |
| 20 | Stress protein expression in early phase spinal cord ischemia/reperfusion injury显示文摘Spinal cord ischemia/reperfusion injury is a stress injury to the spinal cord. Our previous studies using differential proteomics identified 21 differentially expressed proteins (n > 2) in rabbits with spinal cord ischemia/reperfusion injury. Of these proteins, stress-related proteins included protein disulfide isomerase A3, stress-induced-phosphoprotein 1 and heat shock cognate protein 70. In this study, we established New Zealand rabbit models of spinal cord ischemia/reperfusion injury by abdominal aorta occlusion. Results demonstrated that hind limb function initially improved after spinal cord ischemia/reperfusion injury, but then deteriorated. The pathological morphology of the spinal cord became aggravated, but lessened 24 hours after reperfusion. However, the numbers of motor neurons and interneurons in the spinal cord gradually decreased. The expression of protein disulfide isomerase A3, stress-induced-phosphoprotein 1 and heat shock cognate protein 70 was induced by ischemia/reperfusion injury. The expression of these proteins increased within 12 hours after reperfusion, and then decreased, reached a minimum at 24 hours, but subsequently increased again to similar levels seen at 6-12 hours, showing a characterization of induction-inhibition-induction. These three proteins were expressed only in cytoplasm but not in the nuclei. Moreover, the expression was higher in interneurons than in motor neurons, and the survival rate of interneurons was greater than that of motor neurons. It is assumed that the expression of stress-related proteins exhibited a protective effect on neurons. | Shanyong Zhang Dankai Wu Jincheng Wang Yongming Wang Guoxiang Wang Maoguang Yang Xiaoyu Yang | 2013 | Neural Regeneration Research2013，8，24： | 4 |
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