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| 1 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 2 | Tat-functionalized Ag-Fe_3O_4 nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery显示文摘In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide(Tat), producing Tat-modified Ag-Fe_3O_4 nanocomposites(Tat-FeAgNPs). To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin(Dox) in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC_(50) of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor(6.772.4% ID of Tat-FeAgNPs).Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%(P ? 0.009), which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles. | Ergang Liu Meng Zhang Hui Cui Junbo Gong Yongzhuo Huang Jianxin Wang Yanna Cui Weibing Dong Lu Sun Huining He Victor C.Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 3 | Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides显示文摘Brain delivery of macromolecular therapeutics(e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier(BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs,new challenges arise for intranasal delivery of proteins because of their larger size and hydrophilicity. In order to overcome the barriers and take advantage of available pathways(e.g., epithelial tight junctions, uptake by olfactory neurons, transport into brain tissues, and intra-brain diffusion), a low molecular weight protamine(LMWP) cell-penetrating peptide was utilized to facilitate nose-to-brain transport. Cell-penetrating peptides(CPP)have been widely used to mediate macromolecular delivery through many kinds of biobarriers. Our results show that conjugates of LMWP–proteins are able to effectively penetrate into the brain after intranasal administration.The CPP-based intranasal method highlights a promising solution for protein therapy of brain diseases. | Tingting Lin Ergang Liu Huining He Meong Cheol Shin Cheol Moon Victor C.Yang Yongzhuo Huang | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 4 |
| 4 | Effects of cooling rate on the microstructure and electrical properties of Dy_2O_3-doped ZnO-based varistor ceramics显示文摘The microstructure, electrical properties, and density of Dy2O3-doped ZnO-based varistor ceramics, prepared us-ing high-energy ball milling (HEBM) and sintered at 800°C, were investigated by increasing the cooling rate in the order of H (slow cooling in furnace) → L (cooling in furnace) → K (cooling in air). With the increase in cooling rate, the grain size and density decreased, the breakdown voltage (V1 mA / mm) increased, and the nonlinear coefficient (α) and leakage current (IL) exhibited extremum. The sample with the cooling type L showed the best properties with the breakdown voltage of 2650 V/mm, α of 20.3, IL of 5.2 μA, and density of 5.42 g/cm3. The barrier height (φB), donor concentration (Nd), density of the interface states (Ns), and barrier width (ω) all exhibited extremum during the alteration in cooling rate. The different relative amount of Bi-rich phase and its distribution as well as the characteristic parameters of grain boundary, resulting from the alteration of cooling rate, led to the changes in the properties of varistor ceramics. | LIU Hongyu KONG Hui JIANG Dongmei SHI Wangzhou MA Xueming ZHANG Huining | 2007 | Rare Metals2007，26，1： | 4 |
| 5 | Significance and strategies in developing delivery systems for bio-macromolecular drugs显示文摘 | Huining HE Qiuling LIANG Meong Cheoi SHIN Kyuri LEE Junbo GONG Junxiao YE Quan LIU Jingkang WANG Victor YANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 2 |
| 6 | Poly(ethylene oxide) macromonomer-grafted polymer nanoparticles synthesised by emulsifier-free emulsion polymerisation显示文摘 | Zuifang Liu Huining Xiao Nicholas Wiseman Anna Zheng | 2003 | Colloid and Polymer Science2003，，9： | 1 |
| 7 | Montmorillonite intercalated with polyaminoamide-epichlorohydrin:preparation,characterization,and sorption behavior显示文摘 | Liu Wenxia Ni Yonghao Xiao Huining | 2004 | Journal of Colloid and Interface Science2004，275，： | 1 |
| 8 | Montmorillonite mtercalated with polyammoam-ide-epichlorohydrin: preparation characterizahon, and sorption behavior显示文摘 | Wenxia Liu Yonghao Ni Huining Xiao | 2004 | Journal of Colloid and Interface Science2004，，275： | 1 |
| 9 | APSCAN:A Parameter Free Algorithm for Clustering显示文摘 | Chen Xiaoming Liu Wanquan Qiu Huining | 2011 | Pattern Recognition Letters2011，32，7： | 1 |
| 10 | Montmorillonite intercala- ted with polyaminoamide- epichlorohydrin: preparation, charac- terization, and sorption behavior 显示文摘 | Liu Wenxia Ni Yonghao Xiao Huining | 2004 | Journal of Colloid and In- terface Science2004，，275： | 1 |
| 11 | Poly (ethylene oxide)macromonomer-grafted polymer nanoparticles synthesised by emulsifier-free emulsion polymerization 显示文摘 | Zuifang Liu Huining Xiao Nicholas Wiseman | 2003 | Colloid and Polymer Science2003，281，： | 1 |
| 12 | Montmorillonite intercalated with polyaminoamide-epichlorohydrin: preparation, characterization, and sorption behavior显示文摘 | Wenxia Liu Yonghao Ni Huining Xiao | 2004 | Journal of Colloid and Interface Science2004，，275： | 1 |
| 13 | Hypertension knowledge in urban elderly patients:compari-son between adherents to traditional Chinese medicine and Western medicine显示文摘Objective To compare knowledge about hypertension between elderly Chinese urban patients with preferences for either traditional Chinese medicine (TCM) or Western medicine (WM). Methods Elderly (≥ 65 years old) patients with hypertension who prefer TCM treatment (n=112) or WM (n=126) were questioned about hypertension. Their answers were compared. Results Only 32.6% of participants correctly identified hypertension as a main risk factor of coronary heart disease and stroke, 22.3% of patients answered that the main purpose of hypertension control was preventing cardiovascular disease. Other major reasons for these patients to seek medical treatment for their hypertension included: persuasion by physicians or their family members (21.6%), alleviating symptoms such as headache and dizziness (16.8%), lowering blood pressure without knowing specific reason (12.4%). The predictors for poor knowledge of hypertension were similar irrespective of preference for WM or TCM treatment, and included those with lower levels of education and older age. Television and newspaper (46.8%) were the most frequent sources of hypertension information for both groups. Among those who preferred TCM treatment, 'TCM has fewer side effects than WM' and'TCM cures disease while WM only alleviates symptoms' were common beliefs held. Conclusion This study shows that knowledge of hypertension is similar among Chinese urban patients with preferences for either WM or TCM treatment and that misunderstandings about hypertension are common among the elderly patients. In order to control hypertension effectively, public health education is necessary. This should target those with a lower level of education and older age. | Jiangping Lin Huining Lei Fang Liu | 2008 | Journal of Geriatric Cardiology2008，5，2： | 1 |
| 14 | Improved method for synthesis of low molecular weight protamine–siRNA conjugate显示文摘RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular weight and strong anionic charge. Considering their remarkable functions in vivo and features that are often desired in drug delivery carriers, biomimetic systems for siRNA delivery become an effective and promising strategy. Based on this, covalent attachment of synthetic cell penetrating peptides(CPP) to siRNA has become of great interest. We developed a monomeric covalent conjugate of low molecular weight protamine(LMWP, a well-established CPP) and siRNA via a cytosol-cleavable disulfide linkage using PEG as a crosslinker. Results showed that the conjugates didn't generate coagulation, and exhibited much better RNAi potency and intracellular delivery compared with the conventional charge-complexed CPP/siRNA aggregates. Three different synthetic and purification methods were compared in order to optimize synthesis efficiency and product yield. The methodology using hetero-bifunctional NHS–PEG–OPSS as a crosslinker to synthesize LMWP–siRNA simplified the synthesis and purification process and produced the highest yield. These results pave the way towards siRNA biomimetic delivery and future clinical translation. | Zhili Yu Junxiao Ye Xing Pei Lu Sun Ergang Liu Jianxin Wang Yongzhuo Huang Seung Jin Lee Huining He | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 1 |
| 15 | Abnormal characteristics and effectiveness evaluation of the micro-seismic signal before the Debao MS4.8 earthquake显示文摘The Debao MS4.8 earthquake occurred in western Guangxi on August 5,2021,near where the Jingxi MS5.2 earthquake occurred in 2019.To study the increasing seismicity in western Guangxi,it is necessary to determine whether there was an anomaly related to the earthquake source near the Pingxiang gravity station,which is located approximately 100 km from the epicenter of the Debao MS4.8 earthquake.In this study,the R-value scoring method was used to analyze the anomaly and evaluate the prediction efficiency of the double frequency(DF)micro-seismic signal vertical displacement(referred to as vertical displacement,VD)and the absolute value of monthly extreme rate(referred to as the monthly rate).Results show that earthquakes larger than MS4.0 in the 350 km range from the Pingxiang station tend to coincide with yearly typhoons,and the VD of micro-seismic signals correspondingly changes from low to high.The Debao MS4.8 earthquake occurred during a gradual VD increase from 0.05×10^(-6)to 0.10×10^(-6)m.When discussing the relationships among R,the rate threshold,and the effective duration of prediction,the rate threshold of the micro-seismic signal converges from 0.00039×10^(-6)to 0.00031×10^(-6)m/month,the effective duration of prediction is approximately 6-10 months,and R also converges from 0.29 to 0.31.By comparing the results of three gPhone gravity stations in Guangxi,we found that the increase of short-term VD before the Debao earthquake was related to the enhancement of the DF micro-seismic signal excited by the typhoon.When the typhoon track was perpendicular to the coastline of China,the possibility of an earthquake occurring was increased.This study provides evidence and reference for the future occurrence period of earthquakes above MS4.0 in western Guangxi. | Jin Wei Huining Huang Ying Jiang Ziwei Liu | 2023 | Geodesy and Geodynamics2023，14，6： | 0 |
| 16 | Current collapse suppressed GaN diodes with 38 Watts high RF power rectifier capability显示文摘Microwave power transmission(MPT)could realize the point-to-point long-distance transfer of energy without any wires,which makes it attractive for solar-powered satellites,drones,and implantable medical devices,and has aroused enormous attention[1].Microwave rectifiers could convert RF(radio frequency)energy into DC(direct current)power,which is the essential element of the receiving end of the MPT system[2,3]. | Kui DANG Zhilin QIU Shudong HUO Peng ZHAN Huining LIU Yachao ZHANG Jing NING Hong ZHOU Jincheng ZHANG | 2024 | Science China(Information Sciences)2024，67，2： | 0 |
| 17 | Effects of EGF and IGF-I on in vitro Maturation and Cleavage of Ovine Oocytes显示文摘The study investigated the effects of epidermal growth factor(EGF) and insulin-like growth factor 1(IGF-I),alone or together,on the in vitro maturation and cleavage of ovine oocytes,aimed to optimize the in vitro maturation conditions for ovine oocytes.The results showed that the maturation and cleavage rates were 71.2% and 45.5% respectively when the medium was supplemented with 50 ng/mL EGF alone,which was significantly higher than other EGF supplemented groups (0,10,20,30,and 40 ng/mL) (P<0.05).The highest maturation and cleavage rates were 72.9% and 45.7% when the EGF concentration reached 100 ng/mL.The maturation and cleavage rates were 70.7% and 58.5% with 40 ng/mL IGF-I supplemented,which were significantly higher than other treatments (0,10,20,60,80,and 100 ng/mL) (P<0.05).The lowest maturation and cleavage rates were 38.8% and 20.0% when the IGF-I concentration reached 100 ng/mL (P<0.05).When 50 ng/mL EGF and 40 ng/mL IGF-I were used concomitantly,the maturation and cleavage rates were 85.6% and 61.0% respectively,which were significantly higher than the treatments with EGF or IGF-I alone (P<0.05). | Chousheng Liu Huining Lu Liping Zhang Zhigang Wang Junjin Zhao Fei Meng | 2011 | Journal of Animal Science and Biotechnology2011，2，1： | 0 |
| 18 | Curcumin based combination therapy for anti-breast cancer: from in vitro drug screening to in vivo efficacy evaluation显示文摘当药抵抗看起来是在 monotherapy 的越来越多的 anticancer 药的一个不可避免的问题时,联合药治疗成为了一个繁荣的方法减少管理的全部的药剂量以及克服癌房间的药抵抗。Curcumin,考虑了作为 chemoresistance 的一块压板根据它的多重反肿瘤的机制在癌症治疗拥有 multifaceted 角色,能显著地便于它的反癌症功能并且改进经由联合用法与的治疗学的效果许多有不同反应机制的另外的药。探索这可能性,四反癌症都拥有药抵抗问题的某个度的化学疗法的代理人,包括三个酷氨酸 kinase 禁止者( erlotinib , sunitinib 和 sorafenib ),那对不同房间小径和典型 anticancer 药 doxorubicin 正在起作用,个别地与 curcumin 被相结合在 vitro 并且在 vivo 检验 synergistic 反肿瘤效果。结果表明在 0.46 的臼齿的比率与 curcumin 相结合的 sunitinib 在 vitro 产出大多数有势力 synergistic 效果,并且因此为进一步的动物评估被选择。为了推进,提高 anticancer 效果,牛的浆液白朊(BSA ) nanoparticles 作为一个搬运人被利用在 situ 交付选择的药联合。在证实的 vivo 调查结果初步我们能由我们的途径在测试动物为延长时间时期维持类似的注射的药比率的假设,从而最大化还最小化这些药的毒性的治疗学的力量。这个工作能在联合药治疗和实现上开创一条新大街如此的药的临床的用途。 | Sunhui Chen Qiuling Liang Shuping Xie Ergang Liu Zhili Yu Lu Sun Meong Cheol Shin Seung Jin Lee Huining He Victor C. Yang | 2016 | Frontiers of Chemical Science and Engineering2016，10，3： | 0 |
| 19 | A creep model for ultra-deep salt rock considering thermal-mechanical damage under triaxial stress conditions显示文摘To investigate the specific creep behavior of ultra-deep buried salt during oil and gas exploitation,a set of triaxial creep experiments was conducted at elevated temperatures with constant axial pressure and unloading confining pressure conditions.Experimental results show that the salt sample deforms more significantly with the increase of applied temperature and deviatoric loading.The accelerated creep phase is not occurring until the applied temperature reaches 130℃,and higher temperature is beneficial to the occurrence of accelerated creep.To describe the specific creep behavior,a novel three-dimensional(3D)creep constitutive model is developed that incorporates the thermal and mechanical variables into mechanical elements.Subsequently,the standard particle swarm optimization(SPSO)method is adopted to fit the experimental data,and the sensibility of key model parameters is analyzed to further illustrate the model function.As a result,the model can accurately predict the creep behavior of salt under the coupled thermo-mechanical effect in deep-buried condition.Based on the research results,the creep mechanical behavior of wellbore shrinkage is predicted in deep drilling projects crossing salt layer,which has practical implications for deep rock mechanics problems. | Chao Liang Jianfeng Liu Jianxiong Yang Huining Xu Zhaowei Chen Lina Ran | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，2： | 0 |
| 20 | Geochemistry and Geochronology of the Jinghong Ophiolites:Implications for the Tectonic Evolution of the Eastern Paleo-Tethys显示文摘The Jinghong mafic-ultramafic complex,exposed in the eastern margin of the Lancangjiang tectonic belt,is related to the subduction of the Paleo-Tethys Ocean.Its petrogenesis plays a key role in constraining the tectonic evolution of the eastern Paleo-Tethys Ocean in southwestern China.In this study,we present petrological,geochemical and geochronological results of the Jinghong complex rocks,in order to decipher their origin and tectonic significance.The Jinghong mafic-ultramafic complex was composed of peridotite,gabbro,basalt and minor plagiogranite.Whole-rock geochemical data of the mafic rocks indicate that they have both MORB and IAB affinities and plot in the back-arc basin basalt(BABB)field in the FeO^(*)/MgO vs.TiO_(2) diagram.Combined with their trace element characteristics,it can be concluded that the Jinghong mafic-ultramafic complex represents an ophiolite suite that was formed in a back-arc ocean basin.Precise LA-ICP-MS zircon U-Pb dating yielded weighted mean ^(206)Pb/^(238)U ages of 298.4±1.7 Ma,294.3±1.6 Ma,and 292.8±2.0 Ma for gabbroic rocks from this complex,which indicates that the Jinghong ophiolites were formed during the early Permian(298-293 Ma).We propose that during subduction of the main Paleo-Tethys Ocean,a back-arc ocean basin was formed at the east of the Lancangjiang tectonic belt. | ZHU Jianjiang LIU Fulai WANG Fang XIE Shiwen CAI Jia JI Lei WANG Huining | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 0 |
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