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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Z-BUS Loss Allocation显示文摘 | Conejo J Gliana D Ivana Kockar | 2001 | IEEE Trans on Power Systems2001，16，1： | 1 |
| 3 | Influence of the emissions trading scheme on genera- tion scheduIing显示文摘 | Ivana Kockar Antnio J Conejo James R McDonald | 2009 | Electrical Power and Energy Sys- tem2009，，： | 1 |
| 4 | incremental transmission loss allocation under pool dispatch 显示文摘 | Galiana F D Conejo A J Kockar Ivana | 2002 | IEEE Trans on Power Systems2002，17，1： | 1 |
| 5 | Influence of the emission trading scheme on generation scheduling显示文摘 | Ivana K Conejo A J James R M | 2009 | Inter- national Journal of Electrical Power and Energy Systems2009，31，9： | 1 |
| 6 | Determination of vinyl chloride monomer in food contact materials by solid phase microextraction coupled with gas Chromatography/Mass Spectrometry显示文摘 | IVANA J JAROSLAV D MICHAL V | 2003 | Czech Journal of Food Sciences2003，21，1： | 1 |
| 7 | Thermal development of microstructure and precipitation effects in Mg-10%wtGd alloy显示文摘 | JAKUB C IVAN P BOHUMIL A IVANA S RADOMIR K ZDENEK M J VIKTOR C | 2006 | Phys Star A2006，203，： | 1 |
| 8 | Xanthones and C-glucosides from the aerial parts of four species of Gentianella from Serbia and Montenegro 显示文摘 | Teodora J Dijana K Ivana A | 2005 | Biochem Syst Ecol2005，33，7： | 1 |
| 9 | Electrochemical study of corrosion behavior of graphene coatings on copper and alumi- num in a chloride solution 显示文摘 | Vesna M Ivana J Inhua J | 2014 | Carbon2014，75，： | 1 |
| 10 | Incremental Transmission Loss Allocation Under Pool Dispatch 显示文摘 | Galiana D Conejo J Ivana K | 2002 | IEEE Trans on Power Systems2002，17，1： | 1 |
| 11 | Electro- chemical study of corrosion behavior of graphene coatings on copper and aluminum in a chloride solu- tion显示文摘 | VESNA M S IVANA J INHWA J | 2014 | Carbon2014，，75： | 1 |
| 12 | Mutagenicity of Natural Anthraquinones from Rubia tinctorum in the Drosophila Wing Spot Test显示文摘 | Frantisek M Ivana K Alexandr J | 2001 | Planta Med2001，67，： | 1 |
| 13 | Mutagenicity of natural anthraquinones from Rubia tinctorum in the Drosophila Wing Spot Test显示文摘 | M Frantisek K Ivana J Alexandr | 2001 | Planta Med2001，67，： | 1 |
| 14 | Precise assessment of noncompliance with the antihypertensive therapy in patients with resistant hypertension using toxicological serum analysis显示文摘 | Branislav ?trauch Ond?ej Petrák Tomá? Zelinka Ján Rosa Zuzana ?omlóová Tomá? Indra Luká? Chytil Věra Mare?ová Ivana Kurcová Robert Holaj Dan Wichterle Ji?í Widimsky | 2013 | Journal of Hypertension2013，，12： | 1 |
| 15 | Current state of mineral nutrition and risk elements in a beech ecosystem situated near the aluminium smelter in Ziar nad hronom, central slovakia显示文摘 | GABRIELA J KATARiNA B IVANA H | 2007 | Forest Ecology and Management2007，248，： | 1 |
| 16 | Spontaneous tendon ruptures in patients with end-stage renal discasc显示文摘 | Nikolina B J Ivana J Sanjian R | 2009 | Kidney Blood Pressres2009，32，1： | 1 |
| 17 | Inhibition properties of self-assembled corrosion inhibitor talloil diethylenetriamine imidazoline for mild steel corrosion in chloride solution saturated with carbon dioxide显示文摘 | Ivana J Marc S Srdan N | 2013 | Corros Sci2013，77，： | 1 |
| 18 | Determination of bisphenol a, bisphenol f, bisphenol a diglycidyl ether and bisphenol F diglycidyl ether migrated from food cans using gas chromatography-mass spectrometry显示文摘 | IVANA J IAROSLAV D MICHAL V | 2003 | Czech J Food Sci2003，21，3： | 1 |
| 19 | The Impact of Peak Oil on Tourism in Spain: An Input-Output Analysis of Price, Demand and Economy-Wide Effects 显示文摘 | IVANA L BERGH V D JEROEN C J M | 2013 | Energy2013，54，2： | 1 |
| 20 | Invisaligntreatment in the anterior region Were the predicted tooth movements achieved?显示文摘 | Elena K Jrg S Ivana M | 2012 | J Orofac Orthop2012，，73： | 1 |
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