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| 1 | A distributed cooperative guidance law for salvo attack of multiple anti-ship missiles显示文摘The consensus problem of impact time is addressed for multiple anti-ship missiles. A new distributed cooperative guidance law with the form of biased proportional navigation guidance(BPNG) is presented. The proposed guidance law employs the available measurements of relative impact time error as the feedback information to achieve the consensus of impact time among missiles and, by exploiting the special structure of the biased cooperative control term, it can handle the seeker's field-of-view(FOV) constraint. The proposed scheme ensures convergence to consensus of impact time under either fixed or switching sensing/communication network, and the topological requirements are less restrictive than those in the existing results. Numerical examples are provided to illustrate the effectiveness of the proposed guidance law. | Zhang Youan Wang Xingliang Wu Huali | 2015 | Chinese Journal of Aeronautics2015，28，5： | 25 |
| 2 | New Fossil Beetles of the Family Elateridae from the Jehol Biota of China(Coleoptera:Polyphaga)显示文摘摘要:在 prosternum 上与吸引人的窝分到二个新类的 elaterids 的二新种被描述并且说明:Bilineariselater foveatus 情报。et sp。nov。并且 Curtelater wui 情报。et sp。nov。从西方的辽宁的上面的侏罗记降低的白垩纪 Yixian 形成,中国。在这些甲壳虫和二个类的系统的位置的点按的机制的起源简短被讨论。 | CHANG Huali REN Dong | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 14 |
| 3 | A New Darwinopterid Pterosaur from the Middle Jurassic of Western Liaoning,Northeastern China and its Ecological Implications显示文摘Darwinopterus 的新种, D。robustodens sp。nov。被描述并且说出。基于新标本, Darwinopterus 的诊断人物被修改并且包括:喙的出牙好空间的、穗状的牙齿创作了;最长的牙齿被限制到牙齿排的前面的一半;牙齿 alveoli 提起了边缘;nasoantorbital 窗汇合;倾向适合;伸长有低神经脊骨的颈的 vertebrae 并且减少或不在的肋骨;超过 20 caudals 的长尾巴部分由 pre- 和 postzygapophyses 的丝状的延期围住;短掌肱骨的不到 60% 长度,有二的第五个脚趾伸长指骨和有在近似、远侧的片断之间的角度的第五个脚趾的弄弯的秒踏脚板方阵大约 130 度。新翼龙 D 的完全的标本。robustodens sp。nov。提供更骨学的信息。在在 Darwinopterus modularis 和 D 之间的牙齿形态学的差别。robustodens sp。nov。建议他们充满了不同生态的壁龛。努力忍受覆盖物的翘目可以是 Darwinopterus robustodens 的主要食物来源。 | Lu Junchang XU Li CHANG Huali ZHANG Xingliao | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 13 |
| 4 | Synthesis of CNT film on the surface of micro-pyramid array and its intense pulsed emission characteristics显示文摘We developed a new scheme to suppress the electric-field-screening effect in high growth density of a carbon nanotube(CNT) film during its intense pulsed emission.We synthesize the CNT film on a tridimensional surface(t-CNT film).The tridimensional surface includes wet etched silicon pyramids,and the Ni layer is electroless plated thereon.The intense pulsed emission characteristics of the t-CNT and planar-grown CNT(p-CNT) films were measured using a diode structure in single-pulse mode.The even turn-on field decreased from 5.5 V/μm for p-CNTs to 2.8 V/m for t-CNTs,and the peak emission current increased from 232 A for p-CNTs to 324 A for t-CNTs at a peak field intensity ~12.2 V/m.The peak current of the t-CNT film increased by ~39.7% over the p-CNT film.It is clear that the micro-pyramid array can effectively suppress the field screening effect to improve the electron-emission of CNT films. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2012 | Chinese Science Bulletin2012，57，14： | 10 |
| 5 | Rescued virus from infectious cDNA clone of rabbit hemorrhagic disease virus is adapted to RK13 cells line显示文摘Based on the infectious full-length cDNA clone of rabbit hemorrhagic disease virus (RHDV), the in vitro transcripts are introduced into RK13 cells. 12 h later, CPE could be observed clearly, and virual antigen could also be detected by IFA. The titre of the recovered virus is 104.6/mL. Immune electron micro-scopic observation of the virus particles revealed that the particles were rotund with a diameter of about 30 nm. Besides, virus titre quantification obtained by qRT-PCR showed a correlation between time from infection and virus titre. All these results showed that we have recovered RHDV from RK13 cells by re-verse genetics technology successfully, and this would be very useful in studies of the antigenicity, virulence, pathogenesis, maturation and new type vaccines of RHDV. | LIU Guangqing NI Zheng YUN Tao ZHANG Yuying DU Qingyun SHENG Zutian LIANG Huali HUA Jionggang LI Shuangmao Chen Jianping | 2006 | Chinese Science Bulletin2006，51，14： | 9 |
| 6 | Sulfur-encapsulated in heteroatom-doped hierarchical porous carbon derived from goat hair for high performance lithium–sulfur batteries显示文摘Biomass-derived carbon materials have aroused widespread concern as host material of sulfur to enhance electrochemical performances for lithium–sulfur batteries. Herein, goat hair, as a low-cost and eco-friendly precursor, is employed to fabricate cauliflower-like in-situ nitrogen, oxygen and phosphorus tri-doped porous biomass carbon(NOPC) by a facile activation with H_3PO_4 and carbonization process.The morphology and microstructure of NOPC can be readily tuned by altering pyrolysis temperature. The as-prepared NOPC matrix material carbonized at 600 °C possesses 3D hierarchical porous structure, high specific surface area(535.352 m^2 g^(-1)), and appropriate pore size and pore size distribution. Encapsulating sulfur into the NOPC depends on a stem-melting technology as cathode materials of Li–S batteries. Due to the synergistic effect of special physical structure and inherent tri-doping of N, O and P, electrons and ions transfer and utilization of active sulfur in the materials are improved, and the shuttle behaviors of soluble lithium polysulfides are also mitigated. Consequently, the S/NOPC-600 composite exhibits excellent electrochemical performance, giving a high initial discharge capacity of 1185 mA h g^(-1) at 0.05 C and maintaining a relatively considerable capacity of 489 m A h g^(-1) at 0.2 C after 300 cycles. Our work shows that a promising candidate for cathode material of Li–S batteries can be synthesized using low-cost and renewable biomass materials by a facile process. | Juan Ren Yibei Zhou Huali Wu Fengyu Xie Chenggang Xu Dunmin Lin | 2019 | Journal of Energy Chemistry2019，28，3： | 9 |
| 7 | Ni-Co/Mg-Al catalyst derived from hydrotalcite-like compound prepared by plasma for dry reforming of methane显示文摘Ni-Co bimetallic catalysts with different Ni/Co content were derived from cold plasma jet decomposition and reduction of hydrotalcite-like compounds containing Ni,Co,Mg and Al,and their catalytic performance was investigated with dry reforming of methane.Experimental results showed that the hydrotalcite-like precursors could be completely decomposed and partly reduced by cold plasma jet,and the Nicontained catalysts exhibited much higher activity than the catalyst without Ni.Especially,the catalyst with Ni/Co ratio of 8/2 achieved not only the highest conversions of 80.3%and 69.3%for CH4 and CO2,respectively,but also the best stability in 100 h testing.The catalysts were characterized by XRD,XPS,TEM and N2 adsorption techniques,and the results showed that the better performance of the 8Ni2Co bimetallic catalyst was attributed to its higher metal dispersion,smaller metal particle size,as well as the interaction effect between Ni and Co,which were brought by the special catalyst preparation method. | Huali Long Yan Xu Xiaoqing Zhang Shijing Hu Shuyong Shang Yongxiang Yin Xiaoyan Dai | 2013 | Journal of Energy Chemistry2013，22，5： | 8 |
| 8 | Downregulation of wild-type p53 protein by HER-2/neu mediated PI3K pathway activation in human breast cancer cells: its effect on cell proliferation and implication for therapy显示文摘Overexpression and activation of HER-2/neu (also known as c-erbB-2), a proto-oncogene, was found in about 30% of human breast cancers, promoting cancer growth and making cancer cells resistant to chemo- and radio-therapy.Wild-type p53 is crucial in regulating cell growth and apoptosis and is found to be mutated or deleted in 60-70% of human cancers. And some cancers with a wild-type p53 do not have normal p53 function, suggesting that it is implicated in a complex process regulated by many factors. In the present study, we showed that the overexpression of HER-2/neu could decrease the amount of wild-type p53 protein via activating PI3K pathway, as well as inducing MDM2 nuclear translocation in MCF7 human breast cancer cells. Blockage of PI3K pathway with its specific inhibitor LY294002 caused G1-S phase arrest, decreased cell growth rate and increased chemo- and radio-therapeutic sensitivity in MCF7 cells expressing wild-type p53. However, it did not increase the sensitivity to adriamycin in MDA-MB-453 breast cancer cells containing mutant p53. Our study indicates that blocking PI3K pathway activation mediated by HER-2/neu overexpression may be useful in the treatment of breast tumors with HER-2/neu overexpression and wild-type p53. | LiZHENG JiaQiangREN HuaLI ZhaoLuKONG HongGuangZHU | 2004 | Cell Research2004，14，6： | 8 |
| 9 | Comparison of alternative extraction methods for secretome profiling in human hepatocellular carcinoma cells显示文摘Secreted proteins are important sources for early detection and diagnosis of disease, and as such have received considerable attention. The extraction of low concentration proteins from large volumes of culture media, which are rich in salts and other compounds that interfere with most proteomics techniques, presents a problem for secretome studies. Ultrafiltration, precipitation, and dialysis are three major extraction methods that can be used to overcome this problem. The present study for the first time, compared the merits and shortcomings of these three methods, without bias. Centrifugal ultrafiltration provided the best extraction efficiency, and precipitation provided the highest number of identifiable proteins. The three methods yielded closely related, but different, information on the secretome; thus, they should be considered complementary or, at least, supplementary methods. Three hundred and sixty unique proteins were identified, including 211 potential secreted proteins. Compared with previous studies, this study also identified 42 new secreted proteins. The present study not only offers a reference for the selection of secretome extraction methods, but also expands the secretome database for the investigation of hepatocellular carcinoma. | CAO Jing SHEN ChengPin ZHANG Jun YAO Jun SHEN HuaLi LIU YinKun LU HaoJie YANG PengYuan | 2011 | Science China(Life Sciences)2011，54，1： | 8 |
| 10 | The Optimal Cross-section Design of the “Trapezoid-V” Shaped Drainage Canal of Viscous Debris Flow显示文摘Debris flow drainage canal is one of the most widely used engineering measures to prevent and manage debris flow hazards.The shape and the sizes of the cross-section are important parameters when design debris flow drainage canal.Therefore,how to design the appropriate shape and sizes of the cross-section so that the drainage canal can have the optimal drainage capacity is very important and few researched at home and abroad.This study was conducted to analyze the hydraulic condition of a Trapezoid-V shaped drainage canal and optimize its cross-section.By assuming characteristic sizes of the cross-section,the paper deduced the configuration parameter of the cross-section of a Trapezoid-V shaped debris flow drainage canal.By theory analysis,it indicates that the optimal configuration parameter is only related to the side slope coefficient and the bottom transverse slope coefficient.For this study,the Heishui Gully,a first-order tributary of the lower Jinsha River,was used as an example to design the optimal cross-section of the drainage canal of debris flow. | YOU Yong | 2011 | Journal of Mountain Science2011，8，1： | 8 |
| 11 | Improvement in the intense pulsed emission stability of grown CNT films via an electroless plated Ni layer显示文摘Carbon nanotube(CNT)films were grown on silicon wafers with and without a nickel layer(Si-CNT and Ni-CNT)via the pyrolysis of iron phthalocyanine.The nickel layer was prepared using the electroless plating method.To study the emission stability of Si-CNT and Ni-CNT cathodes during intense pulsed emission,emission characteristics were measured repeatedly with a diode structure using a Marx generator as a voltage source.For the peak values of the pulsed voltage,which were in the range between 1.62-1.66 MV(corresponding to electric field intensities between 11.57-11.85 V/μm),the first cycle emission current was 109.4 A for Si-CNT and 180.5 A for Ni-CNT.By comparing the normalized emission currents of the Si-CNT and Ni-CNT cathodes,the improvement in the emission stability can be easily quantified.The number of emission cycles necessary for the peak current to decay from 100%to 50%increased from^3 for Si-CNT to^11 for a Ni-CNT film. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2011 | Chinese Science Bulletin2011，56，22： | 7 |
| 12 | Temporal-spatial dynamics of distribution patterns of microorganism relating to biological soil crusts in the Gurbantunggut Desert显示文摘生物土壤外壳用作贡献沙固定的一个重要生物因素。这研究被进行在关于地点的外壳中调查微生物的时间空间的可变性,沙沙丘和季节的土壤层。在苔藓主导的内部沙丘的区域,更高的土壤营养素和水集中是可能的维持微生物引起的活动。细菌显示出解决和生长的最高的能力在在春天和秋天内部沙丘。土壤水内容在内部沙丘的区域在土壤外壳中到达了最高的价值,特别在春天。放线菌和真菌的数量的变化基本上在沙沙丘的不同地点显示出一致趋势。与加深土壤层,因为环境因素在春天和秋天波动,每个微生物组的数量的垂直分发显示出不同特征。在不同微生物组之中,细菌是占优势的,在在所有的春天和秋天的放线菌下一个和真菌最少玷污层(020 厘米) 。细菌和土壤水内容的比例比在在所有土壤层(020 厘米) 的秋天的那些在春天是更高的。没有一致趋势在放线菌和真菌被发现。结果证明微生物的数量是显著地积极的与有机物内容相关,土壤水满意的、全部的 N,全部的 P,可得到的 P,可得到的 K, pH,电的传导性,全部的盐内容,过氧化氢酶, urease,磷酸酶和碱的磷酸酶。 | WU Nan WANG Hongling LIANG Shaoming NIE Huali ZHANG Yuanming | 2006 | Chinese Science Bulletin2006，51，A01： | 7 |
| 13 | Effects of Flexibility and Suspension Configuration of Main Shaft on Dynamic Characteristics of Wind Turbine Drivetrain显示文摘The current research of wind turbine drivetrain is mainly concentrated in dynamic characteristics of gearbox with a specific suspension of main shaft, such as one-point and two-point suspension. However, little attention is paid to the e ects of these suspension configurations on the dynamic responses of wind turbine gearbox. This paper investigates the influences of suspension configurations of main shaft on the dynamic characteristics of drivetrain. For evaluating the dynamic behaviors of drivetrain with multi-stage transmission system more realistically, a dynamic modeling approach of drivetrain is proposed based on Timoshenko beam theory and Lagrange's equation. Considering the flexibility and di erent suspension configurations of main shaft, time-varying mesh sti ness excitation, time-varying transmission error excitation and gravity excitation, etc., a three-dimensional dynamic model of drivetrain is developed, and the dynamic responses of drivetrain are investigated. Results show that with the one-point suspension of main shaft, the resonance frequencies in gearbox, especially at the low-speed stage, obviously shift to the higher frequency range compared to the gearbox without main shaft, but this trend could be inversed by increasing main shaft length. Meanwhile, the loads in main shaft, main shaft bearing and carrier bearing are greatly sensitive to the main shaft length. Hence, the load sharing is further disrupted by main shaft, but this e ect could be alleviated by larger load torque. Comparing to the one-point suspension of main shaft, there occurs the obvious load reduction at the low-speed stage with two-point suspension of main shaft. However, those advantages greatly depend on the distance between two main bearings, and come at the expense of increased load in upwind main shaft unit and the corresponding main bearing. Finally, a wind field test is conducted to verify the proposed drivetrain model. This study develops a numerical model of drivetrain which is able to evaluate the e ects of di erent suspension configurations of main shaft on gearbox. | Jianjun Tan Caichao Zhu Chaosheng Song Huali Han Yao Li | 2019 | Chinese Journal of Mechanical Engineering2019，32，2： | 7 |
| 14 | Gene Cloning and Expression of the Pyrroline-5-carboxylate Reductase Gene of Perennial Ryegrass(Lolium perenne)显示文摘Salt and drought limit the range of applications of perennial ryegrass(Lolium perenne L.), which is one of the important turf and forage grasses. Previous studies have suggested that pyrroline-5-carboxylate reductase(P5CR) might play a central role in proline accumulation in plants that are responsive to stresses. In the present study, the Lolium perenne L. pyrroline-5-carboxylate reductase(LpP 5CR) gene was cloned from leaves of the cultivar ‘Derby' using the RACE technique. The full-length LpP 5CR gene was 1 047 bp in length, which comprised an open reading frame(ORF) of 840 bp in size. Sequence alignment revealed that the putative Lp P5 CR had a 94.3% similarity to Ta P5 CR. q RT-PCR displayed that the mR NA levels of the LpP 5CR gene were almost the same as that in the roots, stems, and leaves of perennial ryegrass seedlings subjected to normal condition or NaC l treatment for 1 h. Moreover, the transcription level of LpP 5CR was up- or down- regulated with Na Cl, polyethylene glycol(PEG), cold, or abscisic acid(ABA) treatment for 3 to 48 h. In addition, confocal microscopy localized the GFP-Lp P5 CR fusion protein to the cytoplasm of onion epidermal cells. These findings suggest that LpP 5CR encodes a cytoplasmic P5 CR protein that plays an important role in the response of perennial ryegrass to various stresses. | CAO Li WEI Shuqiang HAN Lei QIAN Yongqiang ZHANG Huali XIN Haibo SUN Zhenyuan | 2015 | Horticultural Plant Journal2015，1，2： | 7 |
| 15 | The calcium-dependent protein kinase ZmCDPK7 functions in heat-stress tolerance in maize显示文摘Global warming poses a serious threat to crops.Calcium-dependent protein kinases(CDPKs)/CPKs play vital roles in plant stress responses,but their exact roles in plant thermotolerance remains elusive.Here,we explored the roles of heat-induced ZmCDPK7 in thermotolerance in maize.ZmCDPK7-overexpressing maize plants displayed higher thermotolerance,photosynthetic rates,and antioxidant enzyme activity but lower H2 O2 and malondialdehyde(MDA)contents than wild-type plants under heat stress.ZmCDPK7-knockdown plants displayed the opposite patterns.ZmCDPK7 is attached to the plasma membrane but can translocate to the cytosol under heat stress.ZmCDPK7 interacts with the small heat shock protein sHSP17.4,phosphorylates sHSP17.4 at Ser-44 and the respiratory burst oxidase homolog RBOHB at Ser-99,and up regulates their expression.Site-directed mutagenesis of sHSP17.4 to generate a Ser-44-Ala substitution reduced ZmCDPK7’s enhancement of catalase activity but enhanced ZmCDPK7’s suppression of MDA accumulation in heat-stressed maize protoplasts.sHSP17.4,ZmCDPK7,and RBOHB were less strongly upregulated in response to heat stress in the abscisic acid-deficient mutant vp5 versus the wild type.Pretreatment with an RBOH inhibitor suppressed sHSP17.4 and ZmCDPK7 expression.Therefore,abscisic acid-induced ZmCDPK7 functions both upstream and downstream of RBOH and participates in thermotolerance in maize by mediating the phosphorylation of sHSP17.4,which might be essential for its chaperone function. | Yulong Zhao Hanwei Du Yankai Wang Huali Wang Shaoyu Yang Chaohai Li Ning Chen Hao Yang Yihao Zhang Yulin Zhu Luyao Yang Xiuli Hu | 2021 | Journal of Integrative Plant Biology2021，63，3： | 6 |
| 16 | CRISPR/Cas9 editing of wheat TaQ genes alters spike morphogenesis and grain threshability显示文摘The Ta Q alleles as one of the AP2-like transcription factors in common wheat(Triticum aestivum) play an important role in the evolution of spike characteristics from wild and domesticated emmer to modern wheat cultivars. Its loss-of-function mutant not only changed threshability and spike architecture but also affected plant height, flowering time, and floret structure. However, the comprehensive functions of Ta AQ and Ta Dq genes in wheat have not been fully elucidated yet. Here, CRISPR/Sp Cas9 was used to edit wheat Ta AQ and Ta Dq. We obtained homozygous plants in the T1 generation with loss of function of only Ta AQ or Ta Dq and simultaneous loss of function of Ta AQ and Ta Dq to analyze the effect of these genes on wheat spikes and floret shapes. The results demonstrated that the Ta AQ-edited plants and the Ta AQ and Ta Dq simultaneously-edited plants were nearly similar in spike architecture, whereas the Ta Dq-edited plants were different from the wild-type ones only in plant height. Moreover, the Ta AQ-edited plants or the Ta AQ and Ta Dq simultaneously-edited plants were more brittle than the wild-type and the Ta Dqedited plants. Based on the expression profiling, we postulated that the VRN1, FUL2, SEP2, SEP5, and SEP6 genes might affect the number of spikelets and florets per spike in wheat by regulating the expression of Ta Q. Combining the results of this report and previous reports, we conceived a regulatory network of wheat traits, including plant height, spike shape, and floral organs, which were influenced by AP2-like family genes. The results achieved in this study will help us to understand the regulating mechanisms of Ta AQ and Ta Dq alleles on wheat floral organs and inflorescence development. | Huiyun Liu Ke Wang Huali Tang Qiang Gong Lipu Du Xinwu Pei Xingguo Ye | 2020 | Journal of Genetics and Genomics2020，47，9： | 6 |
| 17 | Current Knowledge of Mesozoic Coleoptera from Daohugou and Liaoning(Northeast China)显示文摘现在的纸在从内部蒙古学习的石块翘目上被奉献给概述, Daohugou (中间的侏罗记, Jiulongshan 形成) 并且辽宁(上面的侏罗记降低的白垩纪, Yixian 形成) 用汉语扔了集合。作为结果,从 Hydrophilidae,家庭和亚科 Silphidae,从 Lucanidae 的 Syndesinae, Pleocomidae, Trogidae, Trogissitidae, Pyrochroidae,从 Tenebrionidae 的 Diaperinae,和 Cerambycidae 的部落 Sperchopsini 和 Hydrophilini 的种类首先在中生代被登记,一些家庭被定义为新。在最近的动物志代表的许多总科在中间的侏罗记和更低的白垩纪以内被形成,这被显示出。检验的材料证实 Cucujiformian 甲壳虫因此比 Polyphaga (Staphyliniformia 和 Elateriformia ) 并且,的另外的 infraordera 是一个更年轻的组的假设,他们仅仅在迟了的中生代出现在石块记录。它被显示出并且证实大多数总科在 Cucujoidea 前出现在石块记录。Notocupes Ponomarenko 的同义, 1964;林西诺库佩斯, 1976, syn。nov;谭阿姆洛马, Ren et Liu 2005, syn。nov;谭尤里奥马, Ren et Shih, 2006, syn。nov,非斯坦因, 1899 并且谭奥瓦托库佩斯 et Ren, 2006, syn。nov;Tetraphalerus Waterhouse 的同义, 1901 并且谭奥登托马, Ren et Ge 2006, syn。nov;并且 Priacmopsis Ponomarenko 的同义, 1966 并且谭拉托库佩斯 et Ren, 2006, syn。nov。被建议。Sinorhombocoleus papposus 黝黑的 et Ren, 2009 从家庭 Rhombocoleidae 被转移到 Schizophoridae。Cervicatinius complanus 黝黑, Ren et Shih, 2007 并且 Forticatinius elegans 黝黑, Ren et Shih, 2007 从家庭 Catiniidae (亚目 Archostemata ) 被转移到总科 Cleroidea (亚目 Polyphaga:第一在是的家庭 Peltidae 和秒之中一个密切相关的组到后者家庭) 。家庭 Parandrexidae 从总科 Cucujoidea 被转移到 Cleroidea。过去的生态系统的生态的情形和顺序翘目的历史的开发的假设被讨论。检验的动物志的年龄被考虑。从 Daohugou 和辽宁描述的 taxa 的表被编。 | Alexander G. KIREJTSHUK Alexander G. PONOMARENKO Alexander A. PROKIN CHANG Huali Georgy V. NIKOLAJEV REN Dong | 2010 | Acta Geologica Sinica(English Edition)2010，84，4： | 6 |
| 18 | New fossil elaterid (Coleoptera: Polyphaga: Elateridae) from Yixian Formation of western Liaoning, China显示文摘A new species of the elaterid genus Cryptocoelus Dolin and Nel, 2002 from the Late Jurassic to Early Cretaceous Yixian Formation in the western Liaoning, China is described. Diagnosis of the genus is revised, and the systematic position of the genus is briefly discussed. Because the elaterids originated in the Early to Mid-Jurassic, this new material from the Late Jurassic-Early Cretaceous will enhance our understanding of the transition between ancient elaterids and extant ones, bridge the gap of cryptic relationships between the Mesozoic cupedids and elaterids, and expand our knowledge of their evolutionary history. | Chang Huali Ren Dong Shih Chungkun | 2007 | Progress in Natural Science:Materials International2007，17，10： | 5 |
| 19 | The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial显示文摘Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE ! 0(Odds Ratio, 1.79; 95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ClinicalTrials.gov,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain. | Huaguang Zheng Yilong Wang Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang | 2019 | Science Bulletin2019，64，2： | 5 |
| 20 | New fossil elaterids(Insect:Coleoptera:Polyphaga:Elateridae) from the Middle Jurassic of Inner Mongolia,China显示文摘A new genus with a new species of fossil elaterid,Paraprotagrypnus superbus gen.et sp.nov.,from the Middle Jurassic Jiulongshan Formation in Daohugou Village(N41°18.9790,E119°14.3180),Shantou Township,Ningcheng County,Inner Mongolia,China is described and illustrated.The genus Paraprotagrypnus belongs to the family of Elateridae,subfamily of Protagrypninae and tribe of Protagrypnini.Some primitive characters of the new genus and new species shed light on the ages between the Jiulongshan Formation in Inner Mongolia and the Yixian Formation in the western Liaoning Province of China.The habitat of the new species is briefly discussed. | Huali Chang Yunyun Zhao Dong Ren | 2009 | Progress in Natural Science:Materials International2009，19，10： | 4 |
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