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| 1 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 2 | TT viral infection through blood transfusion:retrospective investigation on patients in a prospective study of post-transfusion hepatitis显示文摘AIM To investigate the role of bloodtransfusion in TT viral infection(TTV).METHODS We retrospectively studied serumsamples from 192 transfusion recipients whounderwent cardiovascular surgery and bloodtransfusion between July 1991 and June 1992.Allpatients had a follow-up every other week for atleast 6 months after transfusion.Eightyrecipients received blood before screeningdonors for hepatitis C antibody(anti-HCV),and112 recipients received screened blood.Recipients with alanine aminotransferase level>2.5 times the upper normal limit were testedfor serological markers for viral hepatitis A,B,C,G,Epstein-Barr virus and cytomegalovirus.TTV infection was defined by the positivity forserum TTV DNA using the polymerase chainreaction method.RESULTS Eleven and three patients,whoreceived anti-HCV unscreened and screened'blood,respectively,had serum ALT levels>90 IU/L.Five patients(HCV and TTV:1;HCV,HGV,and TTV:1;TTV:2;and CMV and TTV:1)were positive for TTV DNA,and four of them hadsero-conversion of TTV DNA.CONCLUSION TTV can be transmitted viablood transfusion.Two recipients infected byTTV alone may be associated with the hepatitis.However,whether TTV was the causal agentremains unsettled,and further studies arenecessary to define the role of TTV infection inchronic hepatitis. | Yang SS Wu CH Chen TH Huang YY Huang CS | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 3 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 4 | Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci:position statement from the Joint SHEA and APIC Task Force显示文摘 | Weber SG Huang SS Oriola S W.Huskins C Noskin GA Harriman K | | American Journal of Infection Control0，，： | 1 |
| 5 | Relationship Betweenmorphism and Cancer Susceptibility- Results of a Meta-analysis 显示文摘 | Zhou TB Yin SS Huang JJ | 2012 | Asian Pac J Cancer Prev2012，13，7： | 1 |
| 6 | Isolation and identification otriester-diterpenoid from the flowers ofAconitum kusnezoffiReichb显示文摘 | Huang ZH Jia SS | 1999 | Acta Pharm Sin1999，34，11： | 1 |
| 7 | Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan显示文摘 | Tsai HC Lee SS Huang CK | | Am J Trop Med Hyg0，71，2： | 1 |
| 8 | Cytotoxicity of dentine bonding agents on human pulp cells is related to intracellular glutathione levels显示文摘 | Huang FM Li YC Lee SS | 2010 | Int Endod J2010，43，12： | 1 |
| 9 | Application of the Sequential Organ Failure Assessment score for predicting mortality in patients with acute myocardial infarction显示文摘 | Huang SS Chen YH Lu TM | 2012 | Resuscitation2012，83，5： | 1 |
| 10 | Attenuation of oxidative stress after varicocelectomy in subfertile patients with varicocele 显示文摘 | Chen SS Huang WJ Chang LS | 2008 | J Urol2008，179，2： | 1 |
| 11 | Legislative mandates for use of active surveillance cultures to screen for methicillin- resistant Staphylococcus aureus and vancomycin-resistant en- terococci: Position statement from the Joint SHEA and APIC Task Force显示文摘 | Weber SG Huang SS Oriola S | 2007 | Am J Infect Control2007，35，2： | 1 |
| 12 | Prevalence and risk factors of urinary incontinence among Chinese women in Shanghai显示文摘 | Liu B Wang L Huang SS | 2014 | Int J Clin Exp Med2014，7，3： | 1 |
| 13 | Neurodevelopment and cog- nition in children after enterovirus 71 infeetion显示文摘 | Chang LY Huang LM Gau SS | 2007 | N Engl J Med2007，356，12： | 1 |
| 14 | Fentanyl-induced cough is a risk factor for postoperative nausea and vomiting 显示文摘 | LI CC CHEN SS HUANG CH | 2015 | Br J Anaesth2015，115，3： | 1 |
| 15 | Effect of anthraquinore derivatives on lipid peroxidation in rat heart mitochonclria:structure activity relationship 显示文摘 | Yeh SF Hong CY | 1995 | J Nst Prad1995，58，9： | 1 |
| 16 | Resveratrol attenuates ischemia-reperfusion-induced leukocyte-endothelial cell adhesive interactions and prolongs allograft survival across the MHC barrier显示文摘 | Hsieh YH Huang SS Wei FC | 2007 | Circ J2007，71，3： | 1 |
| 17 | Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria:structure-activity relationship显示文摘 | Huang SS Yeh SF Hong CY | 1995 | J Nat Prod1995，58，9： | 1 |
| 18 | Detection of permanent three-rooted mandibular first molars by cone-beam computed tomography imaging in Taiwanese individuals 显示文摘 | Tu MG Huang HL Hsue SS | 2009 | J Endod2009，35，4： | 1 |
| 19 | Temporal correlation analysis between malariaand meteorological factors in Motuo County,Tibet 显示文摘 | Huang F Zhou SS Zhang SS | 2011 | Malaria Journal2011，10，： | 1 |
| 20 | Neurodevelopment and cognition in children after enterovirus 71 infection 显示文摘 | Chang LY Huang LM Gau SS | 2007 | N Engl J Med2007，356，12： | 1 |
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