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| 1 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 2 | Molecular mechanisms underlying the effects of acupuncture on neuropathic pain显示文摘Acupuncture has been used to treat neuropathic pain for a long time,but its mechanisms of action remain unknown.In this study,we observed the effects of electroacupuncture and manua acupuncture on neuropathic pain and on ephrin-B/EphB signaling in rats models of chronic constriction injury-induced neuropathic pain.The results showed that manual acupuncture and electroacupuncture significantly reduced mechanical hypersensitivity following chronic constriction injury,especially electroacupuncture treatment.Real-time PCR results revealed that ephrin-B1/B3and EphB1/B2 mRNA expression levels were significantly increased in the spinal dorsal horns of chronic constriction injury rats.Electroacupuncture and manual acupuncture suppressed the high expression of ephrin-B1 mRNA,and elevated EphB3/B4 mRNA expression.Electroacupuncture significantly enhanced the mRNA expression of ephrin-B3 and EphB3/B6 in the dorsal horns of neuropathic pain rats.Western blot results revealed that electroacupuncture in particular,and manual acupuncture,significantly up-regulated ephrin-B3 protein levels in rat spinal dorsal horns The results of this study suggest that acupuncture could activate ephrin-B/EphB signaling in neuropathic pain rats and improve neurological function. | Ziyong Ju Huashun Cui Xiaohui Guo Huayuan Yang Jinsen He Ke Wang | 2013 | Neural Regeneration Research2013，8，25： | 8 |
| 3 | Preparation of Al-Al_3Ti in situ composites by direct reaction method显示文摘Al-Al_3Ti composites 被一个直接反应方法准备,在 whichAl_3Ti 被 Ti 和艾尔的反应在铝合金形成融化。Al_3Tichanges 的形态学显然从好粒子,对有 Al_3Ticontent 的增加的大块像针。镁罐头的增加显著地改变 Al_3Ti 的形态学并且减少他们的尺寸。短像杆的 Al_3Ti 被形成,同类的分发与 3 wt.% Mg 的增加被获得。Al-Al_3Ti composites 和机制的微观结构上的 Al_3Ti 和 Mg 的效果也被讨论。 | YU Huashun CHEN Hongmei SUN Liming MIN Guanghui | 2006 | Rare Metals2006，25，1： | 7 |
| 4 | Effects of composite scale on high temperature oxidation resistance of Fe-Cr-Ni heat resistant alloy显示文摘Fe-Cr-Ni heat resistant alloys with aluminum and silicon addition,alone and in combination,were melted using an intermediate frequency induction furnace with a non-oxidation method.By the oxidation weight gain method,the oxidation resistances of the test alloys were determined at 1,200 oC for 500 hours.According to the oxidation weight gains,the oxidation kinetic curves were plotted and the functions were regressed by the least squares method.The results show that the oxidation kinetic curves follow the power function of y = axb(a>0,0 | Wang Haitao Wang Yuqing Yu Huashun Min Guanghui Wang Zhifu | 2009 | China Foundry2009，6，2： | 6 |
| 5 | Microstructure and Tensile Properties of ZK60 Alloy Fabricated by Simplified Rapid Solidification Powder Metallurgy (S-RS P/M) Process显示文摘This study investigated the microstructures and mechanical properties of ZK60 alloy prepared by a simplified rapid solidification powder metallurgy (RS P/M) processing system (S-RS P/M), which consists of warm press in dry air and hot extrusion. Microstructure characterizations showed that S-RS P/M alloy consisted of magnesium matrix and oxide stringers of~1 μm in width. TEM (transmission electron microscopy) observations illustrated nano-size magnesia particles (10-30 nm) constituted oxide stringer in detail. Due to a relatively higher volume of nano-size magnesia particle produced during S-RS P/M process, 0.2% yield strength of S-RS P/M ZK60 alloy was found to be as high as 382 MPa, which is 10% higher than that of RS P/M alloy. The improvement in mechanical properties is mainly attributed to the combination effects of Orowan mechanism and coefficient of thermal expansion (CTE) mismatch because of the approximately same average grain size. | Zhenya Zhang, Huashun Yu , Shaoqing Wang, Haitao Wang and Guanghui Min Key Laboratory of Liquid Structure and Heredity of Materials, Ministry of Education, Shandong University, Jinan 250061, China | 2010 | Journal of Materials Science & Technology2010，26，2： | 5 |
| 6 | Al-Si/Al_2O_3 in situ composite prepared by displacement reaction of CuO/Al system显示文摘Al2O3 particle-reinforced ZL109 composite was prepared by in situ reaction between CuO and Al.The microstructure was observed by means of OM,SEM and TEM.The Al2O3 particles in sub-micron sizes distribute uniformly in the matrix,and the Cu displaced from the in situ reaction forms net-like alloy phases with other alloy elements.The hardness and the tensile strength of the composites at room temperature have a slight increase as compared to that of the matrix.However,the tensile strength at 350 ℃ has reached 90.23 MPa,or 16.92 MPa higher than that of the matrix.The mechanism of the reaction in the CuO/Al system was studied by using of differential scanning calorimetry(DSC) and thermodynamic calculation.The reaction between CuO and Al involves two steps.First,CuO reacts with Al to form Cu2O and Al2O3 at the melting temperature of the matrix alloy,and second,Cu2O reacts with Al to form Cu and Al2O3 at a higher temperature.At ZL109 casting temperature of 750-780 ℃,the second step can also take place because of the effect of exothermic reaction of the first step. | Zhang Jing Yu Huashun Chen Hongmei Min Guanghui | 2010 | China Foundry2010，7，1： | 3 |
| 7 | Fabrication of AlN-TiC/Al composites by gas injection processing显示文摘The fabrication of AlN-TiC/Al composites by carbon- and nitrogen-containing gas injection into Al-Mg-Ti melts was studied. It was shown that AlN and TiC particles could be formed by the in situ reaction of mixture gas (N2 + C2H2 + NH3) with Al-Mg-Ti melts. The condition for the formation of AlN was that the treatment temperature must be higher than 1373 K, and the amounts of AlN and TiC increased with the increase of the treatment temperature and the gas injection time. It was considered that AlN was formed by the direct reaction of Al with nitrogen-containing gas at the interface of the gas bubble and the melt. However, the mechanism of TiC formation is a combination mechanism of solution-precipitation and solid-liquid reaction. | YU Huashun CHEN Hongmei MA Rendian MIN Guanghui | 2006 | Rare Metals2006，25，6： | 3 |
| 8 | Operation of the CSNS Penning surface H^- ion source显示文摘The accelerator complex of the China Spallation Neutron Source (CSNS) consists of a H- linear accelerator (linac) and a rapid cycling synchrotron (RCS). The linac contains a Penning surface H- ion source. The designed energy and the beam current of the source are 50 keV and 20 mA respectively, with a normalized root mean square (norm. rms.) emittance of 0.2π mm mrad. The manufactures and tests of the discharge chamber are in great progress. The construction of H- ion source test stand has been completed, and the operation of the source is also in progress. Stable H- ion beams with energy of 50 keV and current up to 50 mA are attained. Emittance measurement for the H- beam is being prepared. | WU XiaoBing OUYANG HuaFu CHI YunLong HE Wei HUANG Tao LI Gang LIU YingMan LU YanHua XU TaoGuang ZHANG JunSong ZHANG HuaShun ZHAO FuXiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 2 |
| 9 | Microstructural Evolution of Rapidly Solidified ZK60 Powders during Extrusion显示文摘The microstructural evolution of rapidly solidified(RS) ZK60 powders extruded at 250 C was investigated.It was shown that formation of new ultrafine grains took place through continuous dynamic recrystallization(CDRX),accompanied by the perfect bonding of powders via severe plastic deformation.At a low strain level,a well-defined structure made up of equiaxed and elongated subgrains was developed.Simultaneously,the operation of basal and non-basal dislocation slip led to the formation of low-angle dislocation cells(LADC) within the elongated subgrains.With increasing strain,the number and average misorientation of LADC increased,resulting in fragmentation of original elongation subgrains into a finally homogeneous fine-grained structure.Almost full-recrystallized structure with an average grain size of 0.4 μm was finally evolved after large cumulative strain.The results suggested that structural change was connected with thermal strain,where dislocation activities dominated this process. | Zhenya Zhang Huashun Yu Shaoqing Wang Hui Yu Guanghui Min | 2011 | Journal of Materials Science & Technology2011，27，2： | 2 |
| 10 | Fabrication and oxidation behavior of LaB6-ZrB2 composites 显示文摘 | Gao Ruilan Min Guanghui Yu Huashun | 2005 | Ceramics International2005，31，1： | 1 |
| 11 | Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Monlb显示文摘 | Ximing Shao Yi Liu Qian Yu Zhihao Ding Wenyu Qian Lei Zhang Jianchao Zhang Nan Jiang Linfei Gui Zhiheng Xu Yang Hong Yifan Ma Yanjie Wei Xiaoqing Liu Changan Jiang Minyan Zhu Hongchang Li Huashun Li | 2016 | Cell Research2016，26，5： | 1 |
| 12 | Effects of boron, silicon on structure and properties of Fe-based superalloy 显示文摘 | Wang Haitao Yu Huashun Wang Yuqing | 2009 | Advanced Materials Research2009，7982，： | 1 |
| 13 | The formation of AlN and TiN particles during nitrogen bearing gas injection into Al–Mg–Ti melt显示文摘 | Yu Huashun J.D. Kim S.B. Kang | 2004 | Materials Science & Engineering A2004，，1： | 1 |
| 14 | Effects of composite oxide scale on oxidation resistance of superalloy K273显示文摘A Si-containing K273 superalloy was made using intermediate frequency induction furnace in the study. In the testing of oxidation resistance,the oxidation process of the alloy specimens during the testing at 900℃ for 500 h was examined by oxidation weight gain method.The morphology and composition of the oxide scales were determined using scanning electron microscope(SEM)and X-ray diffraction(XRD),respectively.The effects of the transferring of ions and electrons on the oxidation resistance were further analyzed microscopically by semiconductor oxide models.The results show that the composite oxide scales consist of Cr2O3,SiO2 and spinel- type oxide MCr2O4,with flat and compact structure,and fine grains in uniform distribution.All of these endow the superalloy K273 with strong oxidation resistance.The reason for the powerful oxidation resistance of the composite scale is that the formation process of P+N type semiconductor oxide enables to consume most of the surplus negative and positive ions in the oxide scales,which makes the number of the mobile ions and electrons dropped enormously,and the transfer rate of them falls heavily.So the oxidation rate of the metal phase in the alloy matrix is reduced significantly. | Wang Haitao Tan Jiwen Chu Zhong Yu Huashun | 2012 | China Foundry2012，9，2： | 1 |
| 15 | Correlation between microstructure and tensile properties in powder metallurgy AZ91 alloys显示文摘 | Zhenya Zhang Huashun Yu Gang Chen Hui Yu Changzheng Xu | 2011 | Materials Letters2011，，17： | 1 |
| 16 | PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice显示文摘 | Chen Sun Jing Zhao Yecheng Jin Congzhe Hou Wen Zong Tingting Lu Huashun Li Jiangang Gao | 2014 | NeuroReport2014，，3： | 1 |
| 17 | Effect of heat treatment on microstructure and mechanical properties of twin roll cast and sequential warm rolled ZK60 alloy sheets显示文摘 | Chen Hongmei Kang Subong Yu Huashun | 2009 | Journal of Alloys and Compounds2009，476，12： | 1 |
| 18 | Strain-dependent constitutive analysis of hot deformation and hot workability of T4-treated ZK60 magnesium alloy显示文摘 | Hui Yu Huashun Yu Guanghui Min Sung Soo Park Bong Sun You Young Min Kim | 2013 | Metals and Materials International2013，，4： | 1 |
| 19 | The formation of AIN and TiN particles during nitrogen bearing gas injection into Al- Mg- Ti melt显示文摘 | Yu Huashun Kim J D Kang S B | 2004 | Materials Science and Engineering2004，386，： | 1 |
| 20 | Oxidation process of lanthanum hexaboride ceramics显示文摘Oxidation process of lanthanum hexaboride (LaB6) ceramic powder was investigated . The LaB6 powder samples were heated continually from room temperature to 1 473 K at a heating rate of 10 K/min by differential scanning calorimetry. The oxidation tests were conducted at different exposure temperatures. The phases and morphologies of the samples before and after exposure were analyzed by XRD and SEM. It was pointed out that before 1 273 K, LaB6 has high oxidation resistant ability, which was due to that the oxide layer hinders the oxygen diffusion from outer to the surface of LaB6 grains. The oxide layer was composed of the transition phases, which were composed of La2O3 and B2O3 formed from the initial oxidation; when the oxidation temperature exceeded 1 273 K, protective layer was destroyed due to the vaporization of liquid B2O3. Based on the results of X-ray diffraction analysis, oxidation process of LaB6 ceramic powder can be described as follows: Before 1 273 K, lanthanum borate,La(BO2)3 was formed on the surface of samples, then lanthanum oxide (La2O3) and boron oxide (B2O3) were present on the surface of samples oxidized when the temperature reached to 1 473 K. | ZHENG Shuqi, MIN Guanghui, ZOU Zengda , YU Huashun, HAN Jiande , and WANG Weiti School of Materials Science and Engineering, Shandong University, Jinan 250061, China | 2002 | Rare Metals2002，21，2： | 0 |
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