|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)has become the most common liver disorder in Western countries and is increasingly being recognized in developing nations.Fatty liver disease encompasses a spectrum of hepatic pathology,ranging from simple steatosis to non-alcoholic steatohepatitis,cirrhosis,hepatocellular carcinoma and end-stage liver disease.Moreover,NAFLD is often associated with other metabolic conditions,such as diabetes mellitus type 2,dyslipidemia and visceral obesity.The most recent guidelines suggest the management and treatment of patients with NAFLD considering both the liver disease and the associated metabolic co-morbidities.Diet and physical exercise are considered the first line of treatment for patients with NAFLD,but their results on therapeutic efficacy are often contrasting.Behavior therapy is necessary most of the time to achieve a sufficient result.Pharmacological therapy includes a wide variety of classes of molecules with different therapeutic targets and,often,little evidence supporting the real efficacy.Despite the abundance of clinical trials,NAFLD therapy remains a challenge for the scientific community,and there are no licensed therapies for NAFLD.Urgently,new pharmacological approaches are needed.Here,we will focus on the challenges facing actual therapeutic strategies and the most recent investigated molecules. | Alessandro Federico Claudio Zulli Ilario de Sio Anna Del Prete Marcello Dallio Mario Masarone Carmela Loguercio | 2014 | World Journal of Gastroenterology2014，20，45： | 10 |
| 2 | Black soldier fly and gut health in broiler chickens:insights into the relationship between cecal microbiota and intestinal mucin composition显示文摘Background:The relationship between diet and intestinal microbiota and mucin composition appears to be fundamental for poultry gut health.The effects of insect meal(whose role as alternative feed ingredient is now well recognized)on gut microbiota and mucin composition have recently been reported in Tenebrio molitor-fed free-range and broiler chickens,but no data are currently available for Hermetia illucens(HI)-fed broilers.The present study evaluated the effects of dietary HI meal inclusion on cecal microbiota and intestinal mucin composition of broiler chickens.Results:A total of 256 male broiler chickens were allotted to 4 dietary treatments(control diet[C]and 5%,10%and 15%HI meal inclusion,with 8 replicate pens/treatment and 8 birds/pen)and slaughtered at 35 d of age(2 animals/pen,16 birds/diet).The cecal microbiota assessment by 16S rRNA amplicon based sequencing showed lower alpha diversity in HI15 chickens(Shannon,P<0.05)and higher beta diversity(Adonis and ANOSIM,P<0.001)in birds fed HI diets than C.Furthermore,HI15 birds displayed significant increase of the relative abundance of Proteobacteria phylum(False Discovery Rate[FDR]<0.05)when compared to HI10.L-Ruminococcus(Ruminococcus from Lachnospiraceae family),Faecalibacterium,Blautia and Clostridium genera were found to be characteristic of HI5 cecal microbiota(FDR<0.05),while broiler chickens fed HI10 and HI15 diets were characterized(FDR<0.05)by Lactobacillus and Ruminococcus(HI10)and Bacteroides,Roseburia and Helicobacter genera(HI15).Periodic-acid Schiff,Alcian Blue pH 2.5 and high iron diamine staining on small and large intestine also demonstrated lower mucin staining intensity in the intestinal villi of HI10 and HI15 birds than C(P<0.05).Conclusions:Dietary HI meal utilization at low inclusion levels(i.e.,5%)positively influenced either the cecal microbiota or the gut mucin dynamics in terms of selection of potentially beneficial bacteria and increase in villi mucins.However,high inclusion levels(in particular the 15%)may have a negative influence in terms of partial reduction of microbial complexity,reduction of potentially beneficial bacteria,selection of bacteria with mucolytic activity and decrease in villi mucins. | Ilaria Biasato Ilario Ferrocino Sihem Dabbou Rocchina Evangelista Francesco Gai Laura Gasco Luca Cocolin Maria Teresa Capucchio Achille Schiavone | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 4 |
| 3 | Safety and efficacy of sorafenib in patients with advanced hepatocellularcarcinoma and Child-Pugh A or B cirrhosis显示文摘 | Alessandro Federico Michele Orditura Gaetano Cotticelli Ilario De Sio Marco Romano Antonietta Gravina Marcello Dallio Alessio Fabozzi Fortunato Ciardiello Carmela Loguercio Ferdinando De Vita | 2015 | Oncology Letters2015，，4： | 2 |
| 4 | Liver failure in an obese middle-aged woman after biliointestinal bypass显示文摘Obesity is considered an emerging epidemic that is often associated with non-alcoholic fatty liver disease. Among the therapeutic options for morbid obesity, bariatric surgery plays an important role when conventional therapies fail. The effects of bariatric surgery on liver function and morphology are controversial in the literature. Liver failure has been reported after jejunoileal bypass(JIB), biliopancreatic diversion and gastric bypass. Biliointestinal bypass(BIB) is considered an effective procedure among recently introduced bariatric surgery techniques. It is a clinically safe, purely malabsorptive operation in which the blind intestinal loop of the JIB is anastomosed to the gallbladder, allowing a portion of bile to transit into excluded intestinal tract. BIB is the only procedure, to our knowledge, to have no liver side effects reported in the literature. We report the case of a young obese woman who developed liver failure 8 mo after BIB. She had a rapid weight loss(70 kg) with a reduction in body mass index of 41% from January to September 2012. Because of a severe hepatic decompensation, she was referred to a transplantation centre. We strongly believe that the most important pathogenetic mechanism involved in the development of liver injury is the rapid weight loss that produced a signif icant fatty liver inf iltration. | Dolores Sgambato Gaetano Cotticelli Ilario de Sio Annalisa Funaro Anna Del Prete Chiara de Sio Lorenzo Romano Alessandro Federico Antonietta Gravina Agnese Miranda Carmelina Loguercio Marco Romano | 2013 | World Journal of Clinical Cases2013，1，1： | 1 |
| 5 | CT colonography after incomplete colonoscopy in subjects with positive faecal occult blood test显示文摘AIM: To report our experience with computed tomog- raphy colonography (CTC) systematically performed in subjects with positive faecal occult blood test (FOBT) and an incomplete colonoscopy in the setting of a population-based screening for colorectal cancer (CRC). METHODS: From April 2006 to April 2007, 43 290 indi- viduals (age range 50-70) who adhered to the regional screening program for the prevention of CRC under-went immunochemical FOBT. FOBT was positive in 1882 subjects (4.3%). 1463 (77.7%) of these subjects underwent colonoscopy, 903 performed in a single center. Of 903 colonoscopies 65 (7.2%) were incom- plete. Forty-two of these subjects underwent CTC. CTC was performed with a 16-MDCT scanner after standard bowel prep (polyethyleneglycole) in both supine and prone position. Subjects whose CTC showed polyps or masses were referred to the endoscopist for repeat colonoscopy under sedation or underwent surgery. Per-lesion and per-segment positive predictive values (PPV) were calculated. RESULTS: Twenty-one (50%) of 42 CTCs showed pol-yps or masses. Fifty-five of these subjects underwent a repeat colonoscopy, whereas 2 subjects underwentsurgery for colonic masses of indeterminate nature. Four subjects refused further examinations. CTC cor- rectly identified 2 colonic masses and 20 polyps. PPV for masses or polyps greater than 9 mm was of 87.5%. Per-lesion and per-segment PPV were, respectively, 83.3% and 83.3% for polyps greater or equal to 10 mm, and 77.8% and 85.7% for polyps of 6-9 mm. CONCLUSION: In the context of a screening program for CRC based on FOBT, CTC shows high per-segment and per-lesion PPV for colonic masses and polyps greater than 9 mm. Therefore, CTC has the potential to become a useful technique for evaluation of the non visualized part of the colon after incomplete colonos-copy. | Lapo Sali Massimo Falchini Andrea Giovanni Bonanomi Guido Castiglione Stefano Ciatto Paola Mantellini Francesco Mungai Ilario Menchi Natale Villari Mario Mascalchi | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 6 | The effectiveness of continuing education in postoperative pain management:Results from a follow-up study显示文摘 | Ilario G Renato T Francesca F | 2008 | The Journal of Continuing Education in Nursing2008，39，6： | 1 |
| 7 | Diagnosis of chronic liver disease: reproducibility and validation of liver biopsy显示文摘 | Marcello Persico Bruno Palmentieri Raffaela Vecchione Roberto Torella Ilario de Sio | 2002 | The American Journal of Gastroenterology2002，，2： | 1 |
| 8 | Topology optimization for hybrid optical/wireless access networks显示文摘 | Ilario Filippini Matteo Cesana | 2009 | Ad Hoc Networks2009，，6： | 1 |
| 9 | Water state effect on drug release from an antibiotic loaded polyurethane matrix containing albumin nanoparticles 显示文摘 | MARTINELLI A D'ILARIO L IOLANDA F | 2011 | Int J Pharm2011，407，12： | 1 |
| 10 | Polyurethane anionomers containing metal ions with antimicrobial properties: Thermal, mechanical and biological characterization 显示文摘 | Francolini I D'Ilario L Guaglianone E | 2010 | Acta Biomaterialia2010，6，9： | 1 |
| 11 | Potential energy calculations of ethylene- butadiene copolymers显示文摘 | Cernia E Conte G D'Ilario L | 1975 | J Polym Sci Polym Chem1975，13，1： | 1 |
| 12 | Physicochemical study of crystals of ethylene - butadiene eopolymers显示文摘 | Cernia E Conte G D'Ilario L | 1978 | J Polym Sci Polym Chem1978，16，1： | 1 |
| 13 | Molecularly imprinted electrosynthesized polymers:New materials for biomimetic sensors显示文摘 | Cosimino Malitesta Ilario Losito Pier Giorgio Zambonin | 1999 | Analytical Chemistry1999，71，7： | 1 |
| 14 | An In- formation Integrati - on Framework for E - Commerce 显示文摘 | Ilario Benetti Domenico Beneventano Sonia Bergamasehi | 2002 | IEEE Intelligent Systems2002，17，1： | 1 |
| 15 | Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ?3<ce:hsp sp='0.25'/>cm. Results of a multicenter Italian survey<!-- Doctopic: CAN -->显示文摘 | Maurizio Pompili Antonio Saviano Nicoletta de Matthaeis Alessandro Cucchetti Francesco Ardito Bruno Federico Franco Brunello Antonio D. Pinna Antonio Giorgio Stefano M. Giulini Ilario De Sio Guido Torzilli Fabio Fornari Lorenzo Capussotti Alfredo Guglielm | 2013 | Journal of Hepatology2013，，1： | 1 |
| 16 | Development of spoilage microbiota in beef stored in nisin activated packaging显示文摘 | Danilo Ercolini Ilario Ferrocino Antonietta La Storia Gianluigi Mauriello Sergio Gigli Paolo Masi Francesco Villani | 2009 | Food Microbiology2009，，1： | 1 |
| 17 | Effects of dietary Hermetia illucens meal inclusion on cecal microbiota and small intestinal mucin dynamics and infiltration with immune cells of weaned piglets显示文摘Background: The constant interaction between diet and intestinal barrier has a crucial role in determining gut health in pigs. Hermetia illucens(HI) meal(that represents a promising, alternative feed ingredient for production animals) has recently been demonstrated to influence colonic microbiota, bacterial metabolite profile and mucosal immune status of pigs, but no data about modulation of gut mucin dynamics are currently available. The present study evaluated the effects of dietary HI meal inclusion on the small intestinal mucin composition of piglets, as well as providing insights into the cecal microbiota and the mucosal infiltration with immune cells.Results: A total of 48 weaned piglets were randomly allotted to 3 dietary treatments(control diet [C] and 5% or10% HI meal inclusion [HI5 and HI10], with 4 replicate boxes/treatment and 4 animals/box) and slaughtered after61 days of trial(3 animals/box, 12 piglets/diet). The cecal microbiota assessment by 16 S r RNA amplicon based sequencing showed higher beta diversity in the piglets fed the HI-based diets than the C(P < 0.001). Furthermore,the HI-fed animals showed increased abundance of Blautia, Chlamydia, Coprococcus, Eubacterium, Prevotella,Roseburia, unclassified members of Ruminococcaceae, Ruminococcus and Staphylococcus when compared to the C group(FDR < 0.05). The gut of the piglets fed the HI-based diets showed greater neutral mucin percentage than the C(P < 0.05), with the intestinal neutral mucins of the HI-fed animals being also higher than the sialomucins and the sulfomucins found in the gut of the C group(P < 0.05). Furthermore, the piglets fed the HI-based diets displayed lower histological scores in the jejunum than the other gut segments(ileum [HI5] or ileum and duodenum [HI10], P < 0.05).Conclusions: Dietary HI meal utilization positively influenced the cecal microbiota and the small intestinal mucin dynamics of the piglets in terms of selection of potentially beneficial bacteria and preservation of mature mucin secretory architecture, without determining the development of gut inflammation. These findings further confirm the suitability of including insect meal in swine diets. | Ilaria Biasato Ilario Ferrocino Elena Colombino Francesco Gai Achille Schiavone Luca Cocolin Valeria Vincenti Maria Teresa Capucchio Laura Gasco | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 1 |
| 18 | Dried fruit pomace inclusion in poultry diet:growth performance, intestinal morphology and physiology显示文摘Background: Fruit pomaces are by-products rich in polyphenol compounds and dietary fiber. They seem to play an important role in regulating the gut microbiota, morphology and physiology. The aim of this study was to assess whether apple(A), blackurrant(B) or strawberry(S) pomaces could be suitable ingredients in broiler diets and their effect on gut health. A total of 480 male broilers were randomly allotted to 8 dietary treatments with lower(3%-L) or higher(6%-H) dietary fiber content: two control groups(CL/CH), two A diets(AL/AH), two B diets(BL/BH), two S diets(SL/SH). Diet and fruit pomaces were chemically analyzed to assess polyphenol concentration and fibre fraction content. After the evaluation of growth performance, 6 birds/group were slaughtered at 35 days of age. Morphometric and histopathological investigations were performed on duodenum, jejunum and ileum.Excreta were collected to perform microbiota evaluation by 16 S DNA sequencing. Weight, viscosity, enzymatic activity, short chain fatty acid(SCFAs) and ammonia concentration were determined in ileum and/or ceca content.Results: A pomace and A diets showed the lowest polyphenol content and the highest content of soluble fibre fraction. No significant differences were observed for growth performance, gut morphometry and histopathology(P > 0.05). Dietary fruit pomace inclusion increased the weight of ileum and ceca and the ileum digesta viscosity(P < 0.05). In the ileum, A and S groups showed lower bacterial α-glucosidase activity than C groups. Moreover,small intestine SCFAs concentration was higher in fruit pomaces diets(P < 0.05). In ceca, B and S groups showed lower ammonia concentration and higher SCFAs than C. Dietary treatments also influenced the activity of α-glucosidase, α-galactosidase, β-galactosidase β-glucuronidase and xylase. Regarding microbiota, at phylum level,Firmicutes were differentially abundant across treatment(maximum for C and minimum in S, FDR > 0.05). At genus level, an increase of Weissella in AH and Erwinia in S/B diets, as well as a decrease of Lactobacillus in all fruit pomace groups were recorded(P < 0.05).Conclusions: Fruit pomaces could be suitable ingredients in poultry nutrition even if further studies are needed to better understand which doses is more recommended to avoid negative effects on gut microbiota. | Elena Colombino Ilario Ferrocino Ilaria Biasato Luca Simone Cocolin Daniel Prieto-Botella Zenon Zduńczyk Jan Jankowski Joanna Milala Monika Kosmala Bartosz Fotschki Maria Teresa Capucchio Jerzy Juśkiewicz | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 1 |
| 19 | Glipizide treatment with short-term alcohol abuse resulting in subfulminant hepatic failure显示文摘 | ILARIO MJM TURYAN HV AXIOTIS CA | 2003 | Virchows Arch2003，443，1： | 1 |
| 20 | An In- formation Integrati - on Framework for E - Commerce 显示文摘 | Ilario Benetti Domenico Beneventano Sonia Bergamaschi | 2002 | IEEE Intelligent Systems2002，17，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员