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| 1 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 2 | Expression of KL-6/MUC1 in pancreatic cancer tissues and its potentialinvolvement in tumor metastasis显示文摘 | Huanli Xu Yoshinori Inagaki Yasuji Seyama Guanhua Du Fengshan Wang Norihiro Kokudo Wei Tang | 2011 | Oncology Reports2011，，2： | 2 |
| 3 | 3-D electrical impedance tomography forward problem with finite element method显示文摘 | Xu Guizhi Wu Huanli Li Ying | 2005 | IEEE Trans on Magn2005，41，5： | 1 |
| 4 | Research advances of antimicrobial peptides and applications in food industry and agriculture 显示文摘 | MENG Shuo XU Huanli WANG Fengshan | 2010 | Curr Protein Pept Sci2010，11，4： | 1 |
| 5 | 3-D electri- cal impedance tomography forward problem with finite element method显示文摘 | Xu Guizhi Wu Huanli Yang Shuo | 2005 | IEEE Transactions on Magnetics2005，41，5： | 1 |
| 6 | High carrier mobility and strong fluorescence emission: Toward highly sensitive single-crystal organic phototransistors显示文摘Organic single crystals(OSCs)offer a unique combination of both individual and collective properties of the employed molecules,but it remains highly challenging to achieve OSCs with both high mobilities and strong fluorescence emissions for their potential applications in multifunctional optoelectronics.Herein,we demonstrate the design and synthesis of two novel triphenylamine-functionalized thienoacenes-based organic semiconductors,4,8-distriphenylamineethynylbenzo[1,2-b:4,5-b′]dithiophene(4,8-DTEBDT)and 2,6-distriphenylamineethynylbenzo[1,2-b:4,5-b′]dithiophene(2,6-DTEBDT),with high-mobility and strong fluorescence emission.The two compounds show the maximum mobilities up to 0.25 and 0.06 cm^(2) V^(-1) s^(-1),the photoluminescence quantum yields(PLQYs)of 51% and 45%,and the small binding energies down to 55.13 and 58.79 meV.The excellent electrical and optical properties ensured the application of 4,8-DTEBDT and 2,6-DTEBDT single crystals in ultrasensitive UV phototransistors,achieving high photoresponsivity of 9.60×105 and 6.43×10^(4) AW^(-1),and detectivity exceeding 5.68×10^(17) and 2.99×10^(16) Jones. | Jingwei Tao Zhaoyang Liu Dan Liu Huanli Dong Jiangbo Jing Jiaxing Song Leijing Liu Bin Xu Wenjing Tian | 2023 | Aggregate2023，4，2： | 0 |
| 7 | Highly delocalized endohedral metal in Gd@C2v(9)-C82 metallofullerenes co-crystallized with α-Se显示文摘 | Cheng Li Xuejiao J. Gao Huanli Yao Huan Huang Rongli Cui Xihong Guo Lele Zhang Bing Liu Binggang Xu Weiqun Shi Jinquan Dong Lai Feng Xingfa Gao Baoyun Sun | 2018 | Nano Research2018，11，4： | 0 |
| 8 | Hexyl substitution of pentathienoacene toward a significant improvement in charge transport显示文摘A novel semiconductor, dihexyl-substituted pentathienoacene(C6-PTA) is designed and synthesized in five steps with the total yield up to 25.2%. The introduction of hexyl chains endow the thin film semiconductor with about threefold increase in carrier mobility and one to three orders of magnitude improvement in current on/off ratio. Furthermore, single crystal FETs based on C6-PTA exhibited mobility up to 0.64 cm^2 V^(-1) s^(-1), which is over 50 times higher than the thin film counterpart. The results indicate clearly that C6-PTA is a promising organic semiconductor with high stability. | Ping He Hantang Zhang Chunhui Xu Yonggang Zhen Huanli Dong Wenping Hu | 2019 | Chinese Chemical Letters2019，30，4： | 0 |
| 9 | Delay-dependent state feedback robust stabilization for uncertain singular time-delay systems显示文摘The problem of robust stabilization for uncertain singular time-delay systems is studied.First,a new delay-dependent asymptotic stability criteria for normal singular time-delay systems is given,which is less conservative.Using this result,the problem of state feedback robust stabilization for uncertain singular time-delay systems is discussed.Finally,two examples are given to illustrate the effectiveness of the results. | Gao Huanli Xu Bugong | 2008 | Journal of Systems Engineering and Electronics2008，19，4： | 0 |
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