|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of octreotide on acute necrotizing pancreatitis in rabbits显示文摘AIM: To assess the role of oxygen-derived free radicals and cytokines in the pathogenesis of taurocholic acid-induced acute pancreatitis, and to evaluate the preventive effects of octreotide towards the development of acute pancreatitis. METHODS: Acute pancreatitis was induced in male New Zealand white rabbits by retrograde injection of 0.8 mL/kg·b·m, of 50 g/L sodium taurocholate(NaTC) in the pancreatic duct. Sham-operated animals served as control. Octreotide 1 mglkg·b.m.was administered subcutaneously before the induction of pancreatitis. Blood was taken from the jugular vein before and at 1, 3, 6, 12 and 24 h after pancreatitis induction.Serum activities of amylase, IL-6 and TNF-α and levels of malonyl dialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), catalase and superoxide dismutase (Mn-,Cu-,and Zn-SOD) in pancreatic tissue were measured.RESULTS: Serum TNF-α and IL-6 levels increased significantly 3 h after the onset of pancreatitis, and then returned to control level. The tissue concentration of MDA was significantly elevated at 24 h, while the GSH level and GP-x, catalase, Mn-SOD, Cu-, Zn-SOD activities were all significantly decreased in animals with pancreatitis as compared to the control. Octreotide pretreatment significantly reversed the changes in cytokines and reactive oxygen metabolites. Octreotide treatment did not alter the serum amylase activity and did not have any beneficial effects on the development of histopathological changes.CONCLUSION: Oxygen-derived free radicals and proinflammatory cytokines are generated at an early stage of NaTc-induced acute pancreatitis in rabbits. Prophylac ticoctreotide treatment can prevent release of cytokines and generation of reactive oxygen metabolites, but does not have any beneficial effects on the development of necrotizing pancreatitis. | Lászl6Czakó PéterHegyi TamásTakács CsabaGóg AndrásFarkas YvetteMándy Ilona Sz.Varga LászlóTiszlavicz JánosLonovics | 2004 | World Journal of Gastroenterology2004，10，14： | 21 |
| 2 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 3 | Proteoglycans in liver cancer显示文摘Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,such as a heparan,dermatan,chondroitin,or keratan sulfate,covalently attached to the protein core.These molecules arecategorized based on their structure,localization,and function,and can be found in the extracellular matrix,on the cell surface,and in the cytoplasm.Cell-surface heparan sulfate proteoglycans,such as syndecans,are the primary type present in healthy liver tissue.However,deterioration of the liver results in overproduction of other proteoglycan types.The purpose of this article is to provide a current summary of the most relevant data implicating proteoglycans in the development and progression of human and experimental liver cancer.A review of our work and other studies in the literature indicate that deterioration of liver function is accompanied by an increase in the amount of chondroitin sulfate proteoglycans.The alteration of proteoglycan composition interferes with the physiologic function of the liver on several levels.This article details and discusses the roles of syndecan-1,glypicans,agrin,perlecan,collagen XVIII/endostatin,endocan,serglycin,decorin,biglycan,asporin,fibromodulin,lumican,and versican in liver function.Specifically,glypicans,agrin,and versican play significant roles in the development of liver cancer.Conversely,the presence of decorin could potentially provide protective effects. | Kornélia Baghy Péter Tátrai Eszter Regős Ilona Kovalszky | 2016 | World Journal of Gastroenterology2016，22，1： | 8 |
| 4 | High Expression of Claudin-1 Protein in Papillary Thyroid Tumor and its Regional Lymph Node Metastasis显示文摘 | Júlia Németh Zsuzsanna Németh Péter Tátrai Ilona Péter áron Somorácz Attila Marcell Szász András Kiss Zsuzsa Schaff | 2010 | Pathology & Oncology Research2010，，1： | 1 |
| 5 | Genetic variationand genotype X environment interaction for yield and otheragronomic traits in cassava in Nigeria显示文摘 | EGESI C N ILONA P OGBE F O | 2007 | Agronomy Journal2007，99，： | 1 |
| 6 | Clinical significance of sentinel lymph node involvement in malignant melanoma显示文摘 | Gabriella Liszkay Gábor Péley István Sinkovics Ilona Péter Zsolt Orosz Zsuzsa Fej?s Béla Horváth István K?ves Katalin Gilde Miklós Kásler | 2003 | Pathology Oncology Research2003，，3： | 1 |
| 7 | Wavefront-guided photorefractive keratectomy for myopia and myopic astigmatism显示文摘 | NAGY Z Z ILONA P D EDIT K | 2002 | Journal of Refractive Surgery2002，18，5： | 1 |
| 8 | Effects of Water Activity in Model Systems on High-Pressure Inactivation of Escherichia coli显示文摘 | ILONA S TATIANA K EDUARDO P | 2009 | Food Bioprocess Technol2009，，2： | 1 |
| 9 | Modification of the properties of gelatin from skins of Baltic cod (Gadus morhua) with transglutaminase 显示文摘 | Ilona K Krzysztof K Barbara P | 2004 | Food Chemistry2004，86，： | 1 |
| 10 | Carcinoma arising in enterocutan fistulae of Crohn’s disease patients: description of two cases显示文摘 | Tamás Zágoni Zoltán Péter Ferenc Sipos Csaba Dicházi Zsolt Tarján István Dobó Ilona Kaszás Zsolt Tulassay | 2006 | International Journal of Colorectal Disease2006，，5： | 1 |
| 11 | Dynamics of Expression of the mRNA for Cytokines and Induciblenitric Synthase in A Murine Model of the Parkinson's Disease 显示文摘 | Agnieszka C Ilona J Adam P | 2003 | Aeta Neurobiol Exp(S0065- 1400)2003，63，2： | 1 |
| 12 | Moral dilemmas of nursing in end-of-life care in hungary:a personal perspective显示文摘 | Bela B Ilona P | 2005 | Nursing Ethics2005，12，1： | 1 |
| 13 | The Choice of Park and Ride Facilities: An Analysis Using a Context-dependent Hierarchical Choice Experiment 显示文摘 | Ilona D M Bos Rob E C M Van der Heijden Eric J E Molin Harry J P Timmermans | 2004 | Environment and Planning A2004，36，9： | 1 |
| 14 | Effects of water activity inmodel systems on high-pressure inactivation of Escherichia coli显示文摘 | Ilona S Tatiana K Eduardo P | 2009 | Food Bioprocess Technology2009，2，： | 1 |
| 15 | Doule-stranded RNA viruess in a mycocinogenic strain of Cystfilobasidium infrirmominiatum显示文摘 | Wladyslav I G Ilona P | 2003 | FEMS Yeast Research2003，3，： | 1 |
| 16 | Effect of soil composition on adsorption of lead as reflected by a study on a natural forest soil profile显示文摘 | Péter Sipos Tibor Németh Ilona Mohai István Dódony | 2004 | Geoderma2004，，3： | 1 |
| 17 | Rapid RP-LC method with fluorescence detection for analysis of fexofenadine in human plasma显示文摘 | LUCYNA K ALINA P ILONA O et ai | 2010 | Chromatographia2010，71，1112： | 1 |
| 18 | Heavy metal retention by soil mineral phases during a potential soil contamination by sewage sludge显示文摘 | Péter Sipos Tibor Németh Viktória Kováics Kis Ilona Mohai | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员