|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review <ce:link locator='eulogo1'/>显示文摘 | James W.F. Catto Antonio Alcaraz Anders S. Bjartell Ralph De Vere White Christopher P. Evans Susanne Fussel Freddie C. Hamdy Olli Kallioniemi Lourdes Mengual Thorsten Schlomm Tapio Visakorpi | 2011 | European Urology2011，，5： | 2 |
| 3 | Circulating miRNAs are correlated with tumor progression in prostate cancer显示文摘 | Brase JC Johannes M Schlomm T | 2011 | Int J Canc- er2011，128，3： | 1 |
| 4 | Circulating miRNAs are correlated with tumor progression in prostate cancer显示文摘 | Brase J C Johannes M Schlomm T | 2011 | &t J Cancer2011，128，3： | 1 |
| 5 | Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer显示文摘 | Nicole Fischer Olaf Hellwinkel Claudia Schulz Felix K.H. Chun Hartwig Huland Martin Aepfelbacher Thorsten Schlomm | 2008 | Journal of Clinical Virology2008，，3： | 1 |
| 6 | Full functional?length urethral sphincter preservation during radical prostatec?tomy显示文摘 | Schlomm T Heinzer H Steuber T | 2011 | EurUrol2011，60，： | 1 |
| 7 | Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer显示文摘 | Schlomm T Kirstein P Iwers L | 2007 | Clin Cancer Res2007，13，221： | 1 |
| 8 | Full functionallength urethral sphincter preservation during radical prostatectomy显示文摘 | Schlomm T Heinzer H Steuber T | 2011 | Eur Urol2011，60，2： | 1 |
| 9 | Circ^tLating miR-NAs are correlated with tumor progression in prostate cancer显示文摘 | Brase J C Johannes M Schlomm T | 2011 | Int J Cancer2011，128，3： | 1 |
| 10 | Extraction and processing of high quality RNA from impalpable and macroscopically invisible prostate cancer for microarray gene expression analysis显示文摘 | SCHLOMM T LUEBKE A M SULTMANN H | 2005 | Int J Oncol2005，27，3： | 1 |
| 11 | Circulating miRNAs are cor- related with tumor progression in prostate cancer显示文摘 | Brase JC Johannes M Schlomm T | 2011 | Int J Cancer2011，128，3： | 1 |
| 12 | Current technique of open intrafascial nerve - sparing retropubic prostatectomy 显示文摘 | Budaus L Isbarn H Schlomm T | 2009 | Eur Urol2009，56，2： | 1 |
| 13 | Full functional-length urethral sphincter preservation during: radical prostatectomy显示文摘 | Schlomm T Heinzer H Steuher T | 2011 | Eur Urol2011，60，2： | 1 |
| 14 | Low level Her2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer显示文摘 | Minner S Jessen B Schlomm T | 2010 | Clin Cancer Res2010，16，5： | 1 |
| 15 | Circulating miRNAs are correlated with tumor progression in prostate cancer显示文摘 | Brase JC Johannes M Schlomm T | | 0，，03： | 1 |
| 16 | prostate cancers in the transition zone:Part I;pathological aspects显示文摘 | Erbersdobler A Augustin H Schlomm T | 2004 | BJU Int2004，947，： | 1 |
| 17 | Clinical significance of p53 alterations in surgically treated prostate cancers 显示文摘 | Schlomm T lwers L Kirstein P | 2008 | Mod Pathal2008，21，11： | 1 |
| 18 | Full functional-length urethral sphincter preservation during:radical prostatectomy显示文摘 | Schlomm T Heinzer H Steuber T et ak | 2011 | J European Urology2011，38，10： | 1 |
| 19 | Immunological microenvironment in prostate cancer:high mast cell densities are associated with favorable tumor characteristics and good prognosis显示文摘 | Fleischmann A Schlomm T K(o)llermann JK | | 0，，： | 1 |
| 20 | Circulating miRNAs are correlated with tumor progression in prostate cancer显示文摘 | Brase JC Johannes M Schlomm T | 2010 | Int J Cancer2010，128，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员