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| 1 | Vertically standing PtSe_2 film: a saturable absorber for a passively mode-locked Nd:LuVO_4 laser显示文摘The novel vertically standing Pt Se2 film on transparent quartz was prepared by selenization of platinum film deposited by the magnetron sputtering method, and an Nd:Lu VO4 passively mode-locked solid-state laser was realized by using the fabricated Pt Se2 film as a saturable absorber. The X-ray diffraction pattern and Raman spectrum of the film indicate its good crystallinity with a layered structure. The thickness of Pt Se2 film is measured to be 24 nm according to the cross-section height profile of the atomic force microscope image. Highresolution transmission electron microscopy images clearly demonstrate its vertically standing structure with an interlayer distance of 0.54 nm along the c-axis direction. The modulation depth(ΔT) and saturation fluence(Φs)of Pt Se2 film are measured to be 12.6% and 17.1 μJ∕cm2, respectively. The obtained mode-locked laser spectrum has a central wavelength of 1066.573 nm, with a 3 d B bandwidth of 0.106 nm. The transform limited pulse width of the mode-locked laser was calculated to be 15.8 ps. A maximum average output power of 180 m W with a working repetition rate of 61.3 MHz is obtained. To the best of our knowledge, this is the first report of the generation of ultrafast mode-locked laser pulses by using layered Pt Se2 as a saturable absorber. | LILI TAO XIAOWEN HUANG JUNSHAN HE YAJUN LOU LONGHUI ZENG YONGHUI LI HUI LONG JINGBO LI LING ZHANG YUEN HONG TSANG | 2018 | Photonics Research2018，6，7： | 8 |
| 2 | Seasonal variation of snow microbial community structure in the East Rongbuk glacier, Mt. Everest显示文摘The bacterial diversity and abundance in the snow of East Rongbuk glacier, Mt. Everest were examined through 16S rRNA gene clone library and flow cytometry approaches. In total, 35 16S rRNA gene sequences were obtained, which belong to α, β, γ-Proteobacteria, Actinobacteria, Firmicutes, CFB, Cyanobacteria, Eukaryotic chloroplast, and TM7 candidate phylum respectively. γ-Proteobacteria was the dominant bacterial group in this region, while the genera Acinetobacter and Leclercia were domi- nant on the genus level. The community structure varied seasonally. The bacterial abundance in sum- mer snow was higher than that in winter. Moreover, the snow bacterial community structures in both seasons were diverse, with not only common species but season-specific species. The common species most likely originated from the Tibet Plateau. Bacteria in summer snow are affiliated with marine environ- ment, whereas bacteria in winter snow are closely related to more diverse environments and show the feature of resistance to cold. Seasonal variations of abundance and bacterial diversity were most proba- bly due to the seasonal characteristics of climate and atmospheric circulation in Mt. Everest. | LIU Yongqin YAO Tandong KANG Shichang JIAO Nianzhi ZENG Yonghui SHI Yang LUO Tingwei JING Zhefang HUANG Shijun | 2006 | Chinese Science Bulletin2006，51，12： | 7 |
| 3 | Comparison of efficacy, safety, and quality of life between sorafenib and sunitinib as first.line therapy for Chinese patients with metastatic renal cell carcinoma显示文摘Background: Sorafenib and sunitinib are widely used as first-line targeted therapy for metastatic renal cell carcinoma(mRCC) in China.This study aimed to compare the efficacy, safety, and quality of life(QoL) in Chinese mRCC patients treated with sorafenib and sunitinib as first-line therapy.Methods: Clinical data of patients with mRCC who received sorafenib(400 mg twice daily; 4 weeks) or sunitinib(50 mg twice daily; on a schedule of 4 weeks on treatment followed by 2 weeks off) were retrieved. Primary outcomes were overall survival(OS), progression-free survival(PFS), adverse events(AEs), and QoL(SF-36 scores), and secondary outcomes were associations of clinical characteristics with QoL.Results: Medical records of 184 patients(110 in the sorafenib group and 74 in the sunitinib group) were reviewed.PFS and OS were comparable between the sorafenib and sunitinib groups(both P > 0.05).The occurrence rates of leukocytopenia, thrombocytopenia, and hypothyroidism were higher in the sunitinib group(36.5% vs. 10.9%,P< 0.001; 40.5% vs. 10.9%, P < 0.001; 17.6% vs. 3.6%, P = 0.001), and that of diarrhea was higher in the sorafenib group(62.7% vs. 35.2%, P < 0.001). There was no significant difference in SF-36 scores between the two groups. Multivariate analysis indicated that role-physical and bodily pain scores were associated with the occurrence rate of grade 3 or 4 AEs(P = 0.017 and 0.005).Conclusions: Sorafenib has comparable efficacy and lower toxicity profile than sunitinib as first-line therapy for mRCC. Both agents showed no significant impact on QoL of patients. | Wen Cai Wen Kong Baijun Dong Jin Zhang Yonghui Chen Wei Xue Yiran Huang Lixin Zhou Jiwei Huang | 2017 | Chinese Journal of Cancer2017，36，11： | 6 |
| 4 | Allergic diseases, immunoglobulin E, and autoimmune pancreatitis: a retrospective study of 22 patients显示文摘 | Guo Limei Huang Yonghui Wang Tianli Shi Xueying Chang Hong Yao Wei Huang Xuebiao | 2014 | Chinese Medical Journal2014，，23： | 5 |
| 5 | Active flutter suppression of a multiple-actuated-wing wind tunnel model显示文摘In this study, a multi-input/multi-output(MIMO) time-delay feedback controller is designed to actively suppress the flutter instability of a multiple-actuated-wing(MAW) wind tunnel model in the low subsonic flow regime. The unsteady aerodynamic forces of the MAW model are computed based on the doublet-lattice method(DLM). As the first attempt, the conventional linear quadratic-Gaussian(LQG) controller is designed to actively suppress the flutter of the MAW model. However, because of the time delay in the control loop, the wind tunnel tests illustrate that the LQG-controlled MAW model has no guaranteed stability margins. To compensate the time delay, hence, a time-delay filter, approximated via the first-order Pade approximation, is added to the LQG controller. Based on the time-delay feedback controller, a new digital control system is constructed by using a fixed-point and embedded digital signal processor(DSP) of high performance. Then, a number of wind tunnel tests are implemented based on the digital control system.The experimental results show that the present time-delay feedback controller can expand the flutter boundary of the MAW model and suppress the flutter instability of the open-loop aeroelastic system effectively. | Qian Wenmin Huang Rui Hu Haiyan Zhao Yonghui | 2014 | Chinese Journal of Aeronautics2014，27，6： | 5 |
| 6 | Microbial community structure in major habitats above 6000 m on Mount Everest显示文摘Bacterial abundance in surface snow between 6600 and 8000 m a.s.l. on the northern slope of Mt. Ev- erest was investigated by flow cytometry. Bacterial diversity in serac ice at 6000 m a.s.l., glacier melt- water at 6350 m, and surface snow at 6600 m a.s.l. was examined by constructing a 16S rRNA gene clone library. Bacterial abundance in snow was higher than that in the Antarctic but similar to other mountain regions in the world. Bacterial abundance in surface snow increased with altitude but showed no correlation with chemical parameters. Bacteria in the cryosphere on Mt. Everest were closely related to those isolated from soil, aquatic environments, plants, animals, humans and other frozen environ- ments. Bacterial community structures in major habitats above 6000 m were variable. The Cyto- phaga-Flavobacterium-Bacteroides (CFB) group absolutely dominated in glacial meltwater, while β-Proteobacteria and the CFB group dominated in serac ice, and β-Proteobacteria and Actinobacteria dominated in surface snow. The remarkable differences among the habitats were most likely due to the bacterial post-deposition changes during acclimation processes. | LIU YongQin YAO TanDong KANG ShiChang JIAO NianZhi ZENG YongHui HUANG SiJun LUO TingWei | 2007 | Chinese Science Bulletin2007，52，17： | 5 |
| 7 | Epitope peptides of influenza H3N2 virus neuraminidase gene designed by immunoinformatics显示文摘病毒表面蛋白质 neuraminidase (NA ) 是在流行性感冒的主要子类型特定的抗原类型 A 病毒。Neuraminidase 作为酶工作打破在红血球凝聚素之间的契约(哈) 并且到版本的 sialic 酸最新从感染的房间形成了病毒。在这研究,从 H3N2 子类型病毒的 NA 基因被定序, NA 蛋白质为 B 房间 epitopes 被屏蔽并且基于 immunoinformatics 估计了。把信息,三肽 ES8, RR9,和 WK7 基于这(盖住氨基酸残余 221228, 292300,和 383389,分别地) NA,蛋白质人工地被选择并且综合。这些肽被用来皮下地使新西兰兔子免疫提起 antisera。结果证明这三肽能够以一种特定、敏感的方式对 H3N2 病毒得到抗体,由连接酶的 immunosorbent 在 vitro 检测了试金。而且, hemadsorption 释放反的效果在 1:40 的冲淡发生在三 antisera 混合物。用数据库软件的排列证明在这三 epitope 肽的氨基酸残余在在这研究定序的所有 NA 在特定的地点被代替。我们建议这些 NA epitope 肽可能被使用与一起哈蛋白质同样疫苗的抗原。 | Lijun Liang Ping Huang Miaoheng Wen Hanzhong Ni Songnuan Tan Yonghui Zhang Qiuxia Chen | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 4 |
| 8 | Increasing the hole energy by grading the alloy composition of the p-type electron blocking layer for very high-performance deep ultraviolet light-emitting diodes显示文摘It is well known that the p-type AlGaN electron blocking layer(p-EBL) can block hole injection for deep ultraviolet light-emitting diodes(DUV LEDs). The polarization induced electric field in the p-EBL for [0001] oriented DUV LEDs makes the holes less mobile and thus further decreases the hole injection capability. Fortunately,enhanced hole injection is doable by making holes lose less energy, and this is enabled by a specifically designed p-EBL structure that has a graded AlN composition. The proposed p-EBL can screen the polarization induced electric field in the p-EBL. As a result, holes will lose less energy after going through the proposed p-EBL, which correspondingly leads to the enhanced hole injection. Thus, an external quantum efficiency of 7.6% for the 275 nm DUV LED structure is obtained. | ZI-HUI ZHANG JIANQUAN KOU SUNG-WEN HUANG CHEN HUA SHAO JIAMANG CHE CHUNSHUANG CHU KANGKAI TIAN YONGHUI ZHANG WENGANG BI HAO-CHUNG KUO | 2019 | Photonics Research2019，7，4： | 4 |
| 9 | Comparison of efficacy and safety among axitinib,sunitinib,and sorafenib as neoadjuvant therapy for renal cell carcinoma:a retrospective study显示文摘Dear editor,Renal cancer accounts for approximately 2%of all can-cer deaths worldwide,and renal cell carcinoma(RCC)is the predominant subtype[1].Radiotherapy and chemo-therapy have been found to have limited roles in the treatment of RCC.However,the treatment outcomes of metastatic RCC(mRCC)have been improved drastically since the application of molecular targeted therapeutic agents such as tyrosine kinase inhibitors(TKIs).TKIs have been gradually used for the preoperative treatment of RCC. | Wen Cai Biao Cai Juan Zhou Yonghui Chen Jin Zhang Yiran Huang Wei Xue Jiwei Huang | 2019 | Cancer Communications2019，39，1： | 4 |
| 10 | Association of post.treatment hypoalbuminemia and survival in Chinese patients with metastatic renal cell carcinoma显示文摘Background:Hypoalbuminemia adversely affects the clinical outcomes of various cancers.The purpose of this study was to estimate the prognostic value of hypoalbuminemia 3-5 weeks after treatment in patients with metastatic renal cell carcinoma(mRCC) who received sorafenib or sunitinib as first-line treatment.Methods:In this single-center,retrospective study,we assessed the progression-free survival(PFS) and overall survival(OS) of 184 mRCC patients who received first-line sorafenib or sunitinib treatment.PFS and OS were compared between patients with post-treatment hypoalbuminemia(post-treatment albumin level <36.4 g/L) and those with normal post-treatment albumin level(albumin level≥36.4 g/L).The Memorial Sloan Kettering Cancer Center(MSKCC)risk model stratified mRCC patients into three risk categories.Prognostic values of all patient characteristics including MSKCC risk category were determined by using univariate and multivariate Cox regression models.Prognostic value was further determined using the Harrell concordance index and receiver operating characteristic curve analysis.Results:The median PFS and OS of the 184 patients were 11 months(95%confidence interval[CI]9-12 months)and 23 months(95%CI 19-33 months),respectively.Patients with post-treatment hypoalbuminemia had significantly shorter median PFS(6 months[95%CI 5-7 months]) and OS(11 months[95%CI 9-15 months]) than patients who had normal post-treatment albumin levels(PFS:12 months[95%CI 11-16 months],P < 0.001;OS:31 months[95%CI24-42 months],P < 0.001),respectively.Multivariate analysis showed that post-treatment hypoalbuminemia was an independent predictor of PFS(hazard ratio[HR],2.113;95%CI 1.390-3.212;P < 0.001) and OS(HR,2.388;95%CI 1.591-3.585;P < 0.001).Post-treatment hypoalbuminemia could also be combined with the MSKCC risk category for better prediction about OS.The model that included post-treatment hypoalbuminemia and MSKCC risk category improved the predictive accuracy for PFS and OS(c-index:0.68 and 0.73,respectively) compared with the basic MSKCC risk model(c-index:0.67 and 0.70,respectively).The prognostic values for PFS and OS of the integrated MSKCC risk model involving post-treatment hypoalbuminemia were significantly more accurate than the basic MSKCC risk model using likelihood ratio analysis(both P < 0.001).Conclusions:Post-treatment hypoalbuminemia can be considered an independent prognostic factor for patients with mRCC who undergo first-line treatment with tyrosine kinase inhibitors.Additionally,integrating post-treatment serum albumin level into the basic MSKCC risk model can improve the accuracy of this model in predicting patient overall survival and progression-free survival. | Wen Cai Jin Zhang Yonghui Chen Wen Kong Yiran Huang Jiwei Huang Lixin Zhou | 2017 | Chinese Journal of Cancer2017，36，7： | 3 |
| 11 | Advances in prostate cancer research models:From transgenic mice to tumor xenografting models显示文摘The identification of the origin and molecular characteristics of prostate cancer(PCa)has crucial implications for personalized treatment.The development of effective treatments for PCa has been limited;however,the recent establishment of several transgenicmouse lines and/or xenografting models is better reflecting the disease in vivo.With appropriate models,valuable tools for elucidating the functions of specific genes have gone deep into prostate development and carcinogenesis.In the present review,we summarize a number of important PCa research models established in our laboratories(PSA-Cre-ERT2/PTEN transgenic mouse models,AP-OX model,tissue recombination-xenografting models and PDX models),which represent advances of translational models from transgenic mouse lines to human tumor xenografting.Better understanding of the developments of these models will offer new insights into tumor progression and may help explain the functional significance of genetic variations in PCa.Additionally,this understanding could lead to new modes for curing PCa based on their particular biological phenotypes. | Yuejiao Huang Chun Cheng Chong Zhang Yonghui Zhang Miaomiao Chen Douglas W.Strand Ming Jiang | 2016 | Asian Journal of Urology2016，3，2： | 3 |
| 12 | Synthesis and characterization of muhifunctional poly(glycidyl methacry late) microspheres and their use in ceil separation显示文摘 | Dong Xiaoqing Zheng Yonghui Huang Yubin | 2010 | Analytical Biochemistry2010，405，2： | 1 |
| 13 | Global Exponential Stability of BAM Neural Networks with Transmission Delays and Nonlinear Impulses 显示文摘 | HUANG Zhenkun XIA Yonghui | 2008 | Chaos Solitons and Fractals2008，38，2： | 1 |
| 14 | Finite element analysis and experimental study on high strength bolted friction grip connections in steel bridges显示文摘 | HUANG Yonghui | 2010 | Journal of Constructional Steel Research2010，6，66： | 1 |
| 15 | Active micro-vibration control based on improved variable step size LMS algorithm显示文摘The contradiction of variable step size least mean square(LMS)algorithm between fast convergence speed and small steady-state error has always existed.So,a new algorithm based on the combination of logarithmic and symbolic function and step size factor is proposed.It establishes a new updating method of step factor that is related to step factor and error signal.This work makes an analysis from 3 aspects:theoretical analysis,theoretical verification and specific experiments.The experimental results show that the proposed algorithm is superior to other variable step size algorithms in convergence speed and steady-state error. | 李相敏 Fang Yubin Zhu Xiaojin Huang Yonghui Zhou Yijia | 2020 | High Technology Letters2020，26，2： | 1 |
| 16 | Model test and numerical analysis of a special joint for a truss bridge显示文摘 | WANG Ronghui HUANG Yonghui LI Qiusheng | 2009 | Journal of Constructional Steel Research2009，65，6： | 1 |
| 17 | Synthesis and characterization of multifunctional poly(glycidyl methacry- late) microspheres and their use in ceil separation显示文摘 | Dong Xiaoqing Zheng Yonghui Huang Yubin | 2010 | Anal Bio- chem2010，405，20： | 1 |
| 18 | Existence of almost periodic solutions for forced perturbed systems with piecewise constant argument显示文摘 | Yonghui XIA Zhengkui HUANG Maoan HAN | | 0，，02： | 1 |
| 19 | Finite element analysis and experimental study on high strength bolted friction grip connections in steel bridges显示文摘 | Huang Yonghui Wang Ronghui Zou Jinhua | 2010 | Journal of Constructional Steel Research2010，66，6： | 1 |
| 20 | Finite element analysis and experimental study on high strength bolted friction grip connections in steel bridges显示文摘 | HUANG Yonghui WANG Ronghui | 2010 | Journal of Constructional Steel Research2010，66，6： | 1 |
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