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您的检索式：作者名="Huiping Tan"
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| 1 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 2 | Effects of Mechanical Activation on the HCl Leaching Behavior of Titanaugite, Ilmenite, and Their Mixtures显示文摘 | Li Zhang Huiping Hu Liangping Wei Qiyuan Chen Jun Tan | 2010 | Metallurgical and Materials Transactions B2010，，6： | 1 |
| 3 | Engineering Komagataella phaffii to biosynthesize cordycepin from methanol which drives global metabolic alterations at the transcription level显示文摘Cordycepin has the potential to be an alternative to the disputed herbicide glyphosate.However,current laborious and time-consuming production strategies at low yields based on Cordyceps militaris lead to extremely high cost and restrict its application in the field of agriculture.In this study,Komagataella phaffii(syn.Pichia pastoris)was engineered to biosynthesize cordycepin from methanol,which could be converted from CO_(2).Combined with fermentation optimization,cordycepin content in broth reached as high as 2.68±0.04 g/L within 168 h,around 15.95 mg/(L⋅h)in productivity.Additionally,a deaminated product of cordycepin was identified at neutral or weakly alkaline starting pH during fermentation.Transcriptome analysis found the yeast producing cordycepin was experiencing severe inhibition in methanol assimilation and peroxisome biogenesis,responsible for delayed growth and decreased carbon flux to pentose phosphate pathway(PPP)which led to lack of precursor supply.Amino acid interconversion and disruption in RNA metabolism were also due to accumu-lation of cordycepin.The study provided a unique platform for the manufacture of cordycepin based on the emerging non-conventional yeast and gave practical strategies for further optimization of the microbial cell factory. | Huiping Tan Liang Wang Huiguo Wang Yanghao Cheng Xiang Li Huihui Wan Chenguang Liu Tian Liu Qian Li | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 4 | Effects of Different Nitrogen Levels on Growth and Nitrogen Utilization of Sugarcane显示文摘[Objectives]To systematically study the effects of different nitrogen levels on the growth and nitrogen utilization of sugarcane in Guangxi.[Methods]Through field experiment and indoor analysis,different nitrogen application levels were set up to determine soil nitrogen content and sugarcane nitrogen content.The effects of different nitrogen levels on sugarcane yield,agronomic characters and nitrogen utilization were studied.[Results]The effect of nitrogen application rate on sugarcane yield showed a quadratic curve,and nitrogen application could significantly increase sugarcane yield,and the sugarcane yield reached the maximum when the nitrogen application rate reached 714 kg/ha.[Conclusions]With the increase of nitrogen application rate,sugarcane yield increased,but when it exceeded a certain range,the sugarcane yield decreased significantly. | Jiayu PENG Huiping QU Jinsheng HUANG Liuqiang ZHOU Rulin XIE Xiaohui ZHU Yan ZENG Hongwei TAN | 2022 | Asian Agricultural Research2022，14，4： | 0 |
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