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| 1 | Lithium-assisted exfoliation of pristine graphite for few-layer graphene nanosheets显示文摘一条帮助锂的途径为太古的石墨的脱落被开发了,它允许很少层 graphene nanosheets 的大规模准备。这个过程包含意外物理插入和脱落,和这个方法准备的 graphene nanosheets 揭示没受到干扰的 sp < 啜 class= “ a-plus-plus ” > 2 -hybridized 结构。可能的二拍子的圆舞机制,包含在石墨层和一个随后的 lithiation 过程的边附近被套住的否定费用,被建议在石墨夹层内解释锂的插入。如果必要,现在的脱落能被重复并且更薄(单身者或 23 层) graphene 能在大规模上被完成。这个简单过程为太古的石墨的脱落提供一个有效过程,它可能支持 graphene 的未来应用程序。 | Minwei Xu Huiting Sun Cai Shen Sen Yang Wenxiu Que Yin Zhang Xiaoping Song | 2015 | Nano Research2015，8，3： | 5 |
| 2 | Extraction and back-extraction behaviors of 14 rare earth elements from sulfuric acid medium by TODGA显示文摘The unique physical and chemical properties of rare earth elements lay the foundation for their extensive application. N,N,N',N' Tetra-octyl-3-oxopentanediamide(TODGA) is excellent in its ability of extracting rare earth elements and it is favored for green initiative. In this paper, the extraction and back-extraction of14 rare earth elements by TODGA were studied. Experiments show that in conditions of 6 mol/L sulfuric acid, the extraction temperature of 25 ℃,the phase ratio of 1:1 and 0.04 mol/LTODGA(aviation kerosene as the diluent), the extraction rates of 14 rare earth elements including lanthanum, cerium, praseodymium,neodymium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, and yttrium were 99.00%-99.73%. Mixed with hydrochloric acid and nitric acid(HCl 3.5 mol/L, HNO_30.5 mol/L), the recoveries of the 14 rare earth elements are 91.52%-99.91% when the extraction temperature is 25 ℃ and the ratio is 1:1. The following application is based on the optimum conditions above with practical samples(from the roasting production line of China North Rare Earth High-tech Company Limited) for extraction and back-extraction experiments. Experiments show that TODGA has excellent enrichment effect on 14 rare earth elements, the extraction rates are 91.36%-99.80%, the back-extraction rates are 87.29%-99.64% and the total recoveries are 81.19%-99.44%. | Huiting Yuan Weixiang Hong Yushan Zhou Baisong Pu Aijun Gong Tao Xu Qishan Yang Fukai Li Lina Qiu Weiwei Zhang Yuning Liu | 2018 | Journal of Rare Earths2018，36，6： | 4 |
| 3 | Fecal metabolomics reveals the positive effect of ethanol extract of propolis on T2DM mice显示文摘A large number of studies have shown that propolis has positive effects in the treatment of type 2 diabetes mellitus(T2DM).However,there are have only been a few reports that are based on an ultra-high performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry(UPLC-Q-TOF-MS)analysis of the fecal metabolomics of ethanol extract of propolis(EEP)in the treatment of T2DM.The present investigation was designed to screen potential biomarkers of T2DM by the metabonomic method and to explain the possible anti-diabetes mechanism of EEP according to the changes in the biomarkers.The results showed that EEP improved the body weight(BW)of T2DM mice,lowered blood sugar levels,and significantly restored blood biochemical indicators related to T2DM,such as fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR),aspartate transaminase(AST),and alanine aminotransferase(ALT).Liver pathology showed that EEP reversed liver damage caused by T2DM.Metabolomics data identified 27 potential biomarkers in fecal samples.EEP effectively regulated the dysfunction in the metabolic pathways of glycerophospholipids,sphingolipids,riboflavins,and sterol lipids caused by T2DM.In summary,our research results revealed positive effects of EEP in the treatment of T2DM and provided potential candidate markers for further research and in the clinical treatment of T2DM. | Chunmei Wang Huiting Zhao Kai Xu Yali Du Jinjia Liu Jinfei Wang Yusuo Jiang | 2023 | Food Science and Human Wellness2023，12，1： | 1 |
| 4 | Application of zeolite MCM-22 for basic dye removal from wastewater显示文摘 | Shaobin Wang Huiting Li Longya Xu | 2006 | Journal of Colloid and Interface Science2006，295，： | 1 |
| 5 | Rapid evaluation of heterologous chimeric RBD-dimer mRNA vaccine for currently-epidemic Omicron sub-variants as booster shot after inactivated vaccine显示文摘With continuous mutations of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the severe immune escape of Omicron sub-variants urges the development of next-generation broad-spectrum vaccines,especially as booster jabs after high-level vaccination coverage of inactivated vaccines in China and many other countries.Previously,we developed a coronavirus disease 2019(COVID-19)protein subunit vaccine ZF2001?based on the tandem homo-prototype receptor-binding domain(RBD)-dimer of the SARS-CoV-2 spike protein.We upgraded the antigen into a hetero-chimeric prototype(PT)-Beta or Delta-BA.1 RBD-dimer to broaden the cross-protection efficacy and prove its efficiency with protein subunit and mRNA vaccine platforms.Herein,we further explored the hetero-chimeric RBD-dimer mRNA vaccines and evaluated their broad-spectrum activities as booster jabs following two doses of inactivated vaccine(Ⅳ)in mice.Our data demonstrated that the chi-meric vaccines significantly boosted neutralizing antibody levels and specific T-cell responses against the vari-ants,and PT-Beta was superior to Delta-BA.1 RBD as a booster in mice,shedding light on the antigen design for the next-generation COVID-19 vaccines. | Qian Chen Pei Du Yuxuan Han Xuehui Ma Rong Zhang Xiaoyu Rong Xu Zhao Renyi Ma Huiting Yang Anqi Zheng Qingrui Huang Jinghua Yan Hui Wang Xin Zhao Lianpan Dai George F.Gao Qihui Wang | 2023 | Biosafety and Health2023，5，2： | 1 |
| 6 | Towards a tailored indoor horticulture:a functional genomics guided phenotypic approach显示文摘As indoor horticulture gathers momentum,electric(also termed artificial)lighting systems with the ability to generate specific and tunable wavelengths have been developed and applied.While the effects of light quality on plant growth and development have been studied,authoritative and reliable sets of light formulae tailored for the cultivation of economically important plants and plant traits are lacking as light qualities employed across laboratories are inconsistent.This is due,at least in part,to the lack of molecular data for plants examined under electric lights in indoor environments.It has hampered progress in the field of indoor horticulture,in particular,the transition from small-scale indoor farming to commercial plant factories.Here,we review the effects of light quality on model and crop plants studied from a physiological,physical and biochemical perspective,and explain how functional genomics can be employed in tandem to generate a wealth of molecular data specific for plants cultivated under indoor lighting.We also review the current state of lighting technologies in indoor horticulture specifically discussing how recent narrow-bandwidth lighting technologies can be tailored to cultivate economically valuable plant species and traits.Knowledge gained from a complementary phenotypic and functional genomics approach can be harvested not only for economical gains but also for sustainable food production.We believe that this review serves as a platform that guides future light-related plant research. | Claudius Marondedze Xinyun Liu Shihui Huang Cynthia Wong Xuan Zhou Xutong Pan Huiting An Nuo Xu Xuechen Tian Aloysius Wong | 2018 | Horticulture Research2018，5，1： | 0 |
| 7 | TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization显示文摘Multiple sclerosis(MS)is a neuroinflammatory demyelinating disease,mediated by pathogenic T helper 17(Th17)cells.However,the therapeutic effect is accompa-nied by the fluctuation of the proportion and function of Th17 cells,which prompted us to find the key regulator of Th17 differentiation in MS.Here,we demonstrated that the triggering receptor expressed on myeloid cells 2(TREM-2),a modulator of pattern recognition receptors on innate immune cells,was highly expressed on pathogenic CD4-positive T lymphocyte(CD4^(+)T)cells in both patients with MS and experimental autoimmune encephalomyelitis(EAE)mouse models.Conditional knockout of Trem-2 in CD4^(+)T cells significantly alleviated the disease activity and reduced Th17 cell infiltration,activation,differentiation,and inflammatory cytokine production and secretion in EAE mice.Furthermore,with Trem-2 knockout in vivo experiments and in vitro inhibitor assays,the TREM-2/zeta-chain associated protein kinase 70(ZAP70)/signal transducer and activator of transcription 3(STAT3)signal axis was essential for Th17 activation and differentiation in EAE progression.In conclusion,TREM-2 is a key regulator of pathogenic Th17 in EAE mice,and this sheds new light on the potential of this therapeutic target for MS. | Siying Qu Shengfeng Hu Huiting Xu Yongjian Wu Siqi Ming Xiaoxia Zhan Cheng Wang Xi Huang | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 8 | Effects of p38 MAPK inhibitor on the rat pain behavior and proinflammatory cytokines in a metastatic bone cancer pain model显示文摘Objective:To observe the effects of p38 mitogen activated protein kinase(MAPK) inhibitor SB203580 by intra-thecal injection on the pain behavior and the spinal proinflammatory cytokines in a rat model of bone cancer pain induced by breast cancer cells. Methods:Eleven rats were used to establish the models of bone cancer pain,six rats were treated by intrathecal SB203580 injection,and the other 5 were as the controls. The paw withdrawal latency(PWL),histology and the spinal levels of IL-1β and TNF-α were detected. Results:All the 11 rats presented evident bone destruction and thermal hyperalgesia after intra-tibial injection of breast cancer cells. No effect of SB203580 on the bone destruction was observed. However,following intrathecal injection of SB203580,the left PWLs(12.12 ± 1.26 s at 16 days and 12.99 ± 1.65 s at 19 days) were significant higher than that of controls(9.05 ± 1.08 s at 16 days and 8.55 ± 1.60 s at 19 days),P < 0.05. Meanwhile,intrathecal injection of SB203580 evidently reduced the levels of spinal IL-1β and TNF-α. Conclusion:Intrathecal injection of SB203580 in a rat model of bone cancer pain cannot prevent the tibial destruction but significantly depress the thermalgia sensitivity,which might result from inhibiting intracellular p38 MAPK signaling transduction,and thereby reducing the release of the proinflammatory cytokines. | Cuiju Tang Shiying Yu Min Zhang Rui Jiang Na Li Huiting Xu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，3： | 0 |
| 9 | Inhibition of Ku80 by RNAi enhances the radiosensitivity of cervical carcinoma cell line SiHa显示文摘Objective: To study the radiosensitivity of SiHa cells with Ku80 inhibition by RNAi. Methods: pKu80-siRNA and pNeg-siRNA were constructed and then transfected into SiHa cells. Western blot and RT-PCR were applied to measure the expression of Ku80. After 10 Gy irradiation with 6 MV X-ray, cells were harvested at 20 h, 28 h and 48 h, and analyzed by flow cytometry for apoptosis rate. The SF2 and α, β values of cells were acquired by clone formation array. Results: Two stable transfection cell clones SiHa/Ku80-siRNA and SiHa/Neg-siRNA were screened from the pKu80-siRNA and pNeg-siRNA transfected cells. Western blot and RT-PCR indicated that the expression of Ku80 was suppressed by the Ku80-siRNA. The apoptosis rates of SiHa/Ku80-siRNA were higher than control cells at 28 h and 48 h after X-ray irradiation (P < 0.05). The SF2 value of SiHa/Ku80-siRNA (0.422) was lower than that of SiHa/Neg-siRNA cells (0.587) or untransfected cells (0.583), and the α value of SiHa/Ku80-siRNA was 0.295 ± 0.016, higher than that of SiHa/Neg-siRNA (0.176 ± 0.010) or control cells (0.188 ± 0.011). Conclusion: Inhibition of Ku80 could enhance the radiosensitivity of SiHa, which showed that Ku80 could be a good target for molecular therapy. | Liang Zhuang Shiying Yu Xiaoyuan Huang Huihua Xiong Huiting Xu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 0 |
| 10 | Observation on the Therapeutical Effect of Adjuvant Arthritis in Rats with Medicinal Indirect Moxibustion显示文摘ObservationontheTherapeuticalEffectofAdjuvantArthritisinRatswithMedicinalIndirectMoxibustion￥ZhuBaijun;WangYuanchao;DaiHuitin... | Zhu Baijun Wang Yuanchao Dai Huiting Xu Qingyan(Institute of Acupuncture and Moxibustion China Academy of TCM, 100700) | 1995 | 中国针灸1995，15，S2： | 0 |
| 11 | Power Grid Fault Diagnosis Based on Deep Pyramid Convolutional Neural Network显示文摘Existing power grid fault diagnosis methods relyon manual experience to design diagnosis models, lack theability to extract fault knowledge, and are difficult to adaptto complex and changeable engineering sites. Considering thissituation, this paper proposes a power grid fault diagnosismethod based on a deep pyramid convolutional neural networkfor the alarm information set. This approach uses the deepfeature extraction ability of the network to extract fault featureknowledge from alarm information texts and achieve end-to-endfault classification and fault device identification. First, a deeppyramid convolutional neural network model for extracting theoverall characteristics of fault events is constructed to identifyfault types. Second, a deep pyramidal convolutional neuralnetwork model for alarm information text is constructed, thetext description characteristics associated with alarm informationtexts are extracted, the key information corresponding to faultsin the alarm information set is identified, and suspicious faultydevices are selected. Then, a fault device identification strategythat integrates fault-type and time sequence priorities is proposedto identify faulty devices. Finally, the actual fault cases and thefault cases generated by the simulation are studied, and theresults verify the effectiveness and practicability of the methodpresented in this paper. | Xu Zhang Huiting Zhang Dongying Zhang Yixian Wang Ruiting Ding Yuchuan Zheng Yongxu Zhang | 2023 | CSEE Journal of Power and Energy Systems2023，9，6： | 0 |
| 12 | Effectiveness and safety of red yeast rice predominated by monacolin Kβ-hydroxy acid form for hyperlipidemia treatment and management显示文摘OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle modifications.METHODS:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 d.The primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.RESULTS:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6%on average(95%CI,9.6%to 21%)with,a decrease in TC by 15.3%on average(95%CI,9.26%to 21.4%),and a decrease in non-HDL-C by 35.4%(95%CI,25.76%to 41.34%).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia.No severe adverse events occurred during the study.CONCLUSION:Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful.It also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well. | CHEN Benjian HUANG Xiaodan PENG Huiting LI Yishi CAO Yongtao WU Huanlin XU Danping | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 0 |
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