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| 1 | Calcium and Calmodulin-Mediated Regulation of Gene Expression in Plants显示文摘无柄的植物开发了一个很精细的系统由使用一个简单 Ca2+ 离子察觉到内长的发展暗示和外长的环境刺激的多样的类型。Calmodulin (凸轮) 是占优势的 Ca2+ 传感器并且在在优核质在各种各样的细胞的分隔空间译码 Ca2+ 签名进合适的细胞的回答起一个关键作用。证据的成长身体在对内长、外长的刺激的植物回答期间在 transcriptional 过程的规定指向 Ca2+ 和凸轮的重要性。这里,我们在 Ca2+ 和凸轮并且在对他们的功能的意义的评价响应关於生命、不能生活的压力和发展暗示在植物信号 transduction 期间调制的 transcriptional 管理者的鉴定考察最近的进步。 | Min Chul Kim Woo Sik Chung Dae-Jin Yun Moo Je Cho | 2009 | Molecular Plant2009，2，1： | 47 |
| 2 | Overexpression of Arabidopsis YUCCA6 in Potato Results in High-Auxin Developmental Phenotypes and Enhanced Resistance to Water Deficit显示文摘Indole-3-acetic 酸(IAA ) ,主要植物植物生长素,在色氨酸依赖者和色氨酸无关的小径被生产。在 Arabidopsis thaliana 的一条主要小径从色氨酸在二反应产生 IAA。步骤一由把国际语音学协会变换成丝兰属植物蛋白质催化的 IAA 的一个限制率的步骤跟随的色氨酸 aminotransferases 把色氨酸变换成 indole-3-pyruvic 酸(国际语音学协会) 。我们识别了推出了氨基酸序列的基因分享的八通常认为的 StYUC (茄属 tuberosum 丝兰属植物) Arabidopsis 丝兰属植物蛋白质的有那些的 50%70% 身份。都包括正规、保存丝兰属植物序列:FATGY 主题, FMO 签名顺序和 NADP 有约束力的序列。另外,五基因与 ~ 被发现 50% 氨基酸顺序身份到 Arabidopsis 色氨酸 aminotransferases。转基因的土豆(茄属 tuberosum cv。Jowon ) 组成地, overexpressing Arabidopsis AtYUC6 显示了象狭窄的向下卷的叶子,增加的高度,直立的身高,和长寿那样的高植物生长素的显型。转基因的土豆植物 overexpressing AtYUC6 基于减少的水损失显示出提高的干旱忍耐。显型在叶子与反应的氧种类的减少的层次被相关。结果在可以被利用改变植物回答到环境的土豆建议植物生长素生合成的一条功能的丝兰属植物小径。 | Jeong Im Kim Dongwon Baek Hyeong Cheol Park Hyun Jin Chun Dong-Ha Oh Min Kyung Lee Joon-Yung Cha Woe-Yeon Kim Min Chul Kim Woo Sik Chung Hans J. Bohner Sang Yeol Lee Ray A. Bressan Shin-Woo Lee Dae-Jin Yun | 2013 | Molecular Plant2013，6，2： | 15 |
| 3 | Arabidopsis thaliana RECEPTOR DEAD KINASE1 Functions as a Positive Regulator in Plant Responses to ABA显示文摘Abscisic 酸(骆驼毛的织物) 是涉及重要压力相关、发展的植物过程的主要植物激素。限定膜的骆驼毛的织物信号 transduction 在早骆驼毛的织物发信号,而是连接核心发信号的分子的机制起一个重要作用到血浆膜的部件仍然保持不清楚。植物发展了很多像受体的 kinases (RLK ) 由察觉细胞外的刺激并且激活下游地发信号的回答调制多样的生物过程。在这研究,通常认为的充满白氨酸的 repeat-RLK 基因说出受体死了的 KINASE1 (AtRDK1 ) 在 Arabidopsis 被鉴别并且描绘 thaliana。RDK1 promoter-GUS 分析表明 RDK1 在 Arabidopsis 在各种各样的纸巾无所不在地被表示,并且它的表示被骆驼毛的织物主要导致。面对骆驼毛的织物, RDK1 缺乏的 rdk1-1 和 rdk1-2 线在子叶 greening 和根生长显示出重要抵抗,而 RDK1-overexpressing 线显示出提高的敏感。一致地,骆驼毛的织物应答的基因的表示是显著地在 rdk1 异种幼苗的 downregulated,它对有增加的水损失的干旱应力也过分敏感。有趣地, RDK1 被发现是不正常的 kinase 局部性到血浆膜并且没在幼苗开发的调停骆驼毛的织物的抑制期间要求它的 kinase 活动。因此, RDK1 与类型 2C 蛋白质磷酸酶 ABSCISIC 酸 INSENSITIVE1 (ABI1 ) 在血浆膜交往了;这个相互作用被骆驼毛的织物的外长的申请进一步提高,建议 ABI1 的调停 RDK1 的招募为骆驼毛的织物发信号是到血浆膜上重要的。一起拿,这些结果以一种骆驼毛的织物依赖者方式在对不能生活的压力条件的植物回答为 RDK1 揭示一个重要角色。 | Dhinesh Kumar Ritesh Kumar Dongwon Baek Tae-Kyung Hyun Woo Sik Chung Dae-Jin Yun Jae-Yean Kim | 2017 | Molecular Plant2017，10，2： | 10 |
| 4 | Risk factors for local recurrence after en bloc endoscopic submucosal dissection for early gastric cancer显示文摘AIM: To investigate factors related to recurrence following en bloc resection using endoscopic submucosal dissection(ESD) in patients with early gastric cancer(EGC). METHODS: A total of 1121 patients(1215 lesions) who had undergone ESD for gastric neoplasia between April 2003 and May 2010 were retrospectively reviewed. Data from 401 patients(415 lesions) were analyzed, following the exclusion of those who underwent piecemeal resection, with deep resection margin invasion or lateral margin infiltration, and diagnosed with benign lesions. RESULTS: Local recurrence after en bloc ESD was found in 36 cases(8.7%). Unclear resection margins, long procedure times, and narrow safety margins were identified as risk factors for recurrence. Lesions located in the upper third of the stomach showed a higher rate of recurrence than those located in the lower third of the stomach(OR = 2.9, P = 0.03). The probability of no recurrence for up to 24 mo was 79.9% in those with a safety resection margin ≤ 1 mm and 89.5% in those with a margin > 1 mm(log-rank test, P = 0.03). CONCLUSION: Even in cases in which en bloc ESD is performed for EGC, local recurrence still occurs. To reduce local recurrences, more careful assessment will be needed prior to the implementation of ESD in casesin which the tumor is located in the upper third of the stomach. In addition, clear identification of tumor boundaries as well as the securing of sufficient safety resection margins will be important. | Ju Yup Lee Kwang Bum Cho Eun Soo Kim Kyung Sik Park Yoo Jin Lee Yoon Suk Lee Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，7： | 8 |
| 5 | Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation显示文摘Dehydrating stresses trigger the accumulation of abscisic acid(ABA),a key plant stress-signaling hormone that activates Snf1-Related Kinases(SnRK2s)to mount adaptive responses.However,the regulatory circuits that terminate the SnRK2s signal relay after acclimation or post-stress conditions remain to be defined.Here,we show that the desensitization of the ABA signal is achieved by the regulation of OST1(SnRK2.6)protein stability via the E3-ubiquitin ligase HOS15.Upon ABA signal,HOS15-induced degradation of OST1 is inhibited and stabilized OST1 promotes the stress response.When the ABA signal terminates,protein phosphatases ABI1/2 promote rapid degradation of OST1 via HOS15.Notably,we found that even in the presence of ABA,OST1 levels are also depleted within hours of ABA signal onset.The unexpected dynamics of OST1 abundance are then resolved by systematic mathematical modeling,demonstrating a desensitizing feedback loop by which OST1-induced upregulation of ABI1/2 leads to the degradation of OST1.This model illustrates the complex rheostat dynamics underlying the ABA-induced stress response and desensitization. | Akhtar Ali Jae Kyoung Kim Masood Jan Haris Ali Khan Irfan Ullah Khan Mingzhe Shen Junghoon Park Chae Jin Lim Shah Hussain Dongwon Baek Kai Wang Woo Sik Chung Vicente Rubio Sang Yeol Lee Zhizhong Gong Woe Yeon Kim Ray ABressan Jose MPardo Dae-Jin Yun | 2019 | Molecular Plant2019，12，11： | 5 |
| 6 | Comparison of a novel bedside portable endoscopy device with nasogastric aspiration for identifying upper gastrointestinal bleeding显示文摘AIM: To compare outcomes using the novel portable endoscopy with that of nasogastric(NG) aspiration in patients with gastrointestinal bleeding.METHODS: Patients who underwent NG aspiration for the evaluation of upper gastrointestinal(UGI) bleeding were eligible for the study. After NG aspiration, we performed the portable endoscopy to identify bleeding evidence in the UGI tract. Then, all patients underwent conventional esophagogastroduodenoscopy as the gold-standard test. The sensitivity, specificity, and accuracy of the portable endoscopy for confirming UGI bleeding were compared with those of NG aspiration.RESULTS: In total, 129 patients who had GI bleedingsigns or symptoms were included in the study(age 64.46 ± 13.79, 91 males). The UGI tract(esophagus, stomach, and duodenum) was the most common site of bleeding(81, 62.8%) and the cause of bleeding was not identified in 12 patients(9.3%). Specificity for identifying UGI bleeding was higher with the portable endoscopy than NG aspiration(85.4% vs 68.8%, P = 0.008) while accuracy was comparable. The accuracy of the portable endoscopy was significantly higher than that of NG in the subgroup analysis of patients with esophageal bleeding(88.2% vs 75%, P = 0.004). Food material could be detected more readily by the portable endoscopy than NG tube aspiration(20.9% vs 9.3%, P = 0.014). No serious adverse effect was observed during the portable endoscopy.CONCLUSION: The portable endoscopy was not superior to NG aspiration for confirming UGI bleeding site. However, this novel portable endoscopy device might provide a benefit over NG aspiration in patients with esophageal bleeding. | Jong Hwan Choi Jae Hyuk Choi Yoo Jin Lee Hyung Ki Lee Wang Yong Choi Eun Soo Kim Kyung Sik Park Kwang Bum Cho Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 7 | Predictive risk factors of perforation in gastric endoscopic submucosal dissection for early gastric cancer: a large, multicenter study显示文摘 | Min Kim Seong Woo Jeon Kwang Bum Cho Kyung Sik Park Eun Soo Kim Chang Keun Park Hyang Eun Seo Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Byeong Ik Jang Si Hyung Lee Kyeong Ok Kim Chang Hun Yang | 2013 | Surgical Endoscopy2013，，4： | 3 |
| 8 | Endoscopic submucosal dissection for early gastric cancer with undifferentiated histology: could we extend the criteria beyond?显示文摘 | Yi Young Kim Seong Woo Jeon JiYeon Kim Jung Chul Park Kwang Bum Cho Kyung Sik Park EunSoo Kim Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Kyeong Ok Kim ByungIk Jang Si Hyung Lee Chang Hun Yang | 2013 | Surgical Endoscopy2013，，12： | 3 |
| 9 | Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease显示文摘 | Jung Mi Choi Myoung Soo Woo Hyeo-Il Ma Suk Yun Kang Young-Hee Sung Seok Woo Yong Sun Ju Chung Joong-Seok Kim Hae-won Shin Chul Hyoung Lyoo Phil Hyu Lee Jong Sam Baik Sang-Jin Kim Mee Young Park Young Ho Sohn Jin-Ho Kim Jae Woo Kim Myung Sik Lee Myoung Cho | 2008 | Neurogenetics2008，，4： | 1 |
| 10 | Comparison of Clinical Outcomes Among Different Endoscopic Resection Methods for Treating Colorectal Neoplasia显示文摘 | Yun Jung Kim Eun Soo Kim Kwang Bum Cho Kyung Sik Park Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang | 2013 | Digestive Diseases and Sciences2013，，6： | 1 |
| 11 | Incidence of Propofol Injection Pain and Effect of Lidocaine Pretreatment During Upper Gastrointestinal Endoscopy显示文摘 | Ji Suk Kwon Eun Soo Kim Kwang Bum Cho Kyung Sik Park Woo Young Park Jeong Eun Lee Tae Yol Kim Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang | 2012 | Digestive Diseases and Sciences2012，，5： | 1 |
| 12 | Penile Sensitivity in Patients with Primary Premature Ejaculation显示文摘 | Zhong Cheng Xin Woo Sik Chung Young Deuk Choi Do Hwan Seong Yeong Jin Choi Hyung Ki Choi | 1996 | The Journal of Urology1996，，3： | 1 |
| 13 | Characterization of a cDNA encoding cysteine proteinase inhibitor from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds显示文摘 | Chae Oh Lim Soo In Lee Woo Sik Chung Sung Han Park Inhwan Hwang Moo Je Cho | 1996 | Plant Molecular Biology1996，，2： | 1 |
| 14 | Sedative action of spinosin显示文摘 | Kuk Hyun Shin Chung Kyu Lee Won Sick Woo Sam Sik Kang | 1978 | Archives of Pharmacal Research1978，，1： | 1 |
| 15 | Outcomes for four-part proximal humerus fractures treated with a locking compression plate and an autologous iliac bone impaction graft显示文摘 | Sae Hoon Kim Young Ho Lee Seok Won Chung Seung Han Shin Woo Young Jang Hyun Sik Gong Goo Hyun Baek | 2012 | Injury2012，，10： | 1 |
| 16 | Identification of SUMO-modified proteins by affinity purification and tandem mass spectrometry in Arabidopsis thaliana显示文摘 | Hee Jin Park Hyeong Cheol Park Jida Choi Wonkyun Choi Woo Sik Chung Soohyun Kim Dae-Jin Yun | 2013 | Journal of Plant Biology2013，，3： | 1 |
| 17 | Optimization of Acquisition Parameters of Diffusion-Tensor Magnetic Resonance Imaging in the Spinal Cord显示文摘 | Joon Woo Lee Jae Hyung Kim Heung Sik Kang Jong Sea Lee Ja-Young Choi Jin-Sup Yeom Hyun-Jib Kim Hye Won Chung | 2006 | Investigative Radiology2006，，： | 1 |
| 18 | Percutaneous vertebroplasty for intravertebral cleft: analysis of therapeutic effects and outcome predictors显示文摘 | Yeo Ju Kim Joon Woo Lee Ki-Jeong Kim Sang-Ki Chung Hyun-Jib Kim Jeong Mi Park Heung Sik Kang | 2010 | Skeletal Radiology2010，，8： | 1 |
| 19 | Outcomes for four-part proximal humerus fractures treated with a locking compression plate and an autologous iliac bone impaction graft显示文摘 | Sae Hoon Kim Young Ho Lee Seok Won Chung Seung Han Shin Woo Young Jang Hyun Sik Gong Goo Hyun Baek | 2012 | Injury2012，，10： | 1 |
| 20 | Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis显示文摘BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal cells.Fexuprazan’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent manner.AIM To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight weeks.The primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week 8.The secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life assessment.Safety profiles and serum gastrin levels were compared between the groups.RESULTS Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life assessments.Additionally,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the groups.CONCLUSION Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week 8.We suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE. | Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il Kim Sung Kook Kim Sang Woo Lee Kyung Sik Park Kook Lae Lee Suck Chei Choi Jae-Young Jang Gwang Ha Kim In-kyung Sung Moo In Park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik Lee Hyun Soo Kim Ki Bae Kim Yong Chan Lee Myung-Gyu Choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun Kim Hyunsoo Chung | 2022 | World Journal of Gastroenterology2022，28，44： | 0 |
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